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The map label for this gene is hisN [H]

Identifier: 110632796

GI number: 110632796

Start: 482450

End: 483244

Strand: Direct

Name: hisN [H]

Synonym: Meso_0435

Alternate gene names: 110632796

Gene position: 482450-483244 (Clockwise)

Preceding gene: 110632795

Following gene: 110632797

Centisome position: 10.93

GC content: 64.91

Gene sequence:

>795_bases
GTGAGTGAGGCCTCCTTCACCCCTGCGCAAGAGCTTTCGCTGATCGTCGAGGCGGCGCGGGAAGCGGGTCGGATCGCGAT
GGGTTATTTCCGGCGCGATCCGGAAGTGTGGTGGAAGGACGGCAGATCGCCGGTAAGCCAGGCCGATTTGGATGTCGATC
TTTTCCTGCGCCGGGTCCTGCTTGAGGAGCGCCCCCACTATGGCTGGCTATCGGAGGAGACGGCCGACAACAAGGAAAGG
CTGAACGCACCACGCACATTCGTGGTGGACCCGATTGACGGGACGCGCGCGTTCATCGACGGGCGGAGCTCCTGGTGCGT
GAGCATAGCGGTGGTCGAAAACGGACGTGCGGTGGCCGGTGTACTGGACTGTCCGGCGTGCGGGGAGATTTTCAGCGCCG
TTCGAGGCGGCGGAGCACACCGCGACGGCCGGGCGATCAGTATCAAGACGCCGGGCCGCGAGCTTTCGCTCGCCGGGCCG
AAAAATATGATCAAGGCCTTGCCGCCGGAGATCTATTCCAAGGTGGCGCCTCACCCCTATGTGCCCTCTCTCGCCTATAG
AATTGCCCTGGTGGCGAGCGGTGCACTGGATGCCACTTTCGTGAAGCCTTCCTCCCATGACTGGGATCTGGCAGCGGCCG
ACCTCATCCTGGAGGAGGCGGGGGGAAGTATCGTCGACGGGGCGATGCGGCGCCCCCATTATGCCGGGCCGGACCCGCGC
CGTGGACCGCTTGCGGCAGGCAGCGGGAGGCTGCTGGAGATCATGGCCGGCGTCGTTGCCGAAATCCGGGAATAG

Upstream 100 bases:

>100_bases
CTGAAGGACATGTTCCTGCGCATGACGCCCGCGAGCGATCTAGACCGGAACTACGGCATTGCCGCCCCGACGCTGCTCAT
CGAAGGGATGACGATTGCCG

Downstream 100 bases:

>100_bases
CCGGCATACGGAGCCTTCTTGGCACCCGGGAAGTGCAAAGGTTTTCAAAGGGCACGAATTAATCTAGATCAGGCGACTGC
TTCGCGGGCTTGCCATAAAA

Product: inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSEASFTPAQELSLIVEAAREAGRIAMGYFRRDPEVWWKDGRSPVSQADLDVDLFLRRVLLEERPHYGWLSEETADNKER
LNAPRTFVVDPIDGTRAFIDGRSSWCVSIAVVENGRAVAGVLDCPACGEIFSAVRGGGAHRDGRAISIKTPGRELSLAGP
KNMIKALPPEIYSKVAPHPYVPSLAYRIALVASGALDATFVKPSSHDWDLAAADLILEEAGGSIVDGAMRRPHYAGPDPR
RGPLAAGSGRLLEIMAGVVAEIRE

Sequences:

>Translated_264_residues
MSEASFTPAQELSLIVEAAREAGRIAMGYFRRDPEVWWKDGRSPVSQADLDVDLFLRRVLLEERPHYGWLSEETADNKER
LNAPRTFVVDPIDGTRAFIDGRSSWCVSIAVVENGRAVAGVLDCPACGEIFSAVRGGGAHRDGRAISIKTPGRELSLAGP
KNMIKALPPEIYSKVAPHPYVPSLAYRIALVASGALDATFVKPSSHDWDLAAADLILEEAGGSIVDGAMRRPHYAGPDPR
RGPLAAGSGRLLEIMAGVVAEIRE
>Mature_263_residues
SEASFTPAQELSLIVEAAREAGRIAMGYFRRDPEVWWKDGRSPVSQADLDVDLFLRRVLLEERPHYGWLSEETADNKERL
NAPRTFVVDPIDGTRAFIDGRSSWCVSIAVVENGRAVAGVLDCPACGEIFSAVRGGGAHRDGRAISIKTPGRELSLAGPK
NMIKALPPEIYSKVAPHPYVPSLAYRIALVASGALDATFVKPSSHDWDLAAADLILEEAGGSIVDGAMRRPHYAGPDPRR
GPLAAGSGRLLEIMAGVVAEIRE

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI221625487, Length=237, Percent_Identity=27.4261603375527, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI5031789, Length=237, Percent_Identity=27.4261603375527, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1788882, Length=227, Percent_Identity=28.6343612334802, Blast_Score=74, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320493, Length=208, Percent_Identity=30.2884615384615, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357329, Length=221, Percent_Identity=30.316742081448, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21357957, Length=275, Percent_Identity=29.8181818181818, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24664918, Length=244, Percent_Identity=31.9672131147541, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357303, Length=237, Percent_Identity=28.6919831223629, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664922, Length=229, Percent_Identity=29.6943231441048, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24664926, Length=210, Percent_Identity=28.0952380952381, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28511; Mature: 28379

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEASFTPAQELSLIVEAAREAGRIAMGYFRRDPEVWWKDGRSPVSQADLDVDLFLRRVL
CCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHCCCHHHHCCCCCCCHHHCCCHHHHHHHHH
LEERPHYGWLSEETADNKERLNAPRTFVVDPIDGTRAFIDGRSSWCVSIAVVENGRAVAG
HHCCCCCCCCCCCCCCCHHHCCCCCEEEEECCCCCEEEECCCCCEEEEEEEEECCCEEEE
VLDCPACGEIFSAVRGGGAHRDGRAISIKTPGRELSLAGPKNMIKALPPEIYSKVAPHPY
EECCCCHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCHHHHHHHCCHHHHHHCCCCCC
VPSLAYRIALVASGALDATFVKPSSHDWDLAAADLILEEAGGSIVDGAMRRPHYAGPDPR
CHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCC
RGPLAAGSGRLLEIMAGVVAEIRE
CCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEASFTPAQELSLIVEAAREAGRIAMGYFRRDPEVWWKDGRSPVSQADLDVDLFLRRVL
CCCCCCCHHHHHHHHHHHHHCCCEEEHHHHCCCHHHHCCCCCCCHHHCCCHHHHHHHHH
LEERPHYGWLSEETADNKERLNAPRTFVVDPIDGTRAFIDGRSSWCVSIAVVENGRAVAG
HHCCCCCCCCCCCCCCCHHHCCCCCEEEEECCCCCEEEECCCCCEEEEEEEEECCCEEEE
VLDCPACGEIFSAVRGGGAHRDGRAISIKTPGRELSLAGPKNMIKALPPEIYSKVAPHPY
EECCCCHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCHHHHHHHCCHHHHHHCCCCCC
VPSLAYRIALVASGALDATFVKPSSHDWDLAAADLILEEAGGSIVDGAMRRPHYAGPDPR
CHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCC
RGPLAAGSGRLLEIMAGVVAEIRE
CCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]