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The map label for this gene is mutL

Identifier: 110632802

GI number: 110632802

Start: 487100

End: 488962

Strand: Reverse

Name: mutL

Synonym: Meso_0441

Alternate gene names: 110632802

Gene position: 488962-487100 (Counterclockwise)

Preceding gene: 110632803

Following gene: 110632801

Centisome position: 11.08

GC content: 65.32

Gene sequence:

>1863_bases
ATGCCGATCCGAGCGCTAGCCGACATTATCATCAATCAGATTGCCGCCGGCGAGGTTATCGAGCGGCCGGCAAGCGTCGT
GAAGGAGCTTGTGGAGAATGCGCTCGACGCCGGCGCGAAGCGCATCGAGGTGGCGACTGCCGGCGGCGGGCTCAACCTTA
TCCGCGTGATCGACGACGGCGGCGGGATTCCGCCGGAAGAATTGCCTTTGGCTGTCGCGCGGCATTGCACCTCCAAGCTC
ACCAGCGACATCCACGACATTCGCACGCTCGGCTTTCGCGGCGAAGCCCTGCCTTCCATCGGCTCGGTGGGCCGGCTCAC
GCTGCGCTCGCGCACGCCGGACGCCGATGGCGGAGCGGAGATCACGGTGGATGGAGGAAAAGCCAGTGCCGTCAAGCCTG
TGGCGGCCAATCGGGGCACGACTGTGGAGGTCCGCGACCTCTTCTTCGCCACTCCGGCGAGGCTCAAATTCATGAAGAGC
GAGCGGGCGGAGGCAGCGGCCATCACGGAGGTGGTGAAGCGCATCGCGCTCGCCTTTCCCGCCGTTCGCTTCATGCTTTC
CGGCACCGACCGCACGTCCACCGAGCTGCCCGCCGTTTCTGCCGACGGCGATGGCCTCCTGCGCCGGCTCGGCCAGATCA
TCGGCAAGGATTTTGCCGAGAACGCCCTGCCGATCGATGCGGAGCGGGAGGGCGTGTTTCTTACCGGTTATGCCTCCATT
CCTTCCTTCACCCGCGGCAACGCGCTTGCCCAGTTTGCCTATGTGAACGGAAGGCCGGTGCGCGACAAGCTGATCGCGGG
CGCCATTCGCGGCGCCTATATGGATGCGCTGCCAAGAGATCGGCACGCCGTAACCGCTCTCTTCATCTCCCTCGATCCCG
CTCTGGTGGACGTCAATGTCCATCCCGCCAAGGCGGATGTGCGCTTCCGCGATCCCGGCCTCGTGCGCGGCCTGATCGTC
GGCGCAATCCGTCAGGCGCTGGAGGGGGCGGGAGTGCGCGCTGCCACCACAGGTGCGGCCGCCATGCTGCAAGCCTTTCG
CGTTCCGGAAGGCCCGTCCCGGGCAAACGGGGCGAATGACTTCACTGGCCGGCCTTTCAGCGGCACAGAGCGCCCTCGAG
GCGGATGGAGCATGGAGCTTTCGCCCAGCCGTCCGCTTGAAGATGCCTTTCCCCCCGCGGCAAACGGCTTTGCCGAGGCG
CAGCAGGTTGTCTTCGACATAGGATCGGTCGTCAGTGCCGATGCGCGCGCCGGCACCCTTGAGGCTCTGTCGGATCTCGT
GGGCCGTCCGCTCGGTGCTGCCAGGGCGCAGGTGCATGAAAACTATATCGTCGCGCAGACGGAGGATTCGCTTGTCATCG
TCGACCAGCACGCGGCCCATGAGAGGCTCGTTTACGAGGCCCTGAAGGATGCAATCCACTCCAAGCCGCTCCCCTCGCAA
ATGCTCCTGATGCCGGAGATCGTGGACCTGCCGGAGGAGGATGCCGAGCGGCTTTGCGCGCACGCGGAATTCCTGGCGCG
GCTCGGCTTCGGTGTCGAGCGGTTCGGGCCGGGTGCCATCTGCGTGCGGGAAACGCCCTCCATGCTGGGCGAGGTGGATA
TTGCCGCCCTCATCCGCGACCTCGCCGACGAAATCGCGGACAATGACACGGCCAACAGCCTCAAAAAGCGCATCGATCAC
ATCGCCGCCACGATGGCCTGCCACGGCTCCATCCGGTCCGGCCGCAGGCTCAAGCCGGAAGAGATGAACGCTCTCTTGAG
ACAGATGGAGGCGACGCCCGGCTCAGGAACGTGCAATCACGGCCGGCCGACCTATATCGAGCTGAAGCTTGCGGATATCG
AGCGTTTGTTCGGCCGTCGTTAG

Upstream 100 bases:

>100_bases
ATCCCTGGGGTTTCAAAGCCTGGCGCTTAGGATTTTCAAGAAAGGGGGTAACCTCCGCGCGGCCCTTCGCCCGGAAGGCG
AATCCCGTTATAAAATCGCC

Downstream 100 bases:

>100_bases
GGGTCGCGCTTGACGGATCAAGCGAATATGGCGCAAGAAGCGCGCAGGCAAAAGGCTAAGGCATGAACCGTTTCGAGGGC
CCGGGCGCCCGTGAAGCACG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MPIRALADIIINQIAAGEVIERPASVVKELVENALDAGAKRIEVATAGGGLNLIRVIDDGGGIPPEELPLAVARHCTSKL
TSDIHDIRTLGFRGEALPSIGSVGRLTLRSRTPDADGGAEITVDGGKASAVKPVAANRGTTVEVRDLFFATPARLKFMKS
ERAEAAAITEVVKRIALAFPAVRFMLSGTDRTSTELPAVSADGDGLLRRLGQIIGKDFAENALPIDAEREGVFLTGYASI
PSFTRGNALAQFAYVNGRPVRDKLIAGAIRGAYMDALPRDRHAVTALFISLDPALVDVNVHPAKADVRFRDPGLVRGLIV
GAIRQALEGAGVRAATTGAAAMLQAFRVPEGPSRANGANDFTGRPFSGTERPRGGWSMELSPSRPLEDAFPPAANGFAEA
QQVVFDIGSVVSADARAGTLEALSDLVGRPLGAARAQVHENYIVAQTEDSLVIVDQHAAHERLVYEALKDAIHSKPLPSQ
MLLMPEIVDLPEEDAERLCAHAEFLARLGFGVERFGPGAICVRETPSMLGEVDIAALIRDLADEIADNDTANSLKKRIDH
IAATMACHGSIRSGRRLKPEEMNALLRQMEATPGSGTCNHGRPTYIELKLADIERLFGRR

Sequences:

>Translated_620_residues
MPIRALADIIINQIAAGEVIERPASVVKELVENALDAGAKRIEVATAGGGLNLIRVIDDGGGIPPEELPLAVARHCTSKL
TSDIHDIRTLGFRGEALPSIGSVGRLTLRSRTPDADGGAEITVDGGKASAVKPVAANRGTTVEVRDLFFATPARLKFMKS
ERAEAAAITEVVKRIALAFPAVRFMLSGTDRTSTELPAVSADGDGLLRRLGQIIGKDFAENALPIDAEREGVFLTGYASI
PSFTRGNALAQFAYVNGRPVRDKLIAGAIRGAYMDALPRDRHAVTALFISLDPALVDVNVHPAKADVRFRDPGLVRGLIV
GAIRQALEGAGVRAATTGAAAMLQAFRVPEGPSRANGANDFTGRPFSGTERPRGGWSMELSPSRPLEDAFPPAANGFAEA
QQVVFDIGSVVSADARAGTLEALSDLVGRPLGAARAQVHENYIVAQTEDSLVIVDQHAAHERLVYEALKDAIHSKPLPSQ
MLLMPEIVDLPEEDAERLCAHAEFLARLGFGVERFGPGAICVRETPSMLGEVDIAALIRDLADEIADNDTANSLKKRIDH
IAATMACHGSIRSGRRLKPEEMNALLRQMEATPGSGTCNHGRPTYIELKLADIERLFGRR
>Mature_619_residues
PIRALADIIINQIAAGEVIERPASVVKELVENALDAGAKRIEVATAGGGLNLIRVIDDGGGIPPEELPLAVARHCTSKLT
SDIHDIRTLGFRGEALPSIGSVGRLTLRSRTPDADGGAEITVDGGKASAVKPVAANRGTTVEVRDLFFATPARLKFMKSE
RAEAAAITEVVKRIALAFPAVRFMLSGTDRTSTELPAVSADGDGLLRRLGQIIGKDFAENALPIDAEREGVFLTGYASIP
SFTRGNALAQFAYVNGRPVRDKLIAGAIRGAYMDALPRDRHAVTALFISLDPALVDVNVHPAKADVRFRDPGLVRGLIVG
AIRQALEGAGVRAATTGAAAMLQAFRVPEGPSRANGANDFTGRPFSGTERPRGGWSMELSPSRPLEDAFPPAANGFAEAQ
QVVFDIGSVVSADARAGTLEALSDLVGRPLGAARAQVHENYIVAQTEDSLVIVDQHAAHERLVYEALKDAIHSKPLPSQM
LLMPEIVDLPEEDAERLCAHAEFLARLGFGVERFGPGAICVRETPSMLGEVDIAALIRDLADEIADNDTANSLKKRIDHI
AATMACHGSIRSGRRLKPEEMNALLRQMEATPGSGTCNHGRPTYIELKLADIERLFGRR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=313, Percent_Identity=35.1437699680511, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI4505913, Length=338, Percent_Identity=26.9230769230769, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI310128478, Length=338, Percent_Identity=26.9230769230769, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI4505911, Length=314, Percent_Identity=29.2993630573248, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI189458898, Length=314, Percent_Identity=29.2993630573248, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI189458896, Length=308, Percent_Identity=28.2467532467532, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI310128480, Length=299, Percent_Identity=24.7491638795987, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI263191589, Length=239, Percent_Identity=28.0334728033473, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI91992162, Length=366, Percent_Identity=25.1366120218579, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI91992160, Length=366, Percent_Identity=25.1366120218579, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1790612, Length=333, Percent_Identity=48.3483483483483, Blast_Score=266, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI71991825, Length=330, Percent_Identity=36.0606060606061, Blast_Score=166, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17562796, Length=341, Percent_Identity=26.6862170087977, Blast_Score=121, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=321, Percent_Identity=33.3333333333333, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=337, Percent_Identity=29.9703264094956, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323063, Length=347, Percent_Identity=28.5302593659942, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6325093, Length=696, Percent_Identity=21.551724137931, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17136968, Length=359, Percent_Identity=33.1476323119777, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI17136970, Length=352, Percent_Identity=28.4090909090909, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_MESSB (Q11L80)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673010.1
- ProteinModelPortal:   Q11L80
- SMR:   Q11L80
- STRING:   Q11L80
- GeneID:   4179982
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0441
- NMPDR:   fig|266779.1.peg.2588
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- PhylomeDB:   Q11L80
- ProtClustDB:   PRK00095
- BioCyc:   MSP266779:MESO_0441-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 66073; Mature: 65942

