Click here to switch to the map view.

The map label for this gene is folK [H]

Identifier: 109947672

GI number: 109947672

Start: 989752

End: 990243

Strand: Reverse

Name: folK [H]

Synonym: Hac_1140

Alternate gene names: 109947672

Gene position: 990243-989752 (Counterclockwise)

Preceding gene: 109947673

Following gene: 109947671

Centisome position: 63.73

GC content: 32.72

Gene sequence:

>492_bases
GTGATGCAAGAGATCCTTACTAGCCACTTTTTCCCTAGCCTTTTTAAAAGAAGACTTGATTTTTCTAACAGAGTGGTTTT
AGGGTTGGGATCTAATATTAAAAATCCTTTAAAAATATTAAAAAATTGTTTTTTATATTTTAAAAATCATAGTAAAATTG
GAAAGATTTTTTCCTCGCCCATTTATGTGAATCCGCCCTTTGGCTATGTTAAGCAACCTGATTTTTATAACGCTACGATT
ATCCTTAGGACATGTTTAGATTTACGAGAGTTTTTTGCTTTGGTTTTTTATATAGAGAGGCGTTTTGGTCGTGCAAGGAA
GCGCGATTTTAAAAACGCTCCAAGAACTTTAGATATTGATATTATCGCTTTCAATCAAGTCATTTTAAGACAAAATGATT
TGACTTTACCTCATCCTAAATGGAATGAAAGGGATTCGGTGTTAGTGCCTTTAACTTTGCAACAAATGCTTTTTAAAAAA
GGGGAGTGGTGA

Upstream 100 bases:

>100_bases
GCATGGTGTTTTCTGTGGAGCCTGGGATTTATATCCCTGGATTTTTTGGGGTGCGCATTGAAGATTTAGTCGTGATTAAA
AATTCTAGGGCTGAGCTTTT

Downstream 100 bases:

>100_bases
AATTCTATACCTATAGTGGGGAGACGGCAGCTGAGGCTTTAAAGATCGCTCAAAGCCACCATGGGGTAGATACGCTAGTG
TTTAAAACTCAAGAAATCCG

Product: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokin ase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MMQEILTSHFFPSLFKRRLDFSNRVVLGLGSNIKNPLKILKNCFLYFKNHSKIGKIFSSPIYVNPPFGYVKQPDFYNATI
ILRTCLDLREFFALVFYIERRFGRARKRDFKNAPRTLDIDIIAFNQVILRQNDLTLPHPKWNERDSVLVPLTLQQMLFKK
GEW

Sequences:

>Translated_163_residues
MMQEILTSHFFPSLFKRRLDFSNRVVLGLGSNIKNPLKILKNCFLYFKNHSKIGKIFSSPIYVNPPFGYVKQPDFYNATI
ILRTCLDLREFFALVFYIERRFGRARKRDFKNAPRTLDIDIIAFNQVILRQNDLTLPHPKWNERDSVLVPLTLQQMLFKK
GEW
>Mature_163_residues
MMQEILTSHFFPSLFKRRLDFSNRVVLGLGSNIKNPLKILKNCFLYFKNHSKIGKIFSSPIYVNPPFGYVKQPDFYNATI
ILRTCLDLREFFALVFYIERRFGRARKRDFKNAPRTLDIDIIAFNQVILRQNDLTLPHPKWNERDSVLVPLTLQQMLFKK
GEW

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=138, Percent_Identity=31.8840579710145, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19359; Mature: 19359

Theoretical pI: Translated: 10.71; Mature: 10.71

Prosite motif: PS00092 N6_MTASE ; PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQEILTSHFFPSLFKRRLDFSNRVVLGLGSNIKNPLKILKNCFLYFKNHSKIGKIFSSP
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHCCC
IYVNPPFGYVKQPDFYNATIILRTCLDLREFFALVFYIERRFGRARKRDFKNAPRTLDID
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
IIAFNQVILRQNDLTLPHPKWNERDSVLVPLTLQQMLFKKGEW
EEEHHHHHHCCCCCCCCCCCCCCCCCEEECHHHHHHHHHCCCC
>Mature Secondary Structure
MMQEILTSHFFPSLFKRRLDFSNRVVLGLGSNIKNPLKILKNCFLYFKNHSKIGKIFSSP
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHCCC
IYVNPPFGYVKQPDFYNATIILRTCLDLREFFALVFYIERRFGRARKRDFKNAPRTLDID
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
IIAFNQVILRQNDLTLPHPKWNERDSVLVPLTLQQMLFKKGEW
EEEHHHHHHCCCCCCCCCCCCCCCCCEEECHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]