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The map label for this gene is rmlA [H]

Identifier: 108797416

GI number: 108797416

Start: 483140

End: 484003

Strand: Direct

Name: rmlA [H]

Synonym: Mmcs_0436

Alternate gene names: 108797416

Gene position: 483140-484003 (Clockwise)

Preceding gene: 108797415

Following gene: 108797425

Centisome position: 8.47

GC content: 66.32

Gene sequence:

>864_bases
ATGCGGGGGATCATCCTGGCGGGCGGCTCGGGCACCCGGCTGTACCCGATCACGCTCGGGGCGAGCAAGCAGCTGCTGCC
CGTCTACGACAAACCGCTCATCTACTACCCGCTGTCCACGCTCATCATGGCCGGCATCCGCGACATCCAGGTGATCACCA
CCGCCGAGGACGCCCCCGCCTTTCACCGATTGCTGGGCGACGGTGCGCATTTCGGCGTCAACCTCACCTATGCGGTGCAG
GACGAGCCGGACGGGCTCGCACAGGCGTTCGTGATCGGCGCCGACCACATCGGCACCGACTCCGTCGCACTGGTGTTGGG
GGACAACATCTTCTACGGCCCCGGGCTCGGCACCGGACTGCGCCGCTTCCACGACGTCAGCGGCGGGTCGATCTTCGCGT
ACTGGGTCGCCAACCCGTCGGCGTACGGGGTGGTGGAGTTCAGCGCCGACGGCACCGCCCTGTCGCTCGAGGAGAAACCC
GCGACACCGAAATCGCACTACGCGGTGCCCGGACTGTACTTCTACGACAACGACGTCATCGAGATCGCGAAGTCGCTGAA
GAAGTCCGCGCGCGGTGAGTACGAGATCACCGAGATCAACCAGCGCTACCTCGATCAGGGCCGGCTCACCGTGGAGGTAC
TCGCGCGCGGCACCGCATGGCTCGACACCGGCACGTTCGACTCGCTGCTCGATGCGAGCGACTACGTCCGCACCATCGAA
CGCCGTCAGGGACTGAAGATCTCGGTACCCGAGGAGGTGGCGTGGCGCGTCGGGTTCATCGACGACGAGCAGTTGGCCGC
CCGCGGGCACAGCCTGCTCAAATCCGGGTACGGCGCCTATCTGCTGGAGTTGCTCGACCGCTGA

Upstream 100 bases:

>100_bases
TCCGCGTCGTGCACGACAAGGTGACGTCGATGTTCCGCCACGCCGACCTGTCGTCCGCGCTGGCCGCCACCGAACTCGGT
GAAGAGGACCTGACCGGCTG

Downstream 100 bases:

>100_bases
TCAGGGCAGCCCGGACAGCACCTTGTCGAGGGTGACCGGCAGATCGCGCACGCGCACACCGGTCGCGTTGTAGACGGCGT
TGACCACCGCGGCGGCCGAT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MRGIILAGGSGTRLYPITLGASKQLLPVYDKPLIYYPLSTLIMAGIRDIQVITTAEDAPAFHRLLGDGAHFGVNLTYAVQ
DEPDGLAQAFVIGADHIGTDSVALVLGDNIFYGPGLGTGLRRFHDVSGGSIFAYWVANPSAYGVVEFSADGTALSLEEKP
ATPKSHYAVPGLYFYDNDVIEIAKSLKKSARGEYEITEINQRYLDQGRLTVEVLARGTAWLDTGTFDSLLDASDYVRTIE
RRQGLKISVPEEVAWRVGFIDDEQLAARGHSLLKSGYGAYLLELLDR

Sequences:

>Translated_287_residues
MRGIILAGGSGTRLYPITLGASKQLLPVYDKPLIYYPLSTLIMAGIRDIQVITTAEDAPAFHRLLGDGAHFGVNLTYAVQ
DEPDGLAQAFVIGADHIGTDSVALVLGDNIFYGPGLGTGLRRFHDVSGGSIFAYWVANPSAYGVVEFSADGTALSLEEKP
ATPKSHYAVPGLYFYDNDVIEIAKSLKKSARGEYEITEINQRYLDQGRLTVEVLARGTAWLDTGTFDSLLDASDYVRTIE
RRQGLKISVPEEVAWRVGFIDDEQLAARGHSLLKSGYGAYLLELLDR
>Mature_287_residues
MRGIILAGGSGTRLYPITLGASKQLLPVYDKPLIYYPLSTLIMAGIRDIQVITTAEDAPAFHRLLGDGAHFGVNLTYAVQ
DEPDGLAQAFVIGADHIGTDSVALVLGDNIFYGPGLGTGLRRFHDVSGGSIFAYWVANPSAYGVVEFSADGTALSLEEKP
ATPKSHYAVPGLYFYDNDVIEIAKSLKKSARGEYEITEINQRYLDQGRLTVEVLARGTAWLDTGTFDSLLDASDYVRTIE
RRQGLKISVPEEVAWRVGFIDDEQLAARGHSLLKSGYGAYLLELLDR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide,

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=284, Percent_Identity=62.3239436619718, Blast_Score=369, Evalue=1e-104,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=60.4895104895105, Blast_Score=351, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI133931050, Length=184, Percent_Identity=27.1739130434783, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=26.4822134387352, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21355443, Length=251, Percent_Identity=25.8964143426295, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24644084, Length=251, Percent_Identity=25.8964143426295, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 31250; Mature: 31250

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGIILAGGSGTRLYPITLGASKQLLPVYDKPLIYYPLSTLIMAGIRDIQVITTAEDAPA
CCEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEEECCCCHH
FHRLLGDGAHFGVNLTYAVQDEPDGLAQAFVIGADHIGTDSVALVLGDNIFYGPGLGTGL
HHHHHCCCCEECEEEEEEECCCCCCCEEEEEEECCCCCCCCEEEEEECCEEECCCCCHHH
RRFHDVSGGSIFAYWVANPSAYGVVEFSADGTALSLEEKPATPKSHYAVPGLYFYDNDVI
HHHHCCCCCCEEEEEECCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEEECCHHH
EIAKSLKKSARGEYEITEINQRYLDQGRLTVEVLARGTAWLDTGTFDSLLDASDYVRTIE
HHHHHHHHHCCCCEEEEHHHHHHHHCCCEEEEEEECCCEEEECCCHHHHHCHHHHHHHHH
RRQGLKISVPEEVAWRVGFIDDEQLAARGHSLLKSGYGAYLLELLDR
HHCCCEEECCHHHHEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MRGIILAGGSGTRLYPITLGASKQLLPVYDKPLIYYPLSTLIMAGIRDIQVITTAEDAPA
CCEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEEECCCCHH
FHRLLGDGAHFGVNLTYAVQDEPDGLAQAFVIGADHIGTDSVALVLGDNIFYGPGLGTGL
HHHHHCCCCEECEEEEEEECCCCCCCEEEEEEECCCCCCCCEEEEEECCEEECCCCCHHH
RRFHDVSGGSIFAYWVANPSAYGVVEFSADGTALSLEEKPATPKSHYAVPGLYFYDNDVI
HHHHCCCCCCEEEEEECCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEEECCHHH
EIAKSLKKSARGEYEITEINQRYLDQGRLTVEVLARGTAWLDTGTFDSLLDASDYVRTIE
HHHHHHHHHCCCCEEEEHHHHHHHHCCCEEEEEEECCCEEEECCCHHHHHCHHHHHHHHH
RRQGLKISVPEEVAWRVGFIDDEQLAARGHSLLKSGYGAYLLELLDR
HHCCCEEECCHHHHEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9084178; 9634230; 12218036 [H]