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The map label for this gene is patB [H]

Identifier: 110636061

GI number: 110636061

Start: 4034759

End: 4035937

Strand: Reverse

Name: patB [H]

Synonym: Meso_3736

Alternate gene names: 110636061

Gene position: 4035937-4034759 (Counterclockwise)

Preceding gene: 110636062

Following gene: 110636060

Centisome position: 91.47

GC content: 59.63

Gene sequence:

>1179_bases
ATGAATCTGCAAGATGATCTGTTCCTCGATGCCGAGTTCCTTCGCGCACGCCGCAATTCAAAATGGAGGAGATTTCCCGA
CACCATAGTCCCCTCATGGATCGCCGATATGGACCTCAAGGTGGCGGACGTCGTGCAGAACGCGGTGGAGGGGACCACGA
AGCAGCGCGACTACGGCTATCCTCGCCGCAGCGCGATCCCGGCCGAGCGAATTGCCGCGGATGCTTGGGCTGGTTGGGTG
TCGCGCCGTCATGGATGGAACGTTGATCCCGCCGACGTGGTCGTGGCGACAGATCTCATGCAGGCCTGCTCTGCGGCCAT
CCTTACCTACTCCGAAGAGGGGGACGGCATCCTCCTGCCGACGCCCTGTTATCCGCCGTTCCGCGCCTGCATCACAGAAG
CCAGGCGCACCTTGATCGATTGCCCGATGATCGAAGGTGAAGACGGCTTCCGGTTCGATTTTGAGGCAATGGAAGCGCAA
ATCGATGACCGCACTCGGATGATCCTCCTCTGCAATCCGCACAACCCTACCGGTCGTGTGATGACCAGGGAAGAACTGTC
GTCAGTGATTGCGATCGCCGAACGACACGACCTGATCGTCTTCGTTGACGAGATCCATGCCGATATCATCTATCCAGGCC
ACCGGCACCTTTCCCTTGCAAACCTATCACCCGAGGCCGCGGCGCGCACCGTCACCGCAAGTTCGGCTACAAAGTCGTTC
ACCACACCGGCTTTGCGGCTCGCCGTCATGCATTTTGGCTCCCGTCCCCTGCGCGAGCGCTTCGACCGTCGCATCCCCAA
AGCGCTTATGGGAAAACCTGCTATCACCGCGATTGACGCCAGCTACGCCGCCTGGACGGAAGGCGACGATTGGTTTGATG
CTACGCTAGGGTATCTAACTACCGCCCGCGAAAAAGTGGTGAAGACCGTCGAGGCGGTGCCTAATCTGAGGCTGCATCAA
CCGGAATCGACGTATCTCGCCTTTATCGATTGTCGCGGATTGAAACTGAGCCGGCCCGCCGCTGCGTTCTTTCTCGACAC
GGCCCGGATCGGCTTCAGTGAAGGCGAAAGCTTCGGAACCGGTTATGAGGGATGGGTTCGGCTGAATTTTGCGACCGCCC
CCGATGTCTTGGGCGAAAAGCTGGCACGCCTGAAGGCCGCATGTCTTGCCGAGGCCTGA

Upstream 100 bases:

>100_bases
CTGCGCGCCTTCGACATGACTCCGGTCGCGAATTGAAAGCCCTGGACGAGGCCAAGCCGCTTGGCTTGGCCTTCGTTGAC
CATCCCCTTTGAAGGACGCC

Downstream 100 bases:

>100_bases
TCACGATCGACGCGTAGACCTGGCTTCGACGGGGCAACTCACGAGGAAGGATCCCATGGTCGATGGCATAGAGCCGACTA
GCTTTTGGAAGGCTACAGGC

Product: aminotransferase, class I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNLQDDLFLDAEFLRARRNSKWRRFPDTIVPSWIADMDLKVADVVQNAVEGTTKQRDYGYPRRSAIPAERIAADAWAGWV
SRRHGWNVDPADVVVATDLMQACSAAILTYSEEGDGILLPTPCYPPFRACITEARRTLIDCPMIEGEDGFRFDFEAMEAQ
IDDRTRMILLCNPHNPTGRVMTREELSSVIAIAERHDLIVFVDEIHADIIYPGHRHLSLANLSPEAAARTVTASSATKSF
TTPALRLAVMHFGSRPLRERFDRRIPKALMGKPAITAIDASYAAWTEGDDWFDATLGYLTTAREKVVKTVEAVPNLRLHQ
PESTYLAFIDCRGLKLSRPAAAFFLDTARIGFSEGESFGTGYEGWVRLNFATAPDVLGEKLARLKAACLAEA

Sequences:

>Translated_392_residues
MNLQDDLFLDAEFLRARRNSKWRRFPDTIVPSWIADMDLKVADVVQNAVEGTTKQRDYGYPRRSAIPAERIAADAWAGWV
SRRHGWNVDPADVVVATDLMQACSAAILTYSEEGDGILLPTPCYPPFRACITEARRTLIDCPMIEGEDGFRFDFEAMEAQ
IDDRTRMILLCNPHNPTGRVMTREELSSVIAIAERHDLIVFVDEIHADIIYPGHRHLSLANLSPEAAARTVTASSATKSF
TTPALRLAVMHFGSRPLRERFDRRIPKALMGKPAITAIDASYAAWTEGDDWFDATLGYLTTAREKVVKTVEAVPNLRLHQ
PESTYLAFIDCRGLKLSRPAAAFFLDTARIGFSEGESFGTGYEGWVRLNFATAPDVLGEKLARLKAACLAEA
>Mature_392_residues
MNLQDDLFLDAEFLRARRNSKWRRFPDTIVPSWIADMDLKVADVVQNAVEGTTKQRDYGYPRRSAIPAERIAADAWAGWV
SRRHGWNVDPADVVVATDLMQACSAAILTYSEEGDGILLPTPCYPPFRACITEARRTLIDCPMIEGEDGFRFDFEAMEAQ
IDDRTRMILLCNPHNPTGRVMTREELSSVIAIAERHDLIVFVDEIHADIIYPGHRHLSLANLSPEAAARTVTASSATKSF
TTPALRLAVMHFGSRPLRERFDRRIPKALMGKPAITAIDASYAAWTEGDDWFDATLGYLTTAREKVVKTVEAVPNLRLHQ
PESTYLAFIDCRGLKLSRPAAAFFLDTARIGFSEGESFGTGYEGWVRLNFATAPDVLGEKLARLKAACLAEA

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=239, Percent_Identity=27.6150627615063, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI169881279, Length=239, Percent_Identity=27.6150627615063, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI56713254, Length=233, Percent_Identity=24.0343347639485, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI56713256, Length=233, Percent_Identity=24.0343347639485, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI169881281, Length=133, Percent_Identity=30.8270676691729, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4507369, Length=241, Percent_Identity=22.4066390041494, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787909, Length=360, Percent_Identity=29.4444444444444, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788627, Length=164, Percent_Identity=31.0975609756098, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788722, Length=352, Percent_Identity=23.8636363636364, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786816, Length=172, Percent_Identity=25.5813953488372, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17567663, Length=246, Percent_Identity=28.0487804878049, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71994472, Length=331, Percent_Identity=26.8882175226586, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994476, Length=331, Percent_Identity=26.8882175226586, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17567369, Length=230, Percent_Identity=26.9565217391304, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322401, Length=167, Percent_Identity=28.1437125748503, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18859735, Length=243, Percent_Identity=27.5720164609054, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573069, Length=348, Percent_Identity=23.5632183908046, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646114, Length=348, Percent_Identity=23.5632183908046, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573067, Length=348, Percent_Identity=23.5632183908046, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573065, Length=348, Percent_Identity=23.5632183908046, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641770, Length=101, Percent_Identity=32.6732673267327, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641760, Length=101, Percent_Identity=32.6732673267327, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641768, Length=101, Percent_Identity=32.6732673267327, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641766, Length=101, Percent_Identity=32.6732673267327, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641764, Length=101, Percent_Identity=32.6732673267327, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45551451, Length=101, Percent_Identity=32.6732673267327, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43695; Mature: 43695

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQDDLFLDAEFLRARRNSKWRRFPDTIVPSWIADMDLKVADVVQNAVEGTTKQRDYGY
CCCCCCCEECHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC
PRRSAIPAERIAADAWAGWVSRRHGWNVDPADVVVATDLMQACSAAILTYSEEGDGILLP
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEC
TPCYPPFRACITEARRTLIDCPMIEGEDGFRFDFEAMEAQIDDRTRMILLCNPHNPTGRV
CCCCCHHHHHHHHHHHHHHCCCCEECCCCCEEEHHHHHHHCCCCEEEEEEECCCCCCCCE
MTREELSSVIAIAERHDLIVFVDEIHADIIYPGHRHLSLANLSPEAAARTVTASSATKSF
EEHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCEEEEECCCHHHHHHEEECCCCCCCC
TTPALRLAVMHFGSRPLRERFDRRIPKALMGKPAITAIDASYAAWTEGDDWFDATLGYLT
CCHHHHHHHHHHCCCHHHHHHHHHCCHHHHCCCCEEEECCCHHCCCCCCCHHHHHHHHHH
TAREKVVKTVEAVPNLRLHQPESTYLAFIDCRGLKLSRPAAAFFLDTARIGFSEGESFGT
HHHHHHHHHHHHCCCCEEECCCCCEEEEEEECCCEECCCHHHHEEHHHHCCCCCCCCCCC
GYEGWVRLNFATAPDVLGEKLARLKAACLAEA
CCCCEEEEEECCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLQDDLFLDAEFLRARRNSKWRRFPDTIVPSWIADMDLKVADVVQNAVEGTTKQRDYGY
CCCCCCCEECHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC
PRRSAIPAERIAADAWAGWVSRRHGWNVDPADVVVATDLMQACSAAILTYSEEGDGILLP
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEC
TPCYPPFRACITEARRTLIDCPMIEGEDGFRFDFEAMEAQIDDRTRMILLCNPHNPTGRV
CCCCCHHHHHHHHHHHHHHCCCCEECCCCCEEEHHHHHHHCCCCEEEEEEECCCCCCCCE
MTREELSSVIAIAERHDLIVFVDEIHADIIYPGHRHLSLANLSPEAAARTVTASSATKSF
EEHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCEEEEECCCHHHHHHEEECCCCCCCC
TTPALRLAVMHFGSRPLRERFDRRIPKALMGKPAITAIDASYAAWTEGDDWFDATLGYLT
CCHHHHHHHHHHCCCHHHHHHHHHCCHHHHCCCCEEEECCCHHCCCCCCCHHHHHHHHHH
TAREKVVKTVEAVPNLRLHQPESTYLAFIDCRGLKLSRPAAAFFLDTARIGFSEGESFGT
HHHHHHHHHHHHCCCCEEECCCCCEEEEEEECCCEECCCHHHHEEHHHHCCCCCCCCCCC
GYEGWVRLNFATAPDVLGEKLARLKAACLAEA
CCCCEEEEEECCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]