| Definition | Yersinia pestis Nepal516, complete genome. |
|---|---|
| Accession | NC_008149 |
| Length | 4,534,590 |
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The map label for this gene is yvgN [H]
Identifier: 108811200
GI number: 108811200
Start: 1192583
End: 1193434
Strand: Reverse
Name: yvgN [H]
Synonym: YPN_1035
Alternate gene names: 108811200
Gene position: 1193434-1192583 (Counterclockwise)
Preceding gene: 108811203
Following gene: 108811199
Centisome position: 26.32
GC content: 49.06
Gene sequence:
>852_bases ATGCAAACAGTAAAACTGAACAACGGTATTGCAATGCCTCTGCTGGGCTTTGGTGTCTTCCAGATGACTAATACCGCGGA ATGCGAGCGCGCAGTTATCGATGCGATTGAAACAGGCTATCGCCTCATAGACACCGCCGCTTCCTACCAGAATGAAACGC AGGTAGGGAATGCGCTTAAGCTGAGTGGTATTGCACGAGATGAACTGTTTATCACGACTAAATTGTGGTTGCAGGATACC TATTATGAAGGTGCGAAAGCGCAGTTTGAACGCTCACTGAATCGCCTACAACTGGATTATGTCGATCTGTACCTGATTCA CCAACCCTATGGCGACGTTCATGGCGCATGGCGTGCAATGGAAGAATTACACCAGGCGGGCAAAATCCGTGCCATTGGCG TCAGTAACTTTCATCCGGACAGACTGGCTGATCTCATGGCATTTAATAAGATCATTCCAGCCGTAAACCAAATTGAAGTT AATCCGTTCAACCAACAACTCCACGCTGTGCCATGGATGCAAAGCCGAGGTATTCAGCCAGAAGCATGGGCACCGTTTGC GGAAGGAAGAAACGGTCTCTTCCAGAATCCGGTATTAACCGCTATCGGCGAAAAATATGGCAAAAGCGTGGGACAGGTTG TATTACGCTGGATTTTCCAGCGCGGCATTGTCTCGCTGGCAAAATCAGTGCGAAAAGGGCGAATGGAAGAGAATATTAAC ATTCTGGACTTCGAGCTCAGTGCTGAAGACATGCTGCAGATAGCGGCTCTTGATACCGCAACGAGCGCCTTCTTCTCACA TCGCGACCCGGCAATGGTGGAATGGCTGACTGGCCGTAAACTTGATGTCTAA
Upstream 100 bases:
>100_bases TTCATGAATATGACTAATAAACCCTAGTTAATTACCCCTTCTAATCAAATAAATTACTTTGCGCTATGCTTTTCCTACAC AACAGTTGAAGGATAACGTC
Downstream 100 bases:
>100_bases GCCGCTATAGAAGAGGAGATTATTGATGCAAAAACGTTATCTCGGTAAATCCGGACTTGAAGTATCGGCACTGGGTCTGG GCTGTATGGGGCTGAGCTAT
Product: aldo/keto reductase
Products: NA
Alternate protein names: GR; Methylglyoxal reductase [H]
Number of amino acids: Translated: 283; Mature: 283
Protein sequence:
>283_residues MQTVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALKLSGIARDELFITTKLWLQDT YYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVNQIEV NPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNGLFQNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSLAKSVRKGRMEENIN ILDFELSAEDMLQIAALDTATSAFFSHRDPAMVEWLTGRKLDV
Sequences:
>Translated_283_residues MQTVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALKLSGIARDELFITTKLWLQDT YYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVNQIEV NPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNGLFQNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSLAKSVRKGRMEENIN ILDFELSAEDMLQIAALDTATSAFFSHRDPAMVEWLTGRKLDV >Mature_283_residues MQTVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALKLSGIARDELFITTKLWLQDT YYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVNQIEV NPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNGLFQNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSLAKSVRKGRMEENIN ILDFELSAEDMLQIAALDTATSAFFSHRDPAMVEWLTGRKLDV
Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=290, Percent_Identity=33.7931034482759, Blast_Score=179, Evalue=2e-45, Organism=Homo sapiens, GI5174391, Length=290, Percent_Identity=33.7931034482759, Blast_Score=179, Evalue=2e-45, Organism=Homo sapiens, GI310109922, Length=275, Percent_Identity=36.3636363636364, Blast_Score=168, Evalue=7e-42, Organism=Homo sapiens, GI310109920, Length=296, Percent_Identity=34.4594594594595, Blast_Score=167, Evalue=1e-41, Organism=Homo sapiens, GI45446745, Length=296, Percent_Identity=34.4594594594595, Blast_Score=167, Evalue=1e-41, Organism=Homo sapiens, GI4503285, Length=296, Percent_Identity=34.4594594594595, Blast_Score=167, Evalue=1e-41, Organism=Homo