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The map label for this gene is tme [H]

Identifier: 110636354

GI number: 110636354

Start: 4333315

End: 4335600

Strand: Reverse

Name: tme [H]

Synonym: Meso_4030

Alternate gene names: 110636354

Gene position: 4335600-4333315 (Counterclockwise)

Preceding gene: 110636356

Following gene: 110636353

Centisome position: 98.26

GC content: 63.08

Gene sequence:

>2286_bases
ATGGCCGAAGCTGAAAAGAACGACAGGGTGGGCCCCTCGGTGAGTGCGCAGGAAGCGCTTGAATTCCACGCCATGGGGCG
ACCCGGAAAGCTGGAAATCACTCCGACCAAGCCGATGGCGACGCAGCGCGACCTGTCGCTCGCCTATTCCCCCGGCGTGG
CCGTGCCTGTCAAGGCCATCGCGGAGGATCCGGCTCGCGCCTTCGATTACACGACACGCGGCAATCTCGTCGCCGTCATT
TCCAACGGCACAGCCATTCTCGGCCTCGGCAATCTGGGCGCATTGGCCTCCAAGCCGGTCATGGAAGGCAAGGCTGTGCT
CTTCAAGCGCTTCGCCGACGTGGATTCAATCGACCTTGAGGTGGAGACGGAGGACGCAGACGAGTTCGTCAATTGCGTCA
AGCTGCTCGGTCCCTCCTTTGGGGGCATCAACCTCGAGGACATCAAGGCGCCGGAATGCTTCATCATCGAGACGCGCCTG
CGCGAGCTCATGGACATCCCGGTCTTCCACGACGACCAGCACGGCACGGCCATCATAGCCGTCGCCGGCCTCATCAACGC
CCTGGATCTCACCGGCCGTGACATGAAGACGACGAAGCTCGTCTGCAACGGCGCGGGAGCAGCCGGCATTGCCTGCATCG
AGCTTGCCAAGGCGATCGGCTTTGCGCCGGGGAACATCCTCCTCTGCGACACGAAGGGCGTGGTCTACAAGGGCCGCACG
GAGGGCATGAACCAGTGGAAGTCGGCCCACGCCGTGGAAACCGACAAGCGCACGCTGGCCGAGGCACTTGACGGGGCGGA
TGTCTTTTTCGGCCTTTCGGCCAAGGGGGCGCTCACGCCCGCCATGGTTCAATCCCTGGCCAAAAACCCCATCATTTTCG
CCATGGCCAATCCCGACCCGGAGATCACTCCGGAGGAGGTGGCCGAGATTCGCACGGACGCCATCATGGCGACGGGCCGG
TCGGACTACCCGAACCAGGTCAACAATGTGCTTGGTTTTCCCTATATTTTCCGCGGCGCTCTCGATGTGCGCGCCACGAC
CATCAACGACGCGATGAAGGTGGCGGCAGCCGAGGCGCTCGCGGCTCTCGCACGGCAGGACGTGCCGGATGATGTGGCCG
CCGCCTATCAGGGAAACCGGCCGAAATACGGGCCGAACTACATCATTCCCGTGCCCTTCGACCCGCGGCTCATCACGGCG
GTCCCGGTGGCCGTCGCAAAGGCGGCGATGGATTCGGGCGTTGCGCGGCGGCCTATCCTCAACCTGGAGCGCTACGAGCA
GGAGCTTTCCGCCCGCAGGGACCCGATCGCCTCGACGCTGCAGCGCATCTATGACCGCGTGCGCCGCCAACCCAAACGCA
TCGTCTTTGCCGAAGGGGAGGAGGAGCAGGTGATGCGCGCGGCGGTCTCCTATGTGAACCAGCGGCTCGGCACGGCGATC
CTGCTGGGGCGCGAGGAGCGCATCCGCGAGACGGCAGTAAATGCGGGAGTCGATCTCGCCCGATCCGGAATCGAGATCAT
CAATGCCAGGCTCTCCCGCCGCAACGGCATTTACGCAGACTATCTTTATGAGCGCCTGCAACGGAAAGGCTATCTTTTCC
GCGACTGCCAGCGGCTCATTAACAACGACCGCAACCACTTTGCTGCCTGCATGGTGGCGCTTGGCGATGCCGACGGCATG
GTGACGGGCGTGACGCGAAACTATTCCACGGCATTGGACGACGTGCGCCGCGTCATTGATGCAAAACCCGGCCACCGGGT
GATCGGTGCTTCCATCGTGCTGGCGCGCGGACGCACCGTCATCGTCGCGGATACCGCCGTGCACGACATGCCGGATGCAC
AACAGATCGCCGACATTGCCGAGGAATCGGCAAATTTTGCCCGTCGCATGGGTTACGAGCCGCGCGTGGCGATGCTCGCC
TATTCCACCTTCGGGCATCCCGCCGGCGAACGATCCGAACGCATCCAGGAAACGGTGAAGATTCTCGACAAGCGGCGCGT
GGATTTCGAGTATGACGGCGAGATGGCCGCCGATGTGGCGCTTAATCCGCAGATCATGCAGCAATATCCGTTCTGCCGCC
TTTCCGGGCCCGCGAATGTACTGGTGATGCCGGCATTCCACTCCGCGTCGATCTCGACCAAGATGCTGCAGGAGCTGGGT
GGTTCCACGGTGATAGGTCCGCTGCTGGTGGGCCTCAACAAGCCGGTGCAGATCGTTTCGCTCAATGCGAAGGACTCAGA
CATCGTGAACATGGCCGCGGTTGCGGCCTACACAGCGGGCGGATGA

Upstream 100 bases:

>100_bases
GGAAAAAAATCTGGTGGCCCATTTACCTACCGCAAATGTGGCCTTATGCACCCGTGTTCGGCAGAACTCCACAAGAAGCC
GACGGGAGAGGCGGATTTAA

Downstream 100 bases:

>100_bases
GCGCGGCGGTTTCTCTGGAACATCGCGCCACATAGGCTGTTTTCAACGGCAGCGGCGACAATGGTCGCGGCGTGCCAACG
GAAGCAGGTTTCCCGCGATG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 761; Mature: 760

Protein sequence:

>761_residues
MAEAEKNDRVGPSVSAQEALEFHAMGRPGKLEITPTKPMATQRDLSLAYSPGVAVPVKAIAEDPARAFDYTTRGNLVAVI
SNGTAILGLGNLGALASKPVMEGKAVLFKRFADVDSIDLEVETEDADEFVNCVKLLGPSFGGINLEDIKAPECFIIETRL
RELMDIPVFHDDQHGTAIIAVAGLINALDLTGRDMKTTKLVCNGAGAAGIACIELAKAIGFAPGNILLCDTKGVVYKGRT
EGMNQWKSAHAVETDKRTLAEALDGADVFFGLSAKGALTPAMVQSLAKNPIIFAMANPDPEITPEEVAEIRTDAIMATGR
SDYPNQVNNVLGFPYIFRGALDVRATTINDAMKVAAAEALAALARQDVPDDVAAAYQGNRPKYGPNYIIPVPFDPRLITA
VPVAVAKAAMDSGVARRPILNLERYEQELSARRDPIASTLQRIYDRVRRQPKRIVFAEGEEEQVMRAAVSYVNQRLGTAI
LLGREERIRETAVNAGVDLARSGIEIINARLSRRNGIYADYLYERLQRKGYLFRDCQRLINNDRNHFAACMVALGDADGM
VTGVTRNYSTALDDVRRVIDAKPGHRVIGASIVLARGRTVIVADTAVHDMPDAQQIADIAEESANFARRMGYEPRVAMLA
YSTFGHPAGERSERIQETVKILDKRRVDFEYDGEMAADVALNPQIMQQYPFCRLSGPANVLVMPAFHSASISTKMLQELG
GSTVIGPLLVGLNKPVQIVSLNAKDSDIVNMAAVAAYTAGG

Sequences:

>Translated_761_residues
MAEAEKNDRVGPSVSAQEALEFHAMGRPGKLEITPTKPMATQRDLSLAYSPGVAVPVKAIAEDPARAFDYTTRGNLVAVI
SNGTAILGLGNLGALASKPVMEGKAVLFKRFADVDSIDLEVETEDADEFVNCVKLLGPSFGGINLEDIKAPECFIIETRL
RELMDIPVFHDDQHGTAIIAVAGLINALDLTGRDMKTTKLVCNGAGAAGIACIELAKAIGFAPGNILLCDTKGVVYKGRT
EGMNQWKSAHAVETDKRTLAEALDGADVFFGLSAKGALTPAMVQSLAKNPIIFAMANPDPEITPEEVAEIRTDAIMATGR
SDYPNQVNNVLGFPYIFRGALDVRATTINDAMKVAAAEALAALARQDVPDDVAAAYQGNRPKYGPNYIIPVPFDPRLITA
VPVAVAKAAMDSGVARRPILNLERYEQELSARRDPIASTLQRIYDRVRRQPKRIVFAEGEEEQVMRAAVSYVNQRLGTAI
LLGREERIRETAVNAGVDLARSGIEIINARLSRRNGIYADYLYERLQRKGYLFRDCQRLINNDRNHFAACMVALGDADGM
VTGVTRNYSTALDDVRRVIDAKPGHRVIGASIVLARGRTVIVADTAVHDMPDAQQIADIAEESANFARRMGYEPRVAMLA
YSTFGHPAGERSERIQETVKILDKRRVDFEYDGEMAADVALNPQIMQQYPFCRLSGPANVLVMPAFHSASISTKMLQELG
GSTVIGPLLVGLNKPVQIVSLNAKDSDIVNMAAVAAYTAGG
>Mature_760_residues
AEAEKNDRVGPSVSAQEALEFHAMGRPGKLEITPTKPMATQRDLSLAYSPGVAVPVKAIAEDPARAFDYTTRGNLVAVIS
NGTAILGLGNLGALASKPVMEGKAVLFKRFADVDSIDLEVETEDADEFVNCVKLLGPSFGGINLEDIKAPECFIIETRLR
ELMDIPVFHDDQHGTAIIAVAGLINALDLTGRDMKTTKLVCNGAGAAGIACIELAKAIGFAPGNILLCDTKGVVYKGRTE
GMNQWKSAHAVETDKRTLAEALDGADVFFGLSAKGALTPAMVQSLAKNPIIFAMANPDPEITPEEVAEIRTDAIMATGRS
DYPNQVNNVLGFPYIFRGALDVRATTINDAMKVAAAEALAALARQDVPDDVAAAYQGNRPKYGPNYIIPVPFDPRLITAV
PVAVAKAAMDSGVARRPILNLERYEQELSARRDPIASTLQRIYDRVRRQPKRIVFAEGEEEQVMRAAVSYVNQRLGTAIL
LGREERIRETAVNAGVDLARSGIEIINARLSRRNGIYADYLYERLQRKGYLFRDCQRLINNDRNHFAACMVALGDADGMV
TGVTRNYSTALDDVRRVIDAKPGHRVIGASIVLARGRTVIVADTAVHDMPDAQQIADIAEESANFARRMGYEPRVAMLAY
STFGHPAGERSERIQETVKILDKRRVDFEYDGEMAADVALNPQIMQQYPFCRLSGPANVLVMPAFHSASISTKMLQELGG
STVIGPLLVGLNKPVQIVSLNAKDSDIVNMAAVAAYTAGG

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=347, Percent_Identity=27.3775216138329, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1788806, Length=754, Percent_Identity=47.3474801061008, Blast_Score=659, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=324, Percent_Identity=31.1728395061728, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1788635, Length=331, Percent_Identity=30.5135951661631, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=28.7313432835821, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646388, Length=403, Percent_Identity=28.7841191066998, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646386, Length=403, Percent_Identity=28.7841191066998, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281362672, Length=449, Percent_Identity=27.6169265033408, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356279, Length=449, Percent_Identity=27.6169265033408, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281362674, Length=449, Percent_Identity=27.6169265033408, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707242, Length=349, Percent_Identity=25.214899713467, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI78707238, Length=349, Percent_Identity=25.214899713467, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI78707240, Length=347, Percent_Identity=25.3602305475504, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82296; Mature: 82165

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAEKNDRVGPSVSAQEALEFHAMGRPGKLEITPTKPMATQRDLSLAYSPGVAVPVKAI
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEECCCCCCCHHHH
AEDPARAFDYTTRGNLVAVISNGTAILGLGNLGALASKPVMEGKAVLFKRFADVDSIDLE
HCCCHHHCCCCCCCCEEEEEECCEEEEEECCCCCHHCCCCCCHHHHHHHHHCCCCCEEEE
VETEDADEFVNCVKLLGPSFGGINLEDIKAPECFIIETRLRELMDIPVFHDDQHGTAIIA
EECCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHHCCCCEECCCCCCEEEE
VAGLINALDLTGRDMKTTKLVCNGAGAAGIACIELAKAIGFAPGNILLCDTKGVVYKGRT
HHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCH
EGMNQWKSAHAVETDKRTLAEALDGADVFFGLSAKGALTPAMVQSLAKNPIIFAMANPDP
HHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCC
EITPEEVAEIRTDAIMATGRSDYPNQVNNVLGFPYIFRGALDVRATTINDAMKVAAAEAL
CCCHHHHHHHHHHHHEECCCCCCCHHHHHHCCCHHHHHCCCEEEEEHHHHHHHHHHHHHH
AALARQDVPDDVAAAYQGNRPKYGPNYIIPVPFDPRLITAVPVAVAKAAMDSGVARRPIL
HHHHHCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
NLERYEQELSARRDPIASTLQRIYDRVRRQPKRIVFAEGEEEQVMRAAVSYVNQRLGTAI
CHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCEE
LLGREERIRETAVNAGVDLARSGIEIINARLSRRNGIYADYLYERLQRKGYLFRDCQRLI
EECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHH
NNDRNHFAACMVALGDADGMVTGVTRNYSTALDDVRRVIDAKPGHRVIGASIVLARGRTV
CCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCEE
IVADTAVHDMPDAQQIADIAEESANFARRMGYEPRVAMLAYSTFGHPAGERSERIQETVK
EEECCHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHH
ILDKRRVDFEYDGEMAADVALNPQIMQQYPFCRLSGPANVLVMPAFHSASISTKMLQELG
HHHHHCCCEEECCCEEECEECCHHHHHHCCCEEECCCCCEEEEECCCCCHHHHHHHHHCC
GSTVIGPLLVGLNKPVQIVSLNAKDSDIVNMAAVAAYTAGG
CCCCHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEAEKNDRVGPSVSAQEALEFHAMGRPGKLEITPTKPMATQRDLSLAYSPGVAVPVKAI
CCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEECCCCCCCHHHH
AEDPARAFDYTTRGNLVAVISNGTAILGLGNLGALASKPVMEGKAVLFKRFADVDSIDLE
HCCCHHHCCCCCCCCEEEEEECCEEEEEECCCCCHHCCCCCCHHHHHHHHHCCCCCEEEE
VETEDADEFVNCVKLLGPSFGGINLEDIKAPECFIIETRLRELMDIPVFHDDQHGTAIIA
EECCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHHCCCCEECCCCCCEEEE
VAGLINALDLTGRDMKTTKLVCNGAGAAGIACIELAKAIGFAPGNILLCDTKGVVYKGRT
HHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCH
EGMNQWKSAHAVETDKRTLAEALDGADVFFGLSAKGALTPAMVQSLAKNPIIFAMANPDP
HHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCC
EITPEEVAEIRTDAIMATGRSDYPNQVNNVLGFPYIFRGALDVRATTINDAMKVAAAEAL
CCCHHHHHHHHHHHHEECCCCCCCHHHHHHCCCHHHHHCCCEEEEEHHHHHHHHHHHHHH
AALARQDVPDDVAAAYQGNRPKYGPNYIIPVPFDPRLITAVPVAVAKAAMDSGVARRPIL
HHHHHCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
NLERYEQELSARRDPIASTLQRIYDRVRRQPKRIVFAEGEEEQVMRAAVSYVNQRLGTAI
CHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCEE
LLGREERIRETAVNAGVDLARSGIEIINARLSRRNGIYADYLYERLQRKGYLFRDCQRLI
EECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHH
NNDRNHFAACMVALGDADGMVTGVTRNYSTALDDVRRVIDAKPGHRVIGASIVLARGRTV
CCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCEE
IVADTAVHDMPDAQQIADIAEESANFARRMGYEPRVAMLAYSTFGHPAGERSERIQETVK
EEECCHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHH
ILDKRRVDFEYDGEMAADVALNPQIMQQYPFCRLSGPANVLVMPAFHSASISTKMLQELG
HHHHHCCCEEECCCEEECEECCHHHHHHCCCEEECCCCCEEEEECCCCCHHHHHHHHHCC
GSTVIGPLLVGLNKPVQIVSLNAKDSDIVNMAAVAAYTAGG
CCCCHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9535928; 11481430; 10407149 [H]