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The map label for this gene is betC [H]

Identifier: 108797370

GI number: 108797370

Start: 437304

End: 438701

Strand: Reverse

Name: betC [H]

Synonym: Mmcs_0390

Alternate gene names: 108797370

Gene position: 438701-437304 (Counterclockwise)

Preceding gene: 108797372

Following gene: 108797369

Centisome position: 7.69

GC content: 66.38

Gene sequence:

>1398_bases
GTGACAGGACAACCACGGGTGACTCCGCAGGACCGCGCCAACGTGCTGATCGTCCACTGGCACGATCTCGGTCGCTACCT
CGGCGCCTACGGACACCCGGACGTACAGAGCCCCCGCCTCGACCGGTTCGCCGCCGAAAGCATCCTGTTCACCCGCGCCC
ACGCCACCGCACCGCTGTGCTCACCGTCGCGCGGGTCGCTGTTCACGGGCCGCTACCCGCAGAGCAACGGCCTGGTCGGA
CTGGCGCACCACGGCTGGGAGTACCGCGCCGGCGTCCGCACCCTACCGCACATCTTGTCTGAAAACGGTTGGCACACCGC
ACTTTTCGGGATGCAGCACGAGACGTCGTATCCGCCGAAACTGGGGTTCGACGAGTTCGACGTGTCCAACTCCTACTGCG
AATACGTGGTCGAACGCGCCACCGGGTGGCTGCTCGACGCACCGCAGCGCCCCTTCCTGCTCACCGCGGGATTCTTCGAG
ACCCACCGGCCCTACCCGCGTGACCGCTACGAACCCGCCGACGCCACCACCGTCGCGCTACCCGACTACCTTCCCGAGGA
CCGGGAGGTGCGCCAGGATCTGGCCGAGTTCTACGGGTCGATCACCGTCGCCGACGCGGCAGTCGGCCAACTGCTCGACA
CGCTCGCGGCCACCGGACTGGACCGCAGCACCTGGGTGGTGTTCATGACCGACCACGGTCCGGCCCTGCCCCGGGCGAAG
TCCACGCTGTACGACGCGGGCACCGGTATCGCGATGATCATCCGGCCGCCGCTTGACGCCGGCATCGCCCCCGGCGTCTA
CGACGATCTGTTCAGCGGCGTCGACCTGCTACCCACGCTGCTCGACGTGCTCGGCGTCGACATTCCCGGGGAGGTCGAGG
GACTCTCGCATGCCGACAATTTGCTGGGCGGCGCGGAGAAAACGCGGGAAGTGCGCACCGCGGTGTACACCACGAAGACC
TATCACGATTCCTTCGACCCAATTCGGGCGATCCGGACAAAAGAATTCAGCTATATCGAGAATTACGCGCAACGGCCGCT
GTTGGATCTGCCGTGGGACATCGCCGAAAGCGCCCCCGGGCGCATCGTCGGACCGCGGGCACGCACGCCACGGCCCGCCC
GCGAACTCTACGACCTCCGCACCGACCCCACCGAGCAACACAACCTGCTGACGTCGGAGAACAAGATCAACGCCGAGGCC
GTCGCGACCGATCTGGCGCTCCTGCTCGACGACTGGCGGGTGAAGACCAACGACGTCATACCGTCGGATTTCGCGGGTAC
GCGGATATCCGACCGATACACCGAGACATATCTGCGAATTCACCGGCGGGAAGTCACCAGTCGCTCGGCCATCGCTGCGG
AACGAGGCGTCAAGGGTGAGCGCCGAACGGCGCAATGA

Upstream 100 bases:

>100_bases
AACTCGTCCATCCGACGAGGTTAGATCCGGCGAGGGATAAGTTGCTTCGGGTGAGCCGAACACTTGCCGAACGGGCCGAG
AACCGCTTCTGTGGGGCAGC

Downstream 100 bases:

>100_bases
ATAAACTCATCGTGAACGTAAATTCCGGATAGGCAGCGGAATTGCGTTGCGGTTAGGCTCACGCCCATGCCTTCGCGATC
CACGGCGTATCTGGTTCTCG

Product: sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTGQPRVTPQDRANVLIVHWHDLGRYLGAYGHPDVQSPRLDRFAAESILFTRAHATAPLCSPSRGSLFTGRYPQSNGLVG
LAHHGWEYRAGVRTLPHILSENGWHTALFGMQHETSYPPKLGFDEFDVSNSYCEYVVERATGWLLDAPQRPFLLTAGFFE
THRPYPRDRYEPADATTVALPDYLPEDREVRQDLAEFYGSITVADAAVGQLLDTLAATGLDRSTWVVFMTDHGPALPRAK
STLYDAGTGIAMIIRPPLDAGIAPGVYDDLFSGVDLLPTLLDVLGVDIPGEVEGLSHADNLLGGAEKTREVRTAVYTTKT
YHDSFDPIRAIRTKEFSYIENYAQRPLLDLPWDIAESAPGRIVGPRARTPRPARELYDLRTDPTEQHNLLTSENKINAEA
VATDLALLLDDWRVKTNDVIPSDFAGTRISDRYTETYLRIHRREVTSRSAIAAERGVKGERRTAQ

Sequences:

>Translated_465_residues
MTGQPRVTPQDRANVLIVHWHDLGRYLGAYGHPDVQSPRLDRFAAESILFTRAHATAPLCSPSRGSLFTGRYPQSNGLVG
LAHHGWEYRAGVRTLPHILSENGWHTALFGMQHETSYPPKLGFDEFDVSNSYCEYVVERATGWLLDAPQRPFLLTAGFFE
THRPYPRDRYEPADATTVALPDYLPEDREVRQDLAEFYGSITVADAAVGQLLDTLAATGLDRSTWVVFMTDHGPALPRAK
STLYDAGTGIAMIIRPPLDAGIAPGVYDDLFSGVDLLPTLLDVLGVDIPGEVEGLSHADNLLGGAEKTREVRTAVYTTKT
YHDSFDPIRAIRTKEFSYIENYAQRPLLDLPWDIAESAPGRIVGPRARTPRPARELYDLRTDPTEQHNLLTSENKINAEA
VATDLALLLDDWRVKTNDVIPSDFAGTRISDRYTETYLRIHRREVTSRSAIAAERGVKGERRTAQ
>Mature_464_residues
TGQPRVTPQDRANVLIVHWHDLGRYLGAYGHPDVQSPRLDRFAAESILFTRAHATAPLCSPSRGSLFTGRYPQSNGLVGL
AHHGWEYRAGVRTLPHILSENGWHTALFGMQHETSYPPKLGFDEFDVSNSYCEYVVERATGWLLDAPQRPFLLTAGFFET
HRPYPRDRYEPADATTVALPDYLPEDREVRQDLAEFYGSITVADAAVGQLLDTLAATGLDRSTWVVFMTDHGPALPRAKS
TLYDAGTGIAMIIRPPLDAGIAPGVYDDLFSGVDLLPTLLDVLGVDIPGEVEGLSHADNLLGGAEKTREVRTAVYTTKTY
HDSFDPIRAIRTKEFSYIENYAQRPLLDLPWDIAESAPGRIVGPRARTPRPARELYDLRTDPTEQHNLLTSENKINAEAV
ATDLALLLDDWRVKTNDVIPSDFAGTRISDRYTETYLRIHRREVTSRSAIAAERGVKGERRTAQ

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4506919, Length=461, Percent_Identity=26.6811279826464, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI146229331, Length=458, Percent_Identity=27.0742358078603, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI146229329, Length=458, Percent_Identity=27.0742358078603, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI6005990, Length=458, Percent_Identity=27.0742358078603, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI146229324, Length=458, Percent_Identity=27.0742358078603, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI4557659, Length=352, Percent_Identity=26.7045454545455, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI5360208, Length=306, Percent_Identity=26.797385620915, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4503899, Length=355, Percent_Identity=26.4788732394366, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI71852586, Length=144, Percent_Identity=30.5555555555556, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI71852584, Length=144, Percent_Identity=30.5555555555556, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI31742482, Length=144, Percent_Identity=31.25, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21356831, Length=461, Percent_Identity=26.0303687635575, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24656835, Length=102, Percent_Identity=38.2352941176471, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 51807; Mature: 51675

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00077 COX1_CUB ; PS00523 SULFATASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGQPRVTPQDRANVLIVHWHDLGRYLGAYGHPDVQSPRLDRFAAESILFTRAHATAPLC
CCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
SPSRGSLFTGRYPQSNGLVGLAHHGWEYRAGVRTLPHILSENGWHTALFGMQHETSYPPK
CCCCCCEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
LGFDEFDVSNSYCEYVVERATGWLLDAPQRPFLLTAGFFETHRPYPRDRYEPADATTVAL
CCCCCCCCCHHHHHHHHHHHCCCEECCCCCCEEEEECHHHHCCCCCCCCCCCCCCEEEEC
PDYLPEDREVRQDLAEFYGSITVADAAVGQLLDTLAATGLDRSTWVVFMTDHGPALPRAK
CCCCCCHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHH
STLYDAGTGIAMIIRPPLDAGIAPGVYDDLFSGVDLLPTLLDVLGVDIPGEVEGLSHADN
HHHHHCCCCEEEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHH
LLGGAEKTREVRTAVYTTKTYHDSFDPIRAIRTKEFSYIENYAQRPLLDLPWDIAESAPG
HHCCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCC
RIVGPRARTPRPARELYDLRTDPTEQHNLLTSENKINAEAVATDLALLLDDWRVKTNDVI
CEECCCCCCCCHHHHHHHCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEECCCCC
PSDFAGTRISDRYTETYLRIHRREVTSRSAIAAERGVKGERRTAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TGQPRVTPQDRANVLIVHWHDLGRYLGAYGHPDVQSPRLDRFAAESILFTRAHATAPLC
CCCCCCCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
SPSRGSLFTGRYPQSNGLVGLAHHGWEYRAGVRTLPHILSENGWHTALFGMQHETSYPPK
CCCCCCEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
LGFDEFDVSNSYCEYVVERATGWLLDAPQRPFLLTAGFFETHRPYPRDRYEPADATTVAL
CCCCCCCCCHHHHHHHHHHHCCCEECCCCCCEEEEECHHHHCCCCCCCCCCCCCCEEEEC
PDYLPEDREVRQDLAEFYGSITVADAAVGQLLDTLAATGLDRSTWVVFMTDHGPALPRAK
CCCCCCHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHH
STLYDAGTGIAMIIRPPLDAGIAPGVYDDLFSGVDLLPTLLDVLGVDIPGEVEGLSHADN
HHHHHCCCCEEEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHH
LLGGAEKTREVRTAVYTTKTYHDSFDPIRAIRTKEFSYIENYAQRPLLDLPWDIAESAPG
HHCCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCC
RIVGPRARTPRPARELYDLRTDPTEQHNLLTSENKINAEAVATDLALLLDDWRVKTNDVI
CEECCCCCCCCHHHHHHHCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEECCCCC
PSDFAGTRISDRYTETYLRIHRREVTSRSAIAAERGVKGERRTAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]