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The map label for this gene is gyaR [H]

Identifier: 110636078

GI number: 110636078

Start: 4055947

End: 4056870

Strand: Reverse

Name: gyaR [H]

Synonym: Meso_3753

Alternate gene names: 110636078

Gene position: 4056870-4055947 (Counterclockwise)

Preceding gene: 110636079

Following gene: 110636075

Centisome position: 91.94

GC content: 62.01

Gene sequence:

>924_bases
ATGGATGACGAGATTGTCATTCTTCAGGCTACGAGTCTTCCCGCACCCACAGTCAACACGTTGCGCGAGCACTTTTCAGT
TCTAGAACTGCCTTCCCAAGGGGCAGAGCGCGATCGACTTATCGAGGCCAATCGGGACAGGATTCGCGGTATCGCCACAC
TCGGGGCCGGCCCCGTGGACGCCGCCCTCATCGGCCGCCTGCCGGCGCTTGAAATTATCGCATGTTTCAGCGCCGGCATG
GACGGCATAGATCTTGAGGCCGCCAAGGCCCGAAACATCGCCGTGACGAATACGTCCCCAGTGCTGGCCGATGACGTGGC
TGATCTTGCGGTGGTGATGCTCTTCTCGCTCCTGCGCGGCATAAGCAGGGCAGAACGCTATGCGCGCGCCGGCTTGTGGC
CCGACGGCAATCTGCCTTTGGCTCGCACCGTACGCGGGTGCCGCGTTGGCATCATAGGTCTTGGCCATATCGGCAAGGCG
GTGGCGCGCCGCCTCGAATGCAGCGGCGCCGAGATCGCCTATAATGGCCCGCGGCGGAAACCGGACAGCGCCTACACCTA
TTTCCCTAGTCTGATCGAACTCGCCAATTGGTCCGATGCGCTTATCGTCTGCTGCCCCGGAGGCGAGGAAACCAGGAATT
TGGTGGGCTCAGCGATATTGGAAGCGCTCGGCCCGGAAGGATGGCTGGTGAATGTGGCGCGCGGCAGCGTCGTCGACGAA
GCCGCCCTTGTGAAGGCGGTGGTGTCTGGTCGCATTGCTGGCGCGGCACTGGACGTGTTTGCGAAGGAACCGCACGTCCC
CGCGGAGCTTCGCGACAAGGAGAACGTGATAGTGCTTCCGCACATAGGGAGCGCAACCAGAGAGACGCGCGATGCCATGG
GCCTGTCTATGATCGCTTCGTTGCGGTCGCATTTCCGCCATTAG

Upstream 100 bases:

>100_bases
ACGGGCCGCACGTCCGTTGGAGGCGCGAGCGGCCTAACCCGGCGGCCGCGCCGGCAATATCCGGTCGGCGCCAGCAACAT
AGCTTTCCAGGAGGGTACAA

Downstream 100 bases:

>100_bases
GCCGGCAGCGATGCTCTGGGGATTCTGCGGTCCGCGGCCTTCATGACTAACGGAGACCGCAACACCGTGGCAGGGGCAAG
TCCAATCAGCGGCGCTTGAA

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MDDEIVILQATSLPAPTVNTLREHFSVLELPSQGAERDRLIEANRDRIRGIATLGAGPVDAALIGRLPALEIIACFSAGM
DGIDLEAAKARNIAVTNTSPVLADDVADLAVVMLFSLLRGISRAERYARAGLWPDGNLPLARTVRGCRVGIIGLGHIGKA
VARRLECSGAEIAYNGPRRKPDSAYTYFPSLIELANWSDALIVCCPGGEETRNLVGSAILEALGPEGWLVNVARGSVVDE
AALVKAVVSGRIAGAALDVFAKEPHVPAELRDKENVIVLPHIGSATRETRDAMGLSMIASLRSHFRH

Sequences:

>Translated_307_residues
MDDEIVILQATSLPAPTVNTLREHFSVLELPSQGAERDRLIEANRDRIRGIATLGAGPVDAALIGRLPALEIIACFSAGM
DGIDLEAAKARNIAVTNTSPVLADDVADLAVVMLFSLLRGISRAERYARAGLWPDGNLPLARTVRGCRVGIIGLGHIGKA
VARRLECSGAEIAYNGPRRKPDSAYTYFPSLIELANWSDALIVCCPGGEETRNLVGSAILEALGPEGWLVNVARGSVVDE
AALVKAVVSGRIAGAALDVFAKEPHVPAELRDKENVIVLPHIGSATRETRDAMGLSMIASLRSHFRH
>Mature_307_residues
MDDEIVILQATSLPAPTVNTLREHFSVLELPSQGAERDRLIEANRDRIRGIATLGAGPVDAALIGRLPALEIIACFSAGM
DGIDLEAAKARNIAVTNTSPVLADDVADLAVVMLFSLLRGISRAERYARAGLWPDGNLPLARTVRGCRVGIIGLGHIGKA
VARRLECSGAEIAYNGPRRKPDSAYTYFPSLIELANWSDALIVCCPGGEETRNLVGSAILEALGPEGWLVNVARGSVVDE
AALVKAVVSGRIAGAALDVFAKEPHVPAELRDKENVIVLPHIGSATRETRDAMGLSMIASLRSHFRH

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=246, Percent_Identity=36.9918699186992, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI23308577, Length=265, Percent_Identity=32.4528301886792, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI61743967, Length=228, Percent_Identity=31.140350877193, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4557497, Length=228, Percent_Identity=31.140350877193, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI145580578, Length=245, Percent_Identity=30.6122448979592, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4557499, Length=245, Percent_Identity=30.6122448979592, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=30.6122448979592, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI87082289, Length=311, Percent_Identity=31.8327974276527, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789279, Length=313, Percent_Identity=30.9904153354633, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787645, Length=235, Percent_Identity=28.936170212766, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87081824, Length=260, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=220, Percent_Identity=32.7272727272727, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=229, Percent_Identity=28.3842794759825, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=247, Percent_Identity=33.1983805668016, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320925, Length=331, Percent_Identity=28.7009063444109, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=326, Percent_Identity=28.2208588957055, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6321253, Length=265, Percent_Identity=30.188679245283, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=285, Percent_Identity=24.9122807017544, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=276, Percent_Identity=25.3623188405797, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45552429, Length=302, Percent_Identity=32.1192052980132, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585514, Length=302, Percent_Identity=32.1192052980132, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574282, Length=302, Percent_Identity=32.1192052980132, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574284, Length=302, Percent_Identity=32.1192052980132, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45551003, Length=302, Percent_Identity=32.1192052980132, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28571528, Length=234, Percent_Identity=34.6153846153846, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574286, Length=312, Percent_Identity=31.0897435897436, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585516, Length=315, Percent_Identity=28.8888888888889, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646446, Length=229, Percent_Identity=31.8777292576419, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24646448, Length=229, Percent_Identity=31.8777292576419, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24646452, Length=229, Percent_Identity=31.8777292576419, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24646450, Length=229, Percent_Identity=31.8777292576419, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI62472511, Length=229, Percent_Identity=31.8777292576419, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI19921140, Length=228, Percent_Identity=31.5789473684211, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 32675; Mature: 32675

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDEIVILQATSLPAPTVNTLREHFSVLELPSQGAERDRLIEANRDRIRGIATLGAGPVD
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHEEHCCCCCCHH
AALIGRLPALEIIACFSAGMDGIDLEAAKARNIAVTNTSPVLADDVADLAVVMLFSLLRG
HHHHCCCCHHHHHHHHHCCCCCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
ISRAERYARAGLWPDGNLPLARTVRGCRVGIIGLGHIGKAVARRLECSGAEIAYNGPRRK
HHHHHHHHHCCCCCCCCCCHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCEEEECCCCCC
PDSAYTYFPSLIELANWSDALIVCCPGGEETRNLVGSAILEALGPEGWLVNVARGSVVDE
CCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
AALVKAVVSGRIAGAALDVFAKEPHVPAELRDKENVIVLPHIGSATRETRDAMGLSMIAS
HHHHHHHHHCCHHHHHHHHHHCCCCCCHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
LRSHFRH
HHHHHCC
>Mature Secondary Structure
MDDEIVILQATSLPAPTVNTLREHFSVLELPSQGAERDRLIEANRDRIRGIATLGAGPVD
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHEEHCCCCCCHH
AALIGRLPALEIIACFSAGMDGIDLEAAKARNIAVTNTSPVLADDVADLAVVMLFSLLRG
HHHHCCCCHHHHHHHHHCCCCCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
ISRAERYARAGLWPDGNLPLARTVRGCRVGIIGLGHIGKAVARRLECSGAEIAYNGPRRK
HHHHHHHHHCCCCCCCCCCHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCEEEECCCCCC
PDSAYTYFPSLIELANWSDALIVCCPGGEETRNLVGSAILEALGPEGWLVNVARGSVVDE
CCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
AALVKAVVSGRIAGAALDVFAKEPHVPAELRDKENVIVLPHIGSATRETRDAMGLSMIAS
HHHHHHHHHCCHHHHHHHHHHCCCCCCHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
LRSHFRH
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA