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The map label for this gene is ykuT [H]

Identifier: 108797822

GI number: 108797822

Start: 935003

End: 935986

Strand: Direct

Name: ykuT [H]

Synonym: Mmcs_0847

Alternate gene names: 108797822

Gene position: 935003-935986 (Clockwise)

Preceding gene: 108797821

Following gene: 108797823

Centisome position: 16.39

GC content: 66.46

Gene sequence:

>984_bases
ATGTGTGTCCCGGTGGGCGTTCTGGGTACGGTCGTGATCATGGACGTCTACACACTCGCTTTCGAATGGACGGACACCAA
CAAACATTGGTTCATCGAGGTCCCCATCCGGATCGTCGCGTACACCGTCGTCGCCCTTATCGCCCGCTACGTACTGCACC
GGATGATCGACCGTGCCGCCACCGGCCGCAGCAAGTCCCGCGGCACGACTGACCTGGAACAGTCCAAGAAGCCGCCGCTG
CTGCGCCACCTGCGTGATCGCGCACCGTCCTCGGTGGCCGGCGTGAAGACCGCCGAACGGCGCCAGCAGCGCGCACAGAC
CATCGGATCGGTGCTCAAGTCGACCGTGTCGATCGTGCTGTTGATCTGGGTGGTGCTGGCCGTGCTCAACGTGGTCGGAG
TGAACATCGCACCGTTCATCGCCTCGGCCGGCGTCGTCGGCCTGGCCATCGGCTTCGGCGCGCAGAACCTGGTCCGCGAC
TTCGTGACCGGCGTGTTCATGCTGCTCGAGGACCAGTACGGCGTCGGTGACACCGTCGACCTCGGCGAAGCGGTCGGCGA
GGTGGAAAGCGTCGGCCTGCGGGTCACCACCGTCCGCGACATCGACGGCACGCTCTGGTACGTCCGCAACGGTGAGATCG
CCCGGGTCGGCAACATGAGCCAGGACTACGCCGTCGCCCGCATCGAGATGCCTGTTGCGCTGACCGCCGATGTTGCGCAG
GCCGAACGGGTGGCGGTCGAGGCCGCCGAGGAGGCCCTCGAAGACCCGGCATTGGCCGCGAAGGTGCTGGGCAAGCCGGA
GATGCTCGGTGTGCAGGAGCTCTCGCCCGACCTGTTGACATTGCGGATGACCCTCAAGACGCGTCCGAACGCGCAGTGGT
CGGTGCAGCGACGGCTGCGGCGGGAGATCCTGCGCGCCTACGACGAGAACGGTATCGAGCTGCCGTACCGGCAGGGGCGG
GTATACGCGATGGCCGAGGAGTAG

Upstream 100 bases:

>100_bases
TACCGATTACGAAGGGGCGTGAGCTCGGCATTCTCAGTGCGCCATCATCGATTTGACGCCCGTGATAGGCCGATCGACCG
CGACGGTGACAGCCGTCGCA

Downstream 100 bases:

>100_bases
GCCGCCTCGCGTCGCTCAGCGAACCCTCGCTCCCGTCGAAATGTCATACCTGCCTGGAATAATGGGTAGGTGACGCAAAC
TTCCATCGACCGTCTGCACA

Product: mechanosensitive ion channel MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MCVPVGVLGTVVIMDVYTLAFEWTDTNKHWFIEVPIRIVAYTVVALIARYVLHRMIDRAATGRSKSRGTTDLEQSKKPPL
LRHLRDRAPSSVAGVKTAERRQQRAQTIGSVLKSTVSIVLLIWVVLAVLNVVGVNIAPFIASAGVVGLAIGFGAQNLVRD
FVTGVFMLLEDQYGVGDTVDLGEAVGEVESVGLRVTTVRDIDGTLWYVRNGEIARVGNMSQDYAVARIEMPVALTADVAQ
AERVAVEAAEEALEDPALAAKVLGKPEMLGVQELSPDLLTLRMTLKTRPNAQWSVQRRLRREILRAYDENGIELPYRQGR
VYAMAEE

Sequences:

