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The map label for this gene is ycdW [C]

Identifier: 108797842

GI number: 108797842

Start: 961292

End: 962338

Strand: Reverse

Name: ycdW [C]

Synonym: Mmcs_0867

Alternate gene names: 108797842

Gene position: 962338-961292 (Counterclockwise)

Preceding gene: 108797843

Following gene: 108797841

Centisome position: 16.87

GC content: 67.43

Gene sequence:

>1047_bases
GTGAGCTTCCCCCTCACCGACGAGCTCGACGTGGTGGTCGCCGGGGTGCCCTACGGCTTCCAGGGGGAATTCAGCGACGG
GCGCTGGCTCACCGACCGCCACATCGCCCGGATCGAGGCGTGCTCCCCGGGAATCCGGTTGGAACATCCGTCCGTCTACG
ACCTCAACGACGGCTACCTGGTGGAGCGCAAACCGCACGCGGTGCTCGTCGAGTGCACCGGCACCGAAGCGAGTTGGGAG
TCGCTGCCGGCGATCCTGTTCCAATCCGGTTTCCGGCAGCTGCTCAGCCCGGAGCTGCGCCTCGTCCAATCCTGCAGTGC
CGGAATCGAACAGATCGCCGGGCTCATCCCCGACGGTGTCACGTTGTGCAACGCCTCCGGGGTGCACGCCCCGGCCATCG
CCGAGAGCGTCATCGCCGCGATCCTGGCGCAGGCCAAGCTCCTGCACCAGAGGCGTATCGAGCAGCGATCGAGGAACTGG
ACCCAGCTGCCCGCGCGCGAACTGGCAGGCACCACGATGTGTGTCCTGGGCACCGGGCACATCGGCACGGCCATCGGCAG
CCTGGCCCAGGCGCTCGGGATTCACACGATCGGGGTACGCCGCAATCCGCTCCCCGCCGAGGGCTTCGACACGACGGTCG
GTCCCGACGGCCTCGACGATGCGCTCTCGCGCGCCGACTACCTCGTCATCGCCTGCCCACTGACCGCCGACACCCGCGGA
CTCATCGACGCCGACCGGTTCGCCAAACTGCCCACCGGCGCCTATCTGGTGAACGTGTCACGCGGCGCGGTCGTCGACGA
GGCGGCGATGATCGACGCGTTCGAGACCGGCCGGCTCGGCGGTGGATTCCTCGACTGCCATGTGCACGAACCACTTCCCG
ACGACAGCCCCCTGTGGGATATGCCGGGGGTGGACATCTCACCGCACGATTCGCATGCGTCGAACCTGCTCGGTGACCGG
CAGGTCGACCTCTTCTGCCGCAACCTCGAACGACTCATCCGCGGTGAGCCGTTGATCAATGTCGTCGACACGAAGGCGGG
TTATTGA

Upstream 100 bases:

>100_bases
CGGAACGCGTCCTCGATGCGCCGAGCAGCGAACGCACCCAACGGTTCCTGTCCGCCCTGCTGCCCGACACCAAACCCCTC
ACCCACCGAAAGGTCCTGCA

Downstream 100 bases:

>100_bases
GCATGAGCGCCGTCGTCTGGAGCGAGAACGCCTCTCCCGATTTGTCTTTCACCGATGTTTCGGACGGCCGTGAGGTGGGT
TTGGTGCCGGTCGGGGCGGT

Product: D-isomer specific 2-hydroxyacid dehydrogenase protein

Products: 3-phosphohydroxypyruvate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSFPLTDELDVVVAGVPYGFQGEFSDGRWLTDRHIARIEACSPGIRLEHPSVYDLNDGYLVERKPHAVLVECTGTEASWE
SLPAILFQSGFRQLLSPELRLVQSCSAGIEQIAGLIPDGVTLCNASGVHAPAIAESVIAAILAQAKLLHQRRIEQRSRNW
TQLPARELAGTTMCVLGTGHIGTAIGSLAQALGIHTIGVRRNPLPAEGFDTTVGPDGLDDALSRADYLVIACPLTADTRG
LIDADRFAKLPTGAYLVNVSRGAVVDEAAMIDAFETGRLGGGFLDCHVHEPLPDDSPLWDMPGVDISPHDSHASNLLGDR
QVDLFCRNLERLIRGEPLINVVDTKAGY

Sequences:

>Translated_348_residues
MSFPLTDELDVVVAGVPYGFQGEFSDGRWLTDRHIARIEACSPGIRLEHPSVYDLNDGYLVERKPHAVLVECTGTEASWE
SLPAILFQSGFRQLLSPELRLVQSCSAGIEQIAGLIPDGVTLCNASGVHAPAIAESVIAAILAQAKLLHQRRIEQRSRNW
TQLPARELAGTTMCVLGTGHIGTAIGSLAQALGIHTIGVRRNPLPAEGFDTTVGPDGLDDALSRADYLVIACPLTADTRG
LIDADRFAKLPTGAYLVNVSRGAVVDEAAMIDAFETGRLGGGFLDCHVHEPLPDDSPLWDMPGVDISPHDSHASNLLGDR
QVDLFCRNLERLIRGEPLINVVDTKAGY
>Mature_347_residues
SFPLTDELDVVVAGVPYGFQGEFSDGRWLTDRHIARIEACSPGIRLEHPSVYDLNDGYLVERKPHAVLVECTGTEASWES
LPAILFQSGFRQLLSPELRLVQSCSAGIEQIAGLIPDGVTLCNASGVHAPAIAESVIAAILAQAKLLHQRRIEQRSRNWT
QLPARELAGTTMCVLGTGHIGTAIGSLAQALGIHTIGVRRNPLPAEGFDTTVGPDGLDDALSRADYLVIACPLTADTRGL
IDADRFAKLPTGAYLVNVSRGAVVDEAAMIDAFETGRLGGGFLDCHVHEPLPDDSPLWDMPGVDISPHDSHASNLLGDRQ
VDLFCRNLERLIRGEPLINVVDTKAGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=27.4193548387097, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI23308577, Length=233, Percent_Identity=26.6094420600858, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI61743967, Length=255, Percent_Identity=28.2352941176471, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4557497, Length=255, Percent_Identity=28.2352941176471, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI145580578, Length=247, Percent_Identity=28.7449392712551, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI4557499, Length=247, Percent_Identity=28.7449392712551, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI87081824, Length=274, Percent_Identity=27.7372262773723, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI87082289, Length=259, Percent_Identity=28.957528957529, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789279, Length=198, Percent_Identity=30.8080808080808, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787645, Length=162, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25147481, Length=209, Percent_Identity=28.2296650717703, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=216, Percent_Identity=25.9259259259259, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320925, Length=205, Percent_Identity=31.7073170731707, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6322116, Length=205, Percent_Identity=31.219512195122, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=174, Percent_Identity=30.4597701149425, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574286, Length=253, Percent_Identity=25.6916996047431, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585516, Length=249, Percent_Identity=26.9076305220884, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24585514, Length=257, Percent_Identity=26.0700389105058, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI28574282, Length=257, Percent_Identity=26.0700389105058, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI28574284, Length=257, Percent_Identity=26.0700389105058, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45552429, Length=257, Percent_Identity=26.0700389105058, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551003, Length=257, Percent_Identity=26.0700389105058, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921140, Length=146, Percent_Identity=34.2465753424658, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571528, Length=177, Percent_Identity=29.3785310734463, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646446, Length=255, Percent_Identity=25.4901960784314, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646448, Length=255, Percent_Identity=25.4901960784314, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646452, Length=255, Percent_Identity=25.4901960784314, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646450, Length=255, Percent_Identity=25.4901960784314, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI62472511, Length=255, Percent_Identity=25.4901960784314, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: 1.1.1.95

Molecular weight: Translated: 37411; Mature: 37280

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPLTDELDVVVAGVPYGFQGEFSDGRWLTDRHIARIEACSPGIRLEHPSVYDLNDGYL
CCCCCCCCCCEEEECCCCCCCCCCCCCCEECHHHHHHHHHCCCCCEECCCCEEECCCCEE
VERKPHAVLVECTGTEASWESLPAILFQSGFRQLLSPELRLVQSCSAGIEQIAGLIPDGV
EECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCC
TLCNASGVHAPAIAESVIAAILAQAKLLHQRRIEQRSRNWTQLPARELAGTTMCVLGTGH
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEECCH
IGTAIGSLAQALGIHTIGVRRNPLPAEGFDTTVGPDGLDDALSRADYLVIACPLTADTRG
HHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEEECCCCCCCC
LIDADRFAKLPTGAYLVNVSRGAVVDEAAMIDAFETGRLGGGFLDCHVHEPLPDDSPLWD
CCCHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
MPGVDISPHDSHASNLLGDRQVDLFCRNLERLIRGEPLINVVDTKAGY
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCC
>Mature Secondary Structure 
SFPLTDELDVVVAGVPYGFQGEFSDGRWLTDRHIARIEACSPGIRLEHPSVYDLNDGYL
CCCCCCCCCEEEECCCCCCCCCCCCCCEECHHHHHHHHHCCCCCEECCCCEEECCCCEE
VERKPHAVLVECTGTEASWESLPAILFQSGFRQLLSPELRLVQSCSAGIEQIAGLIPDGV
EECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCC
TLCNASGVHAPAIAESVIAAILAQAKLLHQRRIEQRSRNWTQLPARELAGTTMCVLGTGH
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEECCH
IGTAIGSLAQALGIHTIGVRRNPLPAEGFDTTVGPDGLDDALSRADYLVIACPLTADTRG
HHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEEECCCCCCCC
LIDADRFAKLPTGAYLVNVSRGAVVDEAAMIDAFETGRLGGGFLDCHVHEPLPDDSPLWD
CCCHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
MPGVDISPHDSHASNLLGDRQVDLFCRNLERLIRGEPLINVVDTKAGY
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-phosphoglycerate; NAD+

Specific reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]