BacMap

Definition	Mycobacterium sp. MCS chromosome, complete genome.
Accession	NC_008146
Length	5,705,448

Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 108797291

GI number: 108797291

Start: 349872

End: 350759

Strand: Direct

Name: fabG [C]

Synonym: Mmcs_0311

Alternate gene names: 108797291

Gene position: 349872-350759 (Clockwise)

Preceding gene: 108797290

Following gene: 108797300

Centisome position: 6.13

GC content: 69.14

Gene sequence:

>888_bases
ATGAGTCGCCTGCTCAGCGGTAAGACCGCGCTCGTCACCGGAAGCAGCCGCGGCATCGGCCGGGCGATCGCGCAGCGCCT
GGCCGCGGAGGGGGCAACGGTGGTCGTCACGGCGCGCTCGCACACCCCGTCACCGTCCGTACGGGCCGGTGCCGCGGCCG
CGCTGCCCGGAACCATCGGGGAGACTGTCGAGATGATCGAGGCGGCGGGCGGAACCGCCTACGGGGTGGCGGCCGACCTC
GAGGACCAGCAGCAGCGGCTGAGACTGATCGACGAGGTGCTCGACCGTACCGGTCGGCTCGACATCCTCGTCAACAACGC
CGGATACGCCGACTACTCCGTCGTCGAGCACATGGCCATGGACACCTTCGACCGCACGGTCGAGCACTATCTACGCACTC
CGTTCGTCCTGTCGCAGTGCGCGATTCCGCACATGCGCACCCAGGGCGCGGGGTGGATCGTCAACATCGGTTCGGTCACC
GGAATGGCGCCCGTGCGGCCGTTCCGTGAGTACAACAAATCGTCCGGCGACGTCGTCTACGCCTCGGTGAAGGCCGCCTT
GCACCGCTTCACCCAGGGTCTGGCCGCCGAGGTGGTCGACGACGACATCGCCGTGAACTGCGTCGGCCCGTCGACGGCTG
TGCGCACTCCCGGTGCGTCCCAGCTGATCCCGGACACGTTCCCGACCGAACCCGTCGAGTATCTCGCCGAGACCGTGCTA
GCGATGTGCCATCTGCCCGCGGCCGATCGCACCGGGCTCGTCGCCTTCAGCCTGCACTATCCGTGGTCGCAGGGGTTACC
GGTGCACACTCTCGACGGCAGCGCGGTCCTGCCGCCGCTGGAGCCGCCGGCGACGGCGAATCCGAACATCCGGCCGGCAG
GGCTGTAG

Upstream 100 bases:

>100_bases
ACCGGTCCGGGTCCGGGCGGGTGGTGGTCGCCACCCCGTACCGTCTGATCGACGTATGGCAGCAGCACCGCGCGCCGGTC
GAAGACCATTTCGTGATCCG

Downstream 100 bases:

>100_bases
CGGCTTCAGGCGTGCACCACCGCGTCGTTGCGGCAGAAGCTGTGGCACACCCGATCCCGCACGATCATGTCCGGACACTC
CGGATCGAACCACCGGTCGA

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSRLLSGKTALVTGSSRGIGRAIAQRLAAEGATVVVTARSHTPSPSVRAGAAAALPGTIGETVEMIEAAGGTAYGVAADL
EDQQQRLRLIDEVLDRTGRLDILVNNAGYADYSVVEHMAMDTFDRTVEHYLRTPFVLSQCAIPHMRTQGAGWIVNIGSVT
GMAPVRPFREYNKSSGDVVYASVKAALHRFTQGLAAEVVDDDIAVNCVGPSTAVRTPGASQLIPDTFPTEPVEYLAETVL
AMCHLPAADRTGLVAFSLHYPWSQGLPVHTLDGSAVLPPLEPPATANPNIRPAGL

Sequences:

>Translated_295_residues
MSRLLSGKTALVTGSSRGIGRAIAQRLAAEGATVVVTARSHTPSPSVRAGAAAALPGTIGETVEMIEAAGGTAYGVAADL
EDQQQRLRLIDEVLDRTGRLDILVNNAGYADYSVVEHMAMDTFDRTVEHYLRTPFVLSQCAIPHMRTQGAGWIVNIGSVT
GMAPVRPFREYNKSSGDVVYASVKAALHRFTQGLAAEVVDDDIAVNCVGPSTAVRTPGASQLIPDTFPTEPVEYLAETVL
AMCHLPAADRTGLVAFSLHYPWSQGLPVHTLDGSAVLPPLEPPATANPNIRPAGL
>Mature_294_residues
SRLLSGKTALVTGSSRGIGRAIAQRLAAEGATVVVTARSHTPSPSVRAGAAAALPGTIGETVEMIEAAGGTAYGVAADLE
DQQQRLRLIDEVLDRTGRLDILVNNAGYADYSVVEHMAMDTFDRTVEHYLRTPFVLSQCAIPHMRTQGAGWIVNIGSVTG
MAPVRPFREYNKSSGDVVYASVKAALHRFTQGLAAEVVDDDIAVNCVGPSTAVRTPGASQLIPDTFPTEPVEYLAETVLA
MCHLPAADRTGLVAFSLHYPWSQGLPVHTLDGSAVLPPLEPPATANPNIRPAGL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254986, Length=218, Percent_Identity=31.1926605504587, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=28.4584980237154, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4504505, Length=259, Percent_Identity=28.1853281853282, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI126723191, Length=205, Percent_Identity=28.2926829268293, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI19923817, Length=258, Percent_Identