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The map label for this gene is cmaA1 [H]

Identifier: 108797766

GI number: 108797766

Start: 848895

End: 849827

Strand: Reverse

Name: cmaA1 [H]

Synonym: Mmcs_0787

Alternate gene names: 108797766

Gene position: 849827-848895 (Counterclockwise)

Preceding gene: 108797767

Following gene: 108797765

Centisome position: 14.9

GC content: 61.41

Gene sequence:

>933_bases
GTGGCAGATACATCGAGTGCAGCACCCAAGGCAGAGTCCCAGTGGCTGTCGAAGTCGGCTTCGCAGACCCGCGGCTCCGA
CAAGGGCGAAGTCCAGTTCCATTACGACATCTCCAATGAATTCTTCAAGCTGTGGCAGGACCCGAACCAGGTCTACAGCT
GCGCCTACTTCGAGAAGGACGACTACACCCTCGAACAGGCCCAGATGGCCAAGATCGACCTGTCATTGGGCAAGCTCGGC
CTGAAGCCGGGCATGACGCTGCTCGACATCGGCTGCGGCTGGGGCGCCACGATCATGCGGGCCGTCGAGAAGTACGACGT
CAACGTCATCGGCCTGACGCTCTCGGAGAACCAGAAGCGCCACATCGAGGAGCACTGGTTCGCCAACTCGAAGAGCGACC
GCAAGATGGAGGTCCGGCTTCAGCCGTGGGAGGACTTCAACGGCCAGGTCGACCGGATCGTGTCGATCGGCGCCTTCGAG
CACTTCGGCTTCAACAAGTACGACGACTACTTCAAGAAGACCTTCGACTGGATGCCCGAGGACGGCGTGCAGATGCTGCA
CACGATCATCATCCCGGAGGATGAGGAGATCAAGGCCAAGGGTCTGCCGCTGACGATGTCGCGCGTGCGGTTCATCAAAT
TCATCATGGACGAGATCTACCCCGGTGGCCGTCTGCCGCTGGCCTCGATGGTCAAGGAGCATGCCGTCAAGGCCGGCTAC
ACCGTGACCCGCGAGCAGCACCTGCAGGAGCACTACGTCAAGACCCTCGACACCTGGGCGCGCAACCTCGAGGCACGCAA
GGACGAGGCCATCGAGATCACCAACGAGGTGATCTACGAGCGCTTCCTCAAGTACCTCGACGGCTGCGCCGACCTGTTCC
GCGAGGGCTACACCGACGTCGCGCAGTTCACGCTCGAGAAGGCACCCGCTTAG

Upstream 100 bases:

>100_bases
TAGCGCGTTGATCAATTGACGGCAGGCGTAGTCTCGGCACCGTGTCGAGCAGCAGGCACCGAAGTGTTCAGCCCATATAG
CAACTTCACCAGGACGGACA

Downstream 100 bases:

>100_bases
CACAGCTAGGCAATCTGCGTATAGAGTTCAAGATCGGTTTTCAGGACAACGGAGGACAACGCAGATGACGGACAGCGGGT
CGGGGGGCTCGACAACAACC

Product: cyclopropane-fatty-acyl-phospholipid synthase

Products: NA

Alternate protein names: CMAS; Cyclopropane-fatty-acyl-phospholipid synthase; CFA synthase; Cyclopropane fatty acid synthase; Mycolic acid methyltransferase; MA-MT; S-adenosylmethionine-dependent methyltransferase; AdoMet-MT; SAM-MT [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MADTSSAAPKAESQWLSKSASQTRGSDKGEVQFHYDISNEFFKLWQDPNQVYSCAYFEKDDYTLEQAQMAKIDLSLGKLG
LKPGMTLLDIGCGWGATIMRAVEKYDVNVIGLTLSENQKRHIEEHWFANSKSDRKMEVRLQPWEDFNGQVDRIVSIGAFE
HFGFNKYDDYFKKTFDWMPEDGVQMLHTIIIPEDEEIKAKGLPLTMSRVRFIKFIMDEIYPGGRLPLASMVKEHAVKAGY
TVTREQHLQEHYVKTLDTWARNLEARKDEAIEITNEVIYERFLKYLDGCADLFREGYTDVAQFTLEKAPA

Sequences:

>Translated_310_residues
MADTSSAAPKAESQWLSKSASQTRGSDKGEVQFHYDISNEFFKLWQDPNQVYSCAYFEKDDYTLEQAQMAKIDLSLGKLG
LKPGMTLLDIGCGWGATIMRAVEKYDVNVIGLTLSENQKRHIEEHWFANSKSDRKMEVRLQPWEDFNGQVDRIVSIGAFE
HFGFNKYDDYFKKTFDWMPEDGVQMLHTIIIPEDEEIKAKGLPLTMSRVRFIKFIMDEIYPGGRLPLASMVKEHAVKAGY
TVTREQHLQEHYVKTLDTWARNLEARKDEAIEITNEVIYERFLKYLDGCADLFREGYTDVAQFTLEKAPA
>Mature_309_residues
ADTSSAAPKAESQWLSKSASQTRGSDKGEVQFHYDISNEFFKLWQDPNQVYSCAYFEKDDYTLEQAQMAKIDLSLGKLGL
KPGMTLLDIGCGWGATIMRAVEKYDVNVIGLTLSENQKRHIEEHWFANSKSDRKMEVRLQPWEDFNGQVDRIVSIGAFEH
FGFNKYDDYFKKTFDWMPEDGVQMLHTIIIPEDEEIKAKGLPLTMSRVRFIKFIMDEIYPGGRLPLASMVKEHAVKAGYT
VTREQHLQEHYVKTLDTWARNLEARKDEAIEITNEVIYERFLKYLDGCADLFREGYTDVAQFTLEKAPA

Specific function: Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfers of a methylene group from S-adenosyl-L- methionine. Cyclopropanated mycolic acids are key factors participating in cell enve

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CFA/CMAS family [H]

Homologues:

Organism=Escherichia coli, GI1787951, Length=261, Percent_Identity=34.4827586206897, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI133904226, Length=293, Percent_Identity=30.0341296928328, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003333 [H]

Pfam domain/function: PF02353 CMAS [H]

EC number: =2.1.1.79 [H]

Molecular weight: Translated: 35773; Mature: 35642

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTSSAAPKAESQWLSKSASQTRGSDKGEVQFHYDISNEFFKLWQDPNQVYSCAYFEKD
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHCCHHHHEEEEEECCC
DYTLEQAQMAKIDLSLGKLGLKPGMTLLDIGCGWGATIMRAVEKYDVNVIGLTLSENQKR
CCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCHHH
HIEEHWFANSKSDRKMEVRLQPWEDFNGQVDRIVSIGAFEHFGFNKYDDYFKKTFDWMPE
HHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHEECCHHHCCCCHHHHHHHHHHCCCCC
DGVQMLHTIIIPEDEEIKAKGLPLTMSRVRFIKFIMDEIYPGGRLPLASMVKEHAVKAGY
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
TVTREQHLQEHYVKTLDTWARNLEARKDEAIEITNEVIYERFLKYLDGCADLFREGYTDV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AQFTLEKAPA
HHHHHHCCCC
>Mature Secondary Structure 
ADTSSAAPKAESQWLSKSASQTRGSDKGEVQFHYDISNEFFKLWQDPNQVYSCAYFEKD
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHCCHHHHEEEEEECCC
DYTLEQAQMAKIDLSLGKLGLKPGMTLLDIGCGWGATIMRAVEKYDVNVIGLTLSENQKR
CCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCHHH
HIEEHWFANSKSDRKMEVRLQPWEDFNGQVDRIVSIGAFEHFGFNKYDDYFKKTFDWMPE
HHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHEECCHHHCCCCHHHHHHHHHHCCCCC
DGVQMLHTIIIPEDEEIKAKGLPLTMSRVRFIKFIMDEIYPGGRLPLASMVKEHAVKAGY
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
TVTREQHLQEHYVKTLDTWARNLEARKDEAIEITNEVIYERFLKYLDGCADLFREGYTDV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AQFTLEKAPA
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7604045 [H]