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The map label for this gene is dxs [H]

Identifier: 108811076

GI number: 108811076

Start: 1061973

End: 1063832

Strand: Reverse

Name: dxs [H]

Synonym: YPN_0911

Alternate gene names: 108811076

Gene position: 1063832-1061973 (Counterclockwise)

Preceding gene: 108811077

Following gene: 108811059

Centisome position: 23.46

GC content: 48.92

Gene sequence:

>1860_bases
ATGAGTCTTGATATAGCCAAATACCCGACATTGGCACTAGCGGAGAACCCAGAAGAACTGCGCATGCTGCCAAAAGAAAG
CTTGCCGAAGTTATGTGATGAACTCCGGCAGTATTTGCTCACCTGTGTCAGCCGATCCAGCGGGCATTTTGCTTCCGGGT
TAGGCGTAGTCGAACTGACTGTCGCTTTACATTACGTTTATAATACGCCGTTTGATCATTTGATATGGGACGTAGGTCAT
CAGGCTTATCCGCACAAAATATTGACCGGCCGCCGTGATCGAATCTCTACTATTCGTCAAAAAGATGGTTTGCACCCTTT
TCCATGGCGCGGAGAGAGTGAATACGACGTGCTTTCTGTTGGTCACTCCTCTACATCGATCAGCGCGGGTCTGGGTATGG
CGGTTGCTGCCGAGCGGGAAGGTAAAGGGCGACGTACCGTTTGCGTTATCGGTGATGGTGCTATCACCGCAGGTATGGCT
TTTGAAGCAATGAGTCATGCCGGAGATATTCACTCAGACATGCTGGTTATCCTCAATGATAATGGAATGTCTATTTCAGA
AAATGTAGGTGGCCTGAACAACCATTTGGCTCAGCTATTATCTGGAAAACTCTATGCCAGCCTACGTGAAGGCGGTAAAA
AAGCATTTTCTGCCTTACCACCAATCAAAGATCTGCTGAAACGAACCGAAGAGCATCTGAAAGGGATGGTAGTCCCCAGT
ACGTTGTTTGAAGAGTTAGGTTTTAATTATATTGGTCCCGTTGATGGGCATGATGTACACACGTTGACGCAAACGCTAAA
AAATATGCGCGACCTGAAAAGTCCACAACTTCTGCACATCATGACTAAAAAGGGCAAAGGCTATGCTCCGGCAGAAAAGG
ATCCAATCGGTTGGCATGCCGTACCTAAGTTTGATCCCGCCTCCGGCACCTTGCCTAAAAGCCAGAGCAGCCTCCCCACT
TACTCCAAAATATTTGGCGAATGGTTATGCGAAACCGCAGCCAAAGATAGCAAATTAATGGCAGTGACACCGGCGATGCG
TGAAGGATCCGGCATGGTGCGTTTCTCGCGCGAATATCCGCAACAATATTTCGATGTCGCCATCGCTGAACAACATGCAG
TGACCTTTGCCGCAGGCCTGGCTATTGGTGGCTACAAGCCTGTGGTTGCCATCTATTCGACTTTCTTGCAACGCGCCTAT
GATCAGTTGATCCATGATGTTGCTATCCAAAATTTGCCCGTGCTCTTTGCCATTGACCGTGGCGGTTTGGTCGGTGCTGA
TGGGCAGACTCACCAAGGTGCATTCGATCTTTCATTTATGCGCTGTATTCCAAACATGGTCATTATGGCACCAAGTGATG
AGAATGAGTGCCGTCAGATGCTATACACCGGCTATCACCATAATGGACCTGCCGCAGTACGTTACCCACGAGGTAATGGT
ACGAGCGCGGTGCTGGAGCCATTGGAGATGTTGCCGATCGGCAAAGGGGTACTACGCCGTGAAGGTGAGAAGATTGCCAT
CCTTTGCTTTGGTACGTTACTTGCTCAGGCACAGCTTGCCGCAGAAAACCTCAATGCCACGCTGGTGGATATGCGTTTCG
TGAAACCGCTAGATGAAGAATTGGTATTGGAAATGGCAGCAAAACATCAGGTATTAGTGACTGTCGAAGAAAACGCCATC
ATGGGGGGGGCGGGTAGCGGTGTGAATGAGCTATTAATGGCAAAACGGCGATGGGTCCCAGTACTCAATATTGGTTTACC
CGATCTATTTGTGCCACAAGGTGAGCAAGACGAAATGCGATCTGAACTCGGTTTAGATGCGGCGGGTATACAGCGTCAAA
TTGAAGCTTGGCTAGCTTAA

Upstream 100 bases:

>100_bases
TAAATCCTGAACAGTGAAAATCGCGAATAACGCAATAACATCAAGGATGATGGAGATGGCAGTTAAGCATCTACATAAAC
ACTTTTGATATGAGCATCGA

Downstream 100 bases:

>100_bases
CCGCGGCTCGCCTAGTTAAACTCACCGAGCATATTTTTTAGATCTCAGAATTTTTTTAGATATCAGAAACAATAAATATC
CTCCGGCATAGCCGGAGGTT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MSLDIAKYPTLALAENPEELRMLPKESLPKLCDELRQYLLTCVSRSSGHFASGLGVVELTVALHYVYNTPFDHLIWDVGH
QAYPHKILTGRRDRISTIRQKDGLHPFPWRGESEYDVLSVGHSSTSISAGLGMAVAAEREGKGRRTVCVIGDGAITAGMA
FEAMSHAGDIHSDMLVILNDNGMSISENVGGLNNHLAQLLSGKLYASLREGGKKAFSALPPIKDLLKRTEEHLKGMVVPS
TLFEELGFNYIGPVDGHDVHTLTQTLKNMRDLKSPQLLHIMTKKGKGYAPAEKDPIGWHAVPKFDPASGTLPKSQSSLPT
YSKIFGEWLCETAAKDSKLMAVTPAMREGSGMVRFSREYPQQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAY
DQLIHDVAIQNLPVLFAIDRGGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYHHNGPAAVRYPRGNG
TSAVLEPLEMLPIGKGVLRREGEKIAILCFGTLLAQAQLAAENLNATLVDMRFVKPLDEELVLEMAAKHQVLVTVEENAI
MGGAGSGVNELLMAKRRWVPVLNIGLPDLFVPQGEQDEMRSELGLDAAGIQRQIEAWLA

Sequences:

>Translated_619_residues
MSLDIAKYPTLALAENPEELRMLPKESLPKLCDELRQYLLTCVSRSSGHFASGLGVVELTVALHYVYNTPFDHLIWDVGH
QAYPHKILTGRRDRISTIRQKDGLHPFPWRGESEYDVLSVGHSSTSISAGLGMAVAAEREGKGRRTVCVIGDGAITAGMA
FEAMSHAGDIHSDMLVILNDNGMSISENVGGLNNHLAQLLSGKLYASLREGGKKAFSALPPIKDLLKRTEEHLKGMVVPS
TLFEELGFNYIGPVDGHDVHTLTQTLKNMRDLKSPQLLHIMTKKGKGYAPAEKDPIGWHAVPKFDPASGTLPKSQSSLPT
YSKIFGEWLCETAAKDSKLMAVTPAMREGSGMVRFSREYPQQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAY
DQLIHDVAIQNLPVLFAIDRGGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYHHNGPAAVRYPRGNG
TSAVLEPLEMLPIGKGVLRREGEKIAILCFGTLLAQAQLAAENLNATLVDMRFVKPLDEELVLEMAAKHQVLVTVEENAI
MGGAGSGVNELLMAKRRWVPVLNIGLPDLFVPQGEQDEMRSELGLDAAGIQRQIEAWLA
>Mature_618_residues
SLDIAKYPTLALAENPEELRMLPKESLPKLCDELRQYLLTCVSRSSGHFASGLGVVELTVALHYVYNTPFDHLIWDVGHQ
AYPHKILTGRRDRISTIRQKDGLHPFPWRGESEYDVLSVGHSSTSISAGLGMAVAAEREGKGRRTVCVIGDGAITAGMAF
EAMSHAGDIHSDMLVILNDNGMSISENVGGLNNHLAQLLSGKLYASLREGGKKAFSALPPIKDLLKRTEEHLKGMVVPST
LFEELGFNYIGPVDGHDVHTLTQTLKNMRDLKSPQLLHIMTKKGKGYAPAEKDPIGWHAVPKFDPASGTLPKSQSSLPTY
SKIFGEWLCETAAKDSKLMAVTPAMREGSGMVRFSREYPQQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYD
QLIHDVAIQNLPVLFAIDRGGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYHHNGPAAVRYPRGNGT
SAVLEPLEMLPIGKGVLRREGEKIAILCFGTLLAQAQLAAENLNATLVDMRFVKPLDEELVLEMAAKHQVLVTVEENAIM
GGAGSGVNELLMAKRRWVPVLNIGLPDLFVPQGEQDEMRSELGLDAAGIQRQIEAWLA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=521, Percent_Identity=23.2245681381958, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4507521, Length=521, Percent_Identity=23.2245681381958, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI133778974, Length=496, Percent_Identity=25, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI225637459, Length=493, Percent_Identity=23.9350912778905, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI225637463, Length=493, Percent_Identity=23.9350912778905, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI225637461, Length=493, Percent_Identity=23.9350912778905, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI156564403, Length=273, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=82.741935483871, Blast_Score=1081, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=606, Percent_Identity=22.2772277227723, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538422, Length=294, Percent_Identity=21.7687074829932, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45551847, Length=642, Percent_Identity=24.6105919003115, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45550715, Length=642, Percent_Identity=24.6105919003115, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24645119, Length=541, Percent_Identity=25.3234750462107, Blast_Score=106, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24666278, Length=528, Percent_Identity=24.2424242424242, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21358145, Length=268, Percent_Identity=23.8805970149254, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650940, Length=268, Percent_Identity=23.8805970149254, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67675; Mature: 67544

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDIAKYPTLALAENPEELRMLPKESLPKLCDELRQYLLTCVSRSSGHFASGLGVVELT
CCCCCCCCCCEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHH
VALHYVYNTPFDHLIWDVGHQAYPHKILTGRRDRISTIRQKDGLHPFPWRGESEYDVLSV
HHHHHHHCCCHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
GHSSTSISAGLGMAVAAEREGKGRRTVCVIGDGAITAGMAFEAMSHAGDIHSDMLVILND
CCCCCCHHCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECC
NGMSISENVGGLNNHLAQLLSGKLYASLREGGKKAFSALPPIKDLLKRTEEHLKGMVVPS
CCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHH
TLFEELGFNYIGPVDGHDVHTLTQTLKNMRDLKSPQLLHIMTKKGKGYAPAEKDPIGWHA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPASGTLPKSQSSLPTYSKIFGEWLCETAAKDSKLMAVTPAMREGSGMVRFSREYP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHCCCCCEEECHHCC
QQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQLIHDVAIQNLPVLFAIDR
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
GGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYHHNGPAAVRYPRGNG
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCC
TSAVLEPLEMLPIGKGVLRREGEKIAILCFGTLLAQAQLAAENLNATLVDMRFVKPLDEE
CHHHHHHHHHCCCCCHHHHCCCCEEEEEEHHHHHHHHHHHHHCCCEEEEEEHHHCCCCHH
LVLEMAAKHQVLVTVEENAIMGGAGSGVNELLMAKRRWVPVLNIGLPDLFVPQGEQDEMR
HHHHHHCCCEEEEEEECCEEECCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHH
SELGLDAAGIQRQIEAWLA
HHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SLDIAKYPTLALAENPEELRMLPKESLPKLCDELRQYLLTCVSRSSGHFASGLGVVELT
CCCCCCCCCEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHH
VALHYVYNTPFDHLIWDVGHQAYPHKILTGRRDRISTIRQKDGLHPFPWRGESEYDVLSV
HHHHHHHCCCHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
GHSSTSISAGLGMAVAAEREGKGRRTVCVIGDGAITAGMAFEAMSHAGDIHSDMLVILND
CCCCCCHHCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECC
NGMSISENVGGLNNHLAQLLSGKLYASLREGGKKAFSALPPIKDLLKRTEEHLKGMVVPS
CCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHH
TLFEELGFNYIGPVDGHDVHTLTQTLKNMRDLKSPQLLHIMTKKGKGYAPAEKDPIGWHA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPASGTLPKSQSSLPTYSKIFGEWLCETAAKDSKLMAVTPAMREGSGMVRFSREYP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHCCCCCEEECHHCC
QQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQLIHDVAIQNLPVLFAIDR
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
GGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYHHNGPAAVRYPRGNG
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCC
TSAVLEPLEMLPIGKGVLRREGEKIAILCFGTLLAQAQLAAENLNATLVDMRFVKPLDEE
CHHHHHHHHHCCCCCHHHHCCCCEEEEEEHHHHHHHHHHHHHCCCEEEEEEHHHCCCCHH
LVLEMAAKHQVLVTVEENAIMGGAGSGVNELLMAKRRWVPVLNIGLPDLFVPQGEQDEMR
HHHHHHCCCEEEEEEECCEEECCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHH
SELGLDAAGIQRQIEAWLA
HHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA