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The map label for this gene is bioI [H]

Identifier: 108797312

GI number: 108797312

Start: 369473

End: 370750

Strand: Direct

Name: bioI [H]

Synonym: Mmcs_0332

Alternate gene names: 108797312

Gene position: 369473-370750 (Clockwise)

Preceding gene: 108797308

Following gene: 108797316

Centisome position: 6.48

GC content: 67.45

Gene sequence:

>1278_bases
ATGACCGATCTCGCCTCAGTCGACTTCTTCTCCGACCCGGACATCAGCCAGAATCCCTACGGGTACTGGGATGCCCTCCG
CGAGCAGGGCCCGGTCGTGCGGGAACCCCACCACGGAGTGGTGGCGGTGACCGGATATCAGGAGGTGCTCGCGGCGTTCC
GGGACCACGACCACTTCTCGGCGGTCAATGCGATCGGCGGACCCTTCCCGCCCCTGCCGTTCGAACCGCAGGGCGACGAC
ATCACCGAGCAGATCGAGGCGCACCGGCACCTCTTCCCGATCCACGAGCACATGGTGGTGATGGATCCGCCCGCCCACGA
GCGGGCGCGGTCGCTGCTCAGCAGGCTCCTCACGCCGCGGCGGCTCAAGGAGAACGAGGACTTCATGTGGCAGCTGGTCG
ATCAGCAGATCGACCAGATCATCGGTAACGGCCGATGCGAGTTCCTCTCGGAGTACGCCAAACCCTTCGCGACGTCGGCG
ATCATCGACCTGCTCGGCGTACCCGAGGACGACCGCCCCGAATTCCTCGCCGCCCTGGGCGCGGAGACGCGCCAGGGCAC
CCGGGTGGGTGCGCTCGACGGCGAATCCGTGGGATTGGACCCCCTGCAGTATCTCGACGACAAGTTCGCCGGGTATCTGG
CCGATCGGCGCCGTGAGCCGCGGGACGACGTGCTGTCGGGGATGGCGACCGCGACCTACCCGGACGGTTCCACCCCCGAA
CTGATGGAGGTCGTGAAACCGGCGACGTTCCTGTTCGCCGCGGGTCAGGAGACCGTCACCAAACTGCTCAGCGCCGCCGT
CCAGACACTGGGCGACCACCCGGAATACCAGGACCTCCTGCGCGAGGATCCCCGTCGTATACCGACGTTCATCGAGGAGG
CGCTACGGATGCACGCGCCGACCAAGGTCGACTTCCGGCTGGTCCGCAAGACCACCACGCTCGGGGATGTGCACCTGCCG
GCAGGCACCATCGTGATGCTCTGCCTCGGCGCCGCCAACCGGGATCCCCTGAAGTTCGACGACCCCCATGAGTTCCGTCC
GGACCGCAAGAACGTCCGGGAGCACCTCGCCTTCGGCCGGGGTATCCACACGTGTGCGGGCGCACCGCTGGCACGCGTGG
AGGGCGTTGTCACCGTGCGCCGTCTGTTGGATCGGCTGCGCGACATCGGCATCGACGAGAGCGTGCACGGCCCGGCCCGG
CGCCGCAACTATGTGTACGAGCCGACCTTCCTGCTGCGCGGGCTCACCAGCCTGCACATCGAGTTCACGCCGGCCTAA

Upstream 100 bases:

>100_bases
ACTCGTGGATCGCTTGACCCCCCGCGAGACGGCGTGATAGGCATGGCGCATTCTATCAGCCTGATCGATCGATCAGGATG
CAGCGAAGGAACCGAGCTCC

Downstream 100 bases:

>100_bases
CCGGTGTCGGCCCACTCGGCGGTGACCCGCTGCTTCTGTTCACGAATGGCCTCGGCCAGGTGGGCCGCCTTGGGCCAGCC
GTAGTGCGCCGCGAAATGCA

Product: cytochrome P450

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTDLASVDFFSDPDISQNPYGYWDALREQGPVVREPHHGVVAVTGYQEVLAAFRDHDHFSAVNAIGGPFPPLPFEPQGDD
ITEQIEAHRHLFPIHEHMVVMDPPAHERARSLLSRLLTPRRLKENEDFMWQLVDQQIDQIIGNGRCEFLSEYAKPFATSA
IIDLLGVPEDDRPEFLAALGAETRQGTRVGALDGESVGLDPLQYLDDKFAGYLADRRREPRDDVLSGMATATYPDGSTPE
LMEVVKPATFLFAAGQETVTKLLSAAVQTLGDHPEYQDLLREDPRRIPTFIEEALRMHAPTKVDFRLVRKTTTLGDVHLP
AGTIVMLCLGAANRDPLKFDDPHEFRPDRKNVREHLAFGRGIHTCAGAPLARVEGVVTVRRLLDRLRDIGIDESVHGPAR
RRNYVYEPTFLLRGLTSLHIEFTPA

Sequences:

>Translated_425_residues
MTDLASVDFFSDPDISQNPYGYWDALREQGPVVREPHHGVVAVTGYQEVLAAFRDHDHFSAVNAIGGPFPPLPFEPQGDD
ITEQIEAHRHLFPIHEHMVVMDPPAHERARSLLSRLLTPRRLKENEDFMWQLVDQQIDQIIGNGRCEFLSEYAKPFATSA
IIDLLGVPEDDRPEFLAALGAETRQGTRVGALDGESVGLDPLQYLDDKFAGYLADRRREPRDDVLSGMATATYPDGSTPE
LMEVVKPATFLFAAGQETVTKLLSAAVQTLGDHPEYQDLLREDPRRIPTFIEEALRMHAPTKVDFRLVRKTTTLGDVHLP
AGTIVMLCLGAANRDPLKFDDPHEFRPDRKNVREHLAFGRGIHTCAGAPLARVEGVVTVRRLLDRLRDIGIDESVHGPAR
RRNYVYEPTFLLRGLTSLHIEFTPA
>Mature_424_residues
TDLASVDFFSDPDISQNPYGYWDALREQGPVVREPHHGVVAVTGYQEVLAAFRDHDHFSAVNAIGGPFPPLPFEPQGDDI
TEQIEAHRHLFPIHEHMVVMDPPAHERARSLLSRLLTPRRLKENEDFMWQLVDQQIDQIIGNGRCEFLSEYAKPFATSAI
IDLLGVPEDDRPEFLAALGAETRQGTRVGALDGESVGLDPLQYLDDKFAGYLADRRREPRDDVLSGMATATYPDGSTPEL
MEVVKPATFLFAAGQETVTKLLSAAVQTLGDHPEYQDLLREDPRRIPTFIEEALRMHAPTKVDFRLVRKTTTLGDVHLPA
GTIVMLCLGAANRDPLKFDDPHEFRPDRKNVREHLAFGRGIHTCAGAPLARVEGVVTVRRLLDRLRDIGIDESVHGPARR
RNYVYEPTFLLRGLTSLHIEFTPA

Specific function: Catalyzes the C-C bond cleavage of fatty acid linked to acyl carrier protein (ACP) to generate pimelic acid for biotin biosynthesis. It has high affinity for long-chain fatty acids with the greatest affinity for myristic acid [H]

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

Organism=Homo sapiens, GI310125130, Length=202, Percent_Identity=34.6534653465347, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI190570174, Length=202, Percent_Identity=34.6534653465347, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI310125128, Length=202, Percent_Identity=34.6534653465347, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI14550409, Length=202, Percent_Identity=34.6534653465347, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: NA

Molecular weight: Translated: 47628; Mature: 47497

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLASVDFFSDPDISQNPYGYWDALREQGPVVREPHHGVVAVTGYQEVLAAFRDHDHFS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHCCHHHH
AVNAIGGPFPPLPFEPQGDDITEQIEAHRHLFPIHEHMVVMDPPAHERARSLLSRLLTPR
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHCEEEECCCHHHHHHHHHHHHCCHH
RLKENEDFMWQLVDQQIDQIIGNGRCEFLSEYAKPFATSAIIDLLGVPEDDRPEFLAALG
HHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHC
AETRQGTRVGALDGESVGLDPLQYLDDKFAGYLADRRREPRDDVLSGMATATYPDGSTPE
CCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHCCCCCCCCHH
LMEVVKPATFLFAAGQETVTKLLSAAVQTLGDHPEYQDLLREDPRRIPTFIEEALRMHAP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHCCC
TKVDFRLVRKTTTLGDVHLPAGTIVMLCLGAANRDPLKFDDPHEFRPDRKNVREHLAFGR
CCHHHHHHHHHCCCCCEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
GIHTCAGAPLARVEGVVTVRRLLDRLRDIGIDESVHGPARRRNYVYEPTFLLRGLTSLHI
CHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHCHHHEEE
EFTPA
EECCC
>Mature Secondary Structure 
TDLASVDFFSDPDISQNPYGYWDALREQGPVVREPHHGVVAVTGYQEVLAAFRDHDHFS
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHCCHHHH
AVNAIGGPFPPLPFEPQGDDITEQIEAHRHLFPIHEHMVVMDPPAHERARSLLSRLLTPR
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHCEEEECCCHHHHHHHHHHHHCCHH
RLKENEDFMWQLVDQQIDQIIGNGRCEFLSEYAKPFATSAIIDLLGVPEDDRPEFLAALG
HHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHC
AETRQGTRVGALDGESVGLDPLQYLDDKFAGYLADRRREPRDDVLSGMATATYPDGSTPE
CCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHCCCCCCCCHH
LMEVVKPATFLFAAGQETVTKLLSAAVQTLGDHPEYQDLLREDPRRIPTFIEEALRMHAP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHCCC
TKVDFRLVRKTTTLGDVHLPAGTIVMLCLGAANRDPLKFDDPHEFRPDRKNVREHLAFGR
CCHHHHHHHHHCCCCCEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
GIHTCAGAPLARVEGVVTVRRLLDRLRDIGIDESVHGPARRRNYVYEPTFLLRGLTSLHI
CHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHCHHHEEE
EFTPA
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763940; 9387221; 9384377 [H]