>Translated_327_residues
MCVPVGVLGTVVIMDVYTLAFEWTDTNKHWFIEVPIRIVAYTVVALIARYVLHRMIDRAATGRSKSRGTTDLEQSKKPPL
LRHLRDRAPSSVAGVKTAERRQQRAQTIGSVLKSTVSIVLLIWVVLAVLNVVGVNIAPFIASAGVVGLAIGFGAQNLVRD
FVTGVFMLLEDQYGVGDTVDLGEAVGEVESVGLRVTTVRDIDGTLWYVRNGEIARVGNMSQDYAVARIEMPVALTADVAQ
AERVAVEAAEEALEDPALAAKVLGKPEMLGVQELSPDLLTLRMTLKTRPNAQWSVQRRLRREILRAYDENGIELPYRQGR
VYAMAEE
>Mature_327_residues
MCVPVGVLGTVVIMDVYTLAFEWTDTNKHWFIEVPIRIVAYTVVALIARYVLHRMIDRAATGRSKSRGTTDLEQSKKPPL
LRHLRDRAPSSVAGVKTAERRQQRAQTIGSVLKSTVSIVLLIWVVLAVLNVVGVNIAPFIASAGVVGLAIGFGAQNLVRD
FVTGVFMLLEDQYGVGDTVDLGEAVGEVESVGLRVTTVRDIDGTLWYVRNGEIARVGNMSQDYAVARIEMPVALTADVAQ
AERVAVEAAEEALEDPALAAKVLGKPEMLGVQELSPDLLTLRMTLKTRPNAQWSVQRRLRREILRAYDENGIELPYRQGR
VYAMAEE

Specific function: May play a role in resistance to osmotic downshock [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI87081787, Length=218, Percent_Identity=29.8165137614679, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1789291, Length=221, Percent_Identity=28.9592760180996, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR011014 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 35951; Mature: 35951

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCVPVGVLGTVVIMDVYTLAFEWTDTNKHWFIEVPIRIVAYTVVALIARYVLHRMIDRAA
CCCCHHHHHHHHHHHHHHHEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
TGRSKSRGTTDLEQSKKPPLLRHLRDRAPSSVAGVKTAERRQQRAQTIGSVLKSTVSIVL
CCCCCCCCCCCHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIWVVLAVLNVVGVNIAPFIASAGVVGLAIGFGAQNLVRDFVTGVFMLLEDQYGVGDTVD
HHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCH
LGEAVGEVESVGLRVTTVRDIDGTLWYVRNGEIARVGNMSQDYAVARIEMPVALTADVAQ
HHHHHHHHHHCCEEEEEEEECCCEEEEEECCCEEEECCCCCCCEEEEEECCEEEHHHHHH
AERVAVEAAEEALEDPALAAKVLGKPEMLGVQELSPDLLTLRMTLKTRPNAQWSVQRRLR
HHHHHHHHHHHHHHCHHHHHHHCCCCCCCCHHHCCCCCEEEEEEECCCCCCCHHHHHHHH
REILRAYDENGIELPYRQGRVYAMAEE
HHHHHHHCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MCVPVGVLGTVVIMDVYTLAFEWTDTNKHWFIEVPIRIVAYTVVALIARYVLHRMIDRAA
CCCCHHHHHHHHHHHHHHHEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
TGRSKSRGTTDLEQSKKPPLLRHLRDRAPSSVAGVKTAERRQQRAQTIGSVLKSTVSIVL
CCCCCCCCCCCHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIWVVLAVLNVVGVNIAPFIASAGVVGLAIGFGAQNLVRDFVTGVFMLLEDQYGVGDTVD
HHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCH
LGEAVGEVESVGLRVTTVRDIDGTLWYVRNGEIARVGNMSQDYAVARIEMPVALTADVAQ
HHHHHHHHHHCCEEEEEEEECCCEEEEEECCCEEEECCCCCCCEEEEEECCEEEHHHHHH
AERVAVEAAEEALEDPALAAKVLGKPEMLGVQELSPDLLTLRMTLKTRPNAQWSVQRRLR
HHHHHHHHHHHHHHCHHHHHHHCCCCCCCCHHHCCCCCEEEEEEECCCCCCCHHHHHHHH
REILRAYDENGIELPYRQGRVYAMAEE
HHHHHHHCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]