sapiens, GI24497583, Length=305, Percent_Identity=34.0983606557377, Blast_Score=166, Evalue=1e-41, Organism=Homo sapiens, GI5453543, Length=297, Percent_Identity=34.3434343434343, Blast_Score=166, Evalue=2e-41, Organism=Homo sapiens, GI5174695, Length=294, Percent_Identity=32.6530612244898, Blast_Score=159, Evalue=2e-39, Organism=Homo sapiens, GI24497585, Length=300, Percent_Identity=34.6666666666667, Blast_Score=158, Evalue=4e-39, Organism=Homo sapiens, GI223468663, Length=292, Percent_Identity=33.2191780821918, Blast_Score=157, Evalue=9e-39, Organism=Homo sapiens, GI4502049, Length=308, Percent_Identity=36.6883116883117, Blast_Score=151, Evalue=6e-37, Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=31.4079422382672, Blast_Score=143, Evalue=1e-34, Organism=Homo sapiens, GI93277124, Length=295, Percent_Identity=30.1694915254237, Blast_Score=142, Evalue=2e-34, Organism=Homo sapiens, GI291291012, Length=283, Percent_Identity=31.8021201413428, Blast_Score=138, Evalue=5e-33, Organism=Homo sapiens, GI300116271, Length=271, Percent_Identity=31.7343173431734, Blast_Score=136, Evalue=2e-32, Organism=Homo sapiens, GI310109926, Length=114, Percent_Identity=45.6140350877193, Blast_Score=94, Evalue=9e-20, Organism=Homo sapiens, GI207028673, Length=114, Percent_Identity=45.6140350877193, Blast_Score=94, Evalue=9e-20, Organism=Homo sapiens, GI310109924, Length=151, Percent_Identity=31.1258278145695, Blast_Score=83, Evalue=3e-16, Organism=Escherichia coli, GI87082198, Length=259, Percent_Identity=42.8571428571429, Blast_Score=213, Evalue=2e-56, Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=34.9019607843137, Blast_Score=147, Evalue=7e-37, Organism=Escherichia coli, GI1788081, Length=281, Percent_Identity=30.2491103202847, Blast_Score=105, Evalue=5e-24, Organism=Escherichia coli, GI48994888, Length=200, Percent_Identity=31.5, Blast_Score=80, Evalue=1e-16, Organism=Caenorhabditis elegans, GI71998625, Length=259, Percent_Identity=37.8378378378378, Blast_Score=176, Evalue=1e-44, Organism=Caenorhabditis elegans, GI17564128, Length=306, Percent_Identity=33.3333333333333, Blast_Score=164, Evalue=7e-41, Organism=Caenorhabditis elegans, GI17537075, Length=294, Percent_Identity=33.6734693877551, Blast_Score=159, Evalue=1e-39, Organism=Caenorhabditis elegans, GI17537077, Length=294, Percent_Identity=32.9931972789116, Blast_Score=159, Evalue=2e-39, Organism=Caenorhabditis elegans, GI17561298, Length=273, Percent_Identity=32.2344322344322, Blast_Score=159, Evalue=2e-39, Organism=Caenorhabditis elegans, GI17550248, Length=285, Percent_Identity=33.6842105263158, Blast_Score=154, Evalue=4e-38, Organism=Caenorhabditis elegans, GI17537079, Length=297, Percent_Identity=31.6498316498317, Blast_Score=152, Evalue=2e-37, Organism=Caenorhabditis elegans, GI17566692, Length=276, Percent_Identity=34.0579710144928, Blast_Score=142, Evalue=2e-34, Organism=Caenorhabditis elegans, GI17552492, Length=280, Percent_Identity=29.6428571428571, Blast_Score=132, Evalue=1e-31, Organism=Caenorhabditis elegans, GI17561300, Length=274, Percent_Identity=31.021897810219, Blast_Score=130, Evalue=8e-31, Organism=Caenorhabditis elegans, GI17538386, Length=275, Percent_Identity=31.2727272727273, Blast_Score=129, Evalue=2e-30, Organism=Caenorhabditis elegans, GI17562292, Length=278, Percent_Identity=27.6978417266187, Blast_Score=128, Evalue=4e-30, Organism=Saccharomyces cerevisiae, GI6324694, Length=284, Percent_Identity=38.3802816901408, Blast_Score=181, Evalue=9e-47, Organism=Saccharomyces cerevisiae, GI6320576, Length=286, Percent_Identity=37.4125874125874, Blast_Score=178, Evalue=9e-46, Organism=Saccharomyces cerevisiae, GI6322556, Length=262, Percent_Identity=33.969465648855, Blast_Score=147, Evalue=2e-36, Organism=Saccharomyces cerevisiae, GI6321896, Length=325, Percent_Identity=31.3846153846154, Blast_Score=147, Evalue=3e-36, Organism=Saccharomyces cerevisiae, GI6320079, Length=282, Percent_Identity=31.2056737588652, Blast_Score=132, Evalue=4e-32, Organism=Saccharomyces cerevisiae, GI6319625, Length=286, Percent_Identity=28.6713286713287, Blast_Score=109, Evalue=6e-25, Organism=Drosophila melanogaster, GI24657054, Length=278, Percent_Identity=39.2086330935252, Blast_Score=173, Evalue=9e-44, Organism=Drosophila melanogaster, GI24663317, Length=290, Percent_Identity=34.8275862068965, Blast_Score=171, Evalue=5e-43, Organism=Drosophila melanogaster, GI45553081, Length=291, Percent_Identity=34.7079037800687, Blast_Score=169, Evalue=2e-42, Organism=Drosophila melanogaster, GI24644950, Length=296, Percent_Identity=36.1486486486487, Blast_Score=169, Evalue=3e-42, Organism=Drosophila melanogaster, GI21356425, Length=312, Percent_Identity=34.9358974358974, Blast_Score=168, Evalue=3e-42, Organism=Drosophila melanogaster, GI221378297, Length=316, Percent_Identity=33.8607594936709, Blast_Score=161, Evalue=6e-40, Organism=Drosophila melanogaster, GI20129731, Length=278, Percent_Identity=35.6115107913669, Blast_Score=156, Evalue=1e-38, Organism=Drosophila melanogaster, GI24662789, Length=290, Percent_Identity=34.8275862068965, Blast_Score=152, Evalue=3e-37, Organism=Drosophila melanogaster, GI281366140, Length=255, Percent_Identity=32.5490196078431, Blast_Score=133, Evalue=1e-31, Organism=Drosophila melanogaster, GI24662781, Length=281, Percent_Identity=33.0960854092527, Blast_Score=125, Evalue=3e-29, Organism=Drosophila melanogaster, GI24662785, Length=273, Percent_Identity=32.967032967033, Blast_Score=121, Evalue=6e-28,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.283 [H]
Molecular weight: Translated: 31872; Mature: 31872
Theoretical pI: Translated: 5.97; Mature: 5.97
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQTVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALK CCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHCCEEE LSGIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAM ECCCCCCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHH EELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVNQIEVNPFNQQLHAVPWMQSRGIQP HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHEEECCCCCHHHHCCCCHHHCCCCC EAWAPFAEGRNGLFQNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSLAKSVRKGRMEENIN CCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCC ILDFELSAEDMLQIAALDTATSAFFSHRDPAMVEWLTGRKLDV EEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC >Mature Secondary Structure MQTVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALK CCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHCCEEE LSGIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAM ECCCCCCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHH EELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVNQIEVNPFNQQLHAVPWMQSRGIQP HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHEEECCCCCHHHHCCCCHHHCCCCC EAWAPFAEGRNGLFQNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSLAKSVRKGRMEENIN CCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCC ILDFELSAEDMLQIAALDTATSAFFSHRDPAMVEWLTGRKLDV EEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9639930; 9384377 [H]