Click here to switch to the map view.

The map label for this gene is frzE [H]

Identifier: 110632957

GI number: 110632957

Start: 673847

End: 675967

Strand: Direct

Name: frzE [H]

Synonym: Meso_0600

Alternate gene names: 110632957

Gene position: 673847-675967 (Clockwise)

Preceding gene: 110632956

Following gene: 110632958

Centisome position: 15.27

GC content: 62.94

Gene sequence:

>2121_bases
ATGGCAAAGGCAGATCTCGATCGCCAGTTGCTCGGCCTGTTCATCAGGGAGGTGCAGGAGCGTTCGGGCGAGTTGGAGCG
CATGCTGCTCGCGGTCGAAGGCGCCGCAGGGGCAGAGGAGCGGCGGCACTTGCTGGAAAGGCTGCTGCGCATCGCACATA
GTCTTAAGGGGGCTGCGGGGCTGGTGGAAATCCGCTCTATTGAGAAGGTGTGCCACAGGATGGAAGATCTTCTTGCCCAG
CTCGCGCGCGCTGAACGCCCCCTGGAGAGGGCGGATCTTGATGTGCTGCTCGAAGCAACGGACTGGATCGCGCAAACCGG
AGGCAAGTTGGAGCGGGAGCCCGGTGCCCCGATGACTCCGACCGAAGATGTGCTCGAACGGCTGGATGCAAGGCTCGGGG
AAAAGCCGAAAGCGCCTCAGGATACCCGCGCCGCTGGCGGCGTGCCCATGCCGCCTGTGCGGACGAGCGATCTCGACGGC
TCTATTCGGCTTTCCGGCCACCGCCTCGACGCGCTTCTTTACAGGAGCGGTGAGTTGCTCGCCGCAAAGTCGCGGCTGAG
CCTGAGGGCTGCTGAAGCCGCCTCCCTGCGGGAGCGGTTCAGGCGGGTTCGTTTCCCGCACACCGCCAACGGCGAGGCGG
CGCCATCGCTCGACGAGAGTTTGCGGGAACTGGCTGCCGGGCTCTCAGAGGACGCAAGACTGATAGGCAGCCTTGTCGGC
GCGCTCGATCACGAGATTCGGCGCGCCCGCATGCAGCGTTTCGCGGAAGCCTGCCAGGGCCTTCCCCGCCTCGTCCGGGA
TATTGGGAATGAGTCTGGAAAACTGGCGGAGCTGAACATCCTCGGCGGTGAAATCGAGGTCGACCGGTCCATCGTCTCGG
GGCTTCAGGATTCTCTCAGGCACCTCGTGCGCAACGCCATGGGACATGGCATCGAGACGCCGCCTGAGCGCCGCAAGGCA
GGCAAGCCAGAGAAGGGTAGGATAACGGTCTCGGCTGCACTGTTCCGCGATCGATTTCAGGTACATGTCGAGGATGACGG
CCGGGGCTTCGACCTGAAGTCGATCGCCGAAGCCGCAGCCGGGAAGGGACTACCCGAAGCGCAGGACGAGCGGCAACTTC
TGCGCCGGGCATTTGAGCCGGGCATTTCGACATCGGCCGAGGTTACCAGCCTTTCGGGCCGCGGTGTCGGGCTCGATATC
GTCCGCAACGCAGTGGAGGCGATGAGGGGTACGGTCGAGCTTTCCAACGTTCGGGGCGGCGGCGCGGCCTTCACCATGAC
GCTGCCGCTGACCCTGGCCACAGTTCGGGCGCTGGAGGTGATGTCTGGCGGTCAAATCTTCACCATCGACACCTCTTCCG
TACGCAAAGTAGGCCAGATCTCCACTCGCGATCTGCCTCAACGCGGCAAGCCGAACCTACTCAAAACGGCTAACGGGAAT
GTGCGGGTTCTCGATCTTGCCACCTGGCTCGGTTTTCCCGGACCACTGATGCCGGATGGGAAAGACATTCGCACGGCTGT
ATTTGTTGGCACGGCCGGTGATGAAACCGCTGTTCTGGTGGAGCAGATCCTGGAGGAACAAGAGATGCTGGTGCGCTCGC
TCGGGCCGCGCCTGGCGAACACGAGGTGCTACAGCGGCGCCACCATCCTTCCGGACGGGCCCATCGCCCTGCTTCTGAAT
GCGGCCGCTCTGATCGAGGCGGCGGCGTCGGGCGAGTATTCTGGAACCGATGCCTATTCCCTCCAAGTGCGGCAGGCACG
GAAGAAAATTCTCGTCGTCGACGATTCTCCTTCCGTGCGCGCACTGGAAAAACTTATCCTCGAGGGTGCCGGCTACGACG
TGGCAATTGCGGCCGATGGGGCCGAGGCATGGAAGCACCTGCGGACCCATGGCGCAGACGTGGTGGTGGCTGATATCGAC
ATGCCGGAAATGGACGGCGTTGCACTCACCCAAACAATAAGACGGTCCCGGAAATTCGCCCAATTGCCGGTCATATTGAT
CTCAGGGCGCGATACTGTCGAGGAGAAGGAGCAGGGTCTGCATGCAGGCGCCAACGCCTACATGGCCAAGAGCAGCTTCG
ACCAGCAGCTCTTCTTGGAAGCGGTTCGCCAGATGGTGTGA

Upstream 100 bases:

>100_bases
GAATCTCGCGGCCGTCCGCCAGTCCGAACAAGCCGCGCGGACCCTGAATGAACTCGGGACACGGTTAAAAACGATGCTGG
GCACACGCAAGGATTGACCC

Downstream 100 bases:

>100_bases
CCTCAGATGCTCCGCATACTCCTTGTTTCAGACAATGGGGAGCTGATCTCGCTGATCAAGCGCGCGCTGGCCGGCGGAGA
GCTGGAGCTGGTCGGCGTGG

Product: CheA signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MAKADLDRQLLGLFIREVQERSGELERMLLAVEGAAGAEERRHLLERLLRIAHSLKGAAGLVEIRSIEKVCHRMEDLLAQ
LARAERPLERADLDVLLEATDWIAQTGGKLEREPGAPMTPTEDVLERLDARLGEKPKAPQDTRAAGGVPMPPVRTSDLDG
SIRLSGHRLDALLYRSGELLAAKSRLSLRAAEAASLRERFRRVRFPHTANGEAAPSLDESLRELAAGLSEDARLIGSLVG
ALDHEIRRARMQRFAEACQGLPRLVRDIGNESGKLAELNILGGEIEVDRSIVSGLQDSLRHLVRNAMGHGIETPPERRKA
GKPEKGRITVSAALFRDRFQVHVEDDGRGFDLKSIAEAAAGKGLPEAQDERQLLRRAFEPGISTSAEVTSLSGRGVGLDI
VRNAVEAMRGTVELSNVRGGGAAFTMTLPLTLATVRALEVMSGGQIFTIDTSSVRKVGQISTRDLPQRGKPNLLKTANGN
VRVLDLATWLGFPGPLMPDGKDIRTAVFVGTAGDETAVLVEQILEEQEMLVRSLGPRLANTRCYSGATILPDGPIALLLN
AAALIEAAASGEYSGTDAYSLQVRQARKKILVVDDSPSVRALEKLILEGAGYDVAIAADGAEAWKHLRTHGADVVVADID
MPEMDGVALTQTIRRSRKFAQLPVILISGRDTVEEKEQGLHAGANAYMAKSSFDQQLFLEAVRQMV

Sequences:

>Translated_706_residues
MAKADLDRQLLGLFIREVQERSGELERMLLAVEGAAGAEERRHLLERLLRIAHSLKGAAGLVEIRSIEKVCHRMEDLLAQ
LARAERPLERADLDVLLEATDWIAQTGGKLEREPGAPMTPTEDVLERLDARLGEKPKAPQDTRAAGGVPMPPVRTSDLDG
SIRLSGHRLDALLYRSGELLAAKSRLSLRAAEAASLRERFRRVRFPHTANGEAAPSLDESLRELAAGLSEDARLIGSLVG
ALDHEIRRARMQRFAEACQGLPRLVRDIGNESGKLAELNILGGEIEVDRSIVSGLQDSLRHLVRNAMGHGIETPPERRKA
GKPEKGRITVSAALFRDRFQVHVEDDGRGFDLKSIAEAAAGKGLPEAQDERQLLRRAFEPGISTSAEVTSLSGRGVGLDI
VRNAVEAMRGTVELSNVRGGGAAFTMTLPLTLATVRALEVMSGGQIFTIDTSSVRKVGQISTRDLPQRGKPNLLKTANGN
VRVLDLATWLGFPGPLMPDGKDIRTAVFVGTAGDETAVLVEQILEEQEMLVRSLGPRLANTRCYSGATILPDGPIALLLN
AAALIEAAASGEYSGTDAYSLQVRQARKKILVVDDSPSVRALEKLILEGAGYDVAIAADGAEAWKHLRTHGADVVVADID
MPEMDGVALTQTIRRSRKFAQLPVILISGRDTVEEKEQGLHAGANAYMAKSSFDQQLFLEAVRQMV
>Mature_705_residues
AKADLDRQLLGLFIREVQERSGELERMLLAVEGAAGAEERRHLLERLLRIAHSLKGAAGLVEIRSIEKVCHRMEDLLAQL
ARAERPLERADLDVLLEATDWIAQTGGKLEREPGAPMTPTEDVLERLDARLGEKPKAPQDTRAAGGVPMPPVRTSDLDGS
IRLSGHRLDALLYRSGELLAAKSRLSLRAAEAASLRERFRRVRFPHTANGEAAPSLDESLRELAAGLSEDARLIGSLVGA
LDHEIRRARMQRFAEACQGLPRLVRDIGNESGKLAELNILGGEIEVDRSIVSGLQDSLRHLVRNAMGHGIETPPERRKAG
KPEKGRITVSAALFRDRFQVHVEDDGRGFDLKSIAEAAAGKGLPEAQDERQLLRRAFEPGISTSAEVTSLSGRGVGLDIV
RNAVEAMRGTVELSNVRGGGAAFTMTLPLTLATVRALEVMSGGQIFTIDTSSVRKVGQISTRDLPQRGKPNLLKTANGNV
RVLDLATWLGFPGPLMPDGKDIRTAVFVGTAGDETAVLVEQILEEQEMLVRSLGPRLANTRCYSGATILPDGPIALLLNA
AALIEAAASGEYSGTDAYSLQVRQARKKILVVDDSPSVRALEKLILEGAGYDVAIAADGAEAWKHLRTHGADVVVADIDM
PEMDGVALTQTIRRSRKFAQLPVILISGRDTVEEKEQGLHAGANAYMAKSSFDQQLFLEAVRQMV

Specific function: FrzE is involved in a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. FrzE seems to be capable of autophosphorylating itself on an histidine residue and then to transfer that group to an aspartate r

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=412, Percent_Identity=29.8543689320388, Blast_Score=169, Evalue=8e-43,
Organism=Escherichia coli, GI145693157, Length=101, Percent_Identity=39.6039603960396, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=101, Percent_Identity=35.6435643564356, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790863, Length=112, Percent_Identity=33.9285714285714, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1790437, Length=107, Percent_Identity=35.5140186915888, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788191, Length=103, Percent_Identity=34.9514563106796, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF01584 CheW; PF02518 HATPase_c; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76458; Mature: 76326

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKADLDRQLLGLFIREVQERSGELERMLLAVEGAAGAEERRHLLERLLRIAHSLKGAAG
CCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHH
LVEIRSIEKVCHRMEDLLAQLARAERPLERADLDVLLEATDWIAQTGGKLEREPGAPMTP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
TEDVLERLDARLGEKPKAPQDTRAAGGVPMPPVRTSDLDGSIRLSGHRLDALLYRSGELL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCE
AAKSRLSLRAAEAASLRERFRRVRFPHTANGEAAPSLDESLRELAAGLSEDARLIGSLVG
EHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
ALDHEIRRARMQRFAEACQGLPRLVRDIGNESGKLAELNILGGEIEVDRSIVSGLQDSLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEHHHHHHHHHHHHH
HLVRNAMGHGIETPPERRKAGKPEKGRITVSAALFRDRFQVHVEDDGRGFDLKSIAEAAA
HHHHHHHCCCCCCCHHHHHCCCCCCCEEEEHHHHHHCCEEEEECCCCCCCCHHHHHHHHH
GKGLPEAQDERQLLRRAFEPGISTSAEVTSLSGRGVGLDIVRNAVEAMRGTVELSNVRGG
CCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCEEEECCCCC
GAAFTMTLPLTLATVRALEVMSGGQIFTIDTSSVRKVGQISTRDLPQRGKPNLLKTANGN
CEEEEEEHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCCCCCCCCCCCEEEECCCC
VRVLDLATWLGFPGPLMPDGKDIRTAVFVGTAGDETAVLVEQILEEQEMLVRSLGPRLAN
EEEEEEHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHCC
TRCYSGATILPDGPIALLLNAAALIEAAASGEYSGTDAYSLQVRQARKKILVVDDSPSVR
CCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEECCCCCHH
ALEKLILEGAGYDVAIAADGAEAWKHLRTHGADVVVADIDMPEMDGVALTQTIRRSRKFA
HHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
QLPVILISGRDTVEEKEQGLHAGANAYMAKSSFDQQLFLEAVRQMV
HCCEEEECCCCHHHHHHCCHHCCCCHHHHHCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
AKADLDRQLLGLFIREVQERSGELERMLLAVEGAAGAEERRHLLERLLRIAHSLKGAAG
CCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHH
LVEIRSIEKVCHRMEDLLAQLARAERPLERADLDVLLEATDWIAQTGGKLEREPGAPMTP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
TEDVLERLDARLGEKPKAPQDTRAAGGVPMPPVRTSDLDGSIRLSGHRLDALLYRSGELL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCE
AAKSRLSLRAAEAASLRERFRRVRFPHTANGEAAPSLDESLRELAAGLSEDARLIGSLVG
EHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
ALDHEIRRARMQRFAEACQGLPRLVRDIGNESGKLAELNILGGEIEVDRSIVSGLQDSLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEHHHHHHHHHHHHH
HLVRNAMGHGIETPPERRKAGKPEKGRITVSAALFRDRFQVHVEDDGRGFDLKSIAEAAA
HHHHHHHCCCCCCCHHHHHCCCCCCCEEEEHHHHHHCCEEEEECCCCCCCCHHHHHHHHH
GKGLPEAQDERQLLRRAFEPGISTSAEVTSLSGRGVGLDIVRNAVEAMRGTVELSNVRGG
CCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCEEEECCCCC
GAAFTMTLPLTLATVRALEVMSGGQIFTIDTSSVRKVGQISTRDLPQRGKPNLLKTANGN
CEEEEEEHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCCCCCCCCCCCEEEECCCC
VRVLDLATWLGFPGPLMPDGKDIRTAVFVGTAGDETAVLVEQILEEQEMLVRSLGPRLAN
EEEEEEHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHCC
TRCYSGATILPDGPIALLLNAAALIEAAASGEYSGTDAYSLQVRQARKKILVVDDSPSVR
CCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEECCCCCHH
ALEKLILEGAGYDVAIAADGAEAWKHLRTHGADVVVADIDMPEMDGVALTQTIRRSRKFA
HHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
QLPVILISGRDTVEEKEQGLHAGANAYMAKSSFDQQLFLEAVRQMV
HCCEEEECCCCHHHHHHCCHHCCCCHHHHHCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2165608; 2123853 [H]