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The map label for this gene is zwf [H]

Identifier: 108797439

GI number: 108797439

Start: 512159

End: 513574

Strand: Reverse

Name: zwf [H]

Synonym: Mmcs_0459

Alternate gene names: 108797439

Gene position: 513574-512159 (Counterclockwise)

Preceding gene: 108797440

Following gene: 108797436

Centisome position: 9.0

GC content: 68.29

Gene sequence:

>1416_bases
GTGAGCGAACAGCGTCCTGCCCCACACATTTTCGTGCTGTTCGGCGCGACCGGCGATCTGGCGAAACGCAAACTGTTCCC
CGGTCTGTACCGGCTGGCCGCGGCGGGACGCCTGCCGGAGGAGTACGCGATCATCGGATCGGGCCGCCACTCCCCGGGCG
GCGACGACGAGTTCCGCGACAGCGTGGGCGACGGGTTGCGCGACTCGGTCGACGACATCGACGATCGCGTGCTGTCAAAC
CTGTTGCAAAGCTTGTCTTTTCAGACCTCCGACAGTGACGACGGCAGCGACCTCGCCGAGGCCGTCCGCTCCGCCCGGAC
GCGACTCGGCGACGGCGCCCAGACGTTGATCTACCTGTCGGTCCCACCCAGGGCGATGCAGCCCATGATCGGGATGCTGG
GCCGTGAGGGGCTCGCCGAGGGTGCACGGGTGGTCGTCGAGAAACCCTTCGGCACCGACCTGGACACCGCGCGCGAACTC
GACGCGACGCTCAAGGACGTCGTCGACGAGGATCAGGTCTACCGCATCGACCACTTCATCGGGAAGGAGGCGGTGCAGAA
CATCCTGGCGGTGCGGTTCGCCAACGGCCTGATCGAACCCGCCTGGCACCGCAACCACCTCGTGTCGGTGCAGATCGACG
TCCCCGAAGAACTCACGATCGAGGGCCGCGGCAGCTTCTACGAGTCGACGGGCTGTTTCCGCGACATGATCTCCACGCAT
CTGTGCCAGGTGCTGGGGTTCGTCGCGATGGAGCCGCCCGTCCACCTCGATCCGGTGTCGCTGCGCAACGAGAAGGCCAA
GGTCTTCGAGGCCATGCGACCGCTGGATCCCGACCGCGTGGTGTTCGGTCAGTACGACGGATACCGCGAGGAGGAGGGCG
TCGCCGACGATTCGCAGGTCGAGACGTTCGTCGCGCTCGAGGCGTTCATCGACACCGAGCGGTGGCAGGGCGTGCCGTTC
TACCTGCGCACCGGCAAGGCGCTCGGGGCCACCCGACGCACCGTCACGCTGACCTTCCGCAGCCCGCCGATGGCGCTGTT
CGGCGCCGACGACAACGAGCACTCCCCCAACCAACTGGTCCTGGAACTGACCGACTCACCGGAGTTCCAGGTCCGGCTGC
TGGCCAAACGACCCGGCCCCGACCTCGGGCTGATGCCGCTCGACCTCAGTCTCGGCGTGGCCGACGAGGATTCCGACGAC
ACCCCGCTCGAGGCCTACGAGCGGTTGCTGCTCGACGTGATGCGCGGGGACCAGACCCTGTTCACCCGCGCCGACGAGGT
GGACCGGCTGTGGCAGGTGTGCCAGCCGGTGCTCGACGCACCGCCACCGGCGCTCACCTACGCTTCCGGCTCGTGGGGTC
CGCAGGAAGCGCTGGCCCTGCCCGGCGCGGCGGGGTGGCGGCTGCCGGATGCGTGA

Upstream 100 bases:

>100_bases
ACCCAGCGCGGCATGTTCGTCTCCGTCGAACGGGTGCAGACTTTCTGACTTGTCGGTCACACCGGTTTGAAGACATGCGG
CCGCCGGGCATGTTGCACCA

Downstream 100 bases:

>100_bases
GCCGGTGTCAGTCGAGCGCGACCTCGACCACCGGTAGCTCGGTGCCCGGCGGCTCGACCCGGCCGCCGAGGTTCCGCTCG
AGGACTCCTCTCAGAGCGCG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSEQRPAPHIFVLFGATGDLAKRKLFPGLYRLAAAGRLPEEYAIIGSGRHSPGGDDEFRDSVGDGLRDSVDDIDDRVLSN
LLQSLSFQTSDSDDGSDLAEAVRSARTRLGDGAQTLIYLSVPPRAMQPMIGMLGREGLAEGARVVVEKPFGTDLDTAREL
DATLKDVVDEDQVYRIDHFIGKEAVQNILAVRFANGLIEPAWHRNHLVSVQIDVPEELTIEGRGSFYESTGCFRDMISTH
LCQVLGFVAMEPPVHLDPVSLRNEKAKVFEAMRPLDPDRVVFGQYDGYREEEGVADDSQVETFVALEAFIDTERWQGVPF
YLRTGKALGATRRTVTLTFRSPPMALFGADDNEHSPNQLVLELTDSPEFQVRLLAKRPGPDLGLMPLDLSLGVADEDSDD
TPLEAYERLLLDVMRGDQTLFTRADEVDRLWQVCQPVLDAPPPALTYASGSWGPQEALALPGAAGWRLPDA

Sequences:

>Translated_471_residues
MSEQRPAPHIFVLFGATGDLAKRKLFPGLYRLAAAGRLPEEYAIIGSGRHSPGGDDEFRDSVGDGLRDSVDDIDDRVLSN
LLQSLSFQTSDSDDGSDLAEAVRSARTRLGDGAQTLIYLSVPPRAMQPMIGMLGREGLAEGARVVVEKPFGTDLDTAREL
DATLKDVVDEDQVYRIDHFIGKEAVQNILAVRFANGLIEPAWHRNHLVSVQIDVPEELTIEGRGSFYESTGCFRDMISTH
LCQVLGFVAMEPPVHLDPVSLRNEKAKVFEAMRPLDPDRVVFGQYDGYREEEGVADDSQVETFVALEAFIDTERWQGVPF
YLRTGKALGATRRTVTLTFRSPPMALFGADDNEHSPNQLVLELTDSPEFQVRLLAKRPGPDLGLMPLDLSLGVADEDSDD
TPLEAYERLLLDVMRGDQTLFTRADEVDRLWQVCQPVLDAPPPALTYASGSWGPQEALALPGAAGWRLPDA
>Mature_470_residues
SEQRPAPHIFVLFGATGDLAKRKLFPGLYRLAAAGRLPEEYAIIGSGRHSPGGDDEFRDSVGDGLRDSVDDIDDRVLSNL
LQSLSFQTSDSDDGSDLAEAVRSARTRLGDGAQTLIYLSVPPRAMQPMIGMLGREGLAEGARVVVEKPFGTDLDTARELD
ATLKDVVDEDQVYRIDHFIGKEAVQNILAVRFANGLIEPAWHRNHLVSVQIDVPEELTIEGRGSFYESTGCFRDMISTHL
CQVLGFVAMEPPVHLDPVSLRNEKAKVFEAMRPLDPDRVVFGQYDGYREEEGVADDSQVETFVALEAFIDTERWQGVPFY
LRTGKALGATRRTVTLTFRSPPMALFGADDNEHSPNQLVLELTDSPEFQVRLLAKRPGPDLGLMPLDLSLGVADEDSDDT
PLEAYERLLLDVMRGDQTLFTRADEVDRLWQVCQPVLDAPPPALTYASGSWGPQEALALPGAAGWRLPDA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=482, Percent_Identity=31.9502074688797, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI109389365, Length=482, Percent_Identity=31.9502074688797, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI52145310, Length=467, Percent_Identity=30.1927194860814, Blast_Score=172, Evalue=5e-43,
Organism=Escherichia coli, GI1788158, Length=480, Percent_Identity=38.75, Blast_Score=294, Evalue=9e-81,
Organism=Caenorhabditis elegans, GI17538218, Length=483, Percent_Identity=32.2981366459627, Blast_Score=270, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6324088, Length=466, Percent_Identity=34.9785407725322, Blast_Score=275, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24643352, Length=482, Percent_Identity=31.9502074688797, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24643350, Length=482, Percent_Identity=31.9502074688797, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI221513548, Length=479, Percent_Identity=30.4801670146138, Blast_Score=200, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 51863; Mature: 51732

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQRPAPHIFVLFGATGDLAKRKLFPGLYRLAAAGRLPEEYAIIGSGRHSPGGDDEFRD
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHH
SVGDGLRDSVDDIDDRVLSNLLQSLSFQTSDSDDGSDLAEAVRSARTRLGDGAQTLIYLS
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
VPPRAMQPMIGMLGREGLAEGARVVVEKPFGTDLDTARELDATLKDVVDEDQVYRIDHFI
CCCHHHHHHHHHHCCHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHH
GKEAVQNILAVRFANGLIEPAWHRNHLVSVQIDVPEELTIEGRGSFYESTGCFRDMISTH
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHH
LCQVLGFVAMEPPVHLDPVSLRNEKAKVFEAMRPLDPDRVVFGQYDGYREEEGVADDSQV
HHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHH
ETFVALEAFIDTERWQGVPFYLRTGKALGATRRTVTLTFRSPPMALFGADDNEHSPNQLV
HHHHHHHHHHHHHHCCCCCEEEECCCHHCCCCEEEEEEECCCCEEEEECCCCCCCCCEEE
LELTDSPEFQVRLLAKRPGPDLGLMPLDLSLGVADEDSDDTPLEAYERLLLDVMRGDQTL
EEECCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHH
FTRADEVDRLWQVCQPVLDAPPPALTYASGSWGPQEALALPGAAGWRLPDA
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SEQRPAPHIFVLFGATGDLAKRKLFPGLYRLAAAGRLPEEYAIIGSGRHSPGGDDEFRD
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHH
SVGDGLRDSVDDIDDRVLSNLLQSLSFQTSDSDDGSDLAEAVRSARTRLGDGAQTLIYLS
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
VPPRAMQPMIGMLGREGLAEGARVVVEKPFGTDLDTARELDATLKDVVDEDQVYRIDHFI
CCCHHHHHHHHHHCCHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHH
GKEAVQNILAVRFANGLIEPAWHRNHLVSVQIDVPEELTIEGRGSFYESTGCFRDMISTH
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHH
LCQVLGFVAMEPPVHLDPVSLRNEKAKVFEAMRPLDPDRVVFGQYDGYREEEGVADDSQV
HHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHH
ETFVALEAFIDTERWQGVPFYLRTGKALGATRRTVTLTFRSPPMALFGADDNEHSPNQLV
HHHHHHHHHHHHHHCCCCCEEEECCCHHCCCCEEEEEEECCCCEEEEECCCCCCCCCEEE
LELTDSPEFQVRLLAKRPGPDLGLMPLDLSLGVADEDSDDTPLEAYERLLLDVMRGDQTL
EEECCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHH
FTRADEVDRLWQVCQPVLDAPPPALTYASGSWGPQEALALPGAAGWRLPDA
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]