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The map label for this gene is nuoN

Identifier: 108812300

GI number: 108812300

Start: 2416891

End: 2418354

Strand: Reverse

Name: nuoN

Synonym: YPN_2138

Alternate gene names: 108812300

Gene position: 2418354-2416891 (Counterclockwise)

Preceding gene: 108812301

Following gene: 108812299

Centisome position: 53.33

GC content: 53.83

Gene sequence:

>1464_bases
ATGACAATAACTCCTCAACAACTGATCGCAATGCTACCGCTGTTGATCGTCGGATTGACGGTGGTGGTTGTGATGCTGTC
CATTGCGTGGCGACGCGATCATTTTATTAATGCCACACTGACCGTCATTGGGCTTAATCTGGCGCTGCTGTCACTTTACT
TTGTTGGACAGGTCGGGCCGATGGATGTCACTCCGCTGATGCGGGTTGACGGCTATTCGATGTTCTACACCGGGCTGGTG
ATTATCGCCAGCTTGGCGACCAGCACGTTTGCTTACCCTTGGTTGGTCGGCTACCCGGATAACCGCGAAGAGTTCTATCT
GCTGGTGCTGATTGCGGCTTTGGGCGGTATTCTGCTCGCCAGTGCCAATCATCTGGCGTCGCTGTTCTTGGGTATTGAAT
TGCTTACTTTGCCGCTGTTTGGTCTGATTGGTTATGCCTATCGCCAGAAGCGTTCACTGGAAGCCAGTATCAAATACATG
CTGTTGTCGGCGGCGGCATCGTCATTCCTGCTGTTCGGTATGGCGCTGTTGTATGCTGAGTCCGGTAGCCTGTCCTTCGT
AGGGTTGGGCCAGAGCCTAAGTGACTCGATGGTGCACCAACCGCTGATTCTGGCGGGTCTGGGCATGATGATTGTTGGCC
TCGGCTTTAAACTGTCGTTGGTACCGTTCCAATTGTGGACACCCGATGTGTATCAGGGCGCACCCGCGCCAGTTTCCACG
TTCCTGGCGACCGCCAGCAAGATTGCTATCTTTGCCGTAGTGATGCGCTTGTTTATGTACGCACCGGCGGCGGATAGCGA
AGCCGTGCGTTTGGTTCTGTCGATTATTGCGGTGGCCTCGATCCTGTTTGGCAACCTGATGGCGATCAGCCAGACCAACA
TCAAACGCCTGTTGGGTTACTCCTCTATTGCCCACCTTGGTTATTTGCTGATTGCATTGGTCGCAGTACAAACACACGAG
CTCGCATTACCGCTGGAAACCATCGGGGTGTATCTGGCGGGGTATCTGTTCAGTAGCCTGGGGGCATTTGGCGTCGTTAG
CCTGATGTCCAGCCCGTACAAAGGCCCAGATGCAGAATCCCTGTTCTCTTACCGTGGCTTGTTCTGGCATAAGCCTATTC
TGTCTGCGGTGATGACAGTGATGATGTTGTCACTGGCCGGTATCCCAATGACACTGGGCTTTATCGGTAAATTCTTTGTG
GTGGCAATGGGGGTCAGCGCCAACTTGTGGTGGTTGACTGGCGCGGTGGTGTTAGGCAGTGCCATCGGCTTGTACTATTA
TCTGCGCGTTACCGTCAGTTTGTTCCTCAGCCCGCCGCAGAGCTTAGTACGTGATACCCCGAGCAACTGGGCATTAACGG
CCGGTGGTGTGGTGGTACTGATCTCCGCGATTTTGGTACTGGTGTTGGGTATCTATCCGCAACCGTTGATAACACTGGTG
CAGATGGCTCAGCCCTTGATGTGA

Upstream 100 bases:

>100_bases
GCCGATCCTCGACACGTCCCATGCGGCAATGAGTAATGTGCAACAGTGGTTTTCAGCTGCATCTATTCCAGCTCCATCTA
TTACAAGGCCATAATTCGCC

Downstream 100 bases:

>100_bases
TGATGTGTTAAACCGGCACAGACGAATGATGTCGAGATAGACCCTACCCCCTGTGAGTATCGGCTTACAGGGGGTTTTGT
TTTATCTGGGGCTCAGGAGG

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MTITPQQLIAMLPLLIVGLTVVVVMLSIAWRRDHFINATLTVIGLNLALLSLYFVGQVGPMDVTPLMRVDGYSMFYTGLV
IIASLATSTFAYPWLVGYPDNREEFYLLVLIAALGGILLASANHLASLFLGIELLTLPLFGLIGYAYRQKRSLEASIKYM
LLSAAASSFLLFGMALLYAESGSLSFVGLGQSLSDSMVHQPLILAGLGMMIVGLGFKLSLVPFQLWTPDVYQGAPAPVST
FLATASKIAIFAVVMRLFMYAPAADSEAVRLVLSIIAVASILFGNLMAISQTNIKRLLGYSSIAHLGYLLIALVAVQTHE
LALPLETIGVYLAGYLFSSLGAFGVVSLMSSPYKGPDAESLFSYRGLFWHKPILSAVMTVMMLSLAGIPMTLGFIGKFFV
VAMGVSANLWWLTGAVVLGSAIGLYYYLRVTVSLFLSPPQSLVRDTPSNWALTAGGVVVLISAILVLVLGIYPQPLITLV
QMAQPLM

Sequences:

>Translated_487_residues
MTITPQQLIAMLPLLIVGLTVVVVMLSIAWRRDHFINATLTVIGLNLALLSLYFVGQVGPMDVTPLMRVDGYSMFYTGLV
IIASLATSTFAYPWLVGYPDNREEFYLLVLIAALGGILLASANHLASLFLGIELLTLPLFGLIGYAYRQKRSLEASIKYM
LLSAAASSFLLFGMALLYAESGSLSFVGLGQSLSDSMVHQPLILAGLGMMIVGLGFKLSLVPFQLWTPDVYQGAPAPVST
FLATASKIAIFAVVMRLFMYAPAADSEAVRLVLSIIAVASILFGNLMAISQTNIKRLLGYSSIAHLGYLLIALVAVQTHE
LALPLETIGVYLAGYLFSSLGAFGVVSLMSSPYKGPDAESLFSYRGLFWHKPILSAVMTVMMLSLAGIPMTLGFIGKFFV
VAMGVSANLWWLTGAVVLGSAIGLYYYLRVTVSLFLSPPQSLVRDTPSNWALTAGGVVVLISAILVLVLGIYPQPLITLV
QMAQPLM
>Mature_486_residues
TITPQQLIAMLPLLIVGLTVVVVMLSIAWRRDHFINATLTVIGLNLALLSLYFVGQVGPMDVTPLMRVDGYSMFYTGLVI
IASLATSTFAYPWLVGYPDNREEFYLLVLIAALGGILLASANHLASLFLGIELLTLPLFGLIGYAYRQKRSLEASIKYML
LSAAASSFLLFGMALLYAESGSLSFVGLGQSLSDSMVHQPLILAGLGMMIVGLGFKLSLVPFQLWTPDVYQGAPAPVSTF
LATASKIAIFAVVMRLFMYAPAADSEAVRLVLSIIAVASILFGNLMAISQTNIKRLLGYSSIAHLGYLLIALVAVQTHEL
ALPLETIGVYLAGYLFSSLGAFGVVSLMSSPYKGPDAESLFSYRGLFWHKPILSAVMTVMMLSLAGIPMTLGFIGKFFVV
AMGVSANLWWLTGAVVLGSAIGLYYYLRVTVSLFLSPPQSLVRDTPSNWALTAGGVVVLISAILVLVLGIYPQPLITLVQ
MAQPLM

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=325, Percent_Identity=22.1538461538462, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI145693160, Length=487, Percent_Identity=80.2874743326489, Blast_Score=789, Evalue=0.0,
Organism=Escherichia coli, GI1788831, Length=391, Percent_Identity=25.0639386189258, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788829, Length=322, Percent_Identity=26.0869565217391, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788614, Length=362, Percent_Identity=25.9668508287293, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788613, Length=312, Percent_Identity=25.9615384615385, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788827, Length=361, Percent_Identity=25.4847645429363, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_YERP3 (A7FGR6)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400444.1
- ProteinModelPortal:   A7FGR6
- STRING:   A7FGR6
- GeneID:   5387472
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1466
- eggNOG:   COG1007
- HOGENOM:   HBG747830
- OMA:   ILSISYN
- ProtClustDB:   PRK05777
- BioCyc:   YPSE349747:YPSIP31758_1466-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 52348; Mature: 52216

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1131f320)-; HASH(0x118fb3bc)-; HASH(0x118617a4)-; HASH(0x10f7c5a4)-; HASH(0xf876d80)-; HASH(0x11103e50)-; HASH(0x114aa764)-; HASH(0x114aa7e8)-; HASH(0x104cdd40)-; HASH(0x11986db8)-; HASH(0xf1ec760)-; HASH(0x10d762a8)-; HASH(0x11800be8)-; HASH(0x10c0ca00)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITPQQLIAMLPLLIVGLTVVVVMLSIAWRRDHFINATLTVIGLNLALLSLYFVGQVGP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCC
MDVTPLMRVDGYSMFYTGLVIIASLATSTFAYPWLVGYPDNREEFYLLVLIAALGGILLA
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
SANHLASLFLGIELLTLPLFGLIGYAYRQKRSLEASIKYMLLSAAASSFLLFGMALLYAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGSLSFVGLGQSLSDSMVHQPLILAGLGMMIVGLGFKLSLVPFQLWTPDVYQGAPAPVST
CCCEEEEECCCHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHCCCCCHHHH
FLATASKIAIFAVVMRLFMYAPAADSEAVRLVLSIIAVASILFGNLMAISQTNIKRLLGY
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSIAHLGYLLIALVAVQTHELALPLETIGVYLAGYLFSSLGAFGVVSLMSSPYKGPDAES
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LFSYRGLFWHKPILSAVMTVMMLSLAGIPMTLGFIGKFFVVAMGVSANLWWLTGAVVLGS
HHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
AIGLYYYLRVTVSLFLSPPQSLVRDTPSNWALTAGGVVVLISAILVLVLGIYPQPLITLV
HHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHH
QMAQPLM
HHHCCCH
>Mature Secondary Structure 
TITPQQLIAMLPLLIVGLTVVVVMLSIAWRRDHFINATLTVIGLNLALLSLYFVGQVGP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCC
MDVTPLMRVDGYSMFYTGLVIIASLATSTFAYPWLVGYPDNREEFYLLVLIAALGGILLA
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
SANHLASLFLGIELLTLPLFGLIGYAYRQKRSLEASIKYMLLSAAASSFLLFGMALLYAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGSLSFVGLGQSLSDSMVHQPLILAGLGMMIVGLGFKLSLVPFQLWTPDVYQGAPAPVST
CCCEEEEECCCHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHCCCCCHHHH
FLATASKIAIFAVVMRLFMYAPAADSEAVRLVLSIIAVASILFGNLMAISQTNIKRLLGY
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSIAHLGYLLIALVAVQTHELALPLETIGVYLAGYLFSSLGAFGVVSLMSSPYKGPDAES
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LFSYRGLFWHKPILSAVMTVMMLSLAGIPMTLGFIGKFFVVAMGVSANLWWLTGAVVLGS
HHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
AIGLYYYLRVTVSLFLSPPQSLVRDTPSNWALTAGGVVVLISAILVLVLGIYPQPLITLV
HHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHH
QMAQPLM
HHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA