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The map label for this gene is ghrA [H]

Identifier: 110636403

GI number: 110636403

Start: 4388007

End: 4388963

Strand: Reverse

Name: ghrA [H]

Synonym: Meso_4079

Alternate gene names: 110636403

Gene position: 4388963-4388007 (Counterclockwise)

Preceding gene: 110636404

Following gene: 110636402

Centisome position: 99.47

GC content: 63.11

Gene sequence:

>957_bases
ATGCCAGAAAAGCCGGCCTCCAGCCGCATCCTGCTTTCCGTCACGGGCATGTACCCGCGGCGTTGGCACGACGCGCTTTC
CAAGGCAAGGACCGTAGTGCTGGAGCCTGACGGCGAAGCAGACCCGACGATCGAATATGCGGTGGTGTGGAAGCAGAAGC
GCGGCGTCTTGAACGGGCTTCCCAACCTAAAACTGATCTTCTCGGCGGGAGCCGGCGTCGACCACCTGCTCGCCGATCCC
GAACTGCCGGCGGGTGTGCCCATCGTGCGCGTGGTGGCAGAAAACCTCACGCAACACATGGTCGAATATGTCTGTTGGCG
CGTGCTCGACCACCACCGGCAGGGCATGACCTACCGGGTGCAGCAGGTTCAGAAGGTCTGGCACGAGCCGCTCCAGCCGC
CGGCAAATGAAGTGGCCGTTGGTATCATGGGCCTTGGCGAACTTGGGAGCGCCGCGGCAAGGGCGCTTCTTTCGCTAGGC
TTCAAGGTGAACGGCTGGAGCCGGCGCGAAAAGCGCGTCGAGGGTGTTTCCACCTTTTATGGGGAAGCCGCGCTAACCCC
GTTCCTCAACGCCACGGACATCCTTGTCGTGCTCCTGCCGCTCACCGGGGCAACTGAGGGCATCATCGATTTTTCCGTGC
TCGACAGGTTGAGGAAGGACGGGCCGCTCGGCGGCCCCTGCCTTATCAATGCAGGGCGCGGGCAGTTGCAGAAGGAAGCG
GATATTTTGCGGGCGCTCGACCAGGGCGTGCTCAAGGAGGCGAGCCTGGACGTGTTCGAGCAGGAGCCGCTCGACCCTAA
AAGCCCGCTCTGGACGCATCCAAAAGTGTTCGTCACGCCGCATGCTGCGGCAACATCCGATCCCGCGCATCTGGTGCCGC
TGATGCTTGAGCAGATGGACGCCTTCGAGCGTGGCGAGCCGCTGAAGAACCTGGTGGACCGCGAAGCGGGCTATTGA

Upstream 100 bases:

>100_bases
ACACGCCAAAAACCGACTACACCAAAGCACTGATCGCCGCCGCCTTCGACATTGCGACGGCTCCCACAGGTGTCGTCAGC
GATTAGTGAGGGGGGGAATG

Downstream 100 bases:

>100_bases
GGCGCCCACTCCGATCGGCTTCCGGGATCGGCTCTTGGTTTGCGTGGTCCCGGCACATCATTTACGATAGCGGCTGAATG
CCGCAGAGAGCGATGGGAAC

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MPEKPASSRILLSVTGMYPRRWHDALSKARTVVLEPDGEADPTIEYAVVWKQKRGVLNGLPNLKLIFSAGAGVDHLLADP
ELPAGVPIVRVVAENLTQHMVEYVCWRVLDHHRQGMTYRVQQVQKVWHEPLQPPANEVAVGIMGLGELGSAAARALLSLG
FKVNGWSRREKRVEGVSTFYGEAALTPFLNATDILVVLLPLTGATEGIIDFSVLDRLRKDGPLGGPCLINAGRGQLQKEA
DILRALDQGVLKEASLDVFEQEPLDPKSPLWTHPKVFVTPHAAATSDPAHLVPLMLEQMDAFERGEPLKNLVDREAGY

Sequences:

>Translated_318_residues
MPEKPASSRILLSVTGMYPRRWHDALSKARTVVLEPDGEADPTIEYAVVWKQKRGVLNGLPNLKLIFSAGAGVDHLLADP
ELPAGVPIVRVVAENLTQHMVEYVCWRVLDHHRQGMTYRVQQVQKVWHEPLQPPANEVAVGIMGLGELGSAAARALLSLG
FKVNGWSRREKRVEGVSTFYGEAALTPFLNATDILVVLLPLTGATEGIIDFSVLDRLRKDGPLGGPCLINAGRGQLQKEA
DILRALDQGVLKEASLDVFEQEPLDPKSPLWTHPKVFVTPHAAATSDPAHLVPLMLEQMDAFERGEPLKNLVDREAGY
>Mature_317_residues
PEKPASSRILLSVTGMYPRRWHDALSKARTVVLEPDGEADPTIEYAVVWKQKRGVLNGLPNLKLIFSAGAGVDHLLADPE
LPAGVPIVRVVAENLTQHMVEYVCWRVLDHHRQGMTYRVQQVQKVWHEPLQPPANEVAVGIMGLGELGSAAARALLSLGF
KVNGWSRREKRVEGVSTFYGEAALTPFLNATDILVVLLPLTGATEGIIDFSVLDRLRKDGPLGGPCLINAGRGQLQKEAD
ILRALDQGVLKEASLDVFEQEPLDPKSPLWTHPKVFVTPHAAATSDPAHLVPLMLEQMDAFERGEPLKNLVDREAGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=256, Percent_Identity=29.6875, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI23308577, Length=237, Percent_Identity=25.3164556962025, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081824, Length=305, Percent_Identity=38.6885245901639, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87082289, Length=149, Percent_Identity=31.5436241610738, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=231, Percent_Identity=28.1385281385281, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28574286, Length=251, Percent_Identity=25.0996015936255, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34898; Mature: 34766

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEKPASSRILLSVTGMYPRRWHDALSKARTVVLEPDGEADPTIEYAVVWKQKRGVLNGL
CCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEECCCCCCCCCEEEEEEEHHHCHHHHCC
PNLKLIFSAGAGVDHLLADPELPAGVPIVRVVAENLTQHMVEYVCWRVLDHHRQGMTYRV
CCEEEEEECCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QQVQKVWHEPLQPPANEVAVGIMGLGELGSAAARALLSLGFKVNGWSRREKRVEGVSTFY
HHHHHHHHCCCCCCHHHHEEHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
GEAALTPFLNATDILVVLLPLTGATEGIIDFSVLDRLRKDGPLGGPCLINAGRGQLQKEA
CCHHHCCCCCHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHH
DILRALDQGVLKEASLDVFEQEPLDPKSPLWTHPKVFVTPHAAATSDPAHLVPLMLEQMD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHH
AFERGEPLKNLVDREAGY
HHHCCCHHHHHHHHCCCC
>Mature Secondary Structure 
PEKPASSRILLSVTGMYPRRWHDALSKARTVVLEPDGEADPTIEYAVVWKQKRGVLNGL
CCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEECCCCCCCCCEEEEEEEHHHCHHHHCC
PNLKLIFSAGAGVDHLLADPELPAGVPIVRVVAENLTQHMVEYVCWRVLDHHRQGMTYRV
CCEEEEEECCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QQVQKVWHEPLQPPANEVAVGIMGLGELGSAAARALLSLGFKVNGWSRREKRVEGVSTFY
HHHHHHHHCCCCCCHHHHEEHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
GEAALTPFLNATDILVVLLPLTGATEGIIDFSVLDRLRKDGPLGGPCLINAGRGQLQKEA
CCHHHCCCCCHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHH
DILRALDQGVLKEASLDVFEQEPLDPKSPLWTHPKVFVTPHAAATSDPAHLVPLMLEQMD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHH
AFERGEPLKNLVDREAGY
HHHCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA