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The map label for this gene is iniA [H]

Identifier: 108797427

GI number: 108797427

Start: 500092

End: 501951

Strand: Direct

Name: iniA [H]

Synonym: Mmcs_0447

Alternate gene names: 108797427

Gene position: 500092-501951 (Clockwise)

Preceding gene: 108797426

Following gene: 108797428

Centisome position: 8.77

GC content: 68.71

Gene sequence:

>1860_bases
ATGACCCGACCGAACGGCCCCCGCAACGTGGCCGATACGCGCAAGGTGGTCACCGAGCTCATCGAGCACACCACCAAGAT
CGCCGAGGCGCAGGACCGCGGCGACCTGGTGGCGCGGCTGGCGCGCGCCCGCACCCGCATCGGTGACCCGCAGATCCGGG
TGGTGATCGCCGGGCAGCTCAAACAGGGCAAGAGCCTGCTGCTCAATTCACTGCTCAACATGCCGGTGGCCCGGGTCGGC
GACGACGAGTCGACGGTCCTGGCCACCGTCGTGTCGTATGCCGAACAGCCGTCGGCGCGGCTGGTGGTGGCCCGTCCCGA
CGGCGAGGAACCCGAACTCGTCGAGATCCCGACCACCGACCTCGGCAAGGATCTGCGCCGCGCACCGCAGGCCGACGGCC
GGGAGGTGCTGCGCGTGGAGGTGACGGTGCCCAGCCCGCTGCTCAAGGGCGGTCTGGCGTTCGTCGACACCCCGGGTGTG
GGCGGCCACGGCCAACCACACCTCTCGGCGACGCTGGGGCTGCTGCCCGACGCCGACGCCATGCTGATGATCAGCGACAC
CAGCCAGGAGTTCACCGAGCCGGAGATGACCTTCATCCGCCAGGCGCTGGAGATCTGCCCGGTCGCCGCGATCGTCGCGA
CCAAGACCGACCTGTATCCGCACTGGCGTCAGGTCGTCGACGCCAACGCCGGCCACCTGCACCGGGCGGGCATCACGACC
CCCTTGATCCCCGCGTCGTCGACGTTGCGCAGCCACGCCGTCCAACTCAACGACAAGGAACTCAACGAGGAGTCCAACTT
CCCGGCGATCGTGAAGTTCCTGTCCGAACAGGTGCTCGCCCGCAACACCGACCGCGTCCGCGATCAGGTGGTCAACGAGA
TCCGCGCCGCCGCCGAACACCTCTCGATGGCCGTGCAGTCGGAGCTGTCCGCACTCGACGATCCGGCGGCCGGCGGCACC
CTGACCGCCGACCTGGAGCGGCGCAAGAAGGAGGCGGAGGAGGCGCTGCAGCAGACCGCGCTGTGGCAGCAGGTGCTCAA
CGACGGCATCGCCGACCTGACCGCCGACGTCGACCACGACCTGCGGCAGCGTTTCCGCAACATCACCTTCCACACCGAGC
GGGTCATCGACGCAGGCGACCCGACATTGCACTGGGCCGAGATCGGTGCGGAACTCGAGGAGTCCGTGGCGACCGCCGTC
GGCGACAACTTCGTCTGGGCCTACCAGCGGGCCGAGGCGTTGGCCGCCGAGGTCGCCCGCACGTTCATGGAGGCCGGGTT
GGACGCAGTGCGGATGCCCGCGATCGACGCCCGCGAGATGGGGGCGGAGTTCGGCGAGTTCCGGTCGCTGGCCCACCTGG
AGGCCAAACCGCTCAAGATCGGCCACAAGATCGTCACCGGGATGCGCGGCTCCTACGGCGGTGTGCTGATGTTCGGCATG
CTGACGTCGTTCGCCGGGCTCGGCATGTTCAACCCGCTGTCGCTCGGTGCCGGCTTCGTCCTCGGCCGCAAGGCCTACAA
GGAGGACATGGAGAACCGGATGCTGCGGGTGCGCAGCGAGGCGAAGACCAACGTGCGCCGATTCGTCGACGACGTCGCAT
TCGTGGTGGGCAAGGAATCGCGCGACCGGCTCAAGGGCATCCAGCGTCAACTGCGCGACCACTACCGCGAGATCGCCAAC
CAGACGACCCGCTCACTCAACGAATCGCTGCAGGCCACGATCGCCGCGGCCAGGCTGGCGGAGTCCGAACGCAACGCCCG
CACCAAGGAACTGCAACGGCAACTCAACATCCTGCGTCAGGTCATCGAGCACGCCGAGAAACTCGGCACGCCGACCGCGG
CACCGGTCGCCGCGCCCTGA

Upstream 100 bases:

>100_bases
TCTGACCGACAACCGGATGACGCAGCTGGCGGGGACCGACATGGTCCCCGCCAGTTTGCGCGCCTACCGTGTGAACAACT
CCGCGTGAGAGAAGGGCGTC

Downstream 100 bases:

>100_bases
CCGGCGGACCGGGTCTGGCAAGCTCGTAGCGTCAGCGAGTCGGGTAACTGGAACGGACTGGGCAAACCCTGAGCACAAGC
GACCAAGTGCGCGCGATCCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MTRPNGPRNVADTRKVVTELIEHTTKIAEAQDRGDLVARLARARTRIGDPQIRVVIAGQLKQGKSLLLNSLLNMPVARVG
DDESTVLATVVSYAEQPSARLVVARPDGEEPELVEIPTTDLGKDLRRAPQADGREVLRVEVTVPSPLLKGGLAFVDTPGV
GGHGQPHLSATLGLLPDADAMLMISDTSQEFTEPEMTFIRQALEICPVAAIVATKTDLYPHWRQVVDANAGHLHRAGITT
PLIPASSTLRSHAVQLNDKELNEESNFPAIVKFLSEQVLARNTDRVRDQVVNEIRAAAEHLSMAVQSELSALDDPAAGGT
LTADLERRKKEAEEALQQTALWQQVLNDGIADLTADVDHDLRQRFRNITFHTERVIDAGDPTLHWAEIGAELEESVATAV
GDNFVWAYQRAEALAAEVARTFMEAGLDAVRMPAIDAREMGAEFGEFRSLAHLEAKPLKIGHKIVTGMRGSYGGVLMFGM
LTSFAGLGMFNPLSLGAGFVLGRKAYKEDMENRMLRVRSEAKTNVRRFVDDVAFVVGKESRDRLKGIQRQLRDHYREIAN
QTTRSLNESLQATIAAARLAESERNARTKELQRQLNILRQVIEHAEKLGTPTAAPVAAP

Sequences:

>Translated_619_residues
MTRPNGPRNVADTRKVVTELIEHTTKIAEAQDRGDLVARLARARTRIGDPQIRVVIAGQLKQGKSLLLNSLLNMPVARVG
DDESTVLATVVSYAEQPSARLVVARPDGEEPELVEIPTTDLGKDLRRAPQADGREVLRVEVTVPSPLLKGGLAFVDTPGV
GGHGQPHLSATLGLLPDADAMLMISDTSQEFTEPEMTFIRQALEICPVAAIVATKTDLYPHWRQVVDANAGHLHRAGITT
PLIPASSTLRSHAVQLNDKELNEESNFPAIVKFLSEQVLARNTDRVRDQVVNEIRAAAEHLSMAVQSELSALDDPAAGGT
LTADLERRKKEAEEALQQTALWQQVLNDGIADLTADVDHDLRQRFRNITFHTERVIDAGDPTLHWAEIGAELEESVATAV
GDNFVWAYQRAEALAAEVARTFMEAGLDAVRMPAIDAREMGAEFGEFRSLAHLEAKPLKIGHKIVTGMRGSYGGVLMFGM
LTSFAGLGMFNPLSLGAGFVLGRKAYKEDMENRMLRVRSEAKTNVRRFVDDVAFVVGKESRDRLKGIQRQLRDHYREIAN
QTTRSLNESLQATIAAARLAESERNARTKELQRQLNILRQVIEHAEKLGTPTAAPVAAP
>Mature_618_residues
TRPNGPRNVADTRKVVTELIEHTTKIAEAQDRGDLVARLARARTRIGDPQIRVVIAGQLKQGKSLLLNSLLNMPVARVGD
DESTVLATVVSYAEQPSARLVVARPDGEEPELVEIPTTDLGKDLRRAPQADGREVLRVEVTVPSPLLKGGLAFVDTPGVG
GHGQPHLSATLGLLPDADAMLMISDTSQEFTEPEMTFIRQALEICPVAAIVATKTDLYPHWRQVVDANAGHLHRAGITTP
LIPASSTLRSHAVQLNDKELNEESNFPAIVKFLSEQVLARNTDRVRDQVVNEIRAAAEHLSMAVQSELSALDDPAAGGTL
TADLERRKKEAEEALQQTALWQQVLNDGIADLTADVDHDLRQRFRNITFHTERVIDAGDPTLHWAEIGAELEESVATAVG
DNFVWAYQRAEALAAEVARTFMEAGLDAVRMPAIDAREMGAEFGEFRSLAHLEAKPLKIGHKIVTGMRGSYGGVLMFGML
TSFAGLGMFNPLSLGAGFVLGRKAYKEDMENRMLRVRSEAKTNVRRFVDDVAFVVGKESRDRLKGIQRQLRDHYREIANQ
TTRSLNESLQATIAAARLAESERNARTKELQRQLNILRQVIEHAEKLGTPTAAPVAAP

Specific function: Participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell [H]

COG id: COG0699

COG function: function code R; Predicted GTPases (dynamin-related)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001401 [H]

Pfam domain/function: PF00350 Dynamin_N [H]

EC number: NA

Molecular weight: Translated: 67850; Mature: 67719

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPNGPRNVADTRKVVTELIEHTTKIAEAQDRGDLVARLARARTRIGDPQIRVVIAGQL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KQGKSLLLNSLLNMPVARVGDDESTVLATVVSYAEQPSARLVVARPDGEEPELVEIPTTD
CCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCHH
LGKDLRRAPQADGREVLRVEVTVPSPLLKGGLAFVDTPGVGGHGQPHLSATLGLLPDADA
HHHHHHHCCCCCCCEEEEEEEECCCHHHHCCEEEEECCCCCCCCCCCHHHHHCCCCCCCC
MLMISDTSQEFTEPEMTFIRQALEICPVAAIVATKTDLYPHWRQVVDANAGHLHRAGITT
EEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEECCCCC
PLIPASSTLRSHAVQLNDKELNEESNFPAIVKFLSEQVLARNTDRVRDQVVNEIRAAAEH
CCCCCHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LSMAVQSELSALDDPAAGGTLTADLERRKKEAEEALQQTALWQQVLNDGIADLTADVDHD
HHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHH
LRQRFRNITFHTERVIDAGDPTLHWAEIGAELEESVATAVGDNFVWAYQRAEALAAEVAR
HHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TFMEAGLDAVRMPAIDAREMGAEFGEFRSLAHLEAKPLKIGHKIVTGMRGSYGGVLMFGM
HHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHH
LTSFAGLGMFNPLSLGAGFVLGRKAYKEDMENRMLRVRSEAKTNVRRFVDDVAFVVGKES
HHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
RDRLKGIQRQLRDHYREIANQTTRSLNESLQATIAAARLAESERNARTKELQRQLNILRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIEHAEKLGTPTAAPVAAP
HHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TRPNGPRNVADTRKVVTELIEHTTKIAEAQDRGDLVARLARARTRIGDPQIRVVIAGQL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KQGKSLLLNSLLNMPVARVGDDESTVLATVVSYAEQPSARLVVARPDGEEPELVEIPTTD
CCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCHH
LGKDLRRAPQADGREVLRVEVTVPSPLLKGGLAFVDTPGVGGHGQPHLSATLGLLPDADA
HHHHHHHCCCCCCCEEEEEEEECCCHHHHCCEEEEECCCCCCCCCCCHHHHHCCCCCCCC
MLMISDTSQEFTEPEMTFIRQALEICPVAAIVATKTDLYPHWRQVVDANAGHLHRAGITT
EEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEECCCCC
PLIPASSTLRSHAVQLNDKELNEESNFPAIVKFLSEQVLARNTDRVRDQVVNEIRAAAEH
CCCCCHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LSMAVQSELSALDDPAAGGTLTADLERRKKEAEEALQQTALWQQVLNDGIADLTADVDHD
HHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHH
LRQRFRNITFHTERVIDAGDPTLHWAEIGAELEESVATAVGDNFVWAYQRAEALAAEVAR
HHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TFMEAGLDAVRMPAIDAREMGAEFGEFRSLAHLEAKPLKIGHKIVTGMRGSYGGVLMFGM
HHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHH
LTSFAGLGMFNPLSLGAGFVLGRKAYKEDMENRMLRVRSEAKTNVRRFVDDVAFVVGKES
HHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
RDRLKGIQRQLRDHYREIANQTTRSLNESLQATIAAARLAESERNARTKELQRQLNILRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIEHAEKLGTPTAAPVAAP
HHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]