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The map label for this gene is metH [H]

Identifier: 110632689

GI number: 110632689

Start: 362558

End: 366352

Strand: Reverse

Name: metH [H]

Synonym: Meso_0328

Alternate gene names: 110632689

Gene position: 366352-362558 (Counterclockwise)

Preceding gene: 110632690

Following gene: 110632687

Centisome position: 8.3

GC content: 61.08

Gene sequence:

>3795_bases
ATGTCGCAGACGAATACTCCACTTGCTGAACTTTTTGGCGACATCGCTGCCAAGCCGGACGGATCGGAAATCAGTGCCGC
GCTTAAGGCGGCTGCGCGCGAGCGGATTCTCGTGCTCGACGGCGCCATGGGCACCCAGATCCAGGGGCTTGGCTTTGACG
AGTCACACTTTCGCGGCGACCGTTTCGGCGGCTGTGCCTGCCATCAGCAGGGCAACAACGACCTCCTGATCCTGACGCAA
CCGAAGGCGATCGAAGAAATTCATTATCAATACGCGATCGCCGGCGCGGATATCATCGAGACGAACACCTTCTCCTCCAC
GCGCATCGCGCAGGCGGATTACGGCATGGAGGAGATGGTGTACGAGCTGAACCGTGACGGCGCGCGATTGGCGCGGCGCG
CCGTAAAGCGGGCTGAGCAGGAGGATGGCAAGCGCCGCTTCGTGGCGGGCGCGCTCGGGCCGACCAACCGTACCGCCTCG
ATCTCACCGGACGTGAACAATCCCGGCTACCGCGCGATCACCTTCGACGATCTCAGGATCGCCAATGGCGAGCAGATCCG
GGGACTGATCGACGGCGGCGTCGACATCATTCTCATCGAAACCATCTTCGACACGCTGAACGCCAAGGCTGCTGTCTTCG
CGGCGGAGGAAGTCTTCATAGAAAAAGGCGTTCGGCTGCCGGTGATGATCTCCGGCACAATTACCGACCTATCCGGCCGT
ACGCTTTCGGGCCAGACGCCGACGGCCTTCTGGCATTCGGTGCGCCACGCCAATCCCTTCACCATCGGGCTCAATTGCGC
GCTGGGCGCTGCCGCGATGCGTCCGCATCTTGCGGAACTTTCAAGCGCCGCCGACACATTCACCTGCGCCTATCCCAATG
CCGGCCTGCCGAATGAATTCGGGCAATATGACGAGAGTCCCGAGGCAATGGCGGCGCAGATCGAAGAGTTTGCGCGCGAA
GGGCTTGTCAATATCGTCGGCGGCTGCTGCGGCTCGACGCCCGAGCACATTCGCGCCATCGCGGAGGCTGCCGCGAAACA
CAAGCCGCGGGAATTGCCGAAGCCTCCGCGGCTGATGCGGCTTTCCGGTCTAGAGCCGTTCACGCTGTCCAAGGATATTC
CGTTCGTGAATATCGGTGAACGGACGAATGTCACCGGCTCTGCCAGGTTCCGCAAGCTGATCACCGCGGGCGACTTTGCC
GCCGCCCTTGACGTTGCGCGCGATCAGGTGGCGAACGGCGCACAGGTCATCGACGTCAATATGGACGAGGGCCTGATCGA
TTCGAAGAAGGCGATGGTCGAATATCTGAACCTGATCGCCGCCGAACCGGATATCGCCCGAGTGCCCGTGATGATCGATT
CCTCCAAATGGGAGGTGATCGAGGCAGGGCTGAAATGCGTCCAGGGAAAGCCGATCGTCAACTCAATCTCGATGAAAGAG
GGAGAGGAAGCATTTCTCCATCAGGCCAGGCTCTGCCGGGCCTATGGCGCGGCAGTGGTCGTGATGGCCTTTGACGAAAC
GGGCCAGGCCGACACGAAGGCGCGCAAGGTGGAGATATGCACCCGTGCCTATAAGATTTTGACGGAAAAGGTCGGTTTCC
CGCCGGAAGACATCATCTTCGACCCCAACATTTTCGCGGTGGCGACGGGTATCGAGGAGCACGACAACTACGGCGTGGAT
TTCATCGAAGCGGCGCGCGAGATCACGAAGACGCTGCCGCATGTGCATGTGTCGGGCGGGGTGTCGAATCTTTCCTTCTC
GTTCCGCGGCAACGAGCCGGTGCGCGAGGCGATGCATGCCGTCTTCCTCTACCACGCCATTCACGCCGGCATGGATATGG
GCATCGTCAATGCCGGCCAGCTCGCTGTCTATGACACGATCGATCCCGAGCTGCGCGAGGCCTGTGAGGATGTCGTTCTC
AACCGCAAACCAGAGGCGGGCGGAACGGCGACGGAGCGGCTGCTGGAGTTAGCCGAGCGTTACAAGGGAACGGGCGGCAA
AGAGGCGAAGGAACGTGATCTCGCCTGGCGCGAATGGCCGGTGGAGAAGCGGCTTGAGCATGCGCTCGTCAACGGCATTA
CCGAGTTTATCGAAGAAGACACCGAGGAAGCCCGCCAAAAGGCCGAAAGGCCGCTTCACGTCATCGAAGGACCGTTGATG
GCCGGCATGAATGTGGTGGGCGATCTTTTCGGCGCCGGCAAGATGTTCCTGCCGCAGGTGGTGAAGTCGGCCCGCGTGAT
GAAGCAGGCGGTGGCTGTGCTCCTGCCCTATATGGAAGCCGAAAAGCTCGCCAATGGCGGCGGCGGGCGGGAAAGCGCCG
GCAAGATCCTGATGGCGACGGTGAAAGGCGACGTGCACGATATCGGCAAGAACATTGTCGGCGTGGTGCTCGCCTGCAAC
AACTATGAGATCATCGATCTCGGCGTGATGGTGCCCGCAACCAAGATCCTGCAGACGGCGCGCGACGAAAAGGTCGACAT
CATTGGCCTTTCCGGTCTCATCACGCCGTCGCTCGACGAGATGGTGCATGTCGCCTCCGAGATGGAGCGCGAGGGCTTCG
ACATTCCGCTTCTTATCGGCGGGGCGACGACGAGCCGCGTGCATACGGCGGTCAAGATTCATCCTCGCTACAGCCAAGGC
CAGGCCATTTACGTCACAGATGCCAGCCGCGCGGTTGGCACTGTTTCGAACCTCCTGTCGCCTGAAACCAAAGCCGAATA
TGTGGAGACGCTGCGCGCCGAATACAAAAAGGTGGCCGAGGCGCATGCGCGCTCGGAAGCAGAGAAGCAGCGCCTGCCAC
TCGCGAAGGCTCGCCAGAACGCCTATCGGATCGACTGGAGCAACTATCAGCCGCCGAAGCCCACATTCCTTGGCACCAAG
GTGTTCGAGACGTGGGATCTGGCGGAGCTTTCCCGCTATATCGACTGGACGCCATTTTTCCAGACATGGGAACTCAAGGG
GCGCTACCCCAAAATTCTGGAGGACGAGAAACAGGGAGCGGCCGCGCGCCAGCTTTTCGATGACGCGCAGGAGATGCTGA
AGAAGATCATCGACGAGAAATGGTTTGCCCCAAGAGCCGCGATCGGCTTCTGGCCGGCCAATTCAGTGGGCGATGACATC
CGGCTTTATACCGACGAAAGCCGAAATGAGGAGCTGGCGACGCTCTTCACGTTGCGCCAGCAACTCACCAAGCGTGACGG
CAAGGCGAATTTGGCCCTTGCGGATTTCATCGCACCAGAGGGTATCGGCAAGCCGGATTATCTCGGCGGCTTCGTCGTGA
CCGCGGGGATCGAGGAAGTGGCTATCGCTGAGCGCTTCGAGCGGGCGAATGACGATTACTCCTCCATCCTCGTCAAGGCG
CTGGCCGATCGTTTCGCGGAAGCGTTCGCCGAACGTATGCACGAGCGGGTGCGCAAGGAGTTCTGGGGCTATGCGTCGGA
CGAAGCCTTCACGCCAGAGGAGCTGATCGGCGAACCCTATAAGGGCATACGCCCTGCCCCCGGCTACCCCGCCCAGCCCG
ATCACACCGAAAAGACGACGCTTTTCGCCTTGCTCGATGCTGAGAAGAACACAGGCGTGACGCTTACGGAAAGCTACGCC
ATGTGGCCGGGATCGTCCGTCTCGGGCCTCTATCTGGCGCACCCGGAGAGCTATTATTTCGGCGTTGCCAAGGTGGAGCG
TGACCAGGTCGAGGACTATGCCCGGCGCAAGGGCATGGAGACGGCCGAGGTGGAGCGCTGGCTCGGCCCCGTCCTCAACT
ATACCGCCGCGCCTTTTGCGGAAGCTGCGGAATAG

Upstream 100 bases:

>100_bases
CCCGGAATACGAAAGGTTGTTCAGCAGTCGCGCTGCGCCACATATTGACATAAAGATATCTTTATGTGAGCAATGAGTGA
CATTCAGAGGTATCGATTTA

Downstream 100 bases:

>100_bases
TCAATTCCGCAGCTTTCATGGTCCATCATTGCGGTGGTTAGCGCCAACCCAGGGCTGGGGCGACGTGCTTAAGGATGGCC
TCTATCACATGGGCGTTGTA

Product: B12-dependent methionine synthase

Products: NA

Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12 dependent; MS [H]

Number of amino acids: Translated: 1264; Mature: 1263

Protein sequence:

>1264_residues
MSQTNTPLAELFGDIAAKPDGSEISAALKAAARERILVLDGAMGTQIQGLGFDESHFRGDRFGGCACHQQGNNDLLILTQ
PKAIEEIHYQYAIAGADIIETNTFSSTRIAQADYGMEEMVYELNRDGARLARRAVKRAEQEDGKRRFVAGALGPTNRTAS
ISPDVNNPGYRAITFDDLRIANGEQIRGLIDGGVDIILIETIFDTLNAKAAVFAAEEVFIEKGVRLPVMISGTITDLSGR
TLSGQTPTAFWHSVRHANPFTIGLNCALGAAAMRPHLAELSSAADTFTCAYPNAGLPNEFGQYDESPEAMAAQIEEFARE
GLVNIVGGCCGSTPEHIRAIAEAAAKHKPRELPKPPRLMRLSGLEPFTLSKDIPFVNIGERTNVTGSARFRKLITAGDFA
AALDVARDQVANGAQVIDVNMDEGLIDSKKAMVEYLNLIAAEPDIARVPVMIDSSKWEVIEAGLKCVQGKPIVNSISMKE
GEEAFLHQARLCRAYGAAVVVMAFDETGQADTKARKVEICTRAYKILTEKVGFPPEDIIFDPNIFAVATGIEEHDNYGVD
FIEAAREITKTLPHVHVSGGVSNLSFSFRGNEPVREAMHAVFLYHAIHAGMDMGIVNAGQLAVYDTIDPELREACEDVVL
NRKPEAGGTATERLLELAERYKGTGGKEAKERDLAWREWPVEKRLEHALVNGITEFIEEDTEEARQKAERPLHVIEGPLM
AGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAVLLPYMEAEKLANGGGGRESAGKILMATVKGDVHDIGKNIVGVVLACN
NYEIIDLGVMVPATKILQTARDEKVDIIGLSGLITPSLDEMVHVASEMEREGFDIPLLIGGATTSRVHTAVKIHPRYSQG
QAIYVTDASRAVGTVSNLLSPETKAEYVETLRAEYKKVAEAHARSEAEKQRLPLAKARQNAYRIDWSNYQPPKPTFLGTK
VFETWDLAELSRYIDWTPFFQTWELKGRYPKILEDEKQGAAARQLFDDAQEMLKKIIDEKWFAPRAAIGFWPANSVGDDI
RLYTDESRNEELATLFTLRQQLTKRDGKANLALADFIAPEGIGKPDYLGGFVVTAGIEEVAIAERFERANDDYSSILVKA
LADRFAEAFAERMHERVRKEFWGYASDEAFTPEELIGEPYKGIRPAPGYPAQPDHTEKTTLFALLDAEKNTGVTLTESYA
MWPGSSVSGLYLAHPESYYFGVAKVERDQVEDYARRKGMETAEVERWLGPVLNYTAAPFAEAAE

Sequences:

>Translated_1264_residues
MSQTNTPLAELFGDIAAKPDGSEISAALKAAARERILVLDGAMGTQIQGLGFDESHFRGDRFGGCACHQQGNNDLLILTQ
PKAIEEIHYQYAIAGADIIETNTFSSTRIAQADYGMEEMVYELNRDGARLARRAVKRAEQEDGKRRFVAGALGPTNRTAS
ISPDVNNPGYRAITFDDLRIANGEQIRGLIDGGVDIILIETIFDTLNAKAAVFAAEEVFIEKGVRLPVMISGTITDLSGR
TLSGQTPTAFWHSVRHANPFTIGLNCALGAAAMRPHLAELSSAADTFTCAYPNAGLPNEFGQYDESPEAMAAQIEEFARE
GLVNIVGGCCGSTPEHIRAIAEAAAKHKPRELPKPPRLMRLSGLEPFTLSKDIPFVNIGERTNVTGSARFRKLITAGDFA
AALDVARDQVANGAQVIDVNMDEGLIDSKKAMVEYLNLIAAEPDIARVPVMIDSSKWEVIEAGLKCVQGKPIVNSISMKE
GEEAFLHQARLCRAYGAAVVVMAFDETGQADTKARKVEICTRAYKILTEKVGFPPEDIIFDPNIFAVATGIEEHDNYGVD
FIEAAREITKTLPHVHVSGGVSNLSFSFRGNEPVREAMHAVFLYHAIHAGMDMGIVNAGQLAVYDTIDPELREACEDVVL
NRKPEAGGTATERLLELAERYKGTGGKEAKERDLAWREWPVEKRLEHALVNGITEFIEEDTEEARQKAERPLHVIEGPLM
AGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAVLLPYMEAEKLANGGGGRESAGKILMATVKGDVHDIGKNIVGVVLACN
NYEIIDLGVMVPATKILQTARDEKVDIIGLSGLITPSLDEMVHVASEMEREGFDIPLLIGGATTSRVHTAVKIHPRYSQG
QAIYVTDASRAVGTVSNLLSPETKAEYVETLRAEYKKVAEAHARSEAEKQRLPLAKARQNAYRIDWSNYQPPKPTFLGTK
VFETWDLAELSRYIDWTPFFQTWELKGRYPKILEDEKQGAAARQLFDDAQEMLKKIIDEKWFAPRAAIGFWPANSVGDDI
RLYTDESRNEELATLFTLRQQLTKRDGKANLALADFIAPEGIGKPDYLGGFVVTAGIEEVAIAERFERANDDYSSILVKA
LADRFAEAFAERMHERVRKEFWGYASDEAFTPEELIGEPYKGIRPAPGYPAQPDHTEKTTLFALLDAEKNTGVTLTESYA
MWPGSSVSGLYLAHPESYYFGVAKVERDQVEDYARRKGMETAEVERWLGPVLNYTAAPFAEAAE
>Mature_1263_residues
SQTNTPLAELFGDIAAKPDGSEISAALKAAARERILVLDGAMGTQIQGLGFDESHFRGDRFGGCACHQQGNNDLLILTQP
KAIEEIHYQYAIAGADIIETNTFSSTRIAQADYGMEEMVYELNRDGARLARRAVKRAEQEDGKRRFVAGALGPTNRTASI
SPDVNNPGYRAITFDDLRIANGEQIRGLIDGGVDIILIETIFDTLNAKAAVFAAEEVFIEKGVRLPVMISGTITDLSGRT
LSGQTPTAFWHSVRHANPFTIGLNCALGAAAMRPHLAELSSAADTFTCAYPNAGLPNEFGQYDESPEAMAAQIEEFAREG
LVNIVGGCCGSTPEHIRAIAEAAAKHKPRELPKPPRLMRLSGLEPFTLSKDIPFVNIGERTNVTGSARFRKLITAGDFAA
