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The map label for this gene is atpB

Identifier: 110633053

GI number: 110633053

Start: 773112

End: 773861

Strand: Direct

Name: atpB

Synonym: Meso_0696

Alternate gene names: 110633053

Gene position: 773112-773861 (Clockwise)

Preceding gene: 110633052

Following gene: 110633054

Centisome position: 17.52

GC content: 58.8

Gene sequence:

>750_bases
GTGGCCACAGACCCGATCCACCAATTTCAGATCTCGAAGTTGATTCCGATCGAGATCGGCGGCCTTGATTTCTCCTTCAC
CAATTCCTCCCTTTTCATGGTCGCCACAGTGGCGGCGGCGGGTGCGTTCCTTTATCTCACCACGTCGAGCCGCGGCCTGG
TTCCGAGCCGGATGCAGTCCGTCTCGGAAATGTCCTACGAATTCGTGGCTTCAATGCTGCGTGACGCTGCGGGAAGCCAC
GGAATGCGGTTCTTCCCGTTCGTCTTCTCGCTATTCATGTTCGTGCTGGTCGCGAACCTGCTCGGTCTGTTTCCTTATTT
CTTCACGGTCACGAGCCATATCGTCGTCACCTTCGCGCTGGCGCTCCTCGTTATTGGAACCGTGCTCGTCTACGGCTTTT
GGAAACATGGCTTTGGGTTCCTGAAGCTGTTTGTGCCGGAGGGCGTTCCAGGTGTGCTTCTGCCTCTGGTGGTGCTCATC
GAGGTGATTTCCTTCCTGTCGCGCCCCATCAGTCTCTCCGTTCGTCTCTTCGCGAACATGCTGGCGGGCCACATCACGCT
CAAGGTTTTCGCCGGCTTTGTCACTTCTCTTGGCGCGCTGGGTGTCGCCGGCGCCGCTGGCGCGGTTCTGCCGCTTGCCA
TGACGGTTGCGCTCACCGGCCTCGAGCTTCTGGTGGCTTTCCTGCAGGCCTATGTTTTCGCAGTGCTCACCTGCATGTAC
CTGAACGACGCCTTGCACCCGGGCCACTAA

Upstream 100 bases:

>100_bases
GGCTGAATTCGGATCGAAGGCGCCCAATAAGGGTGACGCCGGTCCGGGGGAAAAGAAGTAGGCGGCGTTTCGGCCGCGTG
TAGAGGACGAGGGGAGCCAA

Downstream 100 bases:

>100_bases
GGCACCGGGGCTTGTGCCCGGCAAAACAGATCCAATCCATAAGGAGTTTAAAATGGAAGCAGAAGCAGCAAAGTTCATCG
GTGCGGGCATCGCCTGCCTC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MATDPIHQFQISKLIPIEIGGLDFSFTNSSLFMVATVAAAGAFLYLTTSSRGLVPSRMQSVSEMSYEFVASMLRDAAGSH
GMRFFPFVFSLFMFVLVANLLGLFPYFFTVTSHIVVTFALALLVIGTVLVYGFWKHGFGFLKLFVPEGVPGVLLPLVVLI
EVISFLSRPISLSVRLFANMLAGHITLKVFAGFVTSLGALGVAGAAGAVLPLAMTVALTGLELLVAFLQAYVFAVLTCMY
LNDALHPGH

Sequences:

>Translated_249_residues
MATDPIHQFQISKLIPIEIGGLDFSFTNSSLFMVATVAAAGAFLYLTTSSRGLVPSRMQSVSEMSYEFVASMLRDAAGSH
GMRFFPFVFSLFMFVLVANLLGLFPYFFTVTSHIVVTFALALLVIGTVLVYGFWKHGFGFLKLFVPEGVPGVLLPLVVLI
EVISFLSRPISLSVRLFANMLAGHITLKVFAGFVTSLGALGVAGAAGAVLPLAMTVALTGLELLVAFLQAYVFAVLTCMY
LNDALHPGH
>Mature_248_residues
ATDPIHQFQISKLIPIEIGGLDFSFTNSSLFMVATVAAAGAFLYLTTSSRGLVPSRMQSVSEMSYEFVASMLRDAAGSHG
MRFFPFVFSLFMFVLVANLLGLFPYFFTVTSHIVVTFALALLVIGTVLVYGFWKHGFGFLKLFVPEGVPGVLLPLVVLIE
VISFLSRPISLSVRLFANMLAGHITLKVFAGFVTSLGALGVAGAAGAVLPLAMTVALTGLELLVAFLQAYVFAVLTCMYL
NDALHPGH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=195, Percent_Identity=29.7435897435897, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6226527, Length=248, Percent_Identity=33.4677419354839, Blast_Score=149, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_MESSB (Q11KH9)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673261.1
- ProteinModelPortal:   Q11KH9
- SMR:   Q11KH9
- STRING:   Q11KH9
- GeneID:   4180603
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0696
- NMPDR:   fig|266779.1.peg.2833
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   MDQFIVK
- PhylomeDB:   Q11KH9
- ProtClustDB:   PRK05815
- BioCyc:   MSP266779:MESO_0696-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 26756; Mature: 26625

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS00449 ATPASE_A; PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x166ed15c)-; HASH(0x17c86108)-; HASH(0x17904c7c)-; HASH(0x17e06108)-; HASH(0x17accbec)-; HASH(0x174d486c)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCCCH
>Mature Secondary Structure 
ATDPIHQFQISKLIPIEIGGLDFSFTNSSLFMVATVAAAGAFLYLTTSSRGLVPSRMQS
CCCCHHHHHHHHCCEEEECCEEEEECCCHHHHHHHHHHHCEEEEEECCCCCCCHHHHHH
VSEMSYEFVASMLRDAAGSHGMRFFPFVFSLFMFVLVANLLGLFPYFFTVTSHIVVTFAL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLVIGTVLVYGFWKHGFGFLKLFVPEGVPGVLLPLVVLIEVISFLSRPISLSVRLFANM
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LAGHITLKVFAGFVTSLGALGVAGAAGAVLPLAMTVALTGLELLVAFLQAYVFAVLTCMY
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNDALHPGH
HHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA