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The map label for this gene is mdtD

Identifier: 108811451

GI number: 108811451

Start: 1461615

End: 1463012

Strand: Reverse

Name: mdtD

Synonym: YPN_1288

Alternate gene names: 108811451

Gene position: 1463012-1461615 (Counterclockwise)

Preceding gene: 108811452

Following gene: 108811450

Centisome position: 32.26

GC content: 53.79

Gene sequence:

>1398_bases
ATGGTAACGCAAGCAACATCTGTGCGATGGCAATTGTGGATTGTCGCTTTCGGATTTTTTATGCAGACGCTGGATACCAC
CATCGTCAATACCGCCCTGCCCTCCATCGCAGCCAGTCTGGGCGAAAATCCGTTACGGATGCAATCGGTGATTGTCTCGT
ATGTCCTGACCGTCGCGGTGATGTTGCCCGCCAGTGGTTGGCTGGCGGACCGGATCGGCGTCAAGTGGGTGTTCTTCTCA
GCGATTATTCTGTTCACCTTCGGATCGCTGATGTGCGCGCAATCAGCAACACTGAATGAACTGATCCTCTCCCGTGTGCT
TCAGGGGGTGGGCGGCGCAATGATGGTGCCCGTGGGCCGCCTGACGGTGATGAAAATCGTGCCACGCGAGCAATATATGG
CGGCAATGGCGTTTGTCACACTGCCCGGCCAGATTGGGCCATTAGTTGGCCCGGCGCTGGGCGGGTTTTTAGTGGAATTT
GCCAGTTGGCACTGGATTTTCCTGATTAACCTGCCTGTTGGTGTGATCGGCGCATTGGCGACCTTGCTGCTCATGCCTAA
CCACAAAATGTCTACCCGGCGCTTTGATATCAGCGGCTTTATCATGTTGGCAATCGGTATGGCGACCTTAACGCTGGCAC
TGGACGGCCACACGGGACTGGGGTTGTCGCCGCTGGCCATTGCGGGGTTGATCCTGTGTGGCGTAATAGCACTGGGCAGC
TATTGGTGGCATGCACTGGGTAATCGTTTCGCACTGTTCTCACTGCACCTGTTCAAGAATAAAATCTATACCCTTGGTTT
AGTCGGGAGTATGTCCGCCCGGATCGGCAGCGGCATGTTGCCATTTATGACGCCTATCTTTCTGCAAATCGGCCTAGGGT
TTAGCCCATTCCACGCGGGGCTGATGATGATCCCGATGATTATCGGCAGCATGGGCATGAAGCGGATTATCGTACAGGTC
GTCAACCGCTTTGGTTACCGGCGAGTCCTGGTCAACGCCACATTATTACTGGCCGTCGTCAGCCTGAGCTTACCGCTCGT
GGCAATCATGGGTTGGACACTGCTGATGCCAGTAGTGTTATTCTTCCAAGGCATGCTCAACGCATTACGCTTTTCCACCA
TGAATACCTTAACCCTAAAAACGTTACCAGATCGTCTGGCTAGCAGCGGTAACAGCCTATTGTCGATGGCGATGCAACTG
TCCATGAGTATCGGGGTCAGTACTGCCGGAATATTATTGGGTACCTTTGCTCATCATCAGGTAGCCACCAACACGCCTGC
CACTCACAGCGCGTTCTTATACAGTTACTTATGTATGGCAATCATTATCGCCCTACCCGCCCTGATATTTAACCGCGTTC
CCCCGGATACAGGAGCCAATCGTCATTTGGCCCGCTAG

Upstream 100 bases:

>100_bases
GATTTATCTCTATTTTGACCGGTTGCGTAACCGTTTTAGCAAGCAACCGCTGATGAAATTGGAATAGTATGCAACAGAGT
GGAAGTAGGAGTGGGGCGCC

Downstream 100 bases:

>100_bases
ATTGGCCGACTGATAAAGACAGGTGAAATTATGATAAGGATCGGCATTACCGGAAAACTGTTTATGGCTATTTTCGCCAC
TTGCATGTTGGTATTGATAA

Product: multidrug efflux system protein MdtE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MVTQATSVRWQLWIVAFGFFMQTLDTTIVNTALPSIAASLGENPLRMQSVIVSYVLTVAVMLPASGWLADRIGVKWVFFS
AIILFTFGSLMCAQSATLNELILSRVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMAFVTLPGQIGPLVGPALGGFLVEF
ASWHWIFLINLPVGVIGALATLLLMPNHKMSTRRFDISGFIMLAIGMATLTLALDGHTGLGLSPLAIAGLILCGVIALGS
YWWHALGNRFALFSLHLFKNKIYTLGLVGSMSARIGSGMLPFMTPIFLQIGLGFSPFHAGLMMIPMIIGSMGMKRIIVQV
VNRFGYRRVLVNATLLLAVVSLSLPLVAIMGWTLLMPVVLFFQGMLNALRFSTMNTLTLKTLPDRLASSGNSLLSMAMQL
SMSIGVSTAGILLGTFAHHQVATNTPATHSAFLYSYLCMAIIIALPALIFNRVPPDTGANRHLAR

Sequences:

>Translated_465_residues
MVTQATSVRWQLWIVAFGFFMQTLDTTIVNTALPSIAASLGENPLRMQSVIVSYVLTVAVMLPASGWLADRIGVKWVFFS
AIILFTFGSLMCAQSATLNELILSRVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMAFVTLPGQIGPLVGPALGGFLVEF
ASWHWIFLINLPVGVIGALATLLLMPNHKMSTRRFDISGFIMLAIGMATLTLALDGHTGLGLSPLAIAGLILCGVIALGS
YWWHALGNRFALFSLHLFKNKIYTLGLVGSMSARIGSGMLPFMTPIFLQIGLGFSPFHAGLMMIPMIIGSMGMKRIIVQV
VNRFGYRRVLVNATLLLAVVSLSLPLVAIMGWTLLMPVVLFFQGMLNALRFSTMNTLTLKTLPDRLASSGNSLLSMAMQL
SMSIGVSTAGILLGTFAHHQVATNTPATHSAFLYSYLCMAIIIALPALIFNRVPPDTGANRHLAR
>Mature_465_residues
MVTQATSVRWQLWIVAFGFFMQTLDTTIVNTALPSIAASLGENPLRMQSVIVSYVLTVAVMLPASGWLADRIGVKWVFFS
AIILFTFGSLMCAQSATLNELILSRVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMAFVTLPGQIGPLVGPALGGFLVEF
ASWHWIFLINLPVGVIGALATLLLMPNHKMSTRRFDISGFIMLAIGMATLTLALDGHTGLGLSPLAIAGLILCGVIALGS
YWWHALGNRFALFSLHLFKNKIYTLGLVGSMSARIGSGMLPFMTPIFLQIGLGFSPFHAGLMMIPMIIGSMGMKRIIVQV
VNRFGYRRVLVNATLLLAVVSLSLPLVAIMGWTLLMPVVLFFQGMLNALRFSTMNTLTLKTLPDRLASSGNSLLSMAMQL
SMSIGVSTAGILLGTFAHHQVATNTPATHSAFLYSYLCMAIIIALPALIFNRVPPDTGANRHLAR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family

Homologues:

Organism=Escherichia coli, GI1788392, Length=465, Percent_Identity=71.8279569892473, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI1790195, Length=452, Percent_Identity=42.9203539823009, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI1788710, Length=430, Percent_Identity=31.3953488372093, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI1789042, Length=393, Percent_Identity=30.7888040712468, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI87081983, Length=311, Percent_Identity=27.6527331189711, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1788509, Length=136, Percent_Identity=32.3529411764706, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=174, Percent_Identity=28.735632183908, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=30.6666666666667, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323735, Length=164, Percent_Identity=26.219512195122, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325455, Length=151, Percent_Identity=33.112582781457, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MDTD_YERP3 (A7FG15)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400193.1
- ProteinModelPortal:   A7FG15
- STRING:   A7FG15
- GeneID:   5384904
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1212
- eggNOG:   COG0477
- HOGENOM:   HBG679341
- OMA:   LYLLHAK
- ProtClustDB:   PRK10504
- BioCyc:   YPSE349747:YPSIP31758_1212-MONOMER
- HAMAP:   MF_01577
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411
- PRINTS:   PR01036

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 50177; Mature: 50177

Theoretical pI: Translated: 11.14; Mature: 11.14

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf62a818)-; HASH(0xec32350)-; HASH(0x100ef504)-; HASH(0xd968c24)-; HASH(0xda5d300)-; HASH(0x100eba5c)-; HASH(0xd16167c)-; HASH(0x100ed388)-; HASH(0xd968f0c)-; HASH(0xebaa858)-; HASH(0xd968eac)-; HASH(0xec32398)-; HASH(0xfbd3fd8)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
6.5 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTQATSVRWQLWIVAFGFFMQTLDTTIVNTALPSIAASLGENPLRMQSVIVSYVLTVAV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
MLPASGWLADRIGVKWVFFSAIILFTFGSLMCAQSATLNELILSRVLQGVGGAMMVPVGR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCH
LTVMKIVPREQYMAAMAFVTLPGQIGPLVGPALGGFLVEFASWHWIFLINLPVGVIGALA
HHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
TLLLMPNHKMSTRRFDISGFIMLAIGMATLTLALDGHTGLGLSPLAIAGLILCGVIALGS
HHHHCCCCCCCCCEECCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHH
YWWHALGNRFALFSLHLFKNKIYTLGLVGSMSARIGSGMLPFMTPIFLQIGLGFSPFHAG
HHHHHHCCCHHHHHHHHHHCCHHEEEEHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHH
LMMIPMIIGSMGMKRIIVQVVNRFGYRRVLVNATLLLAVVSLSLPLVAIMGWTLLMPVVL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFQGMLNALRFSTMNTLTLKTLPDRLASSGNSLLSMAMQLSMSIGVSTAGILLGTFAHHQ
HHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VATNTPATHSAFLYSYLCMAIIIALPALIFNRVPPDTGANRHLAR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
>Mature Secondary Structure
MVTQATSVRWQLWIVAFGFFMQTLDTTIVNTALPSIAASLGENPLRMQSVIVSYVLTVAV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
MLPASGWLADRIGVKWVFFSAIILFTFGSLMCAQSATLNELILSRVLQGVGGAMMVPVGR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCH
LTVMKIVPREQYMAAMAFVTLPGQIGPLVGPALGGFLVEFASWHWIFLINLPVGVIGALA
HHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
TLLLMPNHKMSTRRFDISGFIMLAIGMATLTLALDGHTGLGLSPLAIAGLILCGVIALGS
HHHHCCCCCCCCCEECCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHH
YWWHALGNRFALFSLHLFKNKIYTLGLVGSMSARIGSGMLPFMTPIFLQIGLGFSPFHAG
HHHHHHCCCHHHHHHHHHHCCHHEEEEHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHH
LMMIPMIIGSMGMKRIIVQVVNRFGYRRVLVNATLLLAVVSLSLPLVAIMGWTLLMPVVL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFQGMLNALRFSTMNTLTLKTLPDRLASSGNSLLSMAMQLSMSIGVSTAGILLGTFAHHQ
HHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VATNTPATHSAFLYSYLCMAIIIALPALIFNRVPPDTGANRHLAR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA