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The map label for this gene is mrpD [H]

Identifier: 108797564

GI number: 108797564

Start: 641676

End: 643283

Strand: Reverse

Name: mrpD [H]

Synonym: Mmcs_0584

Alternate gene names: 108797564

Gene position: 643283-641676 (Counterclockwise)

Preceding gene: 108797565

Following gene: 108797563

Centisome position: 11.27

GC content: 68.47

Gene sequence:

>1608_bases
GTGAGTCTCAGCTCGGTGCTCACGCCCCTGCCGGTGCTCATCCCGACGATCGCGGCCGCGCTGACGCTGTTCGCGGGCCG
CCGCCCGGTGTTGCAGCGGGTGATCGCCCAACTGGCGCTGGTCGCCGTCGTGGTGGTGTGCGCTGCGCTGGTCTACCTGA
CCGACCGCGACGGAACGCTGGCGCTACACGTCGGCGGCTGGGGTCAGAGCGTTCCCGGTATGGGCCCGCTCGGCATCACC
CTGGTCGTCGACCGGCTGTCGGCGCTGATGCTGATGGTGTCGTCGATCGTGCTGCTGGCGGTGGTCGCATACGCCATCGG
GCAGGGCATCCGCGACGGCGACGGCCGTCAGCCGGTGTCGATCTTCCTGCCCACCTATCTGGTGCTGTCGGCGGGTGTGT
GCACCGCCTTCCTCGCGGGTGACCTGTTCAACCTGTACGTCGGGTTCGAGGTTCTGCTGTCCGCGAGCTTCGTTCTGCTC
ACCATCGGTGCGAGCGCCGAACGTGTCCGCGCCGGTATCTCGTACGTGATGGTGTCGATGGTGTCGTCACTGATCTTCCT
GCTCGGCATCGGACTCGTGTACGCCGCGACCGGCACGCTGAACATGGCCGAACTGGCCGTACGCCTCGACGACGTCTCCG
AGGGGACGCGGATGGCGTTGTTCGCCGTGCTGATGGTCGCGTTCGGCATCAAGGCCGCGGTATTCCCGCTGTCGACCTGG
CTGCCCGACTCCTACCCCACGGCACCGGCACCGGTGACGGCCGTGTTCGCCGGCCTGCTGACGAAAGTCGGTGTCTACGC
GATCATCCGGGCACACTCGCTGCTGTTCCCCGGCGGCGGGCTGGACCAGGTGCTGCTGTGGGCGGCGCTGCTCACGATGG
TGGTCGGCATCCTCGGCGCCATCGCGCAGAGCGACATCAAGCGACTGCTGTCGTTCACCCTCGTCAGCCATATCGGGTAC
ATGGTGTTCGGCATCGCGCTGTCGAACGACATCGGGATGGCCGGTGCCATCTACTACGTGGCGCACCACATCGTCGTGCA
GACCACCCTCTTCCTGGTCGTGGGTCTGATCGAGCGCCAGGCCGGGGCGTCGACGATGACCCGCCTCGGCGGACTCGCCG
CCGCGAGCCCGTTGCTCGCCTTCGTCTTCGTCGTGCCGGCGCTGAATCTCGGTGGGATACCGCCGTTCTCCGGGTTCATC
GGCAAGGTGGCGCTGCTCGAAGCCGGCGCGGCCAACGGAACGCCGCTGGCCTGGGCGCTGGTGGCCGGCGGGGTGGTGAC
GAGCCTGCTGACGCTGTACGTGGTGGCGCGGGTGTGGACGAAAGCGTTCTGGCGCTCGCGCGAAGACGCACCGGAGGGGC
ACCTGTCCTCCACCGCGCCCGCCGCACTGCTGGACGACACCGCGGAGTCCGACGACATCCAGTTCGTGGACCGTGATCAC
GTCGGCCGCATGCCCGCAGGCATGCTGGTGCCGACGGGTCTGCTGATAGCCGTCGGCCTGGCGCTGACCGTGGCGGCCGG
ACCGATCTTCGCCTACAGCGGCCGGGCCGCGGACGAGGTGATCCAGCGCGACCACTACATCACCGCGGTGGTGGGTGAGC
GGCCATGA

Upstream 100 bases:

>100_bases
CCGCCGCCCTCGACGAGGACCGCCCACCCGAACCGGATCTGGCCATCGACACCGACCTGCCCGACGAACTCGACGCGCTA
CCCGGTCGGGAGGGGTCCCG

Downstream 100 bases:

>100_bases
AGGTGATCGAAGGGACCAGGTGGTCACCGCGCCGACTGGCACTGCGCGCGTGGGTGTTGTGCTGGCTGACGTTGGTGTGG
GTCCTGTTGTGGGGCACGCT

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSLSSVLTPLPVLIPTIAAALTLFAGRRPVLQRVIAQLALVAVVVVCAALVYLTDRDGTLALHVGGWGQSVPGMGPLGIT
LVVDRLSALMLMVSSIVLLAVVAYAIGQGIRDGDGRQPVSIFLPTYLVLSAGVCTAFLAGDLFNLYVGFEVLLSASFVLL
TIGASAERVRAGISYVMVSMVSSLIFLLGIGLVYAATGTLNMAELAVRLDDVSEGTRMALFAVLMVAFGIKAAVFPLSTW
LPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGGLDQVLLWAALLTMVVGILGAIAQSDIKRLLSFTLVSHIGY
MVFGIALSNDIGMAGAIYYVAHHIVVQTTLFLVVGLIERQAGASTMTRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFI
GKVALLEAGAANGTPLAWALVAGGVVTSLLTLYVVARVWTKAFWRSREDAPEGHLSSTAPAALLDDTAESDDIQFVDRDH
VGRMPAGMLVPTGLLIAVGLALTVAAGPIFAYSGRAADEVIQRDHYITAVVGERP

Sequences:

>Translated_535_residues
MSLSSVLTPLPVLIPTIAAALTLFAGRRPVLQRVIAQLALVAVVVVCAALVYLTDRDGTLALHVGGWGQSVPGMGPLGIT
LVVDRLSALMLMVSSIVLLAVVAYAIGQGIRDGDGRQPVSIFLPTYLVLSAGVCTAFLAGDLFNLYVGFEVLLSASFVLL
TIGASAERVRAGISYVMVSMVSSLIFLLGIGLVYAATGTLNMAELAVRLDDVSEGTRMALFAVLMVAFGIKAAVFPLSTW
LPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGGLDQVLLWAALLTMVVGILGAIAQSDIKRLLSFTLVSHIGY
MVFGIALSNDIGMAGAIYYVAHHIVVQTTLFLVVGLIERQAGASTMTRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFI
GKVALLEAGAANGTPLAWALVAGGVVTSLLTLYVVARVWTKAFWRSREDAPEGHLSSTAPAALLDDTAESDDIQFVDRDH
VGRMPAGMLVPTGLLIAVGLALTVAAGPIFAYSGRAADEVIQRDHYITAVVGERP
>Mature_534_residues
SLSSVLTPLPVLIPTIAAALTLFAGRRPVLQRVIAQLALVAVVVVCAALVYLTDRDGTLALHVGGWGQSVPGMGPLGITL
VVDRLSALMLMVSSIVLLAVVAYAIGQGIRDGDGRQPVSIFLPTYLVLSAGVCTAFLAGDLFNLYVGFEVLLSASFVLLT
IGASAERVRAGISYVMVSMVSSLIFLLGIGLVYAATGTLNMAELAVRLDDVSEGTRMALFAVLMVAFGIKAAVFPLSTWL
PDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGGLDQVLLWAALLTMVVGILGAIAQSDIKRLLSFTLVSHIGYM
VFGIALSNDIGMAGAIYYVAHHIVVQTTLFLVVGLIERQAGASTMTRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIG
KVALLEAGAANGTPLAWALVAGGVVTSLLTLYVVARVWTKAFWRSREDAPEGHLSSTAPAALLDDTAESDDIQFVDRDHV
GRMPAGMLVPTGLLIAVGLALTVAAGPIFAYSGRAADEVIQRDHYITAVVGERP

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=376, Percent_Identity=23.1382978723404, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI251831116, Length=365, Percent_Identity=23.2876712328767, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1788829, Length=343, Percent_Identity=29.7376093294461, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1788827, Length=343, Percent_Identity=27.1137026239067, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI145693160, Length=330, Percent_Identity=32.1212121212121, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788613, Length=426, Percent_Identity=27.9342723004695, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788831, Length=355, Percent_Identity=26.7605633802817, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1788614, Length=378, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI2367154, Length=303, Percent_Identity=24.7524752475248, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 55690; Mature: 55558

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSSVLTPLPVLIPTIAAALTLFAGRRPVLQRVIAQLALVAVVVVCAALVYLTDRDGTL
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
ALHVGGWGQSVPGMGPLGITLVVDRLSALMLMVSSIVLLAVVAYAIGQGIRDGDGRQPVS
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
IFLPTYLVLSAGVCTAFLAGDLFNLYVGFEVLLSASFVLLTIGASAERVRAGISYVMVSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCHHHHHHHHHHHHHHH
VSSLIFLLGIGLVYAATGTLNMAELAVRLDDVSEGTRMALFAVLMVAFGIKAAVFPLSTW
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGGLDQVLLWAALLTMVVGILGA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
IAQSDIKRLLSFTLVSHIGYMVFGIALSNDIGMAGAIYYVAHHIVVQTTLFLVVGLIERQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGASTMTRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGKVALLEAGAANGTPLAWAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHH
VAGGVVTSLLTLYVVARVWTKAFWRSREDAPEGHLSSTAPAALLDDTAESDDIQFVDRDH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCEEECCCC
VGRMPAGMLVPTGLLIAVGLALTVAAGPIFAYSGRAADEVIQRDHYITAVVGERP
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEECCCHHHHHHHCCCEEEEEECCCC
>Mature Secondary Structure 
SLSSVLTPLPVLIPTIAAALTLFAGRRPVLQRVIAQLALVAVVVVCAALVYLTDRDGTL
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
ALHVGGWGQSVPGMGPLGITLVVDRLSALMLMVSSIVLLAVVAYAIGQGIRDGDGRQPVS
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
IFLPTYLVLSAGVCTAFLAGDLFNLYVGFEVLLSASFVLLTIGASAERVRAGISYVMVSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCHHHHHHHHHHHHHHH
VSSLIFLLGIGLVYAATGTLNMAELAVRLDDVSEGTRMALFAVLMVAFGIKAAVFPLSTW
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGGLDQVLLWAALLTMVVGILGA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
IAQSDIKRLLSFTLVSHIGYMVFGIALSNDIGMAGAIYYVAHHIVVQTTLFLVVGLIERQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGASTMTRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGKVALLEAGAANGTPLAWAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHH
VAGGVVTSLLTLYVVARVWTKAFWRSREDAPEGHLSSTAPAALLDDTAESDDIQFVDRDH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCEEECCCC
VGRMPAGMLVPTGLLIAVGLALTVAAGPIFAYSGRAADEVIQRDHYITAVVGERP
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEECCCHHHHHHHCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]