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The map label for this gene is mcrC [H]

Identifier: 108797805

GI number: 108797805

Start: 916140

End: 917225

Strand: Reverse

Name: mcrC [H]

Synonym: Mmcs_0828

Alternate gene names: 108797805

Gene position: 917225-916140 (Counterclockwise)

Preceding gene: 108797806

Following gene: 108797803

Centisome position: 16.08

GC content: 60.87

Gene sequence:

>1086_bases
ATGACGAAACCCCAGGCGATTATCAGTGGCAGCTCCGCCATTCCAGTGCGGAACCTCTGGCTGTTGATGTTGTATGCATC
CCGGCTCTATCAACGCAACCACCTTCTGCGGAATATGGACGTCGAGCAGAATCCCGAGCGATTGCTCGATCTGGTCGCTC
AGGTGCTCGTCTATGCAGTTGAACGACGCCTGCAGCGAAATCTCGGAAGGCAGTACAGGGAGCGCAGGGCGACGCTTGCG
CGGGTGCGGGGCCAGATCGATGTACTGACCACTGAGTCCAAAGCGTTGCTCGCACAGGGCCGCATTGCGTGCAGGTTCGA
CGAGCTGTCCGTCGACAATCTGCGCAACAGGATCATTCGATCCGCATTGGTCCTCGCCGCTCGCGATGCGCGCGACCGTA
CCCTTCAGCGCACGGCGCGCAACATGGCCGACGTCTTTACCCAGTATGGAGTATCACCGCAGTTGGTCAGCGTGCGTGAA
TCACGCCAGCTCGTCCTCGACCGCAACGCCCACGACGATGTCGAGGCTATAGGCGCTGCACAACTGATCCTGGAGATGGC
GATTCCGGCCGAATCCGCGGGCAACAGTACCAACCGCGACCCTGAGCGGGACGCCGCCGAGATCAGGCGGTTGTACGAGG
CAGCAGTTCGCGGCTTCTATCGGTCCGCACTTCCGTCGAGCTGGTCCGTATCGCCCGGCGAAACCCATTACCACTGGCCA
CTTGTCGAAGCGACCGAAGGCCTCAAGTCCATACTTCCGATCATGAAAGCGGACACGGTGCTCGAGACCGTCGGCCGCCG
CATCATCGTCGAGACGAAGTTCGCCGATGCGCTCAAACCGAACCAGTACGGATTGCCCAAGCTGGCACGCAACCACGTCT
TCCAGCTGTATGCCTATGTCCAGTCACAGCACGGTTCAGACGAGCTGTCCGCCACCGCGGAGGGTGTCCTGCTGTATCCC
GTAGTGGGCGAACATGTCGATGAGTCGGCGTCGATCCAGGGGCATCGATACAGGTTCCTGACCGTCGACCTCGGGGGCCC
CGCTGAATCGATCCGCTCGTCACTCCTCCGCGTCACATCCAATTGA

Upstream 100 bases:

>100_bases
GCCACGTCGTCGAACAGGAGATCCGCCCGCTCCTTGCGGAGTATTGGTTCGACGATCCGCAGCGCGTCGAGGCCGAGAGT
TCGGCCTTGATCGGCTCGAT

Downstream 100 bases:

>100_bases
TTGGCCGACTACGACGCCGATGTAATGACCACGCCGTTACGGCACATTCAGCCGCCGCGCCAGGTCAGGTCCGCCGACCT
CACGGATGAAGTCCGGGTCG

Product: 5-methylcytosine-specific restriction enzyme subunit McrC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTKPQAIISGSSAIPVRNLWLLMLYASRLYQRNHLLRNMDVEQNPERLLDLVAQVLVYAVERRLQRNLGRQYRERRATLA
RVRGQIDVLTTESKALLAQGRIACRFDELSVDNLRNRIIRSALVLAARDARDRTLQRTARNMADVFTQYGVSPQLVSVRE
SRQLVLDRNAHDDVEAIGAAQLILEMAIPAESAGNSTNRDPERDAAEIRRLYEAAVRGFYRSALPSSWSVSPGETHYHWP
LVEATEGLKSILPIMKADTVLETVGRRIIVETKFADALKPNQYGLPKLARNHVFQLYAYVQSQHGSDELSATAEGVLLYP
VVGEHVDESASIQGHRYRFLTVDLGGPAESIRSSLLRVTSN

Sequences:

>Translated_361_residues
MTKPQAIISGSSAIPVRNLWLLMLYASRLYQRNHLLRNMDVEQNPERLLDLVAQVLVYAVERRLQRNLGRQYRERRATLA
RVRGQIDVLTTESKALLAQGRIACRFDELSVDNLRNRIIRSALVLAARDARDRTLQRTARNMADVFTQYGVSPQLVSVRE
SRQLVLDRNAHDDVEAIGAAQLILEMAIPAESAGNSTNRDPERDAAEIRRLYEAAVRGFYRSALPSSWSVSPGETHYHWP
LVEATEGLKSILPIMKADTVLETVGRRIIVETKFADALKPNQYGLPKLARNHVFQLYAYVQSQHGSDELSATAEGVLLYP
VVGEHVDESASIQGHRYRFLTVDLGGPAESIRSSLLRVTSN
>Mature_360_residues
TKPQAIISGSSAIPVRNLWLLMLYASRLYQRNHLLRNMDVEQNPERLLDLVAQVLVYAVERRLQRNLGRQYRERRATLAR
VRGQIDVLTTESKALLAQGRIACRFDELSVDNLRNRIIRSALVLAARDARDRTLQRTARNMADVFTQYGVSPQLVSVRES
RQLVLDRNAHDDVEAIGAAQLILEMAIPAESAGNSTNRDPERDAAEIRRLYEAAVRGFYRSALPSSWSVSPGETHYHWPL
VEATEGLKSILPIMKADTVLETVGRRIIVETKFADALKPNQYGLPKLARNHVFQLYAYVQSQHGSDELSATAEGVLLYPV
VGEHVDESASIQGHRYRFLTVDLGGPAESIRSSLLRVTSN

Specific function: Modifies the specificity of mcrB restriction by expanding the range of modified sequences restricted. Does not bind to DNA [H]

COG id: COG4268

COG function: function code V; McrBC 5-methylcytosine restriction system component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790804, Length=348, Percent_Identity=25.2873563218391, Blast_Score=105, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014407
- InterPro:   IPR019292 [H]

Pfam domain/function: PF10117 McrBC [H]

EC number: NA

Molecular weight: Translated: 40592; Mature: 40461

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPQAIISGSSAIPVRNLWLLMLYASRLYQRNHLLRNMDVEQNPERLLDLVAQVLVYAV
CCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ERRLQRNLGRQYRERRATLARVRGQIDVLTTESKALLAQGRIACRFDELSVDNLRNRIIR
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCEEEEECCCCHHHHHHHHHH
SALVLAARDARDRTLQRTARNMADVFTQYGVSPQLVSVRESRQLVLDRNAHDDVEAIGAA
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCHHHHHHHH
QLILEMAIPAESAGNSTNRDPERDAAEIRRLYEAAVRGFYRSALPSSWSVSPGETHYHWP
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECC
LVEATEGLKSILPIMKADTVLETVGRRIIVETKFADALKPNQYGLPKLARNHVFQLYAYV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHH
QSQHGSDELSATAEGVLLYPVVGEHVDESASIQGHRYRFLTVDLGGPAESIRSSLLRVTS
HHCCCCHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCC
N
C
>Mature Secondary Structure 
TKPQAIISGSSAIPVRNLWLLMLYASRLYQRNHLLRNMDVEQNPERLLDLVAQVLVYAV
CCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ERRLQRNLGRQYRERRATLARVRGQIDVLTTESKALLAQGRIACRFDELSVDNLRNRIIR
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCEEEEECCCCHHHHHHHHHH
SALVLAARDARDRTLQRTARNMADVFTQYGVSPQLVSVRESRQLVLDRNAHDDVEAIGAA
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCHHHHHHHH
QLILEMAIPAESAGNSTNRDPERDAAEIRRLYEAAVRGFYRSALPSSWSVSPGETHYHWP
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECC
LVEATEGLKSILPIMKADTVLETVGRRIIVETKFADALKPNQYGLPKLARNHVFQLYAYV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHH
QSQHGSDELSATAEGVLLYPVVGEHVDESASIQGHRYRFLTVDLGGPAESIRSSLLRVTS
HHCCCCHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2203735; 2649480; 7610040; 9278503; 2050643 [H]