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The map label for this gene is acr1 [H]

Identifier: 108797829

GI number: 108797829

Start: 943271

End: 944146

Strand: Reverse

Name: acr1 [H]

Synonym: Mmcs_0854

Alternate gene names: 108797829

Gene position: 944146-943271 (Counterclockwise)

Preceding gene: 108797830

Following gene: 108797828

Centisome position: 16.55

GC content: 68.84

Gene sequence:

>876_bases
ATGATTCCGAGCATCAAGAGGTCGTTGCGGCTGGCCGGGATGCGTCCTGTTCCACGGTGGCCGGCGCGCCCGACGGTCGA
TCTGCGCGGTAAGCGGATCCTGCTGACCGGAGCATCCTCGGGGATCGGTGCCGTCGCCGCGCAGAAGCTCGCCGCCGAAG
GCGCTTTCGTCATCGCGGTCGCGCGCCGAGAGGCGCTGTTGGCCGAGGTGGTCGAACGCATCACCGCGGCCGGCGGCTCC
GCCAGCGCCATCCCGGCCAACCTGGCGAACCTCGACGAGGTCGATGTGTTGATGGAAAGGGTTGGCCCCGTTGATGTTCT
GATCAACAACGCCGCGCGGTCGATCCGCCGGCCGTTGGCCCAGTCACTGGATCGCTGGCACGACGTCGAACGGGTCATGC
AGCTCAACTACTACGCGCCGCTGCGGCTCATCCGCGGCCTGGCACCCGGGATGATCGAACGCGGCGACGGCCACATCATC
AACATCGCCAGCTGGCGGGTGCTGCCGGAGTCGTCGCCGATGTTCGCCGCCTACAACGCATCCAAGGCGGCGCTGAGCGC
CGTCAGCCGCGTCATCGACACCGAATGGGGCCACGCGGGCGTGCACGCGACGACGGTGTACTACCCGTTGGTGTCGACGC
CGATGATCGCACCGACGCAGGCCTACAGCGGCCTCGCGGCCCTGTCCGCCGACGAGGCCGCACAGTGGATGGTCACCGCG
GCGCGCACCCGGCCGATCCGCATCGCGCCCCGCAAGGCGCTGGCGCTGCGGGCGCTCGACGTCGTGGCCCCGCGCGCGCT
CAACAACATTTTCGAGCGCGAGACCAACCGGATGAACCGCAATGCCATCAAAGCGGCTGCCGCTCAGGGGCATTAG

Upstream 100 bases:

>100_bases
TCAAGACCGCCCTCGAGGAAGCGGGTCCCTGACCATTCGGTGAATGCGTCGCATCGCCGTCGGCCTGCGCCTACATTGTC
AGCGGACGGGAGTGGCGCCG

Downstream 100 bases:

>100_bases
TGAGAGCGTCGGTGGGGCACCGGCCCGAGAACCTGGCCCTGGGCGCGGCGCTGACGACGGCGGCGTTCTTCTGCGTGGCG
CTGGTCGGCACGCTGGCGAA

Product: short chain dehydrogenase

Products: D-Gluconate; Nicotinamide adenine dinucleotide phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MIPSIKRSLRLAGMRPVPRWPARPTVDLRGKRILLTGASSGIGAVAAQKLAAEGAFVIAVARREALLAEVVERITAAGGS
ASAIPANLANLDEVDVLMERVGPVDVLINNAARSIRRPLAQSLDRWHDVERVMQLNYYAPLRLIRGLAPGMIERGDGHII
NIASWRVLPESSPMFAAYNASKAALSAVSRVIDTEWGHAGVHATTVYYPLVSTPMIAPTQAYSGLAALSADEAAQWMVTA
ARTRPIRIAPRKALALRALDVVAPRALNNIFERETNRMNRNAIKAAAAQGH

Sequences:

>Translated_291_residues
MIPSIKRSLRLAGMRPVPRWPARPTVDLRGKRILLTGASSGIGAVAAQKLAAEGAFVIAVARREALLAEVVERITAAGGS
ASAIPANLANLDEVDVLMERVGPVDVLINNAARSIRRPLAQSLDRWHDVERVMQLNYYAPLRLIRGLAPGMIERGDGHII
NIASWRVLPESSPMFAAYNASKAALSAVSRVIDTEWGHAGVHATTVYYPLVSTPMIAPTQAYSGLAALSADEAAQWMVTA
ARTRPIRIAPRKALALRALDVVAPRALNNIFERETNRMNRNAIKAAAAQGH
>Mature_291_residues
MIPSIKRSLRLAGMRPVPRWPARPTVDLRGKRILLTGASSGIGAVAAQKLAAEGAFVIAVARREALLAEVVERITAAGGS
ASAIPANLANLDEVDVLMERVGPVDVLINNAARSIRRPLAQSLDRWHDVERVMQLNYYAPLRLIRGLAPGMIERGDGHII
NIASWRVLPESSPMFAAYNASKAALSAVSRVIDTEWGHAGVHATTVYYPLVSTPMIAPTQAYSGLAALSADEAAQWMVTA
ARTRPIRIAPRKALALRALDVVAPRALNNIFERETNRMNRNAIKAAAAQGH

Specific function: Catalyzes the NADPH-dependent reduction of long chain acyl-CoA to the corresponding aldehyde [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=219, Percent_Identity=30.1369863013699, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI7705925, Length=189, Percent_Identity=30.6878306878307, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI109715829, Length=211, Percent_Identity=33.175355450237, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI32455239, Length=181, Percent_Identity=31.4917127071823, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI5031765, Length=181, Percent_Identity=31.4917127071823, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4503817, Length=208, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI226371731, Length=228, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI32483357, Length=173, Percent_Identity=26.0115606936416, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790717, Length=206, Percent_Identity=29.6116504854369, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789208, Length=184, Percent_Identity=29.8913043478261, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787335, Length=195, Percent_Identity=29.2307692307692, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786701, Length=181, Percent_Identity=30.3867403314917, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787905, Length=141, Percent_Identity=31.2056737588652, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=246, Percent_Identity=28.0487804878049, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=186, Percent_Identity=27.9569892473118, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=217, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=246, Percent_Identity=27.6422764227642, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=216, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=226, Percent_Identity=26.1061946902655, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=196, Percent_Identity=29.0816326530612, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=210, Percent_Identity=27.1428571428571, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=195, Percent_Identity=31.7948717948718, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=149, Percent_Identity=30.8724832214765, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=208, Percent_Identity=28.8461538461538, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=221, Percent_Identity=27.6018099547511, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=141, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=188, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=203, Percent_Identity=27.0935960591133, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21358495, Length=233, Percent_Identity=31.7596566523605, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28571526, Length=197, Percent_Identity=32.994923857868, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21357041, Length=197, Percent_Identity=32.48730964467, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640492, Length=269, Percent_Identity=24.907063197026, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI116007236, Length=227, Percent_Identity=29.5154185022026, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.69 [C]

Molecular weight: Translated: 31335; Mature: 31335

Theoretical pI: Translated: 11.30; Mature: 11.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPSIKRSLRLAGMRPVPRWPARPTVDLRGKRILLTGASSGIGAVAAQKLAAEGAFVIAV
CCCHHHHHHHHCCCCCCCCCCCCCCEECCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEE
ARREALLAEVVERITAAGGSASAIPANLANLDEVDVLMERVGPVDVLINNAARSIRRPLA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QSLDRWHDVERVMQLNYYAPLRLIRGLAPGMIERGDGHIINIASWRVLPESSPMFAAYNA
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEECCCCCEEEEEEEEECCCCCCEEEEECC
SKAALSAVSRVIDTEWGHAGVHATTVYYPLVSTPMIAPTQAYSGLAALSADEAAQWMVTA
HHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCHHHHCCHHHHCHHHHHHHHHHH
ARTRPIRIAPRKALALRALDVVAPRALNNIFERETNRMNRNAIKAAAAQGH
HCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIPSIKRSLRLAGMRPVPRWPARPTVDLRGKRILLTGASSGIGAVAAQKLAAEGAFVIAV
CCCHHHHHHHHCCCCCCCCCCCCCCEECCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEE
ARREALLAEVVERITAAGGSASAIPANLANLDEVDVLMERVGPVDVLINNAARSIRRPLA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QSLDRWHDVERVMQLNYYAPLRLIRGLAPGMIERGDGHIINIASWRVLPESSPMFAAYNA
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEECCCCCEEEEEEEEECCCCCCEEEEECC
SKAALSAVSRVIDTEWGHAGVHATTVYYPLVSTPMIAPTQAYSGLAALSADEAAQWMVTA
HHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCHHHHCCHHHHCHHHHHHHHHHH
ARTRPIRIAPRKALALRALDVVAPRALNNIFERETNRMNRNAIKAAAAQGH
HCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+; NADH; NADP+; NADPH [C]

Metal ions: Mn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.02 {NADP+}} 20 {D-gluconate}} 0.006 {NADPH}} 0.9 {5-keto-D-gluconate}} [C]

Substrates: 5-Dehydro-D-gluconate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]

Specific reaction: 5-Dehydro-D-gluconate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced <==> D-Gluconate + Nicotinamide adenine dinucleotide phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: Cd2+; Cs2+; Cu2+; Divalent metal ions; Hg2+; Ni2+; p-Chloromercuribenzoate; Sn2+; Sulfhydryl reagents [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA