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The map label for this gene is pyrF [H]

Identifier: 110633040

GI number: 110633040

Start: 761075

End: 761782

Strand: Direct

Name: pyrF [H]

Synonym: Meso_0683

Alternate gene names: 110633040

Gene position: 761075-761782 (Clockwise)

Preceding gene: 110633039

Following gene: 110633041

Centisome position: 17.25

GC content: 65.25

Gene sequence:

>708_bases
ATGCCGGCTGACGAAATGCGCGGGCGCCTGATCGTCGGCCTCGACGTGCCGACCCTTGCAGAAGCCGAGAAGGTGGTAAG
TGCCCTCGGCGATACGGTGTCCTTCTACAAGATCGGTTATCAGCTCGCTTTTGCGGGCGGGCTCGATTTCGCCGGCGACC
TGATCCGATCCGGCCGGCAGGTCTTCCTGGACATGAAGCTGCTCGACATCGACAACACGGTGGCAAAGGGCGTGGAAAAC
ATCGCCCGAATGGGCGTGGCGATGCTCACCTTGCACGCCTATCCCAAAGCGATGCGCGCCGCGGTGGCAGCCGCGGAAGG
CTCCGGCCTGTGCCTGCTTGGGGTCACCGTCCTCACATCCATGGATGCGCAGGATCTGATCGATGCGGGTTACGAACACG
ACCCGCAGACACTGGTGCTGCGCCGTGCCGAGCAGGCGCGGGCGGCGGGCATGGGCGGCGTGGTCTGTTCGGCGGTCGAG
GCCGCTTTGGTGCGCAGCGTGGTTGGTCCCGATATGGCGGTGGTAACGCCAGGCATCAGGCCCGCCGGTGCTGATCACGG
CGACCAGAAGCGCGTTGTCACGCCCGCCGATGCGATTCGCGCCGGCGCCAGCCATCTCGTCGTCGCACGACCGATCGTCG
CTGCGGATGATCCCAAATCCGCCGCCGAGGCCATTTTGCGGGAAATGCATCGCGCTGTTGGAAACTAG

Upstream 100 bases:

>100_bases
CGGCTCCGTTCAATGCGCGTCGACCGGTGAGCGCGGGGATTGTCAGCCGCAAGCTCTTATGCGACTGGGAGCCGATGCAG
ATATTTCCGGGGAGCTAACG

Downstream 100 bases:

>100_bases
CGAGAGGAGGACGGAATGCCCAAGGGTTACTGGATTGCCCATGTCGATGTGCGCGACCCCGAACGCTACAAGGATTACAT
TGCCGCGGCGAAGCCGGCTT

Product: orotidine 5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MPADEMRGRLIVGLDVPTLAEAEKVVSALGDTVSFYKIGYQLAFAGGLDFAGDLIRSGRQVFLDMKLLDIDNTVAKGVEN
IARMGVAMLTLHAYPKAMRAAVAAAEGSGLCLLGVTVLTSMDAQDLIDAGYEHDPQTLVLRRAEQARAAGMGGVVCSAVE
AALVRSVVGPDMAVVTPGIRPAGADHGDQKRVVTPADAIRAGASHLVVARPIVAADDPKSAAEAILREMHRAVGN

Sequences:

>Translated_235_residues
MPADEMRGRLIVGLDVPTLAEAEKVVSALGDTVSFYKIGYQLAFAGGLDFAGDLIRSGRQVFLDMKLLDIDNTVAKGVEN
IARMGVAMLTLHAYPKAMRAAVAAAEGSGLCLLGVTVLTSMDAQDLIDAGYEHDPQTLVLRRAEQARAAGMGGVVCSAVE
AALVRSVVGPDMAVVTPGIRPAGADHGDQKRVVTPADAIRAGASHLVVARPIVAADDPKSAAEAILREMHRAVGN
>Mature_234_residues
PADEMRGRLIVGLDVPTLAEAEKVVSALGDTVSFYKIGYQLAFAGGLDFAGDLIRSGRQVFLDMKLLDIDNTVAKGVENI
ARMGVAMLTLHAYPKAMRAAVAAAEGSGLCLLGVTVLTSMDAQDLIDAGYEHDPQTLVLRRAEQARAAGMGGVVCSAVEA
ALVRSVVGPDMAVVTPGIRPAGADHGDQKRVVTPADAIRAGASHLVVARPIVAADDPKSAAEAILREMHRAVGN

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) [H]

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787537, Length=228, Percent_Identity=35.9649122807018, Blast_Score=132, Evalue=2e-32,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR018089
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.1.23 [H]

Molecular weight: Translated: 24452; Mature: 24320

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00156 OMPDECASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPADEMRGRLIVGLDVPTLAEAEKVVSALGDTVSFYKIGYQLAFAGGLDFAGDLIRSGRQ
CCCHHHCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCHHHHHHHCCHH
VFLDMKLLDIDNTVAKGVENIARMGVAMLTLHAYPKAMRAAVAAAEGSGLCLLGVTVLTS
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHC
MDAQDLIDAGYEHDPQTLVLRRAEQARAAGMGGVVCSAVEAALVRSVVGPDMAVVTPGIR
CCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCC
PAGADHGDQKRVVTPADAIRAGASHLVVARPIVAADDPKSAAEAILREMHRAVGN
CCCCCCCCCCCEECCHHHHHCCCCCEEEECCEECCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PADEMRGRLIVGLDVPTLAEAEKVVSALGDTVSFYKIGYQLAFAGGLDFAGDLIRSGRQ
CCHHHCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCHHHHHHHCCHH
VFLDMKLLDIDNTVAKGVENIARMGVAMLTLHAYPKAMRAAVAAAEGSGLCLLGVTVLTS
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHC
MDAQDLIDAGYEHDPQTLVLRRAEQARAAGMGGVVCSAVEAALVRSVVGPDMAVVTPGIR
CCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCC
PAGADHGDQKRVVTPADAIRAGASHLVVARPIVAADDPKSAAEAILREMHRAVGN
CCCCCCCCCCCEECCHHHHHCCCCCEEEECCEECCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10972799; 11481430 [H]