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The map label for this gene is nanK [H]

Identifier: 108797939

GI number: 108797939

Start: 1067789

End: 1068697

Strand: Direct

Name: nanK [H]

Synonym: Mmcs_0965

Alternate gene names: 108797939

Gene position: 1067789-1068697 (Clockwise)

Preceding gene: 108797938

Following gene: 108797940

Centisome position: 18.72

GC content: 74.37

Gene sequence:

>909_bases
ATGACCGACCTGACGCTGGCCCTGGACATCGGCGGCACGAAGATCGCCGTCGGACTCGTCGACGCCGACGGCACCGTCGT
GCAGCGGGCCCAGCTGCCCACGCCGCACAGCGACGCCGAGGCGGTGTGGGCGGTGACCTCCCGGCTGATCGCCGAGGCGA
TGTCCGCCGGTGACGGTGCGGTGCGACGCGCGGGTATCGCCTCGGCCGGGCCGATCGACCTGCCGACCGGCACCGTCAGT
CCGATCAATTTGACTGTGTGGCAACACTTTCCGATCGTCTCGCGCGTCGCGTCGCTGACCGGTCTGCCGGTGCGCCTCGG
CGGTGACGGGCTGTGCATGGCGATGGGTGAGCGGTGGCGCGGCGCCGCGCGGGATGCGCAATTCCTGCTCGGCATGGTGG
TGTCGACCGGGGTCGGCGGCGGGCTGGTGCTCGACGGCGCCCCCTACGACGGGCGCACCGGCAACGCGGGGCACGTCGGG
CACGTCGTCGTCGACCCGGGCGGTGCGCTGTGTTCGTGCGGTGGACACGGCTGTGTGGAGACCGTCGCGGCCGGACCCCG
GATGGCGCAGTGGGCGCGCTCGCAGGGATGGGTCGCCCCGCCCGAGGCGGACGCCAAGGAACTGGCCGACGCCGCGCTCG
CCGGATCCGAGGTCGCGCTGCGGGCGTACGCGCGCGGTGCGCGGGCCGTGGCGGCGATGATCGCGTCCGTCGGCGCGGTG
TGCGACCTCGATCTGGTGGTGATCGGCGGGGGAGTGGCCCGGTCGGGTGCGCTGCTGTTCGACCCGGTGCGGGCGGCGCT
GGCCGAGTACGCCGGGCTGAGCTTCCTGCGGGGTCTACGGGTGCTGCCCGCCGAACTGGGCGGTGAGGCCGGGCTCGTCG
GCGCCGCGGCGCTGGCGATTGCCGGATGA

Upstream 100 bases:

>100_bases
CGCTGGCTCGACGCGCGCTGCGCCGCCGCGGTCCGCCTCGCCCCCGGATACGAACACCCCGGCGACCCCACCCAACCCGA
CAACACGCACAGGCACTGAG

Downstream 100 bases:

>100_bases
CCGGATCGGGTACGCGGCCGTCATGACCGCTCCGTCCGAACCCCAGCCCGCCCAGACCCCCAACCCCGGTACGCCGAGCG
AGACACCCGAACGCCTGACC

Product: glucokinase

Products: NA

Alternate protein names: ManNAc kinase; N-acetyl-D-mannosamine kinase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTDLTLALDIGGTKIAVGLVDADGTVVQRAQLPTPHSDAEAVWAVTSRLIAEAMSAGDGAVRRAGIASAGPIDLPTGTVS
PINLTVWQHFPIVSRVASLTGLPVRLGGDGLCMAMGERWRGAARDAQFLLGMVVSTGVGGGLVLDGAPYDGRTGNAGHVG
HVVVDPGGALCSCGGHGCVETVAAGPRMAQWARSQGWVAPPEADAKELADAALAGSEVALRAYARGARAVAAMIASVGAV
CDLDLVVIGGGVARSGALLFDPVRAALAEYAGLSFLRGLRVLPAELGGEAGLVGAAALAIAG

Sequences:

>Translated_302_residues
MTDLTLALDIGGTKIAVGLVDADGTVVQRAQLPTPHSDAEAVWAVTSRLIAEAMSAGDGAVRRAGIASAGPIDLPTGTVS
PINLTVWQHFPIVSRVASLTGLPVRLGGDGLCMAMGERWRGAARDAQFLLGMVVSTGVGGGLVLDGAPYDGRTGNAGHVG
HVVVDPGGALCSCGGHGCVETVAAGPRMAQWARSQGWVAPPEADAKELADAALAGSEVALRAYARGARAVAAMIASVGAV
CDLDLVVIGGGVARSGALLFDPVRAALAEYAGLSFLRGLRVLPAELGGEAGLVGAAALAIAG
>Mature_301_residues
TDLTLALDIGGTKIAVGLVDADGTVVQRAQLPTPHSDAEAVWAVTSRLIAEAMSAGDGAVRRAGIASAGPIDLPTGTVSP
INLTVWQHFPIVSRVASLTGLPVRLGGDGLCMAMGERWRGAARDAQFLLGMVVSTGVGGGLVLDGAPYDGRTGNAGHVGH
VVVDPGGALCSCGGHGCVETVAAGPRMAQWARSQGWVAPPEADAKELADAALAGSEVALRAYARGARAVAAMIASVGAVC
DLDLVVIGGGVARSGALLFDPVRAALAEYAGLSFLRGLRVLPAELGGEAGLVGAAALAIAG

Specific function: Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family. NanK subfamily [H]

Homologues:

Organism=Homo sapiens, GI298566325, Length=193, Percent_Identity=28.4974093264249, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4885285, Length=193, Percent_Identity=28.4974093264249, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI190014632, Length=193, Percent_Identity=28.4974093264249, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI298566315, Length=193, Percent_Identity=28.4974093264249, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI87082230, Length=254, Percent_Identity=40.1574803149606, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787363, Length=312, Percent_Identity=29.1666666666667, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1786891, Length=292, Percent_Identity=23.2876712328767, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081733, Length=267, Percent_Identity=28.8389513108614, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787878, Length=304, Percent_Identity=25.3289473684211, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082127, Length=225, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.60 [H]

Molecular weight: Translated: 30067; Mature: 29936

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00361 RIBOSOMAL_S10 ; PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLTLALDIGGTKIAVGLVDADGTVVQRAQLPTPHSDAEAVWAVTSRLIAEAMSAGDGA
CCCEEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCH
VRRAGIASAGPIDLPTGTVSPINLTVWQHFPIVSRVASLTGLPVRLGGDGLCMAMGERWR
HHHCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHCCCEEEECCCEEEEECCHHCC
GAARDAQFLLGMVVSTGVGGGLVLDGAPYDGRTGNAGHVGHVVVDPGGALCSCGGHGCVE
CCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCCEECCCCCHHHH
TVAAGPRMAQWARSQGWVAPPEADAKELADAALAGSEVALRAYARGARAVAAMIASVGAV
HHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
CDLDLVVIGGGVARSGALLFDPVRAALAEYAGLSFLRGLRVLPAELGGEAGLVGAAALAI
CCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
AG
CC
>Mature Secondary Structure 
TDLTLALDIGGTKIAVGLVDADGTVVQRAQLPTPHSDAEAVWAVTSRLIAEAMSAGDGA
CCEEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCH
VRRAGIASAGPIDLPTGTVSPINLTVWQHFPIVSRVASLTGLPVRLGGDGLCMAMGERWR
HHHCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHCCCEEEECCCEEEEECCHHCC
GAARDAQFLLGMVVSTGVGGGLVLDGAPYDGRTGNAGHVGHVVVDPGGALCSCGGHGCVE
CCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCCEECCCCCHHHH
TVAAGPRMAQWARSQGWVAPPEADAKELADAALAGSEVALRAYARGARAVAAMIASVGAV
HHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
CDLDLVVIGGGVARSGALLFDPVRAALAEYAGLSFLRGLRVLPAELGGEAGLVGAAALAI
CCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
AG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA