Click here to switch to the map view.

The map label for this gene is ywrD [H]

Identifier: 108797847

GI number: 108797847

Start: 966856

End: 968448

Strand: Reverse

Name: ywrD [H]

Synonym: Mmcs_0872

Alternate gene names: 108797847

Gene position: 968448-966856 (Counterclockwise)

Preceding gene: 108797851

Following gene: 108797845

Centisome position: 16.97

GC content: 72.25

Gene sequence:

>1593_bases
ATGACCCATTCCGCTCCCTGCAACGGCGGATCCGCCGGTCGGCATTCCCGATGTCCCGAAACCTGCTACCGTCCAGGCTC
CGTGAGCTCAGCCGCAGGCATGGTCGCCACCAGCCACCCGATGGCCGTCCGCACCGCGGTCACGATCCTCGAGGAGGGCG
GCACCGCGGCGGATGCGGCGGTGGCAGCCGCGGCGATGCTCACGGTCGTCGATCCTCCGTCGACCGGCGTCGGCGGGGAT
CTGTTCGCGCTGTACTGGGAGTCCGGAGGCACGGAGCCGGTCGGCCTGGCAGCGGCGGGGGTGGCACCCGCCGCACTATC
GGTCCAGGCGTTGCGAGACAGCGGGTTCGACACCATGCCCGCCGACGGCCCGTGGACGGTCACCGTTCCCGGCGCCACGT
GGGGCTGGTCGGCGCTGCTCGAGCGGTACGGCACGCTCGGGCGCGACCGGGTCGTGGCGCCGGCCGTCGAGGCCGCACGC
ACCGGCTTCGCCGTCACCCCTGCCGTGGCCGAGGAGTGGAAACTCGGCGCGAACCGGCTGCGGGCCGATCCGCACGCCGC
GGCGCTGTTCCTGCCCGCCGGCCGGGCTCCCCGCGTCGGCGACGTGTTCCGCAACCCCGACCTGGCCGAGACCCTGCAGA
CCTACGCCCGCGAGGGCCACGCACCCTTCTACACCGGGGACATCGCGGCCGACTTCGCCGATGCCGTCCACCCCCTGCGC
ACATCGGACCTCGGCGAATGGGCCGGCCCGGAATGGGTCACGCCGATCCGCGCCCGCTTCCGCGGTGTCGACGTGTACGA
GATGCCGCCGCCCGGGCAGGGTTTGGCCGTGCTGCAGGCATTGCGCCTCTATCAACGGTTCGCTCCGTACTCCGACCATC
ACCTGGTCGAGAGCATCAAGGCCGCGGTCGCCGACGCGGCCGATCACATCGCCGATCCTCGCTTTCACCCGGTGCCGGTG
GCGGAACTTCTCGGCGACGGCCGGGTGGGTGAGCTCGCGGACCGGATAGGCGCGACGGCCTCCGACGGACGGACGCCGGG
CACGCCGTCGGACACCGTGTACGTCTGCGTGGTGGACAGGTGGGGCGCCGCCTGTTCGCTGATCCAGAGCATCTACGACG
GCTTCGGATCCGGTGTGCTCGTGCCGGGACGCGGCGTGCTGCTGCACAACCGCGGTGCCGGGTTCACCCTGCGCGACGGC
CACCCGAACCGGCCCGAACCGCGAAAACGTCCGTACCACACCATCATCCCCGCGATGCTGGGCGGACCGGACGGATTCCG
CGGCTGCCTCGGCGTGGTGGGCGGGTTCATGCAGCCGCAGGGCCAGGTTCAGGTTCTGCGGAACGTGCTCGACCGCGGGA
TGTCCGCACAGCAGGCCGTCGACGCCCCACGGCTGCGGGTGCTCGGCGGTCACACACTGGGCCTCGAGGAGGGTTTCGAC
GCCGGCGGTGCGGCCGAACTGGCTCGCCGCGGTCACCGGCTCAGCGCCCTGCCGCGCTCCGAATGCGGTGGTGCGCAGTT
GATCCTGCGGACACCCGCGGGCCTCGACGGCGGGTCGGACTTCCGCAGGGACGGTTACGTCGGCGTGTGCTGA

Upstream 100 bases:

>100_bases
GGATCGCCCGCCTCGCGGTAGAAGATCCTGTGGCCGTCGATGGTGGCGTAGCGGTGGTGGACAGCGGGCATAGTGGAGTT
CCTTCCTCATTTTGGGTCGC

Downstream 100 bases:

>100_bases
CGCCTCAGATCTCCCACTCGAACGACGCCTTGTCCACGCGCAGCACCAGCGAGGTGTCGATCGACTGCACCCCCGGCAGG
GCGGCCAGGCACTCGTCCTG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MTHSAPCNGGSAGRHSRCPETCYRPGSVSSAAGMVATSHPMAVRTAVTILEEGGTAADAAVAAAAMLTVVDPPSTGVGGD
LFALYWESGGTEPVGLAAAGVAPAALSVQALRDSGFDTMPADGPWTVTVPGATWGWSALLERYGTLGRDRVVAPAVEAAR
TGFAVTPAVAEEWKLGANRLRADPHAAALFLPAGRAPRVGDVFRNPDLAETLQTYAREGHAPFYTGDIAADFADAVHPLR
TSDLGEWAGPEWVTPIRARFRGVDVYEMPPPGQGLAVLQALRLYQRFAPYSDHHLVESIKAAVADAADHIADPRFHPVPV
AELLGDGRVGELADRIGATASDGRTPGTPSDTVYVCVVDRWGAACSLIQSIYDGFGSGVLVPGRGVLLHNRGAGFTLRDG
HPNRPEPRKRPYHTIIPAMLGGPDGFRGCLGVVGGFMQPQGQVQVLRNVLDRGMSAQQAVDAPRLRVLGGHTLGLEEGFD
AGGAAELARRGHRLSALPRSECGGAQLILRTPAGLDGGSDFRRDGYVGVC

Sequences:

>Translated_530_residues
MTHSAPCNGGSAGRHSRCPETCYRPGSVSSAAGMVATSHPMAVRTAVTILEEGGTAADAAVAAAAMLTVVDPPSTGVGGD
LFALYWESGGTEPVGLAAAGVAPAALSVQALRDSGFDTMPADGPWTVTVPGATWGWSALLERYGTLGRDRVVAPAVEAAR
TGFAVTPAVAEEWKLGANRLRADPHAAALFLPAGRAPRVGDVFRNPDLAETLQTYAREGHAPFYTGDIAADFADAVHPLR
TSDLGEWAGPEWVTPIRARFRGVDVYEMPPPGQGLAVLQALRLYQRFAPYSDHHLVESIKAAVADAADHIADPRFHPVPV
AELLGDGRVGELADRIGATASDGRTPGTPSDTVYVCVVDRWGAACSLIQSIYDGFGSGVLVPGRGVLLHNRGAGFTLRDG
HPNRPEPRKRPYHTIIPAMLGGPDGFRGCLGVVGGFMQPQGQVQVLRNVLDRGMSAQQAVDAPRLRVLGGHTLGLEEGFD
AGGAAELARRGHRLSALPRSECGGAQLILRTPAGLDGGSDFRRDGYVGVC
>Mature_529_residues
THSAPCNGGSAGRHSRCPETCYRPGSVSSAAGMVATSHPMAVRTAVTILEEGGTAADAAVAAAAMLTVVDPPSTGVGGDL
FALYWESGGTEPVGLAAAGVAPAALSVQALRDSGFDTMPADGPWTVTVPGATWGWSALLERYGTLGRDRVVAPAVEAART
GFAVTPAVAEEWKLGANRLRADPHAAALFLPAGRAPRVGDVFRNPDLAETLQTYAREGHAPFYTGDIAADFADAVHPLRT
SDLGEWAGPEWVTPIRARFRGVDVYEMPPPGQGLAVLQALRLYQRFAPYSDHHLVESIKAAVADAADHIADPRFHPVPVA
ELLGDGRVGELADRIGATASDGRTPGTPSDTVYVCVVDRWGAACSLIQSIYDGFGSGVLVPGRGVLLHNRGAGFTLRDGH
PNRPEPRKRPYHTIIPAMLGGPDGFRGCLGVVGGFMQPQGQVQVLRNVLDRGMSAQQAVDAPRLRVLGGHTLGLEEGFDA
GGAAELARRGHRLSALPRSECGGAQLILRTPAGLDGGSDFRRDGYVGVC

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=516, Percent_Identity=27.5193798449612, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI73915090, Length=516, Percent_Identity=27.5193798449612, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI73915096, Length=516, Percent_Identity=27.5193798449612, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI73915094, Length=516, Percent_Identity=27.5193798449612, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI113429324, Length=517, Percent_Identity=26.8858800773694, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI113429326, Length=522, Percent_Identity=27.0114942528736, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI153266885, Length=533, Percent_Identity=26.6416510318949, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI153266901, Length=534, Percent_Identity=26.5917602996255, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI109148539, Length=504, Percent_Identity=27.5793650793651, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI153266907, Length=532, Percent_Identity=25.3759398496241, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1789856, Length=550, Percent_Identity=29.0909090909091, Blast_Score=182, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17506189, Length=544, Percent_Identity=25.5514705882353, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI72000294, Length=466, Percent_Identity=25.1072961373391, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI212646519, Length=465, Percent_Identity=25.1612903225806, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI161077880, Length=537, Percent_Identity=24.9534450651769, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24642670, Length=537, Percent_Identity=24.9534450651769, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24642666, Length=537, Percent_Identity=24.9534450651769, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45551474, Length=537, Percent_Identity=24.9534450651769, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161077878, Length=537, Percent_Identity=24.9534450651769, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI18859893, Length=492, Percent_Identity=26.219512195122, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI18859741, Length=538, Percent_Identity=23.6059479553903, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI161077496, Length=497, Percent_Identity=24.3460764587525, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55369; Mature: 55238

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSAPCNGGSAGRHSRCPETCYRPGSVSSAAGMVATSHPMAVRTAVTILEEGGTAADAA
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCHHHHH
VAAAAMLTVVDPPSTGVGGDLFALYWESGGTEPVGLAAAGVAPAALSVQALRDSGFDTMP
HHHHHHHEEECCCCCCCCCCEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCC
ADGPWTVTVPGATWGWSALLERYGTLGRDRVVAPAVEAARTGFAVTPAVAEEWKLGANRL
CCCCEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCEECHHHHHHHHHCHHHH
RADPHAAALFLPAGRAPRVGDVFRNPDLAETLQTYAREGHAPFYTGDIAADFADAVHPLR
CCCCCCEEEEECCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCCC
TSDLGEWAGPEWVTPIRARFRGVDVYEMPPPGQGLAVLQALRLYQRFAPYSDHHLVESIK
CCCCCCCCCCCCCCHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
AAVADAADHIADPRFHPVPVAELLGDGRVGELADRIGATASDGRTPGTPSDTVYVCVVDR
HHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC
WGAACSLIQSIYDGFGSGVLVPGRGVLLHNRGAGFTLRDGHPNRPEPRKRPYHTIIPAML
CCHHHHHHHHHHHHCCCCEEECCCEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHH
GGPDGFRGCLGVVGGFMQPQGQVQVLRNVLDRGMSAQQAVDAPRLRVLGGHTLGLEEGFD
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCEECCCCCCC
AGGAAELARRGHRLSALPRSECGGAQLILRTPAGLDGGSDFRRDGYVGVC
CCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEECC
>Mature Secondary Structure 
THSAPCNGGSAGRHSRCPETCYRPGSVSSAAGMVATSHPMAVRTAVTILEEGGTAADAA
CCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCHHHHH
VAAAAMLTVVDPPSTGVGGDLFALYWESGGTEPVGLAAAGVAPAALSVQALRDSGFDTMP
HHHHHHHEEECCCCCCCCCCEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCC
ADGPWTVTVPGATWGWSALLERYGTLGRDRVVAPAVEAARTGFAVTPAVAEEWKLGANRL
CCCCEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCEECHHHHHHHHHCHHHH
RADPHAAALFLPAGRAPRVGDVFRNPDLAETLQTYAREGHAPFYTGDIAADFADAVHPLR
CCCCCCEEEEECCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCCC
TSDLGEWAGPEWVTPIRARFRGVDVYEMPPPGQGLAVLQALRLYQRFAPYSDHHLVESIK
CCCCCCCCCCCCCCHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
AAVADAADHIADPRFHPVPVAELLGDGRVGELADRIGATASDGRTPGTPSDTVYVCVVDR
HHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC
WGAACSLIQSIYDGFGSGVLVPGRGVLLHNRGAGFTLRDGHPNRPEPRKRPYHTIIPAML
CCHHHHHHHHHHHHCCCCEEECCCEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHH
GGPDGFRGCLGVVGGFMQPQGQVQVLRNVLDRGMSAQQAVDAPRLRVLGGHTLGLEEGFD
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCEECCCCCCC
AGGAAELARRGHRLSALPRSECGGAQLILRTPAGLDGGSDFRRDGYVGVC
CCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]