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The map label for this gene is kefBC [H]

Identifier: 110632794

GI number: 110632794

Start: 479142

End: 480941

Strand: Reverse

Name: kefBC [H]

Synonym: Meso_0433

Alternate gene names: 110632794

Gene position: 480941-479142 (Counterclockwise)

Preceding gene: 110632801

Following gene: 110632788

Centisome position: 10.9

GC content: 62.5

Gene sequence:

>1800_bases
ATGGAAGCAGCCCTGGATACATATTACCAGCCACTCCTCCTTCTGGGAGCCGCCGTGATCGCGGCTCCACTATTCAAGCG
GCTTGGGCTCGGCACCGTCCTCGGCTATCTGGCCGCCGGTATTGCGATGGGGCCGGTTGCGCGCCTAATCTCCGACGGAG
AGGATCTCCTGCCTATCGCCGAGCTTGGCGTCGTCTTCCTGCTCTTTCTCATTGGCCTTGATCTCAATCCCTCCCGCCTC
TGGGCCATGCGGCGGCAGATCTTCGGGCTGGGGGCCGCTCAGGTCGTGGTCACAGGGGCAGTGCTCGCGCTCGCCGCTCT
CGTTTTTTTCGGCTTATCGCCCGCTGCCGCGGTCGTAATCGGCTTCGGCCTCGCGCTCTCCTCCACGGCCTTTGGCGTGC
AGATCATGGAGTCGGAAGGCACGCTCAATCGGCCATATGGCCGAACGGCCATTTCCATCCTGCTCCTGCAGGATCTCGCG
ATCGCACCGCTTCTGGCGCTCATCCCGCTGCTCTCACCGGGGGGCGAGGGCGCCGAGGACATTACCTTTAGCGGTTTTGC
ACTGGCACTTGCCTGCGTTGCCGCGCTCATCCTGGCCGGGCGATATCTCCTCAATCCGCTCTTCCGGCTTATCGGAAGCA
CCGGCGCGCGCGAGGCGATGATCGCCGCGGCTCTTTTGGTGGTGCTCGGCTCTGCCACGCTCCTGCAAGTCGCGGGATTG
TCGATGGGCCTCGGCGCCTTCATCGCCGGCGTGCTGCTCGCGGACTCGTCTTATCGTCACGAGCTTACCGCCGATATCGA
GCCCTTCCGCGGCATCTTGCTCGGGCTCTTCTTCATGGCCATCGGCCTCTCGCTCGATCTAGACGTGGTGCTGGAAAACT
GGCTTCTGGTTCTTGGCCTTGTTCCCGCCTTCATGCTCGCGAAGGCGGTTCTCCTTTACGGCATTTGCCGGCTGTTCGGC
TGTCAACACAACCAGGCTGTCCATGTGGCCTCCTTGCTCCCGCAAGGCGGCGAGTTCGGCTTCGTCCTATTCACGGCAGC
TTCCGCCGCGCTGATCTTCTCGCCTGAAACCGCCTCGCTTCTCATCGCGATCGTCACGCTTTCCATGGCAATGACACCGG
CCGTGGTCCGCATGGGCGCGCTGCTGATGCTTCCCGAGGAGCGCGAGGAAATCGACGAGACGTTCGACGGCGCAGGTTCC
GAGATCTTGATGATCGGCTTCTCGCGTTTCGGCCAGGTCGCCTCGCAGATCCTCCTAGCAGGTGGGGTGGATGTCACGAT
CATCGATCATTCGGCCACACGCGTGCGATCGGTCGAGAAATTCGGCTTTCGCATCTATTTTGGCGACGGGCGGCGCAAAG
AGGTGCTGGAGGCCGCCGGAATCAACAAAGCCAAGGTGGTTGCCGTCTGCACCAATGTTCGTGCGACGACGGATGCTATC
GTCAACATGATCCGGTCCGAGTTTCCGCATGTGAAGCTTTATGTGCGCTCCTACGACCGCGAGCATACGCTTTCGCTCAA
GGCACGAGGCGTCGACTACGAGATTCGCGAGACGTTCGAATCCGCGCTCGTTTTCGGCCAGCGCTCGCTGACAGAGCTCG
GGACCAGCGAAGAGGTCGCCCTGGAAATCGTGGAGGACGTGCGCCGCCGTGACGAAGAGCGGCTTGCGATTCAGGCCGTA
GAGGGTATCCAGGCGGGCGGCGACAGAATGCATGTCCGTCCGGTCACGCCCGAGCCTTTGACAAAGCCCGCGCGCGAAGC
GCGCCGCCTCGATCCGGCAGTGAAGGAGAATTCGGGCTAG

Upstream 100 bases:

>100_bases
AAGACTTGGACATGGACTTCCATTTATGGTGGCCGAAGGGGTGGCGCAATGGCGACTGCGCATACCCCCGTCCGCTGACA
AGAAAAAACGGATAGCGCGC

Downstream 100 bases:

>100_bases
GAATTTTTACGGGTCAGGCCGCGTCCCGCTTCAAAAGCGCCTCCACGCCGCGCTTCAGCTCGTCCTTGATGGATGCGGTT
TCAGCCATGATCTCATCCAT

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MEAALDTYYQPLLLLGAAVIAAPLFKRLGLGTVLGYLAAGIAMGPVARLISDGEDLLPIAELGVVFLLFLIGLDLNPSRL
WAMRRQIFGLGAAQVVVTGAVLALAALVFFGLSPAAAVVIGFGLALSSTAFGVQIMESEGTLNRPYGRTAISILLLQDLA
IAPLLALIPLLSPGGEGAEDITFSGFALALACVAALILAGRYLLNPLFRLIGSTGAREAMIAAALLVVLGSATLLQVAGL
SMGLGAFIAGVLLADSSYRHELTADIEPFRGILLGLFFMAIGLSLDLDVVLENWLLVLGLVPAFMLAKAVLLYGICRLFG
CQHNQAVHVASLLPQGGEFGFVLFTAASAALIFSPETASLLIAIVTLSMAMTPAVVRMGALLMLPEEREEIDETFDGAGS
EILMIGFSRFGQVASQILLAGGVDVTIIDHSATRVRSVEKFGFRIYFGDGRRKEVLEAAGINKAKVVAVCTNVRATTDAI
VNMIRSEFPHVKLYVRSYDREHTLSLKARGVDYEIRETFESALVFGQRSLTELGTSEEVALEIVEDVRRRDEERLAIQAV
EGIQAGGDRMHVRPVTPEPLTKPAREARRLDPAVKENSG

Sequences:

>Translated_599_residues
MEAALDTYYQPLLLLGAAVIAAPLFKRLGLGTVLGYLAAGIAMGPVARLISDGEDLLPIAELGVVFLLFLIGLDLNPSRL
WAMRRQIFGLGAAQVVVTGAVLALAALVFFGLSPAAAVVIGFGLALSSTAFGVQIMESEGTLNRPYGRTAISILLLQDLA
IAPLLALIPLLSPGGEGAEDITFSGFALALACVAALILAGRYLLNPLFRLIGSTGAREAMIAAALLVVLGSATLLQVAGL
SMGLGAFIAGVLLADSSYRHELTADIEPFRGILLGLFFMAIGLSLDLDVVLENWLLVLGLVPAFMLAKAVLLYGICRLFG
CQHNQAVHVASLLPQGGEFGFVLFTAASAALIFSPETASLLIAIVTLSMAMTPAVVRMGALLMLPEEREEIDETFDGAGS
EILMIGFSRFGQVASQILLAGGVDVTIIDHSATRVRSVEKFGFRIYFGDGRRKEVLEAAGINKAKVVAVCTNVRATTDAI
VNMIRSEFPHVKLYVRSYDREHTLSLKARGVDYEIRETFESALVFGQRSLTELGTSEEVALEIVEDVRRRDEERLAIQAV
EGIQAGGDRMHVRPVTPEPLTKPAREARRLDPAVKENSG
>Mature_599_residues
MEAALDTYYQPLLLLGAAVIAAPLFKRLGLGTVLGYLAAGIAMGPVARLISDGEDLLPIAELGVVFLLFLIGLDLNPSRL
WAMRRQIFGLGAAQVVVTGAVLALAALVFFGLSPAAAVVIGFGLALSSTAFGVQIMESEGTLNRPYGRTAISILLLQDLA
IAPLLALIPLLSPGGEGAEDITFSGFALALACVAALILAGRYLLNPLFRLIGSTGAREAMIAAALLVVLGSATLLQVAGL
SMGLGAFIAGVLLADSSYRHELTADIEPFRGILLGLFFMAIGLSLDLDVVLENWLLVLGLVPAFMLAKAVLLYGICRLFG
CQHNQAVHVASLLPQGGEFGFVLFTAASAALIFSPETASLLIAIVTLSMAMTPAVVRMGALLMLPEEREEIDETFDGAGS
EILMIGFSRFGQVASQILLAGGVDVTIIDHSATRVRSVEKFGFRIYFGDGRRKEVLEAAGINKAKVVAVCTNVRATTDAI
VNMIRSEFPHVKLYVRSYDREHTLSLKARGVDYEIRETFESALVFGQRSLTELGTSEEVALEIVEDVRRRDEERLAIQAV
EGIQAGGDRMHVRPVTPEPLTKPAREARRLDPAVKENSG

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=399, Percent_Identity=27.0676691729323, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786232, Length=621, Percent_Identity=38.9694041867955, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1789749, Length=584, Percent_Identity=40.7534246575342, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1786685, Length=522, Percent_Identity=26.0536398467433, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 63771; Mature: 63771

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAALDTYYQPLLLLGAAVIAAPLFKRLGLGTVLGYLAAGIAMGPVARLISDGEDLLPIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ELGVVFLLFLIGLDLNPSRLWAMRRQIFGLGAAQVVVTGAVLALAALVFFGLSPAAAVVI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GFGLALSSTAFGVQIMESEGTLNRPYGRTAISILLLQDLAIAPLLALIPLLSPGGEGAED
HHHHHHHCHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ITFSGFALALACVAALILAGRYLLNPLFRLIGSTGAREAMIAAALLVVLGSATLLQVAGL
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
SMGLGAFIAGVLLADSSYRHELTADIEPFRGILLGLFFMAIGLSLDLDVVLENWLLVLGL
HHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VPAFMLAKAVLLYGICRLFGCQHNQAVHVASLLPQGGEFGFVLFTAASAALIFSPETASL
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEEEHHCEEEEECCCHHHH
LIAIVTLSMAMTPAVVRMGALLMLPEEREEIDETFDGAGSEILMIGFSRFGQVASQILLA
HHHHHHHHHHHHHHHHHHCHHEECCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHH
GGVDVTIIDHSATRVRSVEKFGFRIYFGDGRRKEVLEAAGINKAKVVAVCTNVRATTDAI
CCCEEEEECCCHHHHHHHHHCCEEEEECCCCHHHHHHHCCCCCCEEEEEECCCCHHHHHH
VNMIRSEFPHVKLYVRSYDREHTLSLKARGVDYEIRETFESALVFGQRSLTELGTSEEVA
HHHHHHCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHCCCCHHHH
LEIVEDVRRRDEERLAIQAVEGIQAGGDRMHVRPVTPEPLTKPAREARRLDPAVKENSG
HHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEAALDTYYQPLLLLGAAVIAAPLFKRLGLGTVLGYLAAGIAMGPVARLISDGEDLLPIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ELGVVFLLFLIGLDLNPSRLWAMRRQIFGLGAAQVVVTGAVLALAALVFFGLSPAAAVVI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GFGLALSSTAFGVQIMESEGTLNRPYGRTAISILLLQDLAIAPLLALIPLLSPGGEGAED
HHHHHHHCHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ITFSGFALALACVAALILAGRYLLNPLFRLIGSTGAREAMIAAALLVVLGSATLLQVAGL
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
SMGLGAFIAGVLLADSSYRHELTADIEPFRGILLGLFFMAIGLSLDLDVVLENWLLVLGL
HHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VPAFMLAKAVLLYGICRLFGCQHNQAVHVASLLPQGGEFGFVLFTAASAALIFSPETASL
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEEEHHCEEEEECCCHHHH
LIAIVTLSMAMTPAVVRMGALLMLPEEREEIDETFDGAGSEILMIGFSRFGQVASQILLA
HHHHHHHHHHHHHHHHHHCHHEECCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHH
GGVDVTIIDHSATRVRSVEKFGFRIYFGDGRRKEVLEAAGINKAKVVAVCTNVRATTDAI
CCCEEEEECCCHHHHHHHHHCCEEEEECCCCHHHHHHHCCCCCCEEEEEECCCCHHHHHH
VNMIRSEFPHVKLYVRSYDREHTLSLKARGVDYEIRETFESALVFGQRSLTELGTSEEVA
HHHHHHCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHCCCCHHHH
LEIVEDVRRRDEERLAIQAVEGIQAGGDRMHVRPVTPEPLTKPAREARRLDPAVKENSG
HHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]