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The map label for this gene is gmk

Identifier: 109150048

GI number: 109150048

Start: 1403486

End: 1404055

Strand: Reverse

Name: gmk

Synonym: PMT1318

Alternate gene names: 109150048

Gene position: 1404055-1403486 (Counterclockwise)

Preceding gene: 33863588

Following gene: 33863583

Centisome position: 58.24

GC content: 53.16

Gene sequence:

>570_bases
ATGGCTTCATCCGCCGCTGAAGGAAAGCTCACGGTGATTACTGGGCCCAGTGGCGTTGGCAAGGGTTCGTTAGTGAAGCA
ACTCCTAGAGCTCCATCCAGAGATCTGGCTGTCTATTTCGGCGACAACGCGTGAAGCCAGGCAAGGCGAGATTGAGGGCG
ATCATTACTTCTTCTTGAACCGTGATCGCTTTGCAGAACTGGTTCAAGCTGGCGGTTGTCTTGAATGGGCTGAATTTGCA
GGCAATCGATATGGCACCCCACGCCAACCTGTTGAGCAGCAGCTTTCATTAGGCCGTCCGGTTTTGCTTGAGATTGAACT
GGAAGGGGCCCGACAGGTGCGGCGCAGTTTCCCTGAAGCTTTTCAGATTTTTTTGGCACCGCCCAGTTTTGAGGAGCTTG
AACGACGCATTCGCGGACGGGCCACTGATCCTGAAGAGGCAATTCAGCGACGTTTAGCTAGGGCTAGGGAGGAACTGATG
GCTCAGCAGGAGTTTGATGCAGTGGTGATTAATGACAACCTGCAGGTTGCTGTGATTGAGCTGGAGTCTTTGATGGGTCT
GAGCTGTTGA

Upstream 100 bases:

>100_bases
TGAGAGGTCCATGACCTGGAGGGCAGCATGGGCCATCGATTCAGTCGGGACCTGGATTGCACGCAGCCTTCCTACTCTGC
GATCCGATTCAATGCAATCA

Downstream 100 bases:

>100_bases
TGCGAAGACTTTTTCCTGACCTTAAAGCGTTATTTGACAACATAGGCCAATAAAAAAAGCCCCTTTAGAGGGCTTTTTTA
AGGGGGTTAGCCAAGAAGCT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MASSAAEGKLTVITGPSGVGKGSLVKQLLELHPEIWLSISATTREARQGEIEGDHYFFLNRDRFAELVQAGGCLEWAEFA
GNRYGTPRQPVEQQLSLGRPVLLEIELEGARQVRRSFPEAFQIFLAPPSFEELERRIRGRATDPEEAIQRRLARAREELM
AQQEFDAVVINDNLQVAVIELESLMGLSC

Sequences:

>Translated_189_residues
MASSAAEGKLTVITGPSGVGKGSLVKQLLELHPEIWLSISATTREARQGEIEGDHYFFLNRDRFAELVQAGGCLEWAEFA
GNRYGTPRQPVEQQLSLGRPVLLEIELEGARQVRRSFPEAFQIFLAPPSFEELERRIRGRATDPEEAIQRRLARAREELM
AQQEFDAVVINDNLQVAVIELESLMGLSC
>Mature_188_residues
ASSAAEGKLTVITGPSGVGKGSLVKQLLELHPEIWLSISATTREARQGEIEGDHYFFLNRDRFAELVQAGGCLEWAEFAG
NRYGTPRQPVEQQLSLGRPVLLEIELEGARQVRRSFPEAFQIFLAPPSFEELERRIRGRATDPEEAIQRRLARAREELMA
QQEFDAVVINDNLQVAVIELESLMGLSC

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=39.4285714285714, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=39.4285714285714, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI226874831, Length=176, Percent_Identity=39.2045454545455, Blast_Score=130, Evalue=8e-31,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=29.7752808988764, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI14780902, Length=186, Percent_Identity=30.1075268817204, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI21361598, Length=185, Percent_Identity=27.5675675675676, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI52630447, Length=186, Percent_Identity=27.4193548387097, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI4505237, Length=184, Percent_Identity=27.1739130434783, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118263, Length=184, Percent_Identity=27.1739130434783, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118255, Length=184, Percent_Identity=27.1739130434783, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118259, Length=184, Percent_Identity=27.1739130434783, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI111154074, Length=162, Percent_Identity=30.2469135802469, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1790080, Length=182, Percent_Identity=43.4065934065934, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI193203132, Length=179, Percent_Identity=36.3128491620112, Blast_Score=130, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=179, Percent_Identity=36.3128491620112, Blast_Score=129, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71988041, Length=189, Percent_Identity=23.8095238095238, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=189, Percent_Identity=23.8095238095238, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17557440, Length=179, Percent_Identity=25.6983240223464, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=179, Percent_Identity=39.1061452513966, Blast_Score=141, Evalue=7e-35,
Organism=Drosophila melanogaster, GI21356141, Length=178, Percent_Identity=37.6404494382022, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI116007136, Length=179, Percent_Identity=25.1396648044693, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45554481, Length=179, Percent_Identity=25.1396648044693, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI85724806, Length=179, Percent_Identity=25.1396648044693, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45554489, Length=179, Percent_Identity=25.1396648044693, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640542, Length=179, Percent_Identity=25.1396648044693, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161077626, Length=179, Percent_Identity=25.1396648044693, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330166, Length=159, Percent_Identity=27.0440251572327, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330162, Length=159, Percent_Identity=27.0440251572327, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330164, Length=159, Percent_Identity=27.0440251572327, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_PROMM (P60555)

Other databases:

- EMBL:   BX548175
- RefSeq:   YP_654194.1
- ProteinModelPortal:   P60555
- SMR:   P60555
- STRING:   P60555
- GeneID:   1729186
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT1318
- NMPDR:   fig|74547.1.peg.2302
- eggNOG:   COG0194
- ProtClustDB:   PRK00300
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 21136; Mature: 21005

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSAAEGKLTVITGPSGVGKGSLVKQLLELHPEIWLSISATTREARQGEIEGDHYFFLN
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHEEEEECCHHHHHCCCCCCCEEEEEC
RDRFAELVQAGGCLEWAEFAGNRYGTPRQPVEQQLSLGRPVLLEIELEGARQVRRSFPEA
HHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEEECHHHHHHHHCHHH
FQIFLAPPSFEELERRIRGRATDPEEAIQRRLARAREELMAQQEFDAVVINDNLQVAVIE
HEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEE
LESLMGLSC
EHHHCCCCC
>Mature Secondary Structure 
ASSAAEGKLTVITGPSGVGKGSLVKQLLELHPEIWLSISATTREARQGEIEGDHYFFLN
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHEEEEECCHHHHHCCCCCCCEEEEEC
RDRFAELVQAGGCLEWAEFAGNRYGTPRQPVEQQLSLGRPVLLEIELEGARQVRRSFPEA
HHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEEECHHHHHHHHCHHH
FQIFLAPPSFEELERRIRGRATDPEEAIQRRLARAREELMAQQEFDAVVINDNLQVAVIE
HEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEE
LESLMGLSC
EHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642