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The map label for this gene is nhaA1 [H]

Identifier: 108797466

GI number: 108797466

Start: 540794

End: 542635

Strand: Direct

Name: nhaA1 [H]

Synonym: Mmcs_0486

Alternate gene names: 108797466

Gene position: 540794-542635 (Clockwise)

Preceding gene: 108797465

Following gene: 108797468

Centisome position: 9.48

GC content: 68.62

Gene sequence:

>1842_bases
GTGACCGAGGCGTCCGCGCGCACCATCGGACCGCTGCCCAGCCGCTTCAGCCGGGACCCCAAGACCCCGCGGTCGACCGA
CAACGCCGCGGCCGCCCTGCTGCTGGCCTTCACCGTGCTGGCGATACTGTGGGCGAATTCGCCTTGGGCGCAGAGCTATT
CGATATTCTGGGATACCGATGTCGCGGTGAGCTTCGGTGAGTACCGCGCCGAGTTGTCGGTCAAACACCTCGTCAACGAC
GGCCTGATGGCGTTCTTCTTCTTCATCGTGGGACTGGAGGTCAAGAGCGAGTTCGTGATCGGCGAACTGACCGACCGGTC
GCGGGCAGCGGTGCCCGTCGTCGCGGCGATCGCCGGGCTGATCGTGCCCGCGGTCATCTTCCTCACCTTCAACCCCTCCG
GACCCGACGCCCAGGCGTGGGGTGTCGTCATCTCCACCGACACCGCCTTCCTCGTCGGCGCGTTGGCGGTGATCAAACCC
AAATTCCCCGCGCGCCTTCGGATCTTCCTGCTGACGCTGGCGGTCGTCGACGACGTCGGGGCGCTCGGCGCGATCGCGCT
GTTCTACACCGACGACCTGAAACTCGCGCCGCTGGCGGTCGCGGCGCTGCTCATCGCCGCGCTGGCCATGGTGCGCAGGC
TGCCGTCGCTGCGCGGACCGGCCTACGCCGTCCTGGGTTTCGCGCTGTGGATCGCGCTGTACCTCGCACACGTGCACCCG
ACGCTGGCCGGTGTGGCCGTGGCCGTGCTCATCCCGGTCTTCACCCCCGAGCGCCGACAGGTCGAACAGACCGTCGACCT
CGTCCGGGCGTTCCGCCAGTCACCGAACCCGCAGTACGCCCGGGCGGTGACACGCGGTCTGCGCGAGTCGATCTCGATCA
ACGAGCGGTTGCAGACCGCGGTCGGGCCCTATGTGTCGTTCGTGGTGCTGCCGATCTTCGCCCTCGCCAACGCCGGCGTG
CACCTCGACGAGCAGACCATCACCGCGGCGATGAGCTCGACGCTCACGTGGGGCATCGTGGCCGGACTGGTGGTCGGGAA
GTTCGTCGGGATCACCGCGGCCACCGCGCTGATGAGCGCCACCGGCTGGGGTCAGCTCGCGCCGGGGCTCTCGCTGCGGC
GGGTGGCCGGCGGTGCGGCGCTGTCCGGGATCGGTTTCACCATCTCGCTGTTCATCGTCGACGTCGCGATCGAGGACCCG
GCCCGCCAGGACGAGGCCCGCGTCGGCGTGCTGATCGCCTCGGTCCTGGCGTTCACGTTGAGCTGGGCGCTGTTTCGCAT
CACCGATTGGATCAGCCCACCCGAACCCGTCGGACTCACCCTCGTACGTCCGGTCGATCCGGAGCGCGACCACATCCGCG
GCGATCCGGACGCACCGCTGGTCCTCGTCGAGTACGGCGACTACGAATGCCCGTTCTGCGGCCGCGCGACCGGAGCGATC
GACGAGGTGCGCACCCACTTCGGCGACGACCTGCTCTACGTGTGGCGCCATTTCCCGCTGGAACGCGCGCACCCGCGGTC
GTTCGACGCCGCCCGCGCCAGCGAGGGCGCCGCAGCGCAGGGCAAGTTCTTCGAGATGGGCCGCGAGTTGTTCGCCCATC
AGGACGATCTGGAGTGGTCCGACATGTACCGCTACGCGGTCGCGATCGGCCTCGACATCGAGCAGTTCGACCAGGACGTG
CGCGTCCACGCCTCGAAGGTGCTGCACCGGGTGCGCGACGACGCCCAGGATGCGGAGGTGATGGACCTCAACTCCACACC
TACGTTCTTCGTCAACGGCAAGCGACACAAGGGGCCGTGGGATGCGGCCAGCCTGATCCGTGCGCTGGAGGCGGGGCGTT
AG

Upstream 100 bases:

>100_bases
GCGATCTGTCGGTGCAGCTCTCGGGATGGATGCTCATGGAGGCCGCGCACGCGGTGAGCGATCAGCCCGCGGAGTCCGCT
GATCCGGGGCCCGCCGAAAC

Downstream 100 bases:

>100_bases
CCGCCTCAACTCCAGAGCGTCACATGCACCTTCGGCTTGAAGCGGGTGACGCCGACACCGGTGCCGCGGATCATCGCCTG
TGTGCAGCGGGGAGTGGTGA

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1 [H]

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MTEASARTIGPLPSRFSRDPKTPRSTDNAAAALLLAFTVLAILWANSPWAQSYSIFWDTDVAVSFGEYRAELSVKHLVND
GLMAFFFFIVGLEVKSEFVIGELTDRSRAAVPVVAAIAGLIVPAVIFLTFNPSGPDAQAWGVVISTDTAFLVGALAVIKP
KFPARLRIFLLTLAVVDDVGALGAIALFYTDDLKLAPLAVAALLIAALAMVRRLPSLRGPAYAVLGFALWIALYLAHVHP
TLAGVAVAVLIPVFTPERRQVEQTVDLVRAFRQSPNPQYARAVTRGLRESISINERLQTAVGPYVSFVVLPIFALANAGV
HLDEQTITAAMSSTLTWGIVAGLVVGKFVGITAATALMSATGWGQLAPGLSLRRVAGGAALSGIGFTISLFIVDVAIEDP
ARQDEARVGVLIASVLAFTLSWALFRITDWISPPEPVGLTLVRPVDPERDHIRGDPDAPLVLVEYGDYECPFCGRATGAI
DEVRTHFGDDLLYVWRHFPLERAHPRSFDAARASEGAAAQGKFFEMGRELFAHQDDLEWSDMYRYAVAIGLDIEQFDQDV
RVHASKVLHRVRDDAQDAEVMDLNSTPTFFVNGKRHKGPWDAASLIRALEAGR

Sequences:

>Translated_613_residues
MTEASARTIGPLPSRFSRDPKTPRSTDNAAAALLLAFTVLAILWANSPWAQSYSIFWDTDVAVSFGEYRAELSVKHLVND
GLMAFFFFIVGLEVKSEFVIGELTDRSRAAVPVVAAIAGLIVPAVIFLTFNPSGPDAQAWGVVISTDTAFLVGALAVIKP
KFPARLRIFLLTLAVVDDVGALGAIALFYTDDLKLAPLAVAALLIAALAMVRRLPSLRGPAYAVLGFALWIALYLAHVHP
TLAGVAVAVLIPVFTPERRQVEQTVDLVRAFRQSPNPQYARAVTRGLRESISINERLQTAVGPYVSFVVLPIFALANAGV
HLDEQTITAAMSSTLTWGIVAGLVVGKFVGITAATALMSATGWGQLAPGLSLRRVAGGAALSGIGFTISLFIVDVAIEDP
ARQDEARVGVLIASVLAFTLSWALFRITDWISPPEPVGLTLVRPVDPERDHIRGDPDAPLVLVEYGDYECPFCGRATGAI
DEVRTHFGDDLLYVWRHFPLERAHPRSFDAARASEGAAAQGKFFEMGRELFAHQDDLEWSDMYRYAVAIGLDIEQFDQDV
RVHASKVLHRVRDDAQDAEVMDLNSTPTFFVNGKRHKGPWDAASLIRALEAGR
>Mature_612_residues
TEASARTIGPLPSRFSRDPKTPRSTDNAAAALLLAFTVLAILWANSPWAQSYSIFWDTDVAVSFGEYRAELSVKHLVNDG
LMAFFFFIVGLEVKSEFVIGELTDRSRAAVPVVAAIAGLIVPAVIFLTFNPSGPDAQAWGVVISTDTAFLVGALAVIKPK
FPARLRIFLLTLAVVDDVGALGAIALFYTDDLKLAPLAVAALLIAALAMVRRLPSLRGPAYAVLGFALWIALYLAHVHPT
LAGVAVAVLIPVFTPERRQVEQTVDLVRAFRQSPNPQYARAVTRGLRESISINERLQTAVGPYVSFVVLPIFALANAGVH
LDEQTITAAMSSTLTWGIVAGLVVGKFVGITAATALMSATGWGQLAPGLSLRRVAGGAALSGIGFTISLFIVDVAIEDPA
RQDEARVGVLIASVLAFTLSWALFRITDWISPPEPVGLTLVRPVDPERDHIRGDPDAPLVLVEYGDYECPFCGRATGAID
EVRTHFGDDLLYVWRHFPLERAHPRSFDAARASEGAAAQGKFFEMGRELFAHQDDLEWSDMYRYAVAIGLDIEQFDQDVR
VHASKVLHRVRDDAQDAEVMDLNSTPTFFVNGKRHKGPWDAASLIRALEAGR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=386, Percent_Identity=36.5284974093264, Blast_Score=203, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001853
- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01323 DSBA; PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 66435; Mature: 66304

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEASARTIGPLPSRFSRDPKTPRSTDNAAAALLLAFTVLAILWANSPWAQSYSIFWDTD
CCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
VAVSFGEYRAELSVKHLVNDGLMAFFFFIVGLEVKSEFVIGELTDRSRAAVPVVAAIAGL
CEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH
IVPAVIFLTFNPSGPDAQAWGVVISTDTAFLVGALAVIKPKFPARLRIFLLTLAVVDDVG
HHHHHHEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
ALGAIALFYTDDLKLAPLAVAALLIAALAMVRRLPSLRGPAYAVLGFALWIALYLAHVHP
HHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
TLAGVAVAVLIPVFTPERRQVEQTVDLVRAFRQSPNPQYARAVTRGLRESISINERLQTA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHH
VGPYVSFVVLPIFALANAGVHLDEQTITAAMSSTLTWGIVAGLVVGKFVGITAATALMSA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGWGQLAPGLSLRRVAGGAALSGIGFTISLFIVDVAIEDPARQDEARVGVLIASVLAFTL
CCCCCCCCCCHHHHHCCCCHHHCCCCEEEEEEEEEHCCCCCCCHHHHHHHHHHHHHHHHH
SWALFRITDWISPPEPVGLTLVRPVDPERDHIRGDPDAPLVLVEYGDYECPFCGRATGAI
HHHHHHHHHCCCCCCCCCEEEECCCCCCHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCH
DEVRTHFGDDLLYVWRHFPLERAHPRSFDAARASEGAAAQGKFFEMGRELFAHQDDLEWS
HHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHH
DMYRYAVAIGLDIEQFDQDVRVHASKVLHRVRDDAQDAEVMDLNSTPTFFVNGKRHKGPW
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCCCCCC
DAASLIRALEAGR
HHHHHHHHHHCCC
>Mature Secondary Structure 
TEASARTIGPLPSRFSRDPKTPRSTDNAAAALLLAFTVLAILWANSPWAQSYSIFWDTD
CCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
VAVSFGEYRAELSVKHLVNDGLMAFFFFIVGLEVKSEFVIGELTDRSRAAVPVVAAIAGL
CEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH
IVPAVIFLTFNPSGPDAQAWGVVISTDTAFLVGALAVIKPKFPARLRIFLLTLAVVDDVG
HHHHHHEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
ALGAIALFYTDDLKLAPLAVAALLIAALAMVRRLPSLRGPAYAVLGFALWIALYLAHVHP
HHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
TLAGVAVAVLIPVFTPERRQVEQTVDLVRAFRQSPNPQYARAVTRGLRESISINERLQTA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHH
VGPYVSFVVLPIFALANAGVHLDEQTITAAMSSTLTWGIVAGLVVGKFVGITAATALMSA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGWGQLAPGLSLRRVAGGAALSGIGFTISLFIVDVAIEDPARQDEARVGVLIASVLAFTL
CCCCCCCCCCHHHHHCCCCHHHCCCCEEEEEEEEEHCCCCCCCHHHHHHHHHHHHHHHHH
SWALFRITDWISPPEPVGLTLVRPVDPERDHIRGDPDAPLVLVEYGDYECPFCGRATGAI
HHHHHHHHHCCCCCCCCCEEEECCCCCCHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCH
DEVRTHFGDDLLYVWRHFPLERAHPRSFDAARASEGAAAQGKFFEMGRELFAHQDDLEWS
HHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHH
DMYRYAVAIGLDIEQFDQDVRVHASKVLHRVRDDAQDAEVMDLNSTPTFFVNGKRHKGPW
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCCCCCC
DAASLIRALEAGR
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA