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The map label for this gene is rkpK [H]

Identifier: 108797905

GI number: 108797905

Start: 1025235

End: 1026563

Strand: Direct

Name: rkpK [H]

Synonym: Mmcs_0931

Alternate gene names: 108797905

Gene position: 1025235-1026563 (Clockwise)

Preceding gene: 108797904

Following gene: 108797907

Centisome position: 17.97

GC content: 64.41

Gene sequence:

>1329_bases
ATGAGTCGCCGGATAACAGTGTTCGGTACCGGATATCTAGGTGCTACCCACGCCGCGTGCATGGCTGAGCTCGGCCACGA
GGTGACCGGCGTGGACATCGACGAGGGCAAGCTGGCGAAGCTGGCGGTGGGAGAGCTCCCCTTCTTTGAGCCCGGATTGC
CGGAGGTCTTGCGCTCGAACATTGCTGCTGGACGATTGCACTTCACCACGTCGTACGAGGAAGCTGCCGACTTCGCCGAC
GTTCATTTCATCGCGGTCGGCACGCCGCAGAAGCACGGCGAACTCGCCGCAGACCTGCGTTACGTTCACGGAGTCGTCGA
GTTGTTGGCCCCGCTTCTGACTCGGCCGGCAGTGATCTTCGGGAAGTCGACCGTGCCGGCCGGAACGGCTGCGCGGTTAG
GTGCCCGTCTGCGCAAGCTGGCGCCCGTCGGTGAGCAGGCAGAGCTCGCGTGGAATCCGGAGTTCCTGCGGGAGGGGTTC
GCGGTCAAGGACACGCTGCATCCCGACCGGATTGTGCTCGGTGTGGATCGCGACCGGCCCGGTAACGCCGCTGCGGTCGC
ACGTGAGGTCTACGCACCGCTGCTCGAGGAGAGGATTCCCCTCCTGGTCACCGATCTGGCGACGGCCGAGTTGGTGAAAA
CCTCCGCAAATGCCTTTCTGGCGACGAAGATTTCGTTCATCAACGCCATCGCCGAGGTGTGTAAGGCGACGGGTGCTGAC
GTATCGGTGCTGGCCGACGCGATTGGGTACGACGCGCGGATCGGTCGGCGATTCCTCAACGCAGGCATCGGTTTCGGAGG
TGGGTGTCTTCCGAAGGACATCCGCGCGTTCATCGCGATGGCGGGTGAGCTCGGGGCCGGTCAGGCGTTCGCACTGCTGC
GCGAGGTGGACAGCATCAACATGCGCCGGCGCAACAAGGTGGTGGAAATGGCGCGGGAGGCCGCGGGCGGCTCTTTCATC
GGCACGCGGGTGGCCGTGCTCGGCGCCGCGTTCAAGCCAGACTCCGATGACGTGCGCGATTCTCCGGCGTTGAACATTGC
CGGTCAAATCCAGCTGCAGGGCGCCGCGGTGAGCGTGTACGACCCCGAAGCCATGCAGAACGCGCGCCAGATGTTCCCGA
CGCTGCAGTACGCGTCGAGCATCCGCGAGGCGTGTGCGAGTGCCGACGTTGTAATGCTCCTGACCGAGTGGGAGCAATTC
GTCTCAATGGATCCCGATGAACTTCGTGAGGTGGTGCGCCGACACACGATCATTGACGGCCGTAACTGCCTCAGCCCGCA
GATTTGGCGGGACGCCGGTTGGACGTACCGGGGTATCGGCAGGCCGTAG

Upstream 100 bases:

>100_bases
CCGGGACACAGGTACGCCGCTTTCGCGCCCAGCAACTTCAAAAGCGAGGTAGTTGAGGCGGCGGCTAGGATGACGCGCAG
GGGAAATGGGGGAGCGGTTT

Downstream 100 bases:

>100_bases
TTACGAGCCGGTGCAATCGCTGTTGTCGACCACGGATCGCCTTCGAGCTCGAAATAGACGTTTCGAAAGACACGGTGCTG
GCAGCGACGCTGCCCTTCTA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSRRITVFGTGYLGATHAACMAELGHEVTGVDIDEGKLAKLAVGELPFFEPGLPEVLRSNIAAGRLHFTTSYEEAADFAD
VHFIAVGTPQKHGELAADLRYVHGVVELLAPLLTRPAVIFGKSTVPAGTAARLGARLRKLAPVGEQAELAWNPEFLREGF
AVKDTLHPDRIVLGVDRDRPGNAAAVAREVYAPLLEERIPLLVTDLATAELVKTSANAFLATKISFINAIAEVCKATGAD
VSVLADAIGYDARIGRRFLNAGIGFGGGCLPKDIRAFIAMAGELGAGQAFALLREVDSINMRRRNKVVEMAREAAGGSFI
GTRVAVLGAAFKPDSDDVRDSPALNIAGQIQLQGAAVSVYDPEAMQNARQMFPTLQYASSIREACASADVVMLLTEWEQF
VSMDPDELREVVRRHTIIDGRNCLSPQIWRDAGWTYRGIGRP

Sequences:

>Translated_442_residues
MSRRITVFGTGYLGATHAACMAELGHEVTGVDIDEGKLAKLAVGELPFFEPGLPEVLRSNIAAGRLHFTTSYEEAADFAD
VHFIAVGTPQKHGELAADLRYVHGVVELLAPLLTRPAVIFGKSTVPAGTAARLGARLRKLAPVGEQAELAWNPEFLREGF
AVKDTLHPDRIVLGVDRDRPGNAAAVAREVYAPLLEERIPLLVTDLATAELVKTSANAFLATKISFINAIAEVCKATGAD
VSVLADAIGYDARIGRRFLNAGIGFGGGCLPKDIRAFIAMAGELGAGQAFALLREVDSINMRRRNKVVEMAREAAGGSFI
GTRVAVLGAAFKPDSDDVRDSPALNIAGQIQLQGAAVSVYDPEAMQNARQMFPTLQYASSIREACASADVVMLLTEWEQF
VSMDPDELREVVRRHTIIDGRNCLSPQIWRDAGWTYRGIGRP
>Mature_441_residues
SRRITVFGTGYLGATHAACMAELGHEVTGVDIDEGKLAKLAVGELPFFEPGLPEVLRSNIAAGRLHFTTSYEEAADFADV
HFIAVGTPQKHGELAADLRYVHGVVELLAPLLTRPAVIFGKSTVPAGTAARLGARLRKLAPVGEQAELAWNPEFLREGFA
VKDTLHPDRIVLGVDRDRPGNAAAVAREVYAPLLEERIPLLVTDLATAELVKTSANAFLATKISFINAIAEVCKATGADV
SVLADAIGYDARIGRRFLNAGIGFGGGCLPKDIRAFIAMAGELGAGQAFALLREVDSINMRRRNKVVEMAREAAGGSFIG
TRVAVLGAAFKPDSDDVRDSPALNIAGQIQLQGAAVSVYDPEAMQNARQMFPTLQYASSIREACASADVVMLLTEWEQFV
SMDPDELREVVRRHTIIDGRNCLSPQIWRDAGWTYRGIGRP

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=449, Percent_Identity=31.8485523385301, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI296040438, Length=350, Percent_Identity=31.4285714285714, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI296040443, Length=290, Percent_Identity=33.448275862069, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI48994968, Length=443, Percent_Identity=29.1196388261851, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI1788340, Length=363, Percent_Identity=27.2727272727273, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17560350, Length=463, Percent_Identity=33.6933045356371, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI17136908, Length=464, Percent_Identity=32.3275862068966, Blast_Score=233, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 47532; Mature: 47401

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRITVFGTGYLGATHAACMAELGHEVTGVDIDEGKLAKLAVGELPFFEPGLPEVLRSN
CCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHCC
IAAGRLHFTTSYEEAADFADVHFIAVGTPQKHGELAADLRYVHGVVELLAPLLTRPAVIF
CCCCEEEEECCHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEE
GKSTVPAGTAARLGARLRKLAPVGEQAELAWNPEFLREGFAVKDTLHPDRIVLGVDRDRP
ECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEECCCCCCEEEEEECCCCC
GNAAAVAREVYAPLLEERIPLLVTDLATAELVKTSANAFLATKISFINAIAEVCKATGAD
CCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
VSVLADAIGYDARIGRRFLNAGIGFGGGCLPKDIRAFIAMAGELGAGQAFALLREVDSIN
HHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
MRRRNKVVEMAREAAGGSFIGTRVAVLGAAFKPDSDDVRDSPALNIAGQIQLQGAAVSVY
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECEEEEEE
DPEAMQNARQMFPTLQYASSIREACASADVVMLLTEWEQFVSMDPDELREVVRRHTIIDG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHCCCCC
RNCLSPQIWRDAGWTYRGIGRP
CCCCCCHHHHCCCCEECCCCCC
>Mature Secondary Structure 
SRRITVFGTGYLGATHAACMAELGHEVTGVDIDEGKLAKLAVGELPFFEPGLPEVLRSN
CCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHCC
IAAGRLHFTTSYEEAADFADVHFIAVGTPQKHGELAADLRYVHGVVELLAPLLTRPAVIF
CCCCEEEEECCHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEE
GKSTVPAGTAARLGARLRKLAPVGEQAELAWNPEFLREGFAVKDTLHPDRIVLGVDRDRP
ECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEECCCCCCEEEEEECCCCC
GNAAAVAREVYAPLLEERIPLLVTDLATAELVKTSANAFLATKISFINAIAEVCKATGAD
CCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
VSVLADAIGYDARIGRRFLNAGIGFGGGCLPKDIRAFIAMAGELGAGQAFALLREVDSIN
HHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
MRRRNKVVEMAREAAGGSFIGTRVAVLGAAFKPDSDDVRDSPALNIAGQIQLQGAAVSVY
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECEEEEEE
DPEAMQNARQMFPTLQYASSIREACASADVVMLLTEWEQFVSMDPDELREVVRRHTIIDG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHCCCCC
RNCLSPQIWRDAGWTYRGIGRP
CCCCCCHHHHCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]