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The map label for this gene is lldD1 [H]

Identifier: 108797975

GI number: 108797975

Start: 1106183

End: 1107376

Strand: Direct

Name: lldD1 [H]

Synonym: Mmcs_1002

Alternate gene names: 108797975

Gene position: 1106183-1107376 (Clockwise)

Preceding gene: 108797974

Following gene: 108797976

Centisome position: 19.39

GC content: 68.84

Gene sequence:

>1194_bases
ATGGCGCGCGATACCTGGTTCGAGACCGTCGCCATCGCCCAGCAGCGGGCGAAGAAGCGGTTGCCCAAGTCGGTGTACTC
CTCGCTGATCTCGGCCAGCGAGAAGGGGGTGACGGTCTCCGACAACGTCGAGTCGTTCTCCGAACTCGGCTTCGCCCCCC
ACGTCGTCGGCGCCCCGGAGAAGCGCGACCTGTCGACAACGGTGATGGGACAAGAGATCTCGATGCCGGTCATGATCTCG
CCGACCGGTGTGCAGGCCGTCGACCCCGACGGTGAGGTGGCGGTCGCCCGCGCGGCGGCCGCCCGCGGCACCGCGATGGG
ACTGTCGTCCTTCGCCAGCAAGCCGATCGAAGAGGTCATCGCCGCCAACCCGAAGCTGTTCTTCCAGATCTACTGGCTGG
GCGGTCGCGAGGCGATCCTGGAGCGCGCGCAGCGGGCCAAGGAGGCCGGTGCGGTCGGGTTGATCGCCACGACCGACTGG
AGCTTCTCCCACGGCCGGGACTGGGGCAGCCCGAAGATCCCCGAGCAGATGAACCTCAAGACGATGTTGAAGATGTCGCC
CGAGGTGCTCACCAAACCGCGCTGGCTGTGGGATTTCGGCAAGACGTTCAGCCCGCCCGATCTGCGGGTGCCCAACCAGG
CCCGCCGCGGTGAGCCCGGACCGCCGTTCTTCCAGGCCTACGGCGAGTGGATGGGAACCCCGCCGCCCACCTGGGAGGAC
ATCGCGTGGTTGCGCGAGCGGTGGGACGGTCCGTTCATGCTCAAGGGCATCGTGCGGGTGGACGACGCCAAACGCGCTGT
CGATGCCGGTGTTTCAGCCATCTCGGTGTCCAACCACGGCGGCAACAACCTCGACGGCACCCCGGCCGCCATCCGCTGCC
TGCCCGCGATCGCCGATGCGGTCGGCCAGCAGGTCGAGGTGTTGCTCGACGGCGGTATACGCCGCGGCAGCGACGTCGTC
AAGGCCCTGGCGCTGGGTGCCCGCGCGGTGATGATCGGCCGGGCCTACCTGTGGGGTCTCGCCGCCAACGGACAGGCCGG
CGTCGAGAACGTCCTGGACATCCTGCGCGGCGGGATCGACTCCGCGCTGATGGGGCTCGGACGCGCCTCGATCCATGATC
TGGGCCCCGACGACATCCTCATTCCCGACGGGTTCACCCGCGCGCTCGGCCTGCCGGCCGGGGACCAGAACTGA

Upstream 100 bases:

>100_bases
CGGCGACCACTCCCGAGGGACCAAACTGACGGGCCCGATCCCGTTGAAACTGTTGACCAAGCCGCCCGCCCGGCTGTGTA
ACGAAAGCCCGGTGTAGATC

Downstream 100 bases:

>100_bases
TCGGCTGAACCTCTTGCTGTGACGCAGGGGGCAGACGGTGCTGCCGGGATCGAAACAATTGAATCCCGTGCGCCAACAAC
CGGCGCACGCCAGGTGAATT

Product: (S)-2-hydroxy-acid oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MARDTWFETVAIAQQRAKKRLPKSVYSSLISASEKGVTVSDNVESFSELGFAPHVVGAPEKRDLSTTVMGQEISMPVMIS
PTGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEEVIAANPKLFFQIYWLGGREAILERAQRAKEAGAVGLIATTDW
SFSHGRDWGSPKIPEQMNLKTMLKMSPEVLTKPRWLWDFGKTFSPPDLRVPNQARRGEPGPPFFQAYGEWMGTPPPTWED
IAWLRERWDGPFMLKGIVRVDDAKRAVDAGVSAISVSNHGGNNLDGTPAAIRCLPAIADAVGQQVEVLLDGGIRRGSDVV
KALALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDSALMGLGRASIHDLGPDDILIPDGFTRALGLPAGDQN

Sequences:

>Translated_397_residues
MARDTWFETVAIAQQRAKKRLPKSVYSSLISASEKGVTVSDNVESFSELGFAPHVVGAPEKRDLSTTVMGQEISMPVMIS
PTGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEEVIAANPKLFFQIYWLGGREAILERAQRAKEAGAVGLIATTDW
SFSHGRDWGSPKIPEQMNLKTMLKMSPEVLTKPRWLWDFGKTFSPPDLRVPNQARRGEPGPPFFQAYGEWMGTPPPTWED
IAWLRERWDGPFMLKGIVRVDDAKRAVDAGVSAISVSNHGGNNLDGTPAAIRCLPAIADAVGQQVEVLLDGGIRRGSDVV
KALALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDSALMGLGRASIHDLGPDDILIPDGFTRALGLPAGDQN
>Mature_396_residues
ARDTWFETVAIAQQRAKKRLPKSVYSSLISASEKGVTVSDNVESFSELGFAPHVVGAPEKRDLSTTVMGQEISMPVMISP
TGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEEVIAANPKLFFQIYWLGGREAILERAQRAKEAGAVGLIATTDWS
FSHGRDWGSPKIPEQMNLKTMLKMSPEVLTKPRWLWDFGKTFSPPDLRVPNQARRGEPGPPFFQAYGEWMGTPPPTWEDI
AWLRERWDGPFMLKGIVRVDDAKRAVDAGVSAISVSNHGGNNLDGTPAAIRCLPAIADAVGQQVEVLLDGGIRRGSDVVK
ALALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDSALMGLGRASIHDLGPDDILIPDGFTRALGLPAGDQN

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=347, Percent_Identity=38.0403458213257, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI54234014, Length=370, Percent_Identity=32.1621621621622, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI7705393, Length=370, Percent_Identity=32.1621621621622, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1790033, Length=371, Percent_Identity=36.1185983827493, Blast_Score=209, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI193208036, Length=370, Percent_Identity=32.4324324324324, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI32566217, Length=284, Percent_Identity=27.8169014084507, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323587, Length=390, Percent_Identity=28.7179487179487, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI78707188, Length=365, Percent_Identity=32.0547945205479, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI281363140, Length=365, Percent_Identity=32.0547945205479, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI78707190, Length=365, Percent_Identity=32.0547945205479, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42546; Mature: 42415

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARDTWFETVAIAQQRAKKRLPKSVYSSLISASEKGVTVSDNVESFSELGFAPHVVGAPE
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEECCCHHHHHHCCCCCCCCCCCC
KRDLSTTVMGQEISMPVMISPTGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEEVI
CCCCHHHHCCCCCCCCEEECCCCCEEECCCCCEEHHHHHHHCCHHHHHHHHHCCHHHHHH
AANPKLFFQIYWLGGREAILERAQRAKEAGAVGLIATTDWSFSHGRDWGSPKIPEQMNLK
HCCCEEEEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHH
TMLKMSPEVLTKPRWLWDFGKTFSPPDLRVPNQARRGEPGPPFFQAYGEWMGTPPPTWED
HHHHCCHHHHCCCCHHHHHCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCHHH
IAWLRERWDGPFMLKGIVRVDDAKRAVDAGVSAISVSNHGGNNLDGTPAAIRCLPAIADA
HHHHHHHCCCCEEEEHEEEECHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
VGQQVEVLLDGGIRRGSDVVKALALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGID
HHHHEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHCCHH
SALMGLGRASIHDLGPDDILIPDGFTRALGLPAGDQN
HHHHHCCCHHHHCCCCCCEECCCCCHHHHCCCCCCCC
>Mature Secondary Structure 
ARDTWFETVAIAQQRAKKRLPKSVYSSLISASEKGVTVSDNVESFSELGFAPHVVGAPE
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEECCCHHHHHHCCCCCCCCCCCC
KRDLSTTVMGQEISMPVMISPTGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEEVI
CCCCHHHHCCCCCCCCEEECCCCCEEECCCCCEEHHHHHHHCCHHHHHHHHHCCHHHHHH
AANPKLFFQIYWLGGREAILERAQRAKEAGAVGLIATTDWSFSHGRDWGSPKIPEQMNLK
HCCCEEEEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHH
TMLKMSPEVLTKPRWLWDFGKTFSPPDLRVPNQARRGEPGPPFFQAYGEWMGTPPPTWED
HHHHCCHHHHCCCCHHHHHCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCHHH
IAWLRERWDGPFMLKGIVRVDDAKRAVDAGVSAISVSNHGGNNLDGTPAAIRCLPAIADA
HHHHHHHCCCCEEEEHEEEECHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
VGQQVEVLLDGGIRRGSDVVKALALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGID
HHHHEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHCCHH
SALMGLGRASIHDLGPDDILIPDGFTRALGLPAGDQN
HHHHHCCCHHHHCCCCCCEECCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]