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The map label for this gene is glcD [H]

Identifier: 110632725

GI number: 110632725

Start: 406552

End: 408048

Strand: Reverse

Name: glcD [H]

Synonym: Meso_0364

Alternate gene names: 110632725

Gene position: 408048-406552 (Counterclockwise)

Preceding gene: 110632726

Following gene: 110632724

Centisome position: 9.25

GC content: 61.52

Gene sequence:

>1497_bases
ATGTCCGGAGCCCTACTCCCCAAGCCTGACATGGCGACGCTTGCGAAGCGGGACGAGATCGTGGCGGACATGCGCATTAT
CGTGCCGGGCGAAGGCGTTGTGGAAGCCGAGAGCGCGATGCGCGCATTCGAAAGCGACGGGCTCACGGCCTATCGCCAGC
TGCCGCTCGTCGTGGTGCTGCCGGAAACAGTGGCGCAGGTCTCCCGCATCCTGAAATATTGCGATGAACGCAATATTCGC
GTTGTGCCGCGCGGCTCAGGCACATCGCTTTCGGGCGGCGCGCTGCCGCTGCAGGATGCCGTGCTGCTCGTCATGAGCCG
CTTCAACCGCATACTCGAGATCGACTTCGCCAACAGGGCCGTAGTGACTCAGCCTGGCGTCACCAATCTGGGCATCACCC
ATGCTGTCGAGCATGAAGGCTTCTACTATGCGCCCGACCCCTCCTCGCAGATCGCCTGCTCCATCGGCGGCAATGTGGCG
GAGAATTCGGGCGGGGTGCATTGCCTGAAATACGGGCTTACCGCCAACAACATTCTCGGCATCCAGATGGTTCTGATGAA
TGGAGACGTGATCCGGCTGGGCGGCAAGCATCTCGATTCCGACGGCTATGATCTGATGGGCCTGATGACGGGATCGGAAG
GCCTGTTGGGGGTCGTCACCGAAGTCACGGTTCGCATTCTCAAGAAGCCGGAGACGGCGCGGGCATTGCTGATTGGCTTT
CCCTCCAGCGAGCAGGCCGGCCAATGCGTTGCCGACATTATCGGCGCCGGCATCATTCCGGGCGGCATGGAAATGATGGA
CCGGCCGGCGATTCATGCAGCCGAGTCCTTCGTCAATGCCGGCTATCCGCTCGATGTCGAGGCCCTGCTCATCGTGGAAC
TGGATGGGCCGCAAGCGGAGGTGCATCATCTGATCGAGAGCGTCGACGCCATCGCACGGAAAAACGGCTGCACGACGAAC
CGCGTCTCCAATTCGGACGAAGAGCGGCTTTCCTTCTGGGCAGGAAGGAAGGCAGCCTTCCCCGCTGTGGGCCGCATTTC
GCCCGACTATTACTGCATGGACGGGACCATCCCACGTAAGGAATTACCACGCGTGCTTTCAGGCATGCGCGAGCTTTCGG
AAAAGTATGGGCTGGGCGTCGCCAACGTCTTTCACGCGGGCGACGGCAATCTGCACCCGCTGATCCTTTACGATGCGAAC
AAGCCCGGCGAGCTGGAGAGGGCGGAAGGCTTCGGCGCGGACATCCTGCGCCTTTGCGTGCAAGTGGGCGGCGTGCTCAC
CGGCGAGCATGGCGTGGGAGTGGAAAAGCGCGACCTGATGCCGGAAATGTTCTCCGAGGAGGACCTGAACCAGCAGATCC
GGGTCAAATGTGCCTTCGACCCGAACCATCTGCTCAACCCCGGCAAAGTGTTTCCGCAGCTTCACCGCTGCGCCGAGCTT
GGCCGCATGCACATCCATCGCGGGCAGATGCCCTTTCCGGATCTGGAAAGGTTTTAA

Upstream 100 bases:

>100_bases
CTCGCTCGTTTTTTGAGCCTTGGGCGGATTGACTCAAGCGCCGCCATTTGCGGAGCGAAAAATTAACTGGTAAATAGATT
AGACCAGTGAAGGAGATTGC

Downstream 100 bases:

>100_bases
GGGTGGCCAGTTTTACCCCCGGCAGTGCGCAGGAAGTGCTGAACATCGTGCGCTGGGCAGCAGGCGAGGAATCGCCGCTC
GAAGTGCTGGGACACGGGTC

Product: FAD linked oxidase-like

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSGALLPKPDMATLAKRDEIVADMRIIVPGEGVVEAESAMRAFESDGLTAYRQLPLVVVLPETVAQVSRILKYCDERNIR
VVPRGSGTSLSGGALPLQDAVLLVMSRFNRILEIDFANRAVVTQPGVTNLGITHAVEHEGFYYAPDPSSQIACSIGGNVA
ENSGGVHCLKYGLTANNILGIQMVLMNGDVIRLGGKHLDSDGYDLMGLMTGSEGLLGVVTEVTVRILKKPETARALLIGF
PSSEQAGQCVADIIGAGIIPGGMEMMDRPAIHAAESFVNAGYPLDVEALLIVELDGPQAEVHHLIESVDAIARKNGCTTN
RVSNSDEERLSFWAGRKAAFPAVGRISPDYYCMDGTIPRKELPRVLSGMRELSEKYGLGVANVFHAGDGNLHPLILYDAN
KPGELERAEGFGADILRLCVQVGGVLTGEHGVGVEKRDLMPEMFSEEDLNQQIRVKCAFDPNHLLNPGKVFPQLHRCAEL
GRMHIHRGQMPFPDLERF

Sequences:

>Translated_498_residues
MSGALLPKPDMATLAKRDEIVADMRIIVPGEGVVEAESAMRAFESDGLTAYRQLPLVVVLPETVAQVSRILKYCDERNIR
VVPRGSGTSLSGGALPLQDAVLLVMSRFNRILEIDFANRAVVTQPGVTNLGITHAVEHEGFYYAPDPSSQIACSIGGNVA
ENSGGVHCLKYGLTANNILGIQMVLMNGDVIRLGGKHLDSDGYDLMGLMTGSEGLLGVVTEVTVRILKKPETARALLIGF
PSSEQAGQCVADIIGAGIIPGGMEMMDRPAIHAAESFVNAGYPLDVEALLIVELDGPQAEVHHLIESVDAIARKNGCTTN
RVSNSDEERLSFWAGRKAAFPAVGRISPDYYCMDGTIPRKELPRVLSGMRELSEKYGLGVANVFHAGDGNLHPLILYDAN
KPGELERAEGFGADILRLCVQVGGVLTGEHGVGVEKRDLMPEMFSEEDLNQQIRVKCAFDPNHLLNPGKVFPQLHRCAEL
GRMHIHRGQMPFPDLERF
>Mature_497_residues
SGALLPKPDMATLAKRDEIVADMRIIVPGEGVVEAESAMRAFESDGLTAYRQLPLVVVLPETVAQVSRILKYCDERNIRV
VPRGSGTSLSGGALPLQDAVLLVMSRFNRILEIDFANRAVVTQPGVTNLGITHAVEHEGFYYAPDPSSQIACSIGGNVAE
NSGGVHCLKYGLTANNILGIQMVLMNGDVIRLGGKHLDSDGYDLMGLMTGSEGLLGVVTEVTVRILKKPETARALLIGFP
SSEQAGQCVADIIGAGIIPGGMEMMDRPAIHAAESFVNAGYPLDVEALLIVELDGPQAEVHHLIESVDAIARKNGCTTNR
VSNSDEERLSFWAGRKAAFPAVGRISPDYYCMDGTIPRKELPRVLSGMRELSEKYGLGVANVFHAGDGNLHPLILYDANK
PGELERAEGFGADILRLCVQVGGVLTGEHGVGVEKRDLMPEMFSEEDLNQQIRVKCAFDPNHLLNPGKVFPQLHRCAELG
RMHIHRGQMPFPDLERF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=459, Percent_Identity=29.1938997821351, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI37595754, Length=482, Percent_Identity=28.0082987551867, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI119964728, Length=472, Percent_Identity=30.0847457627119, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4501993, Length=250, Percent_Identity=27.2, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1789351, Length=482, Percent_Identity=57.6763485477178, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1787977, Length=501, Percent_Identity=24.9500998003992, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI48994907, Length=221, Percent_Identity=28.9592760180996, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71992373, Length=463, Percent_Identity=30.0215982721382, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71992381, Length=460, Percent_Identity=30, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71992392, Length=359, Percent_Identity=28.6908077994429, Blast_Score=165, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17534361, Length=430, Percent_Identity=26.7441860465116, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17556096, Length=219, Percent_Identity=26.027397260274, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320027, Length=475, Percent_Identity=28.8421052631579, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6320023, Length=476, Percent_Identity=27.1008403361345, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320764, Length=489, Percent_Identity=26.3803680981595, Blast_Score=160, Evalue=5e-40,
Organism=Drosophila melanogaster, GI18921117, Length=435, Percent_Identity=27.816091954023, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24639277, Length=435, Percent_Identity=27.816091954023, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24639275, Length=435, Percent_Identity=27.816091954023, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24653753, Length=221, Percent_Identity=27.1493212669683, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 53851; Mature: 53719

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGALLPKPDMATLAKRDEIVADMRIIVPGEGVVEAESAMRAFESDGLTAYRQLPLVVVL
CCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHCCCCEEHHHCCEEEEC
PETVAQVSRILKYCDERNIRVVPRGSGTSLSGGALPLQDAVLLVMSRFNRILEIDFANRA
CHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCE
VVTQPGVTNLGITHAVEHEGFYYAPDPSSQIACSIGGNVAENSGGVHCLKYGLTANNILG
EEECCCCCCCCCEEEEECCCEEECCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEE
IQMVLMNGDVIRLGGKHLDSDGYDLMGLMTGSEGLLGVVTEVTVRILKKPETARALLIGF
EEEEEECCCEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
PSSEQAGQCVADIIGAGIIPGGMEMMDRPAIHAAESFVNAGYPLDVEALLIVELDGPQAE
CCCCHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCEEEEEEEEECCCHHH
VHHLIESVDAIARKNGCTTNRVSNSDEERLSFWAGRKAAFPAVGRISPDYYCMDGTIPRK
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHH
ELPRVLSGMRELSEKYGLGVANVFHAGDGNLHPLILYDANKPGELERAEGFGADILRLCV
HHHHHHHHHHHHHHHHCCCHHHEEECCCCCCCEEEEECCCCCCCCHHHCCCCHHHHHHHH
QVGGVLTGEHGVGVEKRDLMPEMFSEEDLNQQIRVKCAFDPNHLLNPGKVFPQLHRCAEL
HHCCEEECCCCCCCCHHHCCHHHHCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHH
GRMHIHRGQMPFPDLERF
HHHHEECCCCCCCHHCCC
>Mature Secondary Structure 
SGALLPKPDMATLAKRDEIVADMRIIVPGEGVVEAESAMRAFESDGLTAYRQLPLVVVL
CCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHCCCCEEHHHCCEEEEC
PETVAQVSRILKYCDERNIRVVPRGSGTSLSGGALPLQDAVLLVMSRFNRILEIDFANRA
CHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCE
VVTQPGVTNLGITHAVEHEGFYYAPDPSSQIACSIGGNVAENSGGVHCLKYGLTANNILG
EEECCCCCCCCCEEEEECCCEEECCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEE
IQMVLMNGDVIRLGGKHLDSDGYDLMGLMTGSEGLLGVVTEVTVRILKKPETARALLIGF
EEEEEECCCEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
PSSEQAGQCVADIIGAGIIPGGMEMMDRPAIHAAESFVNAGYPLDVEALLIVELDGPQAE
CCCCHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCEEEEEEEEECCCHHH
VHHLIESVDAIARKNGCTTNRVSNSDEERLSFWAGRKAAFPAVGRISPDYYCMDGTIPRK
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHH
ELPRVLSGMRELSEKYGLGVANVFHAGDGNLHPLILYDANKPGELERAEGFGADILRLCV
HHHHHHHHHHHHHHHHCCCHHHEEECCCCCCCEEEEECCCCCCCCHHHCCCCHHHHHHHH
QVGGVLTGEHGVGVEKRDLMPEMFSEEDLNQQIRVKCAFDPNHLLNPGKVFPQLHRCAEL
HHCCEEECCCCCCCCHHHCCHHHHCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHH
GRMHIHRGQMPFPDLERF
HHHHEECCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]