BacMap

Definition	Yersinia pestis Nepal516, complete genome.
Accession	NC_008149
Length	4,534,590

Click here to switch to the map view.

The map label for this gene is ccmA

Identifier: 108812374

GI number: 108812374

Start: 2498437

End: 2499093

Strand: Reverse

Name: ccmA

Synonym: YPN_2213

Alternate gene names: 108812374

Gene position: 2499093-2498437 (Counterclockwise)

Preceding gene: 108812375

Following gene: 108812373

Centisome position: 55.11

GC content: 49.47

Gene sequence:

>657_bases
ATGCTGGAAGCAAAAAATCTGACCTGTATCCGCGATGATCGCTGTTTATTTCAGCAGTTGAGTTTCTGTATCGCACCAGG
CGAGATCGTGCAGATTGAAGGGCCAAATGGGGCAGGAAAGACCAGTTTACTGCGTATTTTAGCCGGTCTTGCTGAGGCCG
ATGAGGGGCAAGTGAACTGGCGAGATAAGAATATTCGTCGGGATCGCGCCAAATATCATCAGGATTTATTGTTTCTAGGC
CATCAACCGGGAATTAAATCTGTGCTGACACCGTTTGAAAATCTGCTGTTCTATCAATCGGTTTTTCAGAAGGTTGATAG
CGCCGCCATCTGGCAGGCATTAGCTCAGGTTGGGTTGGTAGGGTATGAAGATTTACCCGTATCTCAGTTATCGGCGGGGC
AGCAACGTCGAGTGGCCTTGGCTCGCTTGTGGTTAAGTCCGGCACCTTTGTGGATTTTGGATGAGCCGCTGACCGCTATC
GATAAGCAAGGGGTCAGTACGTTGTTGGCCCTGTTTGTACAACATGCGGCTAAGGGCGGAATGGTGCTGTTGACCACGCA
TCAGGATTTGGGCGCGGTTAGCCACAATGTCCGTAAAATTTGTTTAGCCAACACGCAGGAGAAGTCATGTTTATCAGCGT
GTTGCGCCGTGAATTAA

Upstream 100 bases:

>100_bases
GGTAGGGATAGTCTTAGGCGTTCCCTACGTAAGGGTTAAGCCTTATGTTATCATTCGGTTTTCCTGAACTGGCCATCCGA
CGATCGGAAGACACCCCCTT

Downstream 100 bases:

>100_bases
AAATAGCCTTTAGAAAAGGTGCGGAAATCGTTAACCCGCTGTGGTTCTTTTTGATCGTTATTACGCTGTTCCCATTGGGG
ATAGGCCCAGAGCCACAATT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MLEAKNLTCIRDDRCLFQQLSFCIAPGEIVQIEGPNGAGKTSLLRILAGLAEADEGQVNWRDKNIRRDRAKYHQDLLFLG
HQPGIKSVLTPFENLLFYQSVFQKVDSAAIWQALAQVGLVGYEDLPVSQLSAGQQRRVALARLWLSPAPLWILDEPLTAI
DKQGVSTLLALFVQHAAKGGMVLLTTHQDLGAVSHNVRKICLANTQEKSCLSACCAVN

Sequences:

>Translated_218_residues
MLEAKNLTCIRDDRCLFQQLSFCIAPGEIVQIEGPNGAGKTSLLRILAGLAEADEGQVNWRDKNIRRDRAKYHQDLLFLG
HQPGIKSVLTPFENLLFYQSVFQKVDSAAIWQALAQVGLVGYEDLPVSQLSAGQQRRVALARLWLSPAPLWILDEPLTAI
DKQGVSTLLALFVQHAAKGGMVLLTTHQDLGAVSHNVRKICLANTQEKSCLSACCAVN
>Mature_218_residues
MLEAKNLTCIRDDRCLFQQLSFCIAPGEIVQIEGPNGAGKTSLLRILAGLAEADEGQVNWRDKNIRRDRAKYHQDLLFLG
HQPGIKSVLTPFENLLFYQSVFQKVDSAAIWQALAQVGLVGYEDLPVSQLSAGQQRRVALARLWLSPAPLWILDEPLTAI
DKQGVSTLLALFVQHAAKGGMVLLTTHQDLGAVSHNVRKICLANTQEKSCLSACCAVN

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI105990541, Length=168, Percent_Identity=29.1666666666667, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI27436953, Length=188, Percent_Identity=31.3829787234043, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI21536376, Length=193, Percent_Identity=28.4974093264249, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI215820660, Length=184, Percent_Identity=28.804347826087, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI20143975, Length=184, Percent_Identity=28.804347826087, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI30795238, Length=192, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI150417984, Length=189, Percent_Identity=29.6296296296296, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI153792144, Length=192, Percent_Identity=28.6458333333333, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI157502203, Length=199, Percent_Identity=29.6482412060301, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI45446740, Length=195, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI47078218, Length=195, Percent_Identity=26.1538461538462, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI27881501, Length=192, Percent_Identity=26.0416666666667, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI157502201, Length=199, Percent_Identity=29.6482412060301, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082064, Length=206, Percent_Identity=56.3106796116505, Blast_Score=213, Evalue=7e-57,
Organism=Escherichia coli, GI1788225, Length=201, Percent_Identity=29.3532338308458, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI87081709, Length=174, Percent_Identity=31.0344827586207, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1790544, Length=186, Percent_Identity=30.1075268817204, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1787370, Length=202, Percent_Identity=31.1881188118812, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1787029, Length=202, Percent_Identity=28.7128712871287, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788761, Length=155, Percent_Identity=31.6129032258064, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788165, Length=220, Percent_Identity=29.5454545454545, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081782, Length=190, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787712, Length=166, Percent_Identity=31.9277108433735, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786872, Length=165, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081791, Length=166, Percent_Identity=30.7228915662651, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790525, Length=220, Percent_Identity=25, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1789586, Length=201, Percent_Identity=26.865671641791, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1787041, Length=169, Percent_Identity=29.585798816568, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786563, Length=203, Percent_Identity=29.064039408867, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789873, Length=195, Percent_Identity=28.2051282051282, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789593, Length=207, Percent_Identity=27.0531400966184, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789672, Length=194, Percent_Identity=25.7731958762887, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787105, Length=184, Percent_Identity=26.6304347826087, Blast_Score=60, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17559834, Length=177, Percent_Identity=27.1186440677966, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=204, Percent_Identity=26.4705882352941, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19920532, Length=171, Percent_Identity=29.2397660818713, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24580930, Length=171, Percent_Identity=29.2397660818713, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI161076682, Length=184, Percent_Identity=27.1739130434783, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI161076684, Length=184, Percent_Identity=27.1739130434783, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24581617, Length=184, Percent_Identity=27.1739130434783, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24581615, Length=184, Percent_Identity=27.1739130434783, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28574744, Length=186, Percent_Identity=26.8817204301075, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574533, Length=171, Percent_Identity=26.9005847953216, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574150, Length=215, Percent_Identity=24.1860465116279, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI116007328, Length=215, Percent_Identity=24.1860465116279, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641342, Length=178, Percent_Identity=30.3370786516854, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_YERPA (Q1C647)

Other databases:

- EMBL:   CP000308
- RefSeq:   YP_652020.1
- ProteinModelPortal:   Q1C647
- SMR:   Q1C647
- STRING:   Q1C647
- GeneID:   4122196
- GenomeReviews:   CP000308_GR
- KEGG:   ypa:YPA_2110
- eggNOG:   COG4133
- HOGENOM:   HBG758042
- OMA:   ARLWHND
- ProtClustDB:   PRK13538
- BioCyc:   YPES360102:YPA_2110-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 23946; Mature: 23946

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEAKNLTCIRDDRCLFQQLSFCIAPGEIVQIEGPNGAGKTSLLRILAGLAEADEGQVNW
CCCCCCCCEEECHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEC
RDKNIRRDRAKYHQDLLFLGHQPGIKSVLTPFENLLFYQSVFQKVDSAAIWQALAQVGLV
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GYEDLPVSQLSAGQQRRVALARLWLSPAPLWILDEPLTAIDKQGVSTLLALFVQHAAKGG
CCCCCCHHHHCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
MVLLTTHQDLGAVSHNVRKICLANTQEKSCLSACCAVN
EEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLEAKNLTCIRDDRCLFQQLSFCIAPGEIVQIEGPNGAGKTSLLRILAGLAEADEGQVNW
CCCCCCCCEEECHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEC
RDKNIRRDRAKYHQDLLFLGHQPGIKSVLTPFENLLFYQSVFQKVDSAAIWQALAQVGLV
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GYEDLPVSQLSAGQQRRVALARLWLSPAPLWILDEPLTAIDKQGVSTLLALFVQHAAKGG
CCCCCCHHHHCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
MVLLTTHQDLGAVSHNVRKICLANTQEKSCLSACCAVN
EEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA