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The map label for this gene is qacA [H]

Identifier: 108797463

GI number: 108797463

Start: 537426

End: 539003

Strand: Reverse

Name: qacA [H]

Synonym: Mmcs_0483

Alternate gene names: 108797463

Gene position: 539003-537426 (Counterclockwise)

Preceding gene: 108797464

Following gene: 108797457

Centisome position: 9.45

GC content: 70.85

Gene sequence:

>1578_bases
ATGACCCGCCGCTGGCTCGCCCTGAGCGTGCTCACCCTGGCGGTCCTCGTCATCGGCATCGACGGCACCGTGCTGGCGCT
GGCGACACCGTTCATCAGCAGCGACCTGCACACCTCCGCCACCGAACTGCTGTGGATCGGCGACATCTACTCGTTCGTGC
TCGCCAGCCTGCTGATCACGATGGGCAGTCTCGGTGACCGCATCGGCCACCGCAGGCTCCTGCTCTGTGGGGCAACGCTT
TTCGCCGCCGTCTCCGTCGTCACCGCCTACGCCCCCACCGCAGAGGCGCTGATCGGCGCCCGCGCACTGCTCGGCGTCGC
AGGCGCGACACTGGCCCCGGCCACCCTCGCGCTGATCCGCGGGATCTTCGCCGACGCCCGGCAGCGCTCCATGGCCGTCG
GTATCTGGGCGGCGGCGTTCTCCGCGGGCGCCGCACTCGGCCCCATGGTGGGCGGTGTTCTGCTCGAACACTTCTGGTGG
GGTTCGGTGTTCCTCATCAACGCACCCGTGATGGCCGTGCTGGTGATCGGTGGGCTCACCCTGCTGCCCGAACATCGCAA
TCCCGAACCGGGCCCGTGGGATCTGCCCAGCGTCGGGTTGTCGATGCTCGGCATCCTGAGCGTGGTCTACGCGATCAAGG
AGACCGCGGCACACGGTCCGCGGCTCAGCGCCCTGGCGACCGCGGTGGTCGGCGTCTCCGCACTGACGGTGTTCGTCCGC
AGGCAGCTGCGGCTGCCCAGCCCGCTCATCGACGTCCGGCTGTTCGGCAACCGGGCGTTCTCGGGTGTGGTCGGGGCGAA
TCTGCTGTCCGTGCTGGGCCTTTCGGGGCTGGTGTTCTTCCTCTCGCAGTACTTCCAGCTGGTGCAGGGGTACAGCCCGC
TGGGCGCCGGACTGGCCGAGCTCCCCGCGGCGGTCACCGCGACGGTGTTCGGTGTGCTGGCCGGGTTCGCGGTACGCCGC
TGGACTCAGCGCGCCGTGCTCACCACCGGGCTCGCCCTGGTCGGTGTCGCGATGGCCACGCTCACCACGATCCACCCGAC
GTCACCGTATCCGCACCTCGGCATCGCGCTGTTCGTCGTCGGTGTCGGACTGGGGCTGGCGTTCACCGTGGCCAGCGACG
TCATCCTGGCCAGCGTTCCCCGCGAACGCGCCGGGGCGGCGGCCGCCGTCTCGGAGACCGCCTACGAACTCGGGATGGCG
CTGGGCATCGCCGTCGTCGGTTCGATTCTCACCGGGGTGTACCGCACCCTCGTCGTGCCGCCGGGCCTTTCGCCCGCCGC
GGCGACGCAGGCCCGCGATTCGCTGGCCGCCGCCACCGACGTCGCCGCCGGACTGCCGCCCGCCCAGGCCGGCGCACTGC
TCGACGCGGCGCGCGAATCCTTCAGCAGCGGACTGGCGGTCGCCTCCGGTGTCGGCGCGGCGCTGATGCTGACCTCGGCG
GTGACGGTGTGGGTGCTGCTGCGTGAGCGGCTACCACGCCTTGCCGAGGTCGGCGTGCTGAACGATCCAGGTGTGCATGG
CGATGCCGGCGGCGACGGCCGCGTTGATACTGCGTGTGGAGCCGAACGCGGCAATTGA

Upstream 100 bases:

>100_bases
TGGTCGCCGGCGCGGGCTGGTGTATCCAGGTCGGCCGCGCGGCCGGCCGCGACTTCGAACGCATGATCTCCGAACTACTG
CTGAGTGGAGTGCAGAACTC

Downstream 100 bases:

>100_bases
GACCGTCAGCCGTGCACCGGTTTTCGCGTCTTCGGTGATCCCGGGCCCCTCCTGCCCGAAGATCAGCAGACACTCGCGCG
GCAGATCGGTGTGTTCCAGC

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MTRRWLALSVLTLAVLVIGIDGTVLALATPFISSDLHTSATELLWIGDIYSFVLASLLITMGSLGDRIGHRRLLLCGATL
FAAVSVVTAYAPTAEALIGARALLGVAGATLAPATLALIRGIFADARQRSMAVGIWAAAFSAGAALGPMVGGVLLEHFWW
GSVFLINAPVMAVLVIGGLTLLPEHRNPEPGPWDLPSVGLSMLGILSVVYAIKETAAHGPRLSALATAVVGVSALTVFVR
RQLRLPSPLIDVRLFGNRAFSGVVGANLLSVLGLSGLVFFLSQYFQLVQGYSPLGAGLAELPAAVTATVFGVLAGFAVRR
WTQRAVLTTGLALVGVAMATLTTIHPTSPYPHLGIALFVVGVGLGLAFTVASDVILASVPRERAGAAAAVSETAYELGMA
LGIAVVGSILTGVYRTLVVPPGLSPAAATQARDSLAAATDVAAGLPPAQAGALLDAARESFSSGLAVASGVGAALMLTSA
VTVWVLLRERLPRLAEVGVLNDPGVHGDAGGDGRVDTACGAERGN

Sequences:

>Translated_525_residues
MTRRWLALSVLTLAVLVIGIDGTVLALATPFISSDLHTSATELLWIGDIYSFVLASLLITMGSLGDRIGHRRLLLCGATL
FAAVSVVTAYAPTAEALIGARALLGVAGATLAPATLALIRGIFADARQRSMAVGIWAAAFSAGAALGPMVGGVLLEHFWW
GSVFLINAPVMAVLVIGGLTLLPEHRNPEPGPWDLPSVGLSMLGILSVVYAIKETAAHGPRLSALATAVVGVSALTVFVR
RQLRLPSPLIDVRLFGNRAFSGVVGANLLSVLGLSGLVFFLSQYFQLVQGYSPLGAGLAELPAAVTATVFGVLAGFAVRR
WTQRAVLTTGLALVGVAMATLTTIHPTSPYPHLGIALFVVGVGLGLAFTVASDVILASVPRERAGAAAAVSETAYELGMA
LGIAVVGSILTGVYRTLVVPPGLSPAAATQARDSLAAATDVAAGLPPAQAGALLDAARESFSSGLAVASGVGAALMLTSA
VTVWVLLRERLPRLAEVGVLNDPGVHGDAGGDGRVDTACGAERGN
>Mature_524_residues
TRRWLALSVLTLAVLVIGIDGTVLALATPFISSDLHTSATELLWIGDIYSFVLASLLITMGSLGDRIGHRRLLLCGATLF
AAVSVVTAYAPTAEALIGARALLGVAGATLAPATLALIRGIFADARQRSMAVGIWAAAFSAGAALGPMVGGVLLEHFWWG
SVFLINAPVMAVLVIGGLTLLPEHRNPEPGPWDLPSVGLSMLGILSVVYAIKETAAHGPRLSALATAVVGVSALTVFVRR
QLRLPSPLIDVRLFGNRAFSGVVGANLLSVLGLSGLVFFLSQYFQLVQGYSPLGAGLAELPAAVTATVFGVLAGFAVRRW
TQRAVLTTGLALVGVAMATLTTIHPTSPYPHLGIALFVVGVGLGLAFTVASDVILASVPRERAGAAAAVSETAYELGMAL
GIAVVGSILTGVYRTLVVPPGLSPAAATQARDSLAAATDVAAGLPPAQAGALLDAARESFSSGLAVASGVGAALMLTSAV
TVWVLLRERLPRLAEVGVLNDPGVHGDAGGDGRVDTACGAERGN

Specific function: Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=416, Percent_Identity=28.8461538461538, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1790195, Length=406, Percent_Identity=28.0788177339901, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788710, Length=393, Percent_Identity=24.9363867684478, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1789042, Length=408, Percent_Identity=23.7745098039216, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1788392, Length=416, Percent_Identity=26.6826923076923, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324954, Length=393, Percent_Identity=22.3918575063613, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53528; Mature: 53397

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRWLALSVLTLAVLVIGIDGTVLALATPFISSDLHTSATELLWIGDIYSFVLASLLIT
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
MGSLGDRIGHRRLLLCGATLFAAVSVVTAYAPTAEALIGARALLGVAGATLAPATLALIR
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
GIFADARQRSMAVGIWAAAFSAGAALGPMVGGVLLEHFWWGSVFLINAPVMAVLVIGGLT
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCHH
LLPEHRNPEPGPWDLPSVGLSMLGILSVVYAIKETAAHGPRLSALATAVVGVSALTVFVR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
RQLRLPSPLIDVRLFGNRAFSGVVGANLLSVLGLSGLVFFLSQYFQLVQGYSPLGAGLAE
HHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LPAAVTATVFGVLAGFAVRRWTQRAVLTTGLALVGVAMATLTTIHPTSPYPHLGIALFVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
GVGLGLAFTVASDVILASVPRERAGAAAAVSETAYELGMALGIAVVGSILTGVYRTLVVP
HHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGLSPAAATQARDSLAAATDVAAGLPPAQAGALLDAARESFSSGLAVASGVGAALMLTSA
CCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VTVWVLLRERLPRLAEVGVLNDPGVHGDAGGDGRVDTACGAERGN
HHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRRWLALSVLTLAVLVIGIDGTVLALATPFISSDLHTSATELLWIGDIYSFVLASLLIT
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
MGSLGDRIGHRRLLLCGATLFAAVSVVTAYAPTAEALIGARALLGVAGATLAPATLALIR
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
GIFADARQRSMAVGIWAAAFSAGAALGPMVGGVLLEHFWWGSVFLINAPVMAVLVIGGLT
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCHH
LLPEHRNPEPGPWDLPSVGLSMLGILSVVYAIKETAAHGPRLSALATAVVGVSALTVFVR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
RQLRLPSPLIDVRLFGNRAFSGVVGANLLSVLGLSGLVFFLSQYFQLVQGYSPLGAGLAE
HHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LPAAVTATVFGVLAGFAVRRWTQRAVLTTGLALVGVAMATLTTIHPTSPYPHLGIALFVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
GVGLGLAFTVASDVILASVPRERAGAAAAVSETAYELGMALGIAVVGSILTGVYRTLVVP
HHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGLSPAAATQARDSLAAATDVAAGLPPAQAGALLDAARESFSSGLAVASGVGAALMLTSA
CCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VTVWVLLRERLPRLAEVGVLNDPGVHGDAGGDGRVDTACGAERGN
HHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]