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The map label for this gene is fba [H]

Identifier: 108797483

GI number: 108797483

Start: 559172

End: 560209

Strand: Direct

Name: fba [H]

Synonym: Mmcs_0503

Alternate gene names: 108797483

Gene position: 559172-560209 (Clockwise)

Preceding gene: 108797482

Following gene: 108797485

Centisome position: 9.8

GC content: 65.22

Gene sequence:

>1038_bases
ATGCCGATCGCCACACCCGAGGTCTACGCCGAGATGCTCGACCGCGCCAAGAAGCACTCGTTCGCGTTCCCCGCCATCAA
CTGCACGTCGTCGGAGACCGTCAACGCCGCGATCAAGGGATTCGCCGACGCGGGCAGCGACGGAATCATCCAATTCTCCA
CCGGTGGAGCGGAATTCGCGTCCGGCCTGGGGGTGAAGGAGATGGTGACCGGCGCCGTCGCGCTGGCCGAGTTCGCGCAC
GTGATCGCCGAGAAGTACCCGATCACCGTCGCCCTGCACACCGACCACTGTCCGAAGGACAAACTCGACACCTACGTCCG
CCCACTGCTGGCCATCTCGGCCGACCGTGTCGCCGCCGGCGGCAACCCCCTGTTCCAGTCGCACATGTGGGACGGGTCGG
CCGTGCCGATCGACGAGAACCTGACGATCGCACAGGAGCTGCTCAAACAGGCCGCCGCCGCCAAGATCGTGCTGGAGGTC
GAGATCGGCGTGGTCGGCGGCGAAGAGGACGGTGTCGAGGCCGAGATCAACGACAAGCTCTACACCACCTCGGAGGACTT
CGAGAAGACCATCGACGCCCTCGGCGCGGGGGAGCACGGCCGGTACCTGCTGGCCGCGACGTTCGGCAACGTGCACGGCG
TGTACAAACCCGGCAACGTCAAACTCAAGCCCGAGGTGTTGGCGGAGGGCCAGAAGGTGGCCGCCGCGAAGCTCGGATTG
GATTCGGACGCACAGCCTTTCGACTTCGTGTTCCACGGCGGCTCGGGGTCGCTGAAGTCGGAGATCGAGGACTCCCTGCG
CTACGGCGTGGTCAAGATGAACGTCGACACCGACACCCAGTACGCGTTCACCCGCCCGATCGCCGCGCACATGTTCACCA
ACTACGACGGTGTGCTCAAGATCGACGGCGAAGTGGGCAACAAGAAGGTTTACGACCCGCGCAGCTATCTGAAGAAGGCC
GAGGCGGGGATGGCCGAGCGTGTCATCGAGGCCTGCCGGGATCTACACAGCGAGGGCCGCTCGGTCACCGCCGATTAG

Upstream 100 bases:

>100_bases
CGAGGCCGCCGAGGCCTACGCCGCGATGGACGAGGGCCGGGCCCGCTATCGCATGGTTCTCACCATGTGATCACGCCCCG
ATAGGGGGATACTTCGTCGT

Downstream 100 bases:

>100_bases
GGCGACGGCGCCTGGCAGATCTTCCACTGGTCGTCGCGGAACTCCAGGTCGAAGCTGCGGGTCGAGCGGGTCTGCGGCGC
ATAGGCCATGAAGGCGGTGA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MPIATPEVYAEMLDRAKKHSFAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFASGLGVKEMVTGAVALAEFAH
VIAEKYPITVALHTDHCPKDKLDTYVRPLLAISADRVAAGGNPLFQSHMWDGSAVPIDENLTIAQELLKQAAAAKIVLEV
EIGVVGGEEDGVEAEINDKLYTTSEDFEKTIDALGAGEHGRYLLAATFGNVHGVYKPGNVKLKPEVLAEGQKVAAAKLGL
DSDAQPFDFVFHGGSGSLKSEIEDSLRYGVVKMNVDTDTQYAFTRPIAAHMFTNYDGVLKIDGEVGNKKVYDPRSYLKKA
EAGMAERVIEACRDLHSEGRSVTAD

Sequences:

>Translated_345_residues
MPIATPEVYAEMLDRAKKHSFAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFASGLGVKEMVTGAVALAEFAH
VIAEKYPITVALHTDHCPKDKLDTYVRPLLAISADRVAAGGNPLFQSHMWDGSAVPIDENLTIAQELLKQAAAAKIVLEV
EIGVVGGEEDGVEAEINDKLYTTSEDFEKTIDALGAGEHGRYLLAATFGNVHGVYKPGNVKLKPEVLAEGQKVAAAKLGL
DSDAQPFDFVFHGGSGSLKSEIEDSLRYGVVKMNVDTDTQYAFTRPIAAHMFTNYDGVLKIDGEVGNKKVYDPRSYLKKA
EAGMAERVIEACRDLHSEGRSVTAD
>Mature_344_residues
PIATPEVYAEMLDRAKKHSFAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFASGLGVKEMVTGAVALAEFAHV
IAEKYPITVALHTDHCPKDKLDTYVRPLLAISADRVAAGGNPLFQSHMWDGSAVPIDENLTIAQELLKQAAAAKIVLEVE
IGVVGGEEDGVEAEINDKLYTTSEDFEKTIDALGAGEHGRYLLAATFGNVHGVYKPGNVKLKPEVLAEGQKVAAAKLGLD
SDAQPFDFVFHGGSGSLKSEIEDSLRYGVVKMNVDTDTQYAFTRPIAAHMFTNYDGVLKIDGEVGNKKVYDPRSYLKKAE
AGMAERVIEACRDLHSEGRSVTAD

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=351, Percent_Identity=39.8860398860399, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87082041, Length=331, Percent_Identity=24.4712990936556, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789526, Length=327, Percent_Identity=24.4648318042813, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322790, Length=338, Percent_Identity=38.1656804733728, Blast_Score=205, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 36870; Mature: 36739

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIATPEVYAEMLDRAKKHSFAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFA
CCCCCHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHH
SGLGVKEMVTGAVALAEFAHVIAEKYPITVALHTDHCPKDKLDTYVRPLLAISADRVAAG
HCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHCCC
GNPLFQSHMWDGSAVPIDENLTIAQELLKQAAAAKIVLEVEIGVVGGEEDGVEAEINDKL
CCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEEEEEECCCCCCCEEEECCCE
YTTSEDFEKTIDALGAGEHGRYLLAATFGNVHGVYKPGNVKLKPEVLAEGQKVAAAKLGL
EECHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCEEECHHHHHCCCCEEHHHCCC
DSDAQPFDFVFHGGSGSLKSEIEDSLRYGVVKMNVDTDTQYAFTRPIAAHMFTNYDGVLK
CCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCEEECCHHHHHHHCCCCCEEE
IDGEVGNKKVYDPRSYLKKAEAGMAERVIEACRDLHSEGRSVTAD
ECCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEECCC
>Mature Secondary Structure 
PIATPEVYAEMLDRAKKHSFAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFA
CCCCHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHH
SGLGVKEMVTGAVALAEFAHVIAEKYPITVALHTDHCPKDKLDTYVRPLLAISADRVAAG
HCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHCCC
GNPLFQSHMWDGSAVPIDENLTIAQELLKQAAAAKIVLEVEIGVVGGEEDGVEAEINDKL
CCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEEEEEECCCCCCCEEEECCCE
YTTSEDFEKTIDALGAGEHGRYLLAATFGNVHGVYKPGNVKLKPEVLAEGQKVAAAKLGL
EECHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCEEECHHHHHCCCCEEHHHCCC
DSDAQPFDFVFHGGSGSLKSEIEDSLRYGVVKMNVDTDTQYAFTRPIAAHMFTNYDGVLK
CCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCEEECCHHHHHHHCCCCCEEE
IDGEVGNKKVYDPRSYLKKAEAGMAERVIEACRDLHSEGRSVTAD
ECCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]