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The map label for this gene is ilvC

Identifier: 109947531

GI number: 109947531

Start: 866025

End: 867017

Strand: Reverse

Name: ilvC

Synonym: Hac_0990

Alternate gene names: 109947531

Gene position: 867017-866025 (Counterclockwise)

Preceding gene: 109947534

Following gene: 109947530

Centisome position: 55.8

GC content: 40.28

Gene sequence:

>993_bases
TTGGCATTATCCGTTTATTACGATAAAGACATTGATTTAGGCGTTATCCAATCCTTACAAGTGGGCATTATTGGTTATGG
CACTCAAGGAGAAGCCCAAGCACTCAATTTAAGAGATTCTAAAGTGAAAGTGCGTGTTGGCTTGTATCAAGGGAGTTTGA
GCATTCCAAAAGCAAAGGCAGAGGGCTTTGAGGTGTTGGAAGTCAAAGAATTAGTCCAAAAGTCTGATGTGATCATGGCG
TTACTTCCGGATGAATTGCATAAGGAAGTTTTAGAAAAAGAAGTGATCCCTTTTTTAAAAGAGGGCCAAATTGTGGGCTT
TGCTCATGGTTTTAGCGTGCATTTCAATCAAGTCTCTTTTAAAAAAGGCGTGGGCGTGATTTTAGTCGCACCAAAAGGAC
CAGGGAGTGCTTTAAGAGAAGAATACCTTAAAAACAAGGGCTTATACCATTTGATTGCCATAGAGCAAGAAAATTCAAAA
AACAACGCTAAAGCCGTGGCTTTAAGCTATGCAAAGGCGATGGGTGGGGGGAGAATGGGGGTTTTAGAAACGAGCTTTAA
AGAAGAATGCGAGAGCGATTTGTTCGGCGAGCAAGCGGTTTTGTGCGGAGGGTTGGAAGCGGTTGTAAGAATGGGGTTTG
AAACTTTAATCAAGGCAGGATACCCTGAAGAATTAGCCTATTTTGAATGCGTGCATGAAGTGAAATTAGTAGCGGATTTA
CTGCATTATAAGGGGGTGGAGGGTTTGAGAAAACACATTTCTAACACCGCTGAATTTGGGGCGATTAAAGCGAGAGAGCC
TATGGAAAATTTATTAGAAAAACGCATGCAAAAAATCTTAAAAAAGATTCAAAACGGCTCATTCGCTAAGGATTTTTTAC
TAGAAAAGAGCTTGAATTACCCCAGGTTAAACACAGAAAGAAAAGCCCTAAAAGAGACTAAAATAGAGCAAGTTGGGGAA
ATTTTACGCACCCCATTCAATCATGAAAAATAA

Upstream 100 bases:

>100_bases
ACACCATTTAATGAGTTTTTAATATTCTGCATGTTTTTAAATATTATCGCTCCCATTATGGTAAAATAATTATCTGCTTA
AACACGCTAGGAGATTTGAT

Downstream 100 bases:

>100_bases
ATCATTAAAATAAAGGAATCATATGGCAATAGTAGTTACTATCACTTCAGGTAAGGGGGGCGTAGGTAAAAGCACCACCA
CGGCTAATTTGGCGATCGGA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MALSVYYDKDIDLGVIQSLQVGIIGYGTQGEAQALNLRDSKVKVRVGLYQGSLSIPKAKAEGFEVLEVKELVQKSDVIMA
LLPDELHKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVSFKKGVGVILVAPKGPGSALREEYLKNKGLYHLIAIEQENSK
NNAKAVALSYAKAMGGGRMGVLETSFKEECESDLFGEQAVLCGGLEAVVRMGFETLIKAGYPEELAYFECVHEVKLVADL
LHYKGVEGLRKHISNTAEFGAIKAREPMENLLEKRMQKILKKIQNGSFAKDFLLEKSLNYPRLNTERKALKETKIEQVGE
ILRTPFNHEK

Sequences:

>Translated_330_residues
MALSVYYDKDIDLGVIQSLQVGIIGYGTQGEAQALNLRDSKVKVRVGLYQGSLSIPKAKAEGFEVLEVKELVQKSDVIMA
LLPDELHKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVSFKKGVGVILVAPKGPGSALREEYLKNKGLYHLIAIEQENSK
NNAKAVALSYAKAMGGGRMGVLETSFKEECESDLFGEQAVLCGGLEAVVRMGFETLIKAGYPEELAYFECVHEVKLVADL
LHYKGVEGLRKHISNTAEFGAIKAREPMENLLEKRMQKILKKIQNGSFAKDFLLEKSLNYPRLNTERKALKETKIEQVGE
ILRTPFNHEK
>Mature_329_residues
ALSVYYDKDIDLGVIQSLQVGIIGYGTQGEAQALNLRDSKVKVRVGLYQGSLSIPKAKAEGFEVLEVKELVQKSDVIMAL
LPDELHKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVSFKKGVGVILVAPKGPGSALREEYLKNKGLYHLIAIEQENSKN
NAKAVALSYAKAMGGGRMGVLETSFKEECESDLFGEQAVLCGGLEAVVRMGFETLIKAGYPEELAYFECVHEVKLVADLL
HYKGVEGLRKHISNTAEFGAIKAREPMENLLEKRMQKILKKIQNGSFAKDFLLEKSLNYPRLNTERKALKETKIEQVGEI
LRTPFNHEK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=311, Percent_Identity=33.4405144694534, Blast_Score=156, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=300, Percent_Identity=29, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_HELAH (Q17X66)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664759.1
- ProteinModelPortal:   Q17X66
- SMR:   Q17X66
- STRING:   Q17X66
- GeneID:   4177678
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0990
- NMPDR:   fig|382638.8.peg.962
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q17X66
- ProtClustDB:   PRK05479
- BioCyc:   HACI382638:HAC_0990-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36683; Mature: 36552

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: ACT_SITE 109-109

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSVYYDKDIDLGVIQSLQVGIIGYGTQGEAQALNLRDSKVKVRVGLYQGSLSIPKAKA
CEEEEEECCCCCHHHHHHHEEEEEEECCCCCCEEECCCCCEEEEEEEEEECCCCCCCCCC
EGFEVLEVKELVQKSDVIMALLPDELHKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVSF
CCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCCHHHCCCEEEEECCCEEEECCEEC
KKGVGVILVAPKGPGSALREEYLKNKGLYHLIAIEQENSKNNAKAVALSYAKAMGGGRMG
CCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEE
VLETSFKEECESDLFGEQAVLCGGLEAVVRMGFETLIKAGYPEELAYFECVHEVKLVADL
EECHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LHYKGVEGLRKHISNTAEFGAIKAREPMENLLEKRMQKILKKIQNGSFAKDFLLEKSLNY
HHHCCHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
PRLNTERKALKETKIEQVGEILRTPFNHEK
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ALSVYYDKDIDLGVIQSLQVGIIGYGTQGEAQALNLRDSKVKVRVGLYQGSLSIPKAKA
EEEEEECCCCCHHHHHHHEEEEEEECCCCCCEEECCCCCEEEEEEEEEECCCCCCCCCC
EGFEVLEVKELVQKSDVIMALLPDELHKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVSF
CCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCCHHHCCCEEEEECCCEEEECCEEC
KKGVGVILVAPKGPGSALREEYLKNKGLYHLIAIEQENSKNNAKAVALSYAKAMGGGRMG
CCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEE
VLETSFKEECESDLFGEQAVLCGGLEAVVRMGFETLIKAGYPEELAYFECVHEVKLVADL
EECHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LHYKGVEGLRKHISNTAEFGAIKAREPMENLLEKRMQKILKKIQNGSFAKDFLLEKSLNY
HHHCCHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
PRLNTERKALKETKIEQVGEILRTPFNHEK
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA