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The map label for this gene is yjcE [H]

Identifier: 108797501

GI number: 108797501

Start: 577969

End: 579570

Strand: Reverse

Name: yjcE [H]

Synonym: Mmcs_0521

Alternate gene names: 108797501

Gene position: 579570-577969 (Counterclockwise)

Preceding gene: 108797508

Following gene: 108797499

Centisome position: 10.16

GC content: 72.85

Gene sequence:

>1602_bases
GTGAGTGCCTCACTGCTGGCCGTCCTGGTCGTCGCGGTGCTGCTGGCCGCCGTCGCCCGTCGGGCGGATGTGTCGGCCCC
GCTGGCGCTGGTGGTCGCCGGGCTGGCCGTCGGCCTGATCCCCGGCGTACCGGACATCCAACTCGATCCGGACCTGGTGC
TGTACGTCGTGCTGCCGCCGCTGCTGTGGTCGGCCGGACTGGAGAGCAGCTACGTGGCGCTGCGGCGCAACGTGCGCTCG
ATCGGGATGCTGGCGGTCGGCCTGCCACTGGCGACGACGTTCGCGGTCGGGGTGGTGGCGTACTGGGCGGTGCCCGAACT
CACCATCGCGGCCGCGCTGACGCTGGGAGCGATCGTGGCGCCCCCGGATGCGGTGTCGGCGACCGCGGTGGGCCGCAGGC
TCGGCCTGCCCCGCCGGCTGATGACTCTGCTGGGTGGCGAGAGCCTGCTCAACGACGCGACCGCGCTGACCGCCTACAAG
GTGGCGCTCGGCCTGGCGATCGGCGGGTCGGCCAGTTGGACGGGCGGCCTCTGGACGTTCGCGCTGGCCGCGGTGGGCGG
CGTCGTCGGCGGCGGCGCGCTCGGCGCGGTGATCGTCTACGTGCGGTCGCGGCTGCGTGATCCGCTGGTCGAGAGCGCCC
TCGGTCTCGTCGCCCCGTTCGGGATCTACCTGCTCGCCGAGGAGGTGCACGGATCGGGGGTGCTCGCGGTGGTGGTGGCC
GCGCTGATCCTCGGGCAGCACTCGACCAACGCGAGTTACGCAACCCGGCTGCAGGACTCGGCGGTGTGGAAGGCCGTGCA
ATTGCTGCTGGAGTCGTTCGCGTTCCTGCTGATCGGCCTGCAGCTGCCGAAGGTCATCGAGGAACTCGCAGGCATTTCGG
CGGCGGTCCTCGTCGTCTCGTCGCTGGCGGTGCTGGCGACGGTGATCGCGGTGCGGATCGTGTGGGTGTACCTGTTCGCC
TACCTGCCCCGGCTGGTCTCGCCCGCGCTGCGTTACCGCGAACCCAGCCCGCGGCCCGCGCAGGTGTTCGTCGTCGCGTG
GGCCGGAATGCGGGGTGTGGTGTCGCTGGCGGCGGCGTTCGCGGTGCCGGCGACCACGCTGAGCGGCGCCGAGTTCCCGG
GCCGGCCGCAACTGGTGTTCCTCACCTTCGTCGTCGTGGTGGGCACCCTGCTGCTGCACGGGCTCACGCTGCCGTGGCTG
ATCAGGCGGCTCGGCGTGCAGGGCGACGAGGCCCACACCGATGCGGTCGCGGCCGCCGCCGCGCAGGACAGGGCGGCCAG
GGCGGCGGCCGAACGCCTCGACGAGTTGCTCGAACAGCAGCGCACCGACGGCACCGTCGACGACGTGCACGAGCGTGCGG
CCGAGGTGCTCCGCGGCTGGAACACCCGGCGGCGCAACTCCGCCTGGGAGCAGCTCGGCCGTGACGAGGCCGACATCGGC
GAGAGCCCGGCCGCGGCGTTCCGCCGGCTGCGGTTGGAGATGCTCGCCGCGGAGCGGGCGACGCTGATCGCCGAACGCGA
CAGCGGGCACATCGACGACGAGGTGCTGCGCTCGGTGCTCCACGGGCTCGACCTCGAGGAGGCGACGCTCAACCGGCGAT
AG

Upstream 100 bases:

>100_bases
GTCCGCCCGGTGGCCCGACGTGCTCTGCTGCGCATGGTGATCGAGGATACGGACGCCCGAGAGAAGTCCGAGAGAGAGAG
CTGAGAGGAGGACTCCGAGG

Downstream 100 bases:

>100_bases
CCCGACCCACCTCAGTCGCCGAGGTCGCGCCGGAAGGCGGCCATGGCATCGATCAGCGCGGTGAGCGTGCGGTGCGCGAC
GGCGATGTCGTCGTCGGGCA

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MSASLLAVLVVAVLLAAVARRADVSAPLALVVAGLAVGLIPGVPDIQLDPDLVLYVVLPPLLWSAGLESSYVALRRNVRS
IGMLAVGLPLATTFAVGVVAYWAVPELTIAAALTLGAIVAPPDAVSATAVGRRLGLPRRLMTLLGGESLLNDATALTAYK
VALGLAIGGSASWTGGLWTFALAAVGGVVGGGALGAVIVYVRSRLRDPLVESALGLVAPFGIYLLAEEVHGSGVLAVVVA
ALILGQHSTNASYATRLQDSAVWKAVQLLLESFAFLLIGLQLPKVIEELAGISAAVLVVSSLAVLATVIAVRIVWVYLFA
YLPRLVSPALRYREPSPRPAQVFVVAWAGMRGVVSLAAAFAVPATTLSGAEFPGRPQLVFLTFVVVVGTLLLHGLTLPWL
IRRLGVQGDEAHTDAVAAAAAQDRAARAAAERLDELLEQQRTDGTVDDVHERAAEVLRGWNTRRRNSAWEQLGRDEADIG
ESPAAAFRRLRLEMLAAERATLIAERDSGHIDDEVLRSVLHGLDLEEATLNRR

Sequences:

>Translated_533_residues
MSASLLAVLVVAVLLAAVARRADVSAPLALVVAGLAVGLIPGVPDIQLDPDLVLYVVLPPLLWSAGLESSYVALRRNVRS
IGMLAVGLPLATTFAVGVVAYWAVPELTIAAALTLGAIVAPPDAVSATAVGRRLGLPRRLMTLLGGESLLNDATALTAYK
VALGLAIGGSASWTGGLWTFALAAVGGVVGGGALGAVIVYVRSRLRDPLVESALGLVAPFGIYLLAEEVHGSGVLAVVVA
ALILGQHSTNASYATRLQDSAVWKAVQLLLESFAFLLIGLQLPKVIEELAGISAAVLVVSSLAVLATVIAVRIVWVYLFA
YLPRLVSPALRYREPSPRPAQVFVVAWAGMRGVVSLAAAFAVPATTLSGAEFPGRPQLVFLTFVVVVGTLLLHGLTLPWL
IRRLGVQGDEAHTDAVAAAAAQDRAARAAAERLDELLEQQRTDGTVDDVHERAAEVLRGWNTRRRNSAWEQLGRDEADIG
ESPAAAFRRLRLEMLAAERATLIAERDSGHIDDEVLRSVLHGLDLEEATLNRR
>Mature_532_residues
SASLLAVLVVAVLLAAVARRADVSAPLALVVAGLAVGLIPGVPDIQLDPDLVLYVVLPPLLWSAGLESSYVALRRNVRSI
GMLAVGLPLATTFAVGVVAYWAVPELTIAAALTLGAIVAPPDAVSATAVGRRLGLPRRLMTLLGGESLLNDATALTAYKV
ALGLAIGGSASWTGGLWTFALAAVGGVVGGGALGAVIVYVRSRLRDPLVESALGLVAPFGIYLLAEEVHGSGVLAVVVAA
LILGQHSTNASYATRLQDSAVWKAVQLLLESFAFLLIGLQLPKVIEELAGISAAVLVVSSLAVLATVIAVRIVWVYLFAY
LPRLVSPALRYREPSPRPAQVFVVAWAGMRGVVSLAAAFAVPATTLSGAEFPGRPQLVFLTFVVVVGTLLLHGLTLPWLI
RRLGVQGDEAHTDAVAAAAAQDRAARAAAERLDELLEQQRTDGTVDDVHERAAEVLRGWNTRRRNSAWEQLGRDEADIGE
SPAAAFRRLRLEMLAAERATLIAERDSGHIDDEVLRSVLHGLDLEEATLNRR

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI41872703, Length=469, Percent_Identity=22.6012793176972, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI15529998, Length=404, Percent_Identity=23.019801980198, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI110227626, Length=391, Percent_Identity=25.3196930946292, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI5454070, Length=391, Percent_Identity=25.3196930946292, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI294997330, Length=391, Percent_Identity=25.3196930946292, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI14211919, Length=385, Percent_Identity=24.6753246753247, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI27734935, Length=391, Percent_Identity=22.2506393861893, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI148727259, Length=396, Percent_Identity=20.959595959596, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI4759144, Length=384, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI194239733, Length=383, Percent_Identity=23.7597911227154, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790501, Length=555, Percent_Identity=28.6486486486486, Blast_Score=181, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI25147678, Length=429, Percent_Identity=22.8438228438228, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25150332, Length=391, Percent_Identity=23.2736572890026, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71980847, Length=387, Percent_Identity=24.031007751938, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71987537, Length=496, Percent_Identity=21.1693548387097, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71987535, Length=496, Percent_Identity=21.1693548387097, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71999819, Length=454, Percent_Identity=21.3656387665198, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71999817, Length=454, Percent_Identity=21.3656387665198, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71999821, Length=406, Percent_Identity=22.9064039408867, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71987559, Length=379, Percent_Identity=22.1635883905013, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71987545, Length=379, Percent_Identity=22.1635883905013, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71992101, Length=331, Percent_Identity=22.9607250755287, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71992107, Length=331, Percent_Identity=22.9607250755287, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71990932, Length=386, Percent_Identity=21.5025906735751, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=369, Percent_Identity=23.5772357723577, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221473212, Length=434, Percent_Identity=24.6543778801843, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI281364513, Length=416, Percent_Identity=25, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221473222, Length=416, Percent_Identity=25, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221473215, Length=458, Percent_Identity=24.235807860262, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI281360447, Length=495, Percent_Identity=20.6060606060606, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI221510734, Length=383, Percent_Identity=22.1932114882507, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221510738, Length=380, Percent_Identity=22.1052631578947, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221510732, Length=380, Percent_Identity=22.1052631578947, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24585580, Length=380, Percent_Identity=22.1052631578947, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24585578, Length=380, Percent_Identity=22.1052631578947, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221510736, Length=380, Percent_Identity=22.1052631578947, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221510740, Length=380, Percent_Identity=22.1052631578947, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 56052; Mature: 55921

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure 
SASLLAVLVVAVLLAAVARRADVSAPLALVVAGLAVGLIPGVPDIQLDPDLVLYVVLPP
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LLWSAGLESSYVALRRNVRSIGMLAVGLPLATTFAVGVVAYWAVPELTIAAALTLGAIVA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPDAVSATAVGRRLGLPRRLMTLLGGESLLNDATALTAYKVALGLAIGGSASWTGGLWTF
CCCHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ALAAVGGVVGGGALGAVIVYVRSRLRDPLVESALGLVAPFGIYLLAEEVHGSGVLAVVVA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ALILGQHSTNASYATRLQDSAVWKAVQLLLESFAFLLIGLQLPKVIEELAGISAAVLVVS
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
SLAVLATVIAVRIVWVYLFAYLPRLVSPALRYREPSPRPAQVFVVAWAGMRGVVSLAAAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHH
AVPATTLSGAEFPGRPQLVFLTFVVVVGTLLLHGLTLPWLIRRLGVQGDEAHTDAVAAAA
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHH
AQDRAARAAAERLDELLEQQRTDGTVDDVHERAAEVLRGWNTRRRNSAWEQLGRDEADIG
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHCCHHHHHHCCCCCCCC
ESPAAAFRRLRLEMLAAERATLIAERDSGHIDDEVLRSVLHGLDLEEATLNRR
CCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]