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRALADIIINQIAAGEVIERPASVVKELVENALDAGAKRIEVATAGGGLNLIRVIDDG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECC
GGIPPEELPLAVARHCTSKLTSDIHDIRTLGFRGEALPSIGSVGRLTLRSRTPDADGGAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCE
ITVDGGKASAVKPVAANRGTTVEVRDLFFATPARLKFMKSERAEAAAITEVVKRIALAFP
EEECCCCCCCCCCHHCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVRFMLSGTDRTSTELPAVSADGDGLLRRLGQIIGKDFAENALPIDAEREGVFLTGYASI
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
PSFTRGNALAQFAYVNGRPVRDKLIAGAIRGAYMDALPRDRHAVTALFISLDPALVDVNV
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEEECCEEEEEEE
HPAKADVRFRDPGLVRGLIVGAIRQALEGAGVRAATTGAAAMLQAFRVPEGPSRANGAND
CCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCC
FTGRPFSGTERPRGGWSMELSPSRPLEDAFPPAANGFAEAQQVVFDIGSVVSADARAGTL
CCCCCCCCCCCCCCCCEEECCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHH
EALSDLVGRPLGAARAQVHENYIVAQTEDSLVIVDQHAAHERLVYEALKDAIHSKPLPSQ
HHHHHHHCCCCCHHHHHHHCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCHH
MLLMPEIVDLPEEDAERLCAHAEFLARLGFGVERFGPGAICVRETPSMLGEVDIAALIRD
HHHCHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEECCHHHHHHHHHHHHHHH
LADEIADNDTANSLKKRIDHIAATMACHGSIRSGRRLKPEEMNALLRQMEATPGSGTCNH
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GRPTYIELKLADIERLFGRR
CCCCEEEEEHHHHHHHHCCC
>Mature Secondary Structure 
PIRALADIIINQIAAGEVIERPASVVKELVENALDAGAKRIEVATAGGGLNLIRVIDDG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECC
GGIPPEELPLAVARHCTSKLTSDIHDIRTLGFRGEALPSIGSVGRLTLRSRTPDADGGAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCE
ITVDGGKASAVKPVAANRGTTVEVRDLFFATPARLKFMKSERAEAAAITEVVKRIALAFP
EEECCCCCCCCCCHHCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVRFMLSGTDRTSTELPAVSADGDGLLRRLGQIIGKDFAENALPIDAEREGVFLTGYASI
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
PSFTRGNALAQFAYVNGRPVRDKLIAGAIRGAYMDALPRDRHAVTALFISLDPALVDVNV
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEEECCEEEEEEE
HPAKADVRFRDPGLVRGLIVGAIRQALEGAGVRAATTGAAAMLQAFRVPEGPSRANGAND
CCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCC
FTGRPFSGTERPRGGWSMELSPSRPLEDAFPPAANGFAEAQQVVFDIGSVVSADARAGTL
CCCCCCCCCCCCCCCCEEECCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHH
EALSDLVGRPLGAARAQVHENYIVAQTEDSLVIVDQHAAHERLVYEALKDAIHSKPLPSQ
HHHHHHHCCCCCHHHHHHHCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCHH
MLLMPEIVDLPEEDAERLCAHAEFLARLGFGVERFGPGAICVRETPSMLGEVDIAALIRD
HHHCHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEECCHHHHHHHHHHHHHHH
LADEIADNDTANSLKKRIDHIAATMACHGSIRSGRRLKPEEMNALLRQMEATPGSGTCNH
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GRPTYIELKLADIERLFGRR
CCCCEEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA