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The map label for this gene is rocD [H]

Identifier: 108797965

GI number: 108797965

Start: 1098181

End: 1099407

Strand: Reverse

Name: rocD [H]

Synonym: Mmcs_0992

Alternate gene names: 108797965

Gene position: 1099407-1098181 (Counterclockwise)

Preceding gene: 108797966

Following gene: 108797963

Centisome position: 19.27

GC content: 71.56

Gene sequence:

>1227_bases
GTGACCGTCACCGATCGCACAACCGTCACCGACGCGGTGATCGCCGCCGACCACCGCTACGTCGCGCACAACTACTCCCC
GCTGCCGGTGGTGGCCGCCGCCGCGGAGGGCGCCTGGATCACCGACGTGGAGGGTCGGCGCCACCTCGACTGCCTCGCCG
CGTACTCGGCGGTCAACTTCGGCCACCGCCACCCGCGGATCGTCGCGGCCGCCCACGCCCAGCTCGATGCGGTCACGTTG
GTCAGCCGCGCCTTCCACTCCGACCGGCTCGCCCCGTTCTGCCAGGCGCTGGCCGGGCTGTGCGGTAAGGACATGGTGCT
GCCGATGAACAGCGGCGCCGAGGCCGTCGAGAGCGGGATCAAGGTGGCCCGCAAATGGGGCACCGACGTCAAGGGCGTAC
CGGCAGGCCTGGGCAACATCGTGGTGGCGCACAACAACTTCCACGGCCGCACCACCACCATCATCAGCTTCTCCGACGAC
GACACCGCGCGGCGGGGCTTCGGCCCGTACACACCGGGCTTCCGGGCCGTGCCGTTCGGTGACACCGATGCGCTCGCCGC
CGCCGTCGACGACCACACCGTCGCGGTGCTGCTGGAACCGATCCAGGGCGAGGCCGGGATCATCGTCCCACCCGACGACT
ACCTGCCGCGGGTGCGGCGGATCTGCACCGACCGTGGCGTGTTGCTGATCGCCGACGAGATCCAGTCCGGCCTGGCGCGC
ACCGGGCGCACGTTCGCCTGCGACCACTGGGACGTGGTGCCCGACCTGTACCTGCTCGGCAAGGCGCTCGGCGGCGGTGT
CGTCCCGGTGTCGGCCGTGGTCGGCGACCGGGATGTGCTGGGCGTGCTGCATCCCGGAGAGCACGGCTCCACCTTCGGCG
GCAACCCGCTGGCGGCGGCGGTCGGCTCGGTGGTGGTCGACCTGCTGAGGACCGGCGAATTCCAGACGCGCGCCGTCGAA
CTCGGCGACCATCTGCACACGCGGCTGCGCGGGCTCATCGGTCACGGCGTGGTGGCGGTGCGCGGGAAGGGACTGTGGGC
CGGTGTCGACGTGGACCCCGCGCTGGGCACCGGTAAGCAGATCAGCCTGGCCCTGGCCGAACGCCGCGTGCTGGTCAAGG
ACACCCACGGTTCGACGCTGCGGTTCGCTCCCCCGCTGGTCATCACCGCCGACGAAATCGACTGGGCGGTGGACCGATTC
GCGGCGGTGCTGGCCGACCGCGGATGA

Upstream 100 bases:

>100_bases
AACAGCTGCGGGCGGCGGGTTTCGACCCCGTCGGCGTGGACCTGTCCGAGCTGCTCAAGGGCGGCGGCTCCGTCAAATGC
TGCACGCTGGAGGTGCACCC

Downstream 100 bases:

>100_bases
GGGACTAGTACTTCATCACACCGCGGTCGACGGCGATCTGGCTGCCCGACAGCGTCGCCGAACCGTCCCCGGCCAGCCAG
GCCACCACGTCGGCGACCTC

Product: aminotransferase

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MTVTDRTTVTDAVIAADHRYVAHNYSPLPVVAAAAEGAWITDVEGRRHLDCLAAYSAVNFGHRHPRIVAAAHAQLDAVTL
VSRAFHSDRLAPFCQALAGLCGKDMVLPMNSGAEAVESGIKVARKWGTDVKGVPAGLGNIVVAHNNFHGRTTTIISFSDD
DTARRGFGPYTPGFRAVPFGDTDALAAAVDDHTVAVLLEPIQGEAGIIVPPDDYLPRVRRICTDRGVLLIADEIQSGLAR
TGRTFACDHWDVVPDLYLLGKALGGGVVPVSAVVGDRDVLGVLHPGEHGSTFGGNPLAAAVGSVVVDLLRTGEFQTRAVE
LGDHLHTRLRGLIGHGVVAVRGKGLWAGVDVDPALGTGKQISLALAERRVLVKDTHGSTLRFAPPLVITADEIDWAVDRF
AAVLADRG

Sequences:

>Translated_408_residues
MTVTDRTTVTDAVIAADHRYVAHNYSPLPVVAAAAEGAWITDVEGRRHLDCLAAYSAVNFGHRHPRIVAAAHAQLDAVTL
VSRAFHSDRLAPFCQALAGLCGKDMVLPMNSGAEAVESGIKVARKWGTDVKGVPAGLGNIVVAHNNFHGRTTTIISFSDD
DTARRGFGPYTPGFRAVPFGDTDALAAAVDDHTVAVLLEPIQGEAGIIVPPDDYLPRVRRICTDRGVLLIADEIQSGLAR
TGRTFACDHWDVVPDLYLLGKALGGGVVPVSAVVGDRDVLGVLHPGEHGSTFGGNPLAAAVGSVVVDLLRTGEFQTRAVE
LGDHLHTRLRGLIGHGVVAVRGKGLWAGVDVDPALGTGKQISLALAERRVLVKDTHGSTLRFAPPLVITADEIDWAVDRF
AAVLADRG
>Mature_407_residues
TVTDRTTVTDAVIAADHRYVAHNYSPLPVVAAAAEGAWITDVEGRRHLDCLAAYSAVNFGHRHPRIVAAAHAQLDAVTLV
SRAFHSDRLAPFCQALAGLCGKDMVLPMNSGAEAVESGIKVARKWGTDVKGVPAGLGNIVVAHNNFHGRTTTIISFSDDD
TARRGFGPYTPGFRAVPFGDTDALAAAVDDHTVAVLLEPIQGEAGIIVPPDDYLPRVRRICTDRGVLLIADEIQSGLART
GRTFACDHWDVVPDLYLLGKALGGGVVPVSAVVGDRDVLGVLHPGEHGSTFGGNPLAAAVGSVVVDLLRTGEFQTRAVEL
GDHLHTRLRGLIGHGVVAVRGKGLWAGVDVDPALGTGKQISLALAERRVLVKDTHGSTLRFAPPLVITADEIDWAVDRFA
AVLADRG

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=391, Percent_Identity=46.5473145780051, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI284507298, Length=292, Percent_Identity=47.6027397260274, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI37574042, Length=416, Percent_Identity=26.2019230769231, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI13994255, Length=436, Percent_Identity=25.6880733944954, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI24119277, Length=421, Percent_Identity=28.2660332541568, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI226442705, Length=416, Percent_Identity=25.4807692307692, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI226442709, Length=385, Percent_Identity=26.2337662337662, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI145693181, Length=375, Percent_Identity=35.7333333333333, Blast_Score=234, Evalue=5e-63,
Organism=Escherichia coli, GI1789759, Length=387, Percent_Identity=34.8837209302326, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1788044, Length=383, Percent_Identity=35.2480417754569, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1787560, Length=405, Percent_Identity=32.5925925925926, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1786991, Length=347, Percent_Identity=33.4293948126801, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789016, Length=326, Percent_Identity=31.2883435582822, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1786349, Length=321, Percent_Identity=29.595015576324, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=402, Percent_Identity=42.0398009950249, Blast_Score=340, Evalue=6e-94,
Organism=Caenorhabditis elegans, GI25144274, Length=268, Percent_Identity=42.1641791044776, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71981843, Length=177, Percent_Identity=42.3728813559322, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI32564660, Length=436, Percent_Identity=25.9174311926606, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=429, Percent_Identity=27.7389277389277, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17541228, Length=422, Percent_Identity=24.1706161137441, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=421, Percent_Identity=41.3301662707838, Blast_Score=326, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6324432, Length=380, Percent_Identity=30, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6324386, Length=457, Percent_Identity=25.164113785558, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357415, Length=390, Percent_Identity=45.8974358974359, Blast_Score=358, Evalue=3e-99,
Organism=Drosophila melanogaster, GI28574759, Length=436, Percent_Identity=27.2935779816514, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=26.8691588785047, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21356575, Length=361, Percent_Identity=25.7617728531856, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.13 [H]

Molecular weight: Translated: 43043; Mature: 42912

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTDRTTVTDAVIAADHRYVAHNYSPLPVVAAAAEGAWITDVEGRRHLDCLAAYSAVNF
CCCCCCCHHHHHHHCCCCEEEECCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHC
GHRHPRIVAAAHAQLDAVTLVSRAFHSDRLAPFCQALAGLCGKDMVLPMNSGAEAVESGI
CCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHH
KVARKWGTDVKGVPAGLGNIVVAHNNFHGRTTTIISFSDDDTARRGFGPYTPGFRAVPFG
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCHHHCCCCCCCCCCEEECCC
DTDALAAAVDDHTVAVLLEPIQGEAGIIVPPDDYLPRVRRICTDRGVLLIADEIQSGLAR
CCHHHEECCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHCCCCEEEEHHHHHHHHHH
TGRTFACDHWDVVPDLYLLGKALGGGVVPVSAVVGDRDVLGVLHPGEHGSTFGGNPLAAA
CCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHH
VGSVVVDLLRTGEFQTRAVELGDHLHTRLRGLIGHGVVAVRGKGLWAGVDVDPALGTGKQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEECCCCCCCCCCCCE
ISLALAERRVLVKDTHGSTLRFAPPLVITADEIDWAVDRFAAVLADRG
EEEEEHHCEEEEEECCCCEEEECCCEEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVTDRTTVTDAVIAADHRYVAHNYSPLPVVAAAAEGAWITDVEGRRHLDCLAAYSAVNF
CCCCCCHHHHHHHCCCCEEEECCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHC
GHRHPRIVAAAHAQLDAVTLVSRAFHSDRLAPFCQALAGLCGKDMVLPMNSGAEAVESGI
CCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHH
KVARKWGTDVKGVPAGLGNIVVAHNNFHGRTTTIISFSDDDTARRGFGPYTPGFRAVPFG
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCHHHCCCCCCCCCCEEECCC
DTDALAAAVDDHTVAVLLEPIQGEAGIIVPPDDYLPRVRRICTDRGVLLIADEIQSGLAR
CCHHHEECCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHCCCCEEEEHHHHHHHHHH
TGRTFACDHWDVVPDLYLLGKALGGGVVPVSAVVGDRDVLGVLHPGEHGSTFGGNPLAAA
CCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHH
VGSVVVDLLRTGEFQTRAVELGDHLHTRLRGLIGHGVVAVRGKGLWAGVDVDPALGTGKQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEECCCCCCCCCCCCE
ISLALAERRVLVKDTHGSTLRFAPPLVITADEIDWAVDRFAAVLADRG
EEEEEHHCEEEEEECCCCEEEECCCEEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]