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The map label for this gene is ldh [H]

Identifier: 108797362

GI number: 108797362

Start: 428165

End: 429154

Strand: Reverse

Name: ldh [H]

Synonym: Mmcs_0382

Alternate gene names: 108797362

Gene position: 429154-428165 (Counterclockwise)

Preceding gene: 108797364

Following gene: 108797355

Centisome position: 7.52

GC content: 70.4

Gene sequence:

>990_bases
ATGATTGGAGCGGTGACCACTCCCCCGGCATCTCCCGAAGTGCGGTCCGCTCGGCCGAAGGTGTCGATCATCGGTGCGGG
CAGTGTCGGCACCGCGATCGCCTACGCCTGCCTGATCCGCGGCTCCGCGGGGACGCTGGCGCTCTACGACACCAACAGCG
CCAAGGTGCGCGCCGAGGTCCTCGACCTGAATCACGGCAGCCAGTTCGTTCCCGAGTGCCGGGTCGGTGGATCCGACGAC
ATCGCCGTCACCGCCGGCTCCGCGATCGTCGTCGTCACCGCCGGCGCCAAACAGCACCCGGGCCAGAGCCGGCTCGACCT
GGCGGCGGCGAACGTCGCCATGGCGCAGACGCTGACACCGCAGCTCCTCGAGCACTCGCCGGACGCTGTGGTGATCTTCG
TCACCAACCCCGTCGACGTCGTCACCTACGCGGCGTCCAGCGTGGTCGACGCCCAGCCGGGCCAGATCTTCGGAACGGGA
ACCGTGCTCGACTCCAGCAGGTTCCGGTACCTCGTGGCGCAGCGGGCGGCGATCGCGGTCGGCAACGTGCACGCCCTCGT
CATCGGCGAACACGGTGACTCCGAGATCCCGTTGTGGTCGACGCTGTCCATCGGTGGCGTCGGCGCCGACGCCTATCGGG
TGGACGGCCGCCTGGTCTTCGACGAGCCGACGCGGACGGCCGTGGCCACCGATGTGGTCAACGCCGCGTACGAGATCATC
GCGGGCAAGGGCGCCACCAACCTCGCGATCGGTCTCGCCACCGCCCGGGTCGTCGAGGCGGTACTCGGCGACCAGCACCG
GGTGCTGCCGGTGTCGACGGTGCAGGACGGCGCTTACGGCATCACCGGTGTCGCGCTCTCGCTGCCCACGGTCGTATCGG
CCGGCGGCGCGCGACGCGTCCTCGAAGTGGAGCTGTCCCCCGGCGAACTCGACGGCCTGCGGCGGTCGGCGCAGACGCTG
GCAGACGTGCGGCGATCACTGGGGATCTGA

Upstream 100 bases:

>100_bases
CGGCACTCCTGGTTCTCTGTCGGAGTTCGCCACGCTAACGGCCGCGGGTTACCTCCCGGTGAACGCCGGGGGCCGCGAGA
CAGCATGATCGCGAGCCAGC

Downstream 100 bases:

>100_bases
GGTACCCACCTCGACGAGCTCGGTAACCGGCGGGTGGTCGACCGGCCACCGCAGCCGGTGCAGGCCGTCGCCGGTCACCG
GTACGGGCCGGCCCTCGAGC

Product: lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MIGAVTTPPASPEVRSARPKVSIIGAGSVGTAIAYACLIRGSAGTLALYDTNSAKVRAEVLDLNHGSQFVPECRVGGSDD
IAVTAGSAIVVVTAGAKQHPGQSRLDLAAANVAMAQTLTPQLLEHSPDAVVIFVTNPVDVVTYAASSVVDAQPGQIFGTG
TVLDSSRFRYLVAQRAAIAVGNVHALVIGEHGDSEIPLWSTLSIGGVGADAYRVDGRLVFDEPTRTAVATDVVNAAYEII
AGKGATNLAIGLATARVVEAVLGDQHRVLPVSTVQDGAYGITGVALSLPTVVSAGGARRVLEVELSPGELDGLRRSAQTL
ADVRRSLGI

Sequences:

>Translated_329_residues
MIGAVTTPPASPEVRSARPKVSIIGAGSVGTAIAYACLIRGSAGTLALYDTNSAKVRAEVLDLNHGSQFVPECRVGGSDD
IAVTAGSAIVVVTAGAKQHPGQSRLDLAAANVAMAQTLTPQLLEHSPDAVVIFVTNPVDVVTYAASSVVDAQPGQIFGTG
TVLDSSRFRYLVAQRAAIAVGNVHALVIGEHGDSEIPLWSTLSIGGVGADAYRVDGRLVFDEPTRTAVATDVVNAAYEII
AGKGATNLAIGLATARVVEAVLGDQHRVLPVSTVQDGAYGITGVALSLPTVVSAGGARRVLEVELSPGELDGLRRSAQTL
ADVRRSLGI
>Mature_329_residues
MIGAVTTPPASPEVRSARPKVSIIGAGSVGTAIAYACLIRGSAGTLALYDTNSAKVRAEVLDLNHGSQFVPECRVGGSDD
IAVTAGSAIVVVTAGAKQHPGQSRLDLAAANVAMAQTLTPQLLEHSPDAVVIFVTNPVDVVTYAASSVVDAQPGQIFGTG
TVLDSSRFRYLVAQRAAIAVGNVHALVIGEHGDSEIPLWSTLSIGGVGADAYRVDGRLVFDEPTRTAVATDVVNAAYEII
AGKGATNLAIGLATARVVEAVLGDQHRVLPVSTVQDGAYGITGVALSLPTVVSAGGARRVLEVELSPGELDGLRRSAQTL
ADVRRSLGI

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI291575128, Length=321, Percent_Identity=38.9408099688474, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4557032, Length=321, Percent_Identity=38.9408099688474, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI15082234, Length=311, Percent_Identity=39.2282958199357, Blast_Score=237, Evalue=9e-63,
Organism=Homo sapiens, GI47059044, Length=311, Percent_Identity=37.620578778135, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI221136809, Length=311, Percent_Identity=37.620578778135, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI260099723, Length=316, Percent_Identity=37.0253164556962, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI5031857, Length=316, Percent_Identity=37.0253164556962, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI9257228, Length=316, Percent_Identity=37.0253164556962, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI4504973, Length=316, Percent_Identity=37.0253164556962, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI260099727, Length=225, Percent_Identity=35.5555555555556, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI260099725, Length=195, Percent_Identity=38.4615384615385, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI207028494, Length=316, Percent_Identity=29.1139240506329, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI103472011, Length=316, Percent_Identity=25.6329113924051, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI103472015, Length=185, Percent_Identity=28.1081081081081, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI21735621, Length=261, Percent_Identity=28.735632183908, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789632, Length=275, Percent_Identity=30.1818181818182, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17535107, Length=298, Percent_Identity=37.9194630872483, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17554310, Length=257, Percent_Identity=26.4591439688716, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17136226, Length=309, Percent_Identity=39.1585760517799, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI45550422, Length=325, Percent_Identity=37.2307692307692, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24663595, Length=236, Percent_Identity=32.2033898305085, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24663599, Length=254, Percent_Identity=26.7716535433071, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 33631; Mature: 33631

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGAVTTPPASPEVRSARPKVSIIGAGSVGTAIAYACLIRGSAGTLALYDTNSAKVRAEV
CCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHEECCCCEEEEEECCCCEEEEEE
LDLNHGSQFVPECRVGGSDDIAVTAGSAIVVVTAGAKQHPGQSRLDLAAANVAMAQTLTP
EECCCCCCCCCCCCCCCCCCEEEEECCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCH
QLLEHSPDAVVIFVTNPVDVVTYAASSVVDAQPGQIFGTGTVLDSSRFRYLVAQRAAIAV
HHHHCCCCEEEEEEECCHHEEHHHHHHCCCCCCCEEEEEEEEECCCHHHEEEHHHHEEEE
GNVHALVIGEHGDSEIPLWSTLSIGGVGADAYRVDGRLVFDEPTRTAVATDVVNAAYEII
CCEEEEEEECCCCCCCCEEEEEEECCCCCCEEEECCEEEECCCCCHHHHHHHHHHHHHHH
AGKGATNLAIGLATARVVEAVLGDQHRVLPVSTVQDGAYGITGVALSLPTVVSAGGARRV
CCCCCCCEEEHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEHHHHHCCCCCEEE
LEVELSPGELDGLRRSAQTLADVRRSLGI
EEEEECCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIGAVTTPPASPEVRSARPKVSIIGAGSVGTAIAYACLIRGSAGTLALYDTNSAKVRAEV
CCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHEECCCCEEEEEECCCCEEEEEE
LDLNHGSQFVPECRVGGSDDIAVTAGSAIVVVTAGAKQHPGQSRLDLAAANVAMAQTLTP
EECCCCCCCCCCCCCCCCCCEEEEECCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCH
QLLEHSPDAVVIFVTNPVDVVTYAASSVVDAQPGQIFGTGTVLDSSRFRYLVAQRAAIAV
HHHHCCCCEEEEEEECCHHEEHHHHHHCCCCCCCEEEEEEEEECCCHHHEEEHHHHEEEE
GNVHALVIGEHGDSEIPLWSTLSIGGVGADAYRVDGRLVFDEPTRTAVATDVVNAAYEII
CCEEEEEEECCCCCCCCEEEEEEECCCCCCEEEECCEEEECCCCCHHHHHHHHHHHHHHH
AGKGATNLAIGLATARVVEAVLGDQHRVLPVSTVQDGAYGITGVALSLPTVVSAGGARRV
CCCCCCCEEEHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEHHHHHCCCCCEEE
LEVELSPGELDGLRRSAQTLADVRRSLGI
EEEEECCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA