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The map label for this gene is accC [H]

Identifier: 109947094

GI number: 109947094

Start: 437141

End: 438508

Strand: Direct

Name: accC [H]

Synonym: Hac_0497

Alternate gene names: 109947094

Gene position: 437141-438508 (Clockwise)

Preceding gene: 109947093

Following gene: 109947095

Centisome position: 28.13

GC content: 42.54

Gene sequence:

>1368_bases
ATGGCTAAAGAAAATAAAAAGGTGGAAAAAAAAGAGCTTTCGCGCATTTTGATCGCTAATAGGGGCGAGATCGCTTTAAG
GGCGATCCAAACCATTCAAGAAATGGGGAAAGAATCCATAGCGATTTATTCAATTGCTGATAAGGACGCCCACTATCTCA
ATACAGCTAACGCTAAAGTGTGTATAGGGGGGGCAAAATCCAGCGAAAGTTATTTGAATATCCCAGCCATTATTAGCACG
GCGGAGTTGTTTGAAGCGGATGCGATTTTCCCTGGGTATGGGTTTTTGAGTGAAAACCAGAATTTTGTAGAGATTTGCTC
GCACCATTCTTTGGAATTTATTGGCCCAAGCGCAAAAGTGATGGCTTTAATGAGCGATAAATCTAAAGCCAAAAGCGTGA
TGAAAGAAGCCGGCATGCCTGTGATTGAGGGCAGTGATGGGTTGCTTAAAAGCTATCAAGAAGCAGAAGAAATTGCTGAT
AAAATCGGCTATCCTGTCATCATTAAAGCGGCTGCTGGTGGGGGTGGGAGAGGCATGCGTGTCGTAGAAGATAAATCCAA
GTTAAAAAACCTCTATTTAGCTGCAGAAACGGAAGCTTTGAGCGCGTTTGGTGATGGGAGCGTGTATTTAGAAAAATTCA
TCAACAAGCCCAAACACATTGAAGTCCAAATTTTAGCCGATAAGCATGGCAATGTCATTCATGTGGGTGAAAGGGATTGC
TCCGTGCAAAGACGCCAGCAAAAGCTCATTGAAGAAACCCCAGCGGTGGTTTTAGAAGAAAGTGTTCGTAAGCGTTTGTT
AGAGACGGCGATTAAGGCCACTAAACACATCGGCTATGTGGGGGCTGGGACTTTTGAATTTTTGCTTGATTCTAACATGA
AAGATTTTTATTTCATGGAGATGAACACTCGTTTGCAAGTGGAACACACTATTAGCGAAATGGTGAGTGGGTTAAACCTC
ATTGAATGGATGATTAGAATCGCTCAAGGTGAAGAATTGCCCAAGCAAGAAAGCTTTTCTCTTAAAGGGCATGCGATAGA
ATGCCGCATCACTGCAGAAGATCCTAAAAAATTCTACCCAAGCCCGGGTAAAATCACTGAATGGATCGCTCCTGGTGGGG
TGAATGTGCGCCTTGATTCGCACGCGCATGCCAATTATGTCGTGCCTACGCACTATGATTCCATGATAGGCAAGCTCATT
GTGTGGGGTGAAAACAGAGAAAGGGCGATCGCTAAAATGAAAAGAGCTTTGAAAGAATTTAAAGTAGAGGGTATTAAAAC
GACCATTCCTTTCCATATTGAAATGCTTGAAAATGCACATTTCAGGCAAGCAAAAATCCACACGAAGTATTTAGAAGAAA
ATTTTTAA

Upstream 100 bases:

>100_bases
AAGTGGAATACCCTTGCAAGGTCGTTTCTATTGAAGTGGGAGACGCTCAACCGGTAGAATACGGCACGAAACTCATCAAA
GTGGAAAAGCTTTAAAATCC

Downstream 100 bases:

>100_bases
ACTTAATTGCAAGGAGATTTAATGAAGCAAATGATTAAAAAAGTTCTTAAAGGTTTATTACCCACTAGGGTTTTAAACGC
ATATTGTCATGTTGAAAACT

Product: biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MAKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKVCIGGAKSSESYLNIPAIIST
AELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIAD
KIGYPVIIKAAAGGGGRGMRVVEDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGERDC
SVQRRQQKLIEETPAVVLEESVRKRLLETAIKATKHIGYVGAGTFEFLLDSNMKDFYFMEMNTRLQVEHTISEMVSGLNL
IEWMIRIAQGEELPKQESFSLKGHAIECRITAEDPKKFYPSPGKITEWIAPGGVNVRLDSHAHANYVVPTHYDSMIGKLI
VWGENRERAIAKMKRALKEFKVEGIKTTIPFHIEMLENAHFRQAKIHTKYLEENF

Sequences:

>Translated_455_residues
MAKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKVCIGGAKSSESYLNIPAIIST
AELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIAD
KIGYPVIIKAAAGGGGRGMRVVEDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGERDC
SVQRRQQKLIEETPAVVLEESVRKRLLETAIKATKHIGYVGAGTFEFLLDSNMKDFYFMEMNTRLQVEHTISEMVSGLNL
IEWMIRIAQGEELPKQESFSLKGHAIECRITAEDPKKFYPSPGKITEWIAPGGVNVRLDSHAHANYVVPTHYDSMIGKLI
VWGENRERAIAKMKRALKEFKVEGIKTTIPFHIEMLENAHFRQAKIHTKYLEENF
>Mature_454_residues
AKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKVCIGGAKSSESYLNIPAIISTA
ELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIADK
IGYPVIIKAAAGGGGRGMRVVEDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGERDCS
VQRRQQKLIEETPAVVLEESVRKRLLETAIKATKHIGYVGAGTFEFLLDSNMKDFYFMEMNTRLQVEHTISEMVSGLNLI
EWMIRIAQGEELPKQESFSLKGHAIECRITAEDPKKFYPSPGKITEWIAPGGVNVRLDSHAHANYVVPTHYDSMIGKLIV
WGENRERAIAKMKRALKEFKVEGIKTTIPFHIEMLENAHFRQAKIHTKYLEENF

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=43.4004474272931, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI106049528, Length=456, Percent_Identity=43.421052631579, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI106049295, Length=456, Percent_Identity=43.421052631579, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI106049292, Length=456, Percent_Identity=43.421052631579, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI189095269, Length=449, Percent_Identity=42.5389755011136, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI65506442, Length=450, Percent_Identity=42.4444444444444, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI295821183, Length=450, Percent_Identity=42.4444444444444, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI38679960, Length=516, Percent_Identity=31.7829457364341, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI38679974, Length=510, Percent_Identity=31.5686274509804, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI38679971, Length=516, Percent_Identity=31.7829457364341, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=31.5068493150685, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=31.5068493150685, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI134142062, Length=503, Percent_Identity=30.4174950298211, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI18105007, Length=238, Percent_Identity=24.7899159663866, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI170295797, Length=305, Percent_Identity=23.6065573770492, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI169790915, Length=305, Percent_Identity=23.6065573770492, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI21361331, Length=305, Percent_Identity=23.6065573770492, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=51.2359550561798, Blast_Score=438, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17562816, Length=457, Percent_Identity=44.2013129102845, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71987519, Length=447, Percent_Identity=43.4004474272931, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=41.5178571428571, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133931226, Length=495, Percent_Identity=29.4949494949495, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71997168, Length=512, Percent_Identity=28.515625, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=512, Percent_Identity=28.515625, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI193204318, Length=200, Percent_Identity=25.5, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=40.3153153153153, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=452, Percent_Identity=43.3628318584071, Blast_Score=342, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6319695, Length=452, Percent_Identity=42.6991150442478, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6323863, Length=455, Percent_Identity=34.0659340659341, Blast_Score=244, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=31.5686274509804, Blast_Score=239, Evalue=8e-64,
Organism=Saccharomyces cerevisiae, GI6322569, Length=321, Percent_Identity=22.7414330218069, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24651757, Length=448, Percent_Identity=44.6428571428571, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652212, Length=457, Percent_Identity=43.3260393873085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652210, Length=457, Percent_Identity=43.3260393873085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652214, Length=457, Percent_Identity=43.3260393873085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19921944, Length=457, Percent_Identity=43.3260393873085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652216, Length=457, Percent_Identity=43.3260393873085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281363050, Length=457, Percent_Identity=43.3260393873085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652224, Length=457, Percent_Identity=43.3260393873085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652222, Length=457, Percent_Identity=43.3260393873085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652220, Length=457, Percent_Identity=43.3260393873085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652218, Length=457, Percent_Identity=43.3260393873085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651759, Length=403, Percent_Identity=45.409429280397, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=30.9859154929577, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=30.9859154929577, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=30.9859154929577, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=30.9859154929577, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI45555749, Length=296, Percent_Identity=23.6486486486486, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24642586, Length=296, Percent_Identity=23.6486486486486, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50831; Mature: 50700

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKV
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCEE
CIGGAKSSESYLNIPAIISTAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKV
EEECCCCCCCEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCHHE
MALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIADKIGYPVIIKAAAGGGGRGMR
EEECCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCE
VVEDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGERDC
EECCHHHHHHEEEEECHHHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCH
SVQRRQQKLIEETPAVVLEESVRKRLLETAIKATKHIGYVGAGTFEFLLDSNMKDFYFME
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHCCCCCCCEEEEE
MNTRLQVEHTISEMVSGLNLIEWMIRIAQGEELPKQESFSLKGHAIECRITAEDPKKFYP
ECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCHHHCC
SPGKITEWIAPGGVNVRLDSHAHANYVVPTHYDSMIGKLIVWGENRERAIAKMKRALKEF
CCCCEEEEECCCCEEEEECCCCCCCEEECCCHHHHHCEEEEECCCHHHHHHHHHHHHHHH
KVEGIKTTIPFHIEMLENAHFRQAKIHTKYLEENF
HHCCCEEECCEEEEECCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKV
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCEE
CIGGAKSSESYLNIPAIISTAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKV
EEECCCCCCCEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCHHE
MALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIADKIGYPVIIKAAAGGGGRGMR
EEECCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCE
VVEDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGERDC
EECCHHHHHHEEEEECHHHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCH
SVQRRQQKLIEETPAVVLEESVRKRLLETAIKATKHIGYVGAGTFEFLLDSNMKDFYFME
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHCCCCCCCEEEEE
MNTRLQVEHTISEMVSGLNLIEWMIRIAQGEELPKQESFSLKGHAIECRITAEDPKKFYP
ECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCHHHCC
SPGKITEWIAPGGVNVRLDSHAHANYVVPTHYDSMIGKLIVWGENRERAIAKMKRALKEF
CCCCEEEEECCCCEEEEECCCCCCCEEECCCHHHHHCEEEEECCCHHHHHHHHHHHHHHH
KVEGIKTTIPFHIEMLENAHFRQAKIHTKYLEENF
HHCCCEEECCEEEEECCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]