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The map label for this gene is virB6 [H]

Identifier: 110834933

GI number: 110834933

Start: 2357553

End: 2358485

Strand: Direct

Name: virB6 [H]

Synonym: ABO_2072

Alternate gene names: 110834933

Gene position: 2357553-2358485 (Clockwise)

Preceding gene: 110834932

Following gene: 110834934

Centisome position: 75.56

GC content: 57.02

Gene sequence:

>933_bases
ATGTCCACCATCGCCAGCATGCACGCCCTTCTGGTCACTGACATTGTCACCGCCGTTTCCGGTCTGGCCCAGCAGACCAT
GGGTTGGTTACGCCCCATCTTTATCAACCTGGTGGTGATCTATCTGGCCCTGACCGGCTACGCGCTGTGGGCGGGCAAGA
TAGAGATACCACTCAATGAGTTGATATCGAGGCTGATTCGTATCGCGGCGGTATCCACCTTCGCCCTGACCTGGAGCATC
TACAGCGACCACATCATCGACATTGCCTTCCATGGGCCCGATGAAGTCCTTAGCGGCATCACCGGCTCTGGCAACGATGC
CATCAATGCCCTTGACGGGCTCTGGGAACGCATCACCGACACCTCCGAGGAGAAGTTCGACGAAAACAGCGGCATGAGTA
TCAGCCAGGCTCTGGAGAACAAGATCCTGGGGGTCATGCTCAGCATCACCGGTTGGCTGATTTGCTTCCCGGCTTTTCTG
ATCATCGTGGCTAGTCAGCTTGTCAGCGCCCTACTGATCATCATTGGCCCCATCTTCATTGTGGCCTCGCTCTTTCGCAG
AAGCAGTAGATATACGGAGGCCTGGGTCAATCAGCTTCTCACCTACTTCATGCTGTATGTCTTGATCATTCTCGTAGAGC
ACTTGGCGGCAGAAATCTTCGAGCAGATGCATCTGCGCCTGGAGAACAAGGCCGCGCTGGCTCAGCTTGGCTTTATCTCC
GAGATGCTGTTGGTCGGCCTGATCATGATGGGCGTCTCACTGATGACACCCTTCCTGGCCGGTGGCCTGGTTGGCGTTAC
CGCACCCGGCATCCAGAACGCCCTGCGTTTTATACCCGGGCCAGGCATGTTGCGACACCTGAACCCCAGCACACCCTCCC
CGCGACCGGGTGGCCCAGGCGGCAGCGGGTATCTCAAAAAGTGGAACAAATGA

Upstream 100 bases:

>100_bases
GGAGCTGGGCCTGGGCTATGAAGAGGCCAAGAAACTCGGCCTGGGCGACCGCTATCAACCCAAAGTCCGGCACCGGCTGT
TTGAGTAAGGGAGAGAGGTC

Downstream 100 bases:

>100_bases
TGACGAAACCCGAATTCGCTCTATGGCTGAGACGATTCCGCACCGGCTGCTGGATGGTCTTCGGTGTGGCAACGCTCGTA
TTCGCCGTGACCAGTTTTAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSTIASMHALLVTDIVTAVSGLAQQTMGWLRPIFINLVVIYLALTGYALWAGKIEIPLNELISRLIRIAAVSTFALTWSI
YSDHIIDIAFHGPDEVLSGITGSGNDAINALDGLWERITDTSEEKFDENSGMSISQALENKILGVMLSITGWLICFPAFL
IIVASQLVSALLIIIGPIFIVASLFRRSSRYTEAWVNQLLTYFMLYVLIILVEHLAAEIFEQMHLRLENKAALAQLGFIS
EMLLVGLIMMGVSLMTPFLAGGLVGVTAPGIQNALRFIPGPGMLRHLNPSTPSPRPGGPGGSGYLKKWNK

Sequences:

>Translated_310_residues
MSTIASMHALLVTDIVTAVSGLAQQTMGWLRPIFINLVVIYLALTGYALWAGKIEIPLNELISRLIRIAAVSTFALTWSI
YSDHIIDIAFHGPDEVLSGITGSGNDAINALDGLWERITDTSEEKFDENSGMSISQALENKILGVMLSITGWLICFPAFL
IIVASQLVSALLIIIGPIFIVASLFRRSSRYTEAWVNQLLTYFMLYVLIILVEHLAAEIFEQMHLRLENKAALAQLGFIS
EMLLVGLIMMGVSLMTPFLAGGLVGVTAPGIQNALRFIPGPGMLRHLNPSTPSPRPGGPGGSGYLKKWNK
>Mature_309_residues
STIASMHALLVTDIVTAVSGLAQQTMGWLRPIFINLVVIYLALTGYALWAGKIEIPLNELISRLIRIAAVSTFALTWSIY
SDHIIDIAFHGPDEVLSGITGSGNDAINALDGLWERITDTSEEKFDENSGMSISQALENKILGVMLSITGWLICFPAFLI
IVASQLVSALLIIIGPIFIVASLFRRSSRYTEAWVNQLLTYFMLYVLIILVEHLAAEIFEQMHLRLENKAALAQLGFISE
MLLVGLIMMGVSLMTPFLAGGLVGVTAPGIQNALRFIPGPGMLRHLNPSTPSPRPGGPGGSGYLKKWNK

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG3704

COG function: function code U; Type IV secretory pathway, VirB6 components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbL/virB6 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007688 [H]

Pfam domain/function: PF04610 TrbL [H]

EC number: NA

Molecular weight: Translated: 33752; Mature: 33621

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIASMHALLVTDIVTAVSGLAQQTMGWLRPIFINLVVIYLALTGYALWAGKIEIPLNE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LISRLIRIAAVSTFALTWSIYSDHIIDIAFHGPDEVLSGITGSGNDAINALDGLWERITD
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHHCC
TSEEKFDENSGMSISQALENKILGVMLSITGWLICFPAFLIIVASQLVSALLIIIGPIFI
CCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VASLFRRSSRYTEAWVNQLLTYFMLYVLIILVEHLAAEIFEQMHLRLENKAALAQLGFIS
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMLLVGLIMMGVSLMTPFLAGGLVGVTAPGIQNALRFIPGPGMLRHLNPSTPSPRPGGPG
HHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GSGYLKKWNK
CCCCCCCCCC
>Mature Secondary Structure 
STIASMHALLVTDIVTAVSGLAQQTMGWLRPIFINLVVIYLALTGYALWAGKIEIPLNE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LISRLIRIAAVSTFALTWSIYSDHIIDIAFHGPDEVLSGITGSGNDAINALDGLWERITD
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHHCC
TSEEKFDENSGMSISQALENKILGVMLSITGWLICFPAFLIIVASQLVSALLIIIGPIFI
CCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VASLFRRSSRYTEAWVNQLLTYFMLYVLIILVEHLAAEIFEQMHLRLENKAALAQLGFIS
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMLLVGLIMMGVSLMTPFLAGGLVGVTAPGIQNALRFIPGPGMLRHLNPSTPSPRPGGPG
HHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GSGYLKKWNK
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]