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The map label for this gene is fabG [C]

Identifier: 108797585

GI number: 108797585

Start: 667581

End: 668483

Strand: Reverse

Name: fabG [C]

Synonym: Mmcs_0605

Alternate gene names: 108797585

Gene position: 668483-667581 (Counterclockwise)

Preceding gene: 108797589

Following gene: 108797584

Centisome position: 11.72

GC content: 70.43

Gene sequence:

>903_bases
GTGACGAAATGGACCACCGCCGACATCCCGAGCCAGTCCGGCCGCACCGCGGTCGTCACCGGCGCCAACACCGGGCTCGG
CCTCGAAACCGCCAAAGCGCTGGCCGCACGCGGCGCACACGTCGTGCTCGCGGTCCGCGACACCGAGAAGGGCAAACGCG
CCGCCGACGAGATCACCGCCGCCCATCCCGAGGCCGCGGTGGGCGTGCAGAGCCTCGACCTCGGGTCGCTGCGCTCGGTG
CGCACCGCGGCCGAGGCGCTCAAGGCCGACTTCCCGCGCATCGACCTGCTGATCAACAACGCCGGGGTGATGTACCCGCC
CAAGCAGACCACCGAGGACGGTTTCGAGCTCACGTTCGGCACCAACCACCTCGGCCACTTCGCCCTCACCGGACTGCTGC
TGGAGAACGTCCTGGCGGCGCCGAACTCGCGGGTGGTGACCGTCAGCAGCCAGGGGCACCGCATCCGGGCCGCGATCCAC
TTCGACGATCTGCAATGGGAGCGCAGCTACAGCCGCGTCGGCGCCTACGGACAGTCGAAGCTGTCGAATCTGCTGTTCAC
CTACGAACTCCAGCGCCGCCTCGACACCCGCGACGCCATCGCGGTCGCCGCCCACCCCGGGGTGTCCAACACCGAACTCA
TGCGTCACCTGCATCTGCCGCCGGTGTTCAACCCGCTGGTCGGTGTCCTCACGCAGAGCCCCACGATGGGGGCACTGCCG
ACGCTGCGGGCCGCGACCGACCCCACCGTGCGGGGCGGGCAGTACTTCGGGCCGAGCGGACTGGGCGAGATCCGCGGCTA
CCCCGAGCTCGTCACGTCGAGCGCGCAGTCGCGCGACGTGGACCTGGCCCGCCGGCTGTGGACGGTGTCCGAAGAGCTCA
CCGGAGTGGCGTTTCCGCTCTAG

Upstream 100 bases:

>100_bases
CATATCCCAGCCGCTCCTCTCGAAACCTTGAAACGGAGCGAGCGTTCCGTATAGTGGAAAGCAACCGGAGCGCACGTTCC
GCTTCAGTCTAGGAGACCTG

Downstream 100 bases:

>100_bases
GCTCGTTTCCTGTGTCGCTGGTCGTACCGCCCTATCCCCCGCCGCGCTACACCGAGGACGAACCTGCGGTGAGCGCGTGG
GTCCGGCGCGGGGACGAGCC

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTKWTTADIPSQSGRTAVVTGANTGLGLETAKALAARGAHVVLAVRDTEKGKRAADEITAAHPEAAVGVQSLDLGSLRSV
RTAAEALKADFPRIDLLINNAGVMYPPKQTTEDGFELTFGTNHLGHFALTGLLLENVLAAPNSRVVTVSSQGHRIRAAIH
FDDLQWERSYSRVGAYGQSKLSNLLFTYELQRRLDTRDAIAVAAHPGVSNTELMRHLHLPPVFNPLVGVLTQSPTMGALP
TLRAATDPTVRGGQYFGPSGLGEIRGYPELVTSSAQSRDVDLARRLWTVSEELTGVAFPL

Sequences:

>Translated_300_residues
MTKWTTADIPSQSGRTAVVTGANTGLGLETAKALAARGAHVVLAVRDTEKGKRAADEITAAHPEAAVGVQSLDLGSLRSV
RTAAEALKADFPRIDLLINNAGVMYPPKQTTEDGFELTFGTNHLGHFALTGLLLENVLAAPNSRVVTVSSQGHRIRAAIH
FDDLQWERSYSRVGAYGQSKLSNLLFTYELQRRLDTRDAIAVAAHPGVSNTELMRHLHLPPVFNPLVGVLTQSPTMGALP
TLRAATDPTVRGGQYFGPSGLGEIRGYPELVTSSAQSRDVDLARRLWTVSEELTGVAFPL
>Mature_299_residues
TKWTTADIPSQSGRTAVVTGANTGLGLETAKALAARGAHVVLAVRDTEKGKRAADEITAAHPEAAVGVQSLDLGSLRSVR
TAAEALKADFPRIDLLINNAGVMYPPKQTTEDGFELTFGTNHLGHFALTGLLLENVLAAPNSRVVTVSSQGHRIRAAIHF
DDLQWERSYSRVGAYGQSKLSNLLFTYELQRRLDTRDAIAVAAHPGVSNTELMRHLHLPPVFNPLVGVLTQSPTMGALPT
LRAATDPTVRGGQYFGPSGLGEIRGYPELVTSSAQSRDVDLARRLWTVSEELTGVAFPL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI225579078, Length=304, Percent_Identity=43.0921052631579, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI10190746, Length=302, Percent_Identity=39.7350993377483, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI166795268, Length=294, Percent_Identity=42.1768707482993, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI186928839, Length=294, Percent_Identity=42.5170068027211, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI19923931, Length=260, Percent_Identity=41.5384615384615, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI7706523, Length=291, Percent_Identity=36.7697594501718, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI193804850, Length=299, Percent_Identity=38.1270903010033, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI146231950, Length=293, Percent_Identity=38.5665529010239, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI13375997, Length=216, Percent_Identity=27.3148148148148, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI20149619, Length=205, Percent_Identity=29.7560975609756, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532805, Length=299, Percent_Identity=35.4515050167224, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193207620, Length=299, Percent_Identity=33.4448160535117, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17532791, Length=299, Percent_Identity=32.4414715719064, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17558006, Length=299, Percent_Identity=32.7759197324415, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71992402, Length=292, Percent_Identity=31.5068493150685, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17535059, Length=293, Percent_Identity=32.0819112627986, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17505416, Length=242, Percent_Identity=31.8181818181818, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI72001364, Length=218, Percent_Identity=34.4036697247706, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI115533172, Length=291, Percent_Identity=30.2405498281787, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI115533174, Length=291, Percent_Identity=30.2405498281787, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI32565532, Length=134, Percent_Identity=38.0597014925373, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71997402, Length=170, Percent_Identity=32.9411764705882, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324820, Length=332, Percent_Identity=29.5180722891566, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28573296, Length=294, Percent_Identity=42.5170068027211, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24586328, Length=296, Percent_Identity=39.527027027027, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI22024069, Length=293, Percent_Identity=40.9556313993174, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19921754, Length=295, Percent_Identity=39.6610169491525, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI161076371, Length=295, Percent_Identity=38.6440677966102, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI45554248, Length=250, Percent_Identity=43.2, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24640117, Length=250, Percent_Identity=43.2, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24647946, Length=252, Percent_Identity=34.9206349206349, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45553409, Length=249, Percent_Identity=35.3413654618474, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24647948, Length=249, Percent_Identity=35.3413654618474, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24656154, Length=263, Percent_Identity=37.2623574144487, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI19922628, Length=263, Percent_Identity=37.2623574144487, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI20129347, Length=291, Percent_Identity=34.3642611683849, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24647931, Length=303, Percent_Identity=34.983498349835, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32168; Mature: 32037

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKWTTADIPSQSGRTAVVTGANTGLGLETAKALAARGAHVVLAVRDTEKGKRAADEITA
CCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHH
AHPEAAVGVQSLDLGSLRSVRTAAEALKADFPRIDLLINNAGVMYPPKQTTEDGFELTFG
CCCCHHCCEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCCCCEEEEEC
TNHLGHFALTGLLLENVLAAPNSRVVTVSSQGHRIRAAIHFDDLQWERSYSRVGAYGQSK
CCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEECCCHHHHHHHHHCCCCHHH
LSNLLFTYELQRRLDTRDAIAVAAHPGVSNTELMRHLHLPPVFNPLVGVLTQSPTMGALP
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
TLRAATDPTVRGGQYFGPSGLGEIRGYPELVTSSAQSRDVDLARRLWTVSEELTGVAFPL
CCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TKWTTADIPSQSGRTAVVTGANTGLGLETAKALAARGAHVVLAVRDTEKGKRAADEITA
CCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHH
AHPEAAVGVQSLDLGSLRSVRTAAEALKADFPRIDLLINNAGVMYPPKQTTEDGFELTFG
CCCCHHCCEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCCCCEEEEEC
TNHLGHFALTGLLLENVLAAPNSRVVTVSSQGHRIRAAIHFDDLQWERSYSRVGAYGQSK
CCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEECCCHHHHHHHHHCCCCHHH
LSNLLFTYELQRRLDTRDAIAVAAHPGVSNTELMRHLHLPPVFNPLVGVLTQSPTMGALP
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
TLRAATDPTVRGGQYFGPSGLGEIRGYPELVTSSAQSRDVDLARRLWTVSEELTGVAFPL
CCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]