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The map label for this gene is dnaX [H]

Identifier: 109947487

GI number: 109947487

Start: 822325

End: 824055

Strand: Reverse

Name: dnaX [H]

Synonym: Hac_0940

Alternate gene names: 109947487

Gene position: 824055-822325 (Counterclockwise)

Preceding gene: 109947488

Following gene: 109947486

Centisome position: 53.03

GC content: 37.03

Gene sequence:

>1731_bases
ATGCAAGTTTTAGCGTTAAAATACCGCCCCAAACATTTTAGCGAGCTAGTCGGACAAGAGAGCGTGGCTAAAACGCTTTC
TTTAGCCTTAGACAACCAGCGTTTGGCTAACGCTTATTTATTCAGTGGGTTAAGAGGTTCGGGTAAAACAAGCTCTTCTA
GGATTTTTGCAAGGGCTTTAATGTGTGAAGCAGGGCCAAAAGCCATGCCTTGTGATACTTGCATCCAATGCCAGAGCGCT
TTAAATAACCACCATATAGATATTATAGAAATGGATGGGGCGTCTAATAGGGGGATTGATGATGTCCGTAATCTCATAGA
GCAAACCCGCTACAAACCAAGCTTTGGGCGCTATAAAATCTTTATTATTGATGAAGTGCATATGTTCACTACCGAAGCAT
TTAACGCGCTTTTAAAGACTTTAGAAGAGCCTCCTAGCCATGTGAAATTCCTTTTAGCGACAACGGACGCTTTGAAGTTA
CCCACTACCATACTCAGTCGCACCCAGCATTTTAGGTTTAAAAAAATCCCTGAAAATTCTGTTATTTCTCATTTAAAAAC
CATTTTAGAAAAAGAACAAGTGTATTATGAAGAGAGCGCGTTAGAAAAACTAGCTCACAGCGGTCAAGGGAGCTTGAGAG
ACACGCTCACCCTTTTAGAGCAAGCCATCAACTATTGCGATAACGCTATCACAGAAAGCAAAGTGGCTGAAATGTTAGGG
GCGATTGACAGAAGCGTTTTGGAAGATTTTTTTCAAAGCTTAATCAACCAAGATGAAGCTAAATTGCAAGAGCGTTATGA
AATTTTAGAAAATTATGAAACCGAGGGCGTTTTAGAAGAAATGATGCTTTTTTTGAAAGCGAAGTTGTTAAGCCCTGATA
CTTATTCAATCCTTTTGATAGAGCGCTTTTTTAAAATCATTATGAGCGCTTTGAGCCTTTTAAAAGAGGGAGCAAATTCT
GGTTTTGTGCTACTATTATTGAAAATGAAATTTAAAGAAGCTTTGAAACTCAAAGCATTAGATGATGCGATTTTAGAATT
GGAGCAAACAAAAGAAAGTGCTTTGAAACCTTTAAATCAAAACGCTAACGCCATCCAACAAGAAAACCAAACACTAAAAA
CCCCACCACTAAAAACCCCAATAGTGGAGGCCCCACAAACGCCAATGCTTTCAGCTAAAGATCGTATTTTCTACAACCTT
TTTAAACAAGTCCAAAAATTGATTTATGAGCGCAACTACGAGTTAGGGGCTGTGTTTGAAAAAAATATCCGTTTCATTGA
TTTTGATAGCCACACTAAAACTTTGACTTGGGAGTCTTTAGCGGTTGATAAAGATAAGGAGCTTTTAAGAGAGTGTTTTA
AAATCGTGAAAAATATCGTTGATAGCGTTTTTGGCAAGGGTGAAAGTATCAAAATCGCTTTAAACAATCATTTAGAAAAT
AAAAACGCTCCACTAGAAGAGATTAAAGAGTTTAAAATCTCTTCCTTAAGGGAAAAAATCTTACCCAAACCAACCACAGA
AACGATGCCAACGGCTGAAATTGAAAAAAAAGAAGTGGTTGAAAAAAAAACAAAAGAAAACAAGAATAAAGAGAATAAAG
AGAATAAAGAGAATAAAGAGAATAAACAACAAGAAGCCCCCACAGAATTGCAAGAATTTTTGGTCAATAACTCTGATCTT
ATTGAAGAAATTAAGGGCGAGTTTGAAATCAAAAGCGTGGAATTGTTATGA

Upstream 100 bases:

>100_bases
ACAAAGCTTTTTATTTTATTTTTAATAGAGAGAGACTTTGGGAGTTTTAAGTCATTTTACATTACAATACCCCTAAACAA
ATTTAAGGATTAAAACCAAT

Downstream 100 bases:

>100_bases
GAGCGAATTTAGACGAATTAGACAAAGTGGCTGTTGCAATTTTAAAAGATGATTTTAGGGGGGTGGTGTTTTTAAAAGGT
GTTGTAGGGAGCGGTAAAAC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MQVLALKYRPKHFSELVGQESVAKTLSLALDNQRLANAYLFSGLRGSGKTSSSRIFARALMCEAGPKAMPCDTCIQCQSA
LNNHHIDIIEMDGASNRGIDDVRNLIEQTRYKPSFGRYKIFIIDEVHMFTTEAFNALLKTLEEPPSHVKFLLATTDALKL
PTTILSRTQHFRFKKIPENSVISHLKTILEKEQVYYEESALEKLAHSGQGSLRDTLTLLEQAINYCDNAITESKVAEMLG
AIDRSVLEDFFQSLINQDEAKLQERYEILENYETEGVLEEMMLFLKAKLLSPDTYSILLIERFFKIIMSALSLLKEGANS
GFVLLLLKMKFKEALKLKALDDAILELEQTKESALKPLNQNANAIQQENQTLKTPPLKTPIVEAPQTPMLSAKDRIFYNL
FKQVQKLIYERNYELGAVFEKNIRFIDFDSHTKTLTWESLAVDKDKELLRECFKIVKNIVDSVFGKGESIKIALNNHLEN
KNAPLEEIKEFKISSLREKILPKPTTETMPTAEIEKKEVVEKKTKENKNKENKENKENKENKQQEAPTELQEFLVNNSDL
IEEIKGEFEIKSVELL

Sequences:

>Translated_576_residues
MQVLALKYRPKHFSELVGQESVAKTLSLALDNQRLANAYLFSGLRGSGKTSSSRIFARALMCEAGPKAMPCDTCIQCQSA
LNNHHIDIIEMDGASNRGIDDVRNLIEQTRYKPSFGRYKIFIIDEVHMFTTEAFNALLKTLEEPPSHVKFLLATTDALKL
PTTILSRTQHFRFKKIPENSVISHLKTILEKEQVYYEESALEKLAHSGQGSLRDTLTLLEQAINYCDNAITESKVAEMLG
AIDRSVLEDFFQSLINQDEAKLQERYEILENYETEGVLEEMMLFLKAKLLSPDTYSILLIERFFKIIMSALSLLKEGANS
GFVLLLLKMKFKEALKLKALDDAILELEQTKESALKPLNQNANAIQQENQTLKTPPLKTPIVEAPQTPMLSAKDRIFYNL
FKQVQKLIYERNYELGAVFEKNIRFIDFDSHTKTLTWESLAVDKDKELLRECFKIVKNIVDSVFGKGESIKIALNNHLEN
KNAPLEEIKEFKISSLREKILPKPTTETMPTAEIEKKEVVEKKTKENKNKENKENKENKENKQQEAPTELQEFLVNNSDL
IEEIKGEFEIKSVELL
>Mature_576_residues
MQVLALKYRPKHFSELVGQESVAKTLSLALDNQRLANAYLFSGLRGSGKTSSSRIFARALMCEAGPKAMPCDTCIQCQSA
LNNHHIDIIEMDGASNRGIDDVRNLIEQTRYKPSFGRYKIFIIDEVHMFTTEAFNALLKTLEEPPSHVKFLLATTDALKL
PTTILSRTQHFRFKKIPENSVISHLKTILEKEQVYYEESALEKLAHSGQGSLRDTLTLLEQAINYCDNAITESKVAEMLG
AIDRSVLEDFFQSLINQDEAKLQERYEILENYETEGVLEEMMLFLKAKLLSPDTYSILLIERFFKIIMSALSLLKEGANS
GFVLLLLKMKFKEALKLKALDDAILELEQTKESALKPLNQNANAIQQENQTLKTPPLKTPIVEAPQTPMLSAKDRIFYNL
FKQVQKLIYERNYELGAVFEKNIRFIDFDSHTKTLTWESLAVDKDKELLRECFKIVKNIVDSVFGKGESIKIALNNHLEN
KNAPLEEIKEFKISSLREKILPKPTTETMPTAEIEKKEVVEKKTKENKNKENKENKENKENKQQEAPTELQEFLVNNSDL
IEEIKGEFEIKSVELL

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI31563534, Length=217, Percent_Identity=31.3364055299539, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI6677723, Length=257, Percent_Identity=25.6809338521401, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI194306571, Length=257, Percent_Identity=25.6809338521401, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI194306567, Length=257, Percent_Identity=25.6809338521401, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI4506491, Length=258, Percent_Identity=27.5193798449612, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI31881687, Length=258, Percent_Identity=27.5193798449612, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI194306569, Length=176, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1786676, Length=295, Percent_Identity=43.3898305084746, Blast_Score=246, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17541988, Length=221, Percent_Identity=29.8642533936652, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17554730, Length=260, Percent_Identity=26.9230769230769, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71986063, Length=267, Percent_Identity=26.2172284644195, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324039, Length=259, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322528, Length=269, Percent_Identity=28.6245353159851, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324478, Length=221, Percent_Identity=26.6968325791855, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17647857, Length=217, Percent_Identity=31.3364055299539, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI18859927, Length=294, Percent_Identity=26.530612244898, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921076, Length=288, Percent_Identity=25.3472222222222, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 65836; Mature: 65836

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVLALKYRPKHFSELVGQESVAKTLSLALDNQRLANAYLFSGLRGSGKTSSSRIFARAL
CCEEEEECCCHHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
MCEAGPKAMPCDTCIQCQSALNNHHIDIIEMDGASNRGIDDVRNLIEQTRYKPSFGRYKI
HHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEE
FIIDEVHMFTTEAFNALLKTLEEPPSHVKFLLATTDALKLPTTILSRTQHFRFKKIPENS
EEEECHHHHHHHHHHHHHHHHHCCHHHHEEHHEECCHHHHHHHHHHHHHHCHHHCCCCHH
VISHLKTILEKEQVYYEESALEKLAHSGQGSLRDTLTLLEQAINYCDNAITESKVAEMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIDRSVLEDFFQSLINQDEAKLQERYEILENYETEGVLEEMMLFLKAKLLSPDTYSILLI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
ERFFKIIMSALSLLKEGANSGFVLLLLKMKFKEALKLKALDDAILELEQTKESALKPLNQ
HHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NANAIQQENQTLKTPPLKTPIVEAPQTPMLSAKDRIFYNLFKQVQKLIYERNYELGAVFE
CHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHEEC
KNIRFIDFDSHTKTLTWESLAVDKDKELLRECFKIVKNIVDSVFGKGESIKIALNNHLEN
CCCEEEEECCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
KNAPLEEIKEFKISSLREKILPKPTTETMPTAEIEKKEVVEKKTKENKNKENKENKENKE
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NKQQEAPTELQEFLVNNSDLIEEIKGEFEIKSVELL
HHHHCCHHHHHHHHCCCHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MQVLALKYRPKHFSELVGQESVAKTLSLALDNQRLANAYLFSGLRGSGKTSSSRIFARAL
CCEEEEECCCHHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
MCEAGPKAMPCDTCIQCQSALNNHHIDIIEMDGASNRGIDDVRNLIEQTRYKPSFGRYKI
HHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEE
FIIDEVHMFTTEAFNALLKTLEEPPSHVKFLLATTDALKLPTTILSRTQHFRFKKIPENS
EEEECHHHHHHHHHHHHHHHHHCCHHHHEEHHEECCHHHHHHHHHHHHHHCHHHCCCCHH
VISHLKTILEKEQVYYEESALEKLAHSGQGSLRDTLTLLEQAINYCDNAITESKVAEMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIDRSVLEDFFQSLINQDEAKLQERYEILENYETEGVLEEMMLFLKAKLLSPDTYSILLI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
ERFFKIIMSALSLLKEGANSGFVLLLLKMKFKEALKLKALDDAILELEQTKESALKPLNQ
HHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NANAIQQENQTLKTPPLKTPIVEAPQTPMLSAKDRIFYNLFKQVQKLIYERNYELGAVFE
CHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHEEC
KNIRFIDFDSHTKTLTWESLAVDKDKELLRECFKIVKNIVDSVFGKGESIKIALNNHLEN
CCCEEEEECCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
KNAPLEEIKEFKISSLREKILPKPTTETMPTAEIEKKEVVEKKTKENKNKENKENKENKE
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NKQQEAPTELQEFLVNNSDLIEEIKGEFEIKSVELL
HHHHCCHHHHHHHHCCCHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]