ALDVARDQVANGAQVIDVNMDEGLIDSKKAMVEYLNLIAAEPDIARVPVMIDSSKWEVIEAGLKCVQGKPIVNSISMKEG
EEAFLHQARLCRAYGAAVVVMAFDETGQADTKARKVEICTRAYKILTEKVGFPPEDIIFDPNIFAVATGIEEHDNYGVDF
IEAAREITKTLPHVHVSGGVSNLSFSFRGNEPVREAMHAVFLYHAIHAGMDMGIVNAGQLAVYDTIDPELREACEDVVLN
RKPEAGGTATERLLELAERYKGTGGKEAKERDLAWREWPVEKRLEHALVNGITEFIEEDTEEARQKAERPLHVIEGPLMA
GMNVVGDLFGAGKMFLPQVVKSARVMKQAVAVLLPYMEAEKLANGGGGRESAGKILMATVKGDVHDIGKNIVGVVLACNN
YEIIDLGVMVPATKILQTARDEKVDIIGLSGLITPSLDEMVHVASEMEREGFDIPLLIGGATTSRVHTAVKIHPRYSQGQ
AIYVTDASRAVGTVSNLLSPETKAEYVETLRAEYKKVAEAHARSEAEKQRLPLAKARQNAYRIDWSNYQPPKPTFLGTKV
FETWDLAELSRYIDWTPFFQTWELKGRYPKILEDEKQGAAARQLFDDAQEMLKKIIDEKWFAPRAAIGFWPANSVGDDIR
LYTDESRNEELATLFTLRQQLTKRDGKANLALADFIAPEGIGKPDYLGGFVVTAGIEEVAIAERFERANDDYSSILVKAL
ADRFAEAFAERMHERVRKEFWGYASDEAFTPEELIGEPYKGIRPAPGYPAQPDHTEKTTLFALLDAEKNTGVTLTESYAM
WPGSSVSGLYLAHPESYYFGVAKVERDQVEDYARRKGMETAEVERWLGPVLNYTAAPFAEAAE

Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]

COG id: COG1410

COG function: function code E; Methionine synthase I, cobalamin-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=1266, Percent_Identity=56.7930489731438, Blast_Score=1400, Evalue=0.0,
Organism=Escherichia coli, GI1790450, Length=1231, Percent_Identity=62.3070674248578, Blast_Score=1540, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17535405, Length=1251, Percent_Identity=54.2765787370104, Blast_Score=1312, Evalue=0.0,

Paralogues:

None

Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006158
- InterPro:   IPR011005
- InterPro:   IPR003759
- InterPro:   IPR011822
- InterPro:   IPR000489
- InterPro:   IPR003726
- InterPro:   IPR004223 [H]

Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]

EC number: =2.1.1.13 [H]

Molecular weight: Translated: 138789; Mature: 138658

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50970 HCY ; PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTNTPLAELFGDIAAKPDGSEISAALKAAARERILVLDGAMGTQIQGLGFDESHFRGD
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCEEEEEECCCCCEEECCCCCHHHCCCC
RFGGCACHQQGNNDLLILTQPKAIEEIHYQYAIAGADIIETNTFSSTRIAQADYGMEEMV
CCCCEEECCCCCCCEEEEECCHHHHHHHHHHEEECCCEEECCCCCCCEEEHHHCCHHHHH
YELNRDGARLARRAVKRAEQEDGKRRFVAGALGPTNRTASISPDVNNPGYRAITFDDLRI
HHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCCCCCCEEEEEECCEEE
ANGEQIRGLIDGGVDIILIETIFDTLNAKAAVFAAEEVFIEKGVRLPVMISGTITDLSGR
CCCHHHHHHCCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECEEECCCCC
TLSGQTPTAFWHSVRHANPFTIGLNCALGAAAMRPHLAELSSAADTFTCAYPNAGLPNEF
EECCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHH
GQYDESPEAMAAQIEEFAREGLVNIVGGCCGSTPEHIRAIAEAAAKHKPRELPKPPRLMR
HCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEE
LSGLEPFTLSKDIPFVNIGERTNVTGSARFRKLITAGDFAAALDVARDQVANGAQVIDVN
ECCCCCCEECCCCCEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEC
MDEGLIDSKKAMVEYLNLIAAEPDIARVPVMIDSSKWEVIEAGLKCVQGKPIVNSISMKE
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCHHCCCCCC
GEEAFLHQARLCRAYGAAVVVMAFDETGQADTKARKVEICTRAYKILTEKVGFPPEDIIF
CHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHEEE
DPNIFAVATGIEEHDNYGVDFIEAAREITKTLPHVHVSGGVSNLSFSFRGNEPVREAMHA
CCCEEEEEECCHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCHHHHHHHH
VFLYHAIHAGMDMGIVNAGQLAVYDTIDPELREACEDVVLNRKPEAGGTATERLLELAER
HHHHHHHHCCCCCCEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
YKGTGGKEAKERDLAWREWPVEKRLEHALVNGITEFIEEDTEEARQKAERPLHVIEGPLM
HCCCCCCCHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHH
AGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAVLLPYMEAEKLANGGGGRESAGKILMAT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
VKGDVHDIGKNIVGVVLACNNYEIIDLGVMVPATKILQTARDEKVDIIGLSGLITPSLDE
ECCCHHHHHHHHEEEEEEECCEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHH
MVHVASEMEREGFDIPLLIGGATTSRVHTAVKIHPRYSQGQAIYVTDASRAVGTVSNLLS
HHHHHHHHHHCCCCCEEEECCCCCHHEEEEEEEECCCCCCCEEEEECCHHHHHHHHHHCC
PETKAEYVETLRAEYKKVAEAHARSEAEKQRLPLAKARQNAYRIDWSNYQPPKPTFLGTK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCCCCCCCCCCCCCH
VFETWDLAELSRYIDWTPFFQTWELKGRYPKILEDEKQGAAARQLFDDAQEMLKKIIDEK
HHHHCCHHHHHHHCCCCCCCCCEECCCCCCCHHCHHHCCHHHHHHHHHHHHHHHHHHHHH
WFAPRAAIGFWPANSVGDDIRLYTDESRNEELATLFTLRQQLTKRDGKANLALADFIAPE
CCCCCCEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCC
GIGKPDYLGGFVVTAGIEEVAIAERFERANDDYSSILVKALADRFAEAFAERMHERVRKE
CCCCCCCCCCEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FWGYASDEAFTPEELIGEPYKGIRPAPGYPAQPDHTEKTTLFALLDAEKNTGVTLTESYA
HCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECEE
MWPGSSVSGLYLAHPESYYFGVAKVERDQVEDYARRKGMETAEVERWLGPVLNYTAAPFA
ECCCCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCH
EAAE
HCCC
>Mature Secondary Structure 
SQTNTPLAELFGDIAAKPDGSEISAALKAAARERILVLDGAMGTQIQGLGFDESHFRGD
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCEEEEEECCCCCEEECCCCCHHHCCCC
RFGGCACHQQGNNDLLILTQPKAIEEIHYQYAIAGADIIETNTFSSTRIAQADYGMEEMV
CCCCEEECCCCCCCEEEEECCHHHHHHHHHHEEECCCEEECCCCCCCEEEHHHCCHHHHH
YELNRDGARLARRAVKRAEQEDGKRRFVAGALGPTNRTASISPDVNNPGYRAITFDDLRI
HHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCCCCCCEEEEEECCEEE
ANGEQIRGLIDGGVDIILIETIFDTLNAKAAVFAAEEVFIEKGVRLPVMISGTITDLSGR
CCCHHHHHHCCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECEEECCCCC
TLSGQTPTAFWHSVRHANPFTIGLNCALGAAAMRPHLAELSSAADTFTCAYPNAGLPNEF
EECCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHH
GQYDESPEAMAAQIEEFAREGLVNIVGGCCGSTPEHIRAIAEAAAKHKPRELPKPPRLMR
HCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEE
LSGLEPFTLSKDIPFVNIGERTNVTGSARFRKLITAGDFAAALDVARDQVANGAQVIDVN
ECCCCCCEECCCCCEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEC
MDEGLIDSKKAMVEYLNLIAAEPDIARVPVMIDSSKWEVIEAGLKCVQGKPIVNSISMKE
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCHHCCCCCC
GEEAFLHQARLCRAYGAAVVVMAFDETGQADTKARKVEICTRAYKILTEKVGFPPEDIIF
CHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHEEE
DPNIFAVATGIEEHDNYGVDFIEAAREITKTLPHVHVSGGVSNLSFSFRGNEPVREAMHA
CCCEEEEEECCHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCHHHHHHHH
VFLYHAIHAGMDMGIVNAGQLAVYDTIDPELREACEDVVLNRKPEAGGTATERLLELAER
HHHHHHHHCCCCCCEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
YKGTGGKEAKERDLAWREWPVEKRLEHALVNGITEFIEEDTEEARQKAERPLHVIEGPLM
HCCCCCCCHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHH
AGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAVLLPYMEAEKLANGGGGRESAGKILMAT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
VKGDVHDIGKNIVGVVLACNNYEIIDLGVMVPATKILQTARDEKVDIIGLSGLITPSLDE
ECCCHHHHHHHHEEEEEEECCEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHH
MVHVASEMEREGFDIPLLIGGATTSRVHTAVKIHPRYSQGQAIYVTDASRAVGTVSNLLS
HHHHHHHHHHCCCCCEEEECCCCCHHEEEEEEEECCCCCCCEEEEECCHHHHHHHHHHCC
PETKAEYVETLRAEYKKVAEAHARSEAEKQRLPLAKARQNAYRIDWSNYQPPKPTFLGTK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCCCCCCCCCCCCCH
VFETWDLAELSRYIDWTPFFQTWELKGRYPKILEDEKQGAAARQLFDDAQEMLKKIIDEK
HHHHCCHHHHHHHCCCCCCCCCEECCCCCCCHHCHHHCCHHHHHHHHHHHHHHHHHHHHH
WFAPRAAIGFWPANSVGDDIRLYTDESRNEELATLFTLRQQLTKRDGKANLALADFIAPE
CCCCCCEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCC
GIGKPDYLGGFVVTAGIEEVAIAERFERANDDYSSILVKALADRFAEAFAERMHERVRKE
CCCCCCCCCCEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FWGYASDEAFTPEELIGEPYKGIRPAPGYPAQPDHTEKTTLFALLDAEKNTGVTLTESYA
HCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECEE
MWPGSSVSGLYLAHPESYYFGVAKVERDQVEDYARRKGMETAEVERWLGPVLNYTAAPFA
ECCCCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCH
EAAE
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]