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The map label for this gene is hisS [H]

Identifier: 110632783

GI number: 110632783

Start: 465179

End: 466690

Strand: Reverse

Name: hisS [H]

Synonym: Meso_0422

Alternate gene names: 110632783

Gene position: 466690-465179 (Counterclockwise)

Preceding gene: 110632788

Following gene: 110632782

Centisome position: 10.58

GC content: 64.22

Gene sequence:

>1512_bases
ATGCGGGCGCGGTTTCCACATCAGAAGAGACGGATTTTTGGCATGGCTGACAAGGCGGACAAGGTGAAGGCAAGGCTCCC
GCGCGGGCTTGTCGACCGCCATCCGGCCGATATCCGCGCCGTGGACGAGATGATGGCGAAGATCCGCGCCGTCTACGAGC
TTTACGGTTTCGAGCCGGTCGAGACTCCGCTCATCGAATATACGGACGCGCTGGGCAAGTTCCTGCCCGACCAGGACCGG
CCGAACGAAGGCGTCTTCTCCTTCCAGGACGAGGACGAGCAGTGGCTTTCGCTGCGCTACGACCTCACCGCCCCCCTCGC
CCGCTTCGTGGCGGAGAATTTCGAGCGCCTTCCAAAGCCCTATCGCAGCTACCGCGCCGGCTGGGTCTTCCGCAACGAAA
AGCCCGGCCCCGGCCGTTTCCGCCAGTTCATGCAGTTCGACGCCGATACGGTCGGCACGCCCGGCGTCGCGGCGGACGCC
GAGATGTGCATGATGATGGCGGATGTCATGGAAGCGCTGGGCATCAAGCGCGGCGATTACGTGATCCGCGTGAACAACCG
CAAAGTGCTTGATGGCGTGCTGGAGGCGATTGGCGTCACCAGCGAAGGCCAGAAACTTACGGTTCTCCGTGCAATCGACA
AGCTCGATAAGTTCGGGCCGGAAGGTGTGAAGCAGCTTTTGGGCAAGGGACGTCTGGACGAGAGCGGCGATTTTACCAAG
GGCGCTGAGCTTGGTGCGGAGCAACAAGATACGGTCCTGGCCATGTGTCTTGGCGAGGACGGTGGGTCAGCAGCGGCAGC
GCGGAACGAGATCTGGGCGCAAGGCGCCGACGAGTTGCGAGAGATCGCCGCGCTTGTATCCGCCGCCGGCTACGGCTCCG
ACCGTATCCGTATCGACCCCTCCGTCGTTCGCGGGCTCGAATACTATACCGGCCCCGTCTTTGAAGCCGAACTGACCTTC
CCCGTCGTCAATGAGGACGGCGAGACGGTGCGCTTCGGCTCGGTAGGCGGCGGTGGGCGGTATGACGGGCTGGTCTCGCG
CTTCCGCGGCGAGCCGGTTCCGGCGACGGGCTTTTCCATCGGCGTTTCCCGCCTCATGACGGCGCTGAAGAATCTCGGCA
AGCTCGAAACCGCAGAAGCGGTCGCGCCGGTGGTTGTCCTCGTCATGGACAAGGACACCGAAAGCCTTGGGCGCTATCAG
CGGCTGGTCTCTCTGCTTCGCCAGGCAGGCATCCGCGCGGAAATGTATCTGGGCGGCGCGGGCATGAAGGCGCAGATGAA
ATATGCCGACCGGCGCGGCAGCCCCTGCGTCGTCATCCAGGGCGGCGACGAGCGTGAGAAGGGCGAGGTGCAGATCAAGG
ATCTCGTGGAAGGCAAGCGCCTCTCCGAAGAGATCGAGGACAATGTGACCTGGCGCGAGTCGCGCCCCGCGCAGTTCTCC
GTGCCCGAGAGCGAGATGGTCGCCGCCGTAAAGCGCGTGCTCGACGCGCAGGCGAAAGAGCGGAGCGCGTAG

Upstream 100 bases:

>100_bases
AACGCGAGAGGAATTAGCCGAAGAGCCGCCACGTGTCACCCGCTTTCAGCCGACCGCCCTTGCTGCTCCCATGCTTATCG
GTTAGGACAGCCGCGCTCGC

Downstream 100 bases:

>100_bases
GCCGCATGTCCCGCCTCGCCATCAGGTGGCACACCCCCCTCTGCCCTGCCGGGCATCTCCCCCTCAAGGGGGGAGATCAG
CTGGCCGTTATGCCGGTGCC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MRARFPHQKRRIFGMADKADKVKARLPRGLVDRHPADIRAVDEMMAKIRAVYELYGFEPVETPLIEYTDALGKFLPDQDR
PNEGVFSFQDEDEQWLSLRYDLTAPLARFVAENFERLPKPYRSYRAGWVFRNEKPGPGRFRQFMQFDADTVGTPGVAADA
EMCMMMADVMEALGIKRGDYVIRVNNRKVLDGVLEAIGVTSEGQKLTVLRAIDKLDKFGPEGVKQLLGKGRLDESGDFTK
GAELGAEQQDTVLAMCLGEDGGSAAAARNEIWAQGADELREIAALVSAAGYGSDRIRIDPSVVRGLEYYTGPVFEAELTF
PVVNEDGETVRFGSVGGGGRYDGLVSRFRGEPVPATGFSIGVSRLMTALKNLGKLETAEAVAPVVVLVMDKDTESLGRYQ
RLVSLLRQAGIRAEMYLGGAGMKAQMKYADRRGSPCVVIQGGDEREKGEVQIKDLVEGKRLSEEIEDNVTWRESRPAQFS
VPESEMVAAVKRVLDAQAKERSA

Sequences:

>Translated_503_residues
MRARFPHQKRRIFGMADKADKVKARLPRGLVDRHPADIRAVDEMMAKIRAVYELYGFEPVETPLIEYTDALGKFLPDQDR
PNEGVFSFQDEDEQWLSLRYDLTAPLARFVAENFERLPKPYRSYRAGWVFRNEKPGPGRFRQFMQFDADTVGTPGVAADA
EMCMMMADVMEALGIKRGDYVIRVNNRKVLDGVLEAIGVTSEGQKLTVLRAIDKLDKFGPEGVKQLLGKGRLDESGDFTK
GAELGAEQQDTVLAMCLGEDGGSAAAARNEIWAQGADELREIAALVSAAGYGSDRIRIDPSVVRGLEYYTGPVFEAELTF
PVVNEDGETVRFGSVGGGGRYDGLVSRFRGEPVPATGFSIGVSRLMTALKNLGKLETAEAVAPVVVLVMDKDTESLGRYQ
RLVSLLRQAGIRAEMYLGGAGMKAQMKYADRRGSPCVVIQGGDEREKGEVQIKDLVEGKRLSEEIEDNVTWRESRPAQFS
VPESEMVAAVKRVLDAQAKERSA
>Mature_503_residues
MRARFPHQKRRIFGMADKADKVKARLPRGLVDRHPADIRAVDEMMAKIRAVYELYGFEPVETPLIEYTDALGKFLPDQDR
PNEGVFSFQDEDEQWLSLRYDLTAPLARFVAENFERLPKPYRSYRAGWVFRNEKPGPGRFRQFMQFDADTVGTPGVAADA
EMCMMMADVMEALGIKRGDYVIRVNNRKVLDGVLEAIGVTSEGQKLTVLRAIDKLDKFGPEGVKQLLGKGRLDESGDFTK
GAELGAEQQDTVLAMCLGEDGGSAAAARNEIWAQGADELREIAALVSAAGYGSDRIRIDPSVVRGLEYYTGPVFEAELTF
PVVNEDGETVRFGSVGGGGRYDGLVSRFRGEPVPATGFSIGVSRLMTALKNLGKLETAEAVAPVVVLVMDKDTESLGRYQ
RLVSLLRQAGIRAEMYLGGAGMKAQMKYADRRGSPCVVIQGGDEREKGEVQIKDLVEGKRLSEEIEDNVTWRESRPAQFS
VPESEMVAAVKRVLDAQAKERSA

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=480, Percent_Identity=31.0416666666667, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI15029520, Length=472, Percent_Identity=29.4491525423729, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1788861, Length=447, Percent_Identity=26.6219239373602, Blast_Score=121, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI71993693, Length=465, Percent_Identity=30.5376344086021, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71993686, Length=465, Percent_Identity=30.5376344086021, Blast_Score=176, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6325290, Length=483, Percent_Identity=29.1925465838509, Blast_Score=164, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24643061, Length=478, Percent_Identity=30.5439330543933, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24643059, Length=497, Percent_Identity=29.1750503018109, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 55549; Mature: 55549

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARFPHQKRRIFGMADKADKVKARLPRGLVDRHPADIRAVDEMMAKIRAVYELYGFEPV
CCCCCCCHHHHHHCCCCCHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
ETPLIEYTDALGKFLPDQDRPNEGVFSFQDEDEQWLSLRYDLTAPLARFVAENFERLPKP
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHEEECCHHHHHHHHHHHHHHHCCCH
YRSYRAGWVFRNEKPGPGRFRQFMQFDADTVGTPGVAADAEMCMMMADVMEALGIKRGDY
HHHHCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
VIRVNNRKVLDGVLEAIGVTSEGQKLTVLRAIDKLDKFGPEGVKQLLGKGRLDESGDFTK
EEEECCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCC
GAELGAEQQDTVLAMCLGEDGGSAAAARNEIWAQGADELREIAALVSAAGYGSDRIRIDP
HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEECH
SVVRGLEYYTGPVFEAELTFPVVNEDGETVRFGSVGGGGRYDGLVSRFRGEPVPATGFSI
HHHHHHHHHCCCEEEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHH
GVSRLMTALKNLGKLETAEAVAPVVVLVMDKDTESLGRYQRLVSLLRQAGIRAEMYLGGA
HHHHHHHHHHHCCCHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCC
GMKAQMKYADRRGSPCVVIQGGDEREKGEVQIKDLVEGKRLSEEIEDNVTWRESRPAQFS
CCCHHHHHHHCCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
VPESEMVAAVKRVLDAQAKERSA
CCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRARFPHQKRRIFGMADKADKVKARLPRGLVDRHPADIRAVDEMMAKIRAVYELYGFEPV
CCCCCCCHHHHHHCCCCCHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
ETPLIEYTDALGKFLPDQDRPNEGVFSFQDEDEQWLSLRYDLTAPLARFVAENFERLPKP
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHEEECCHHHHHHHHHHHHHHHCCCH
YRSYRAGWVFRNEKPGPGRFRQFMQFDADTVGTPGVAADAEMCMMMADVMEALGIKRGDY
HHHHCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
VIRVNNRKVLDGVLEAIGVTSEGQKLTVLRAIDKLDKFGPEGVKQLLGKGRLDESGDFTK
EEEECCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCC
GAELGAEQQDTVLAMCLGEDGGSAAAARNEIWAQGADELREIAALVSAAGYGSDRIRIDP
HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEECH
SVVRGLEYYTGPVFEAELTFPVVNEDGETVRFGSVGGGGRYDGLVSRFRGEPVPATGFSI
HHHHHHHHHCCCEEEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHH
GVSRLMTALKNLGKLETAEAVAPVVVLVMDKDTESLGRYQRLVSLLRQAGIRAEMYLGGA
HHHHHHHHHHHCCCHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCC
GMKAQMKYADRRGSPCVVIQGGDEREKGEVQIKDLVEGKRLSEEIEDNVTWRESRPAQFS
CCCHHHHHHHCCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
VPESEMVAAVKRVLDAQAKERSA
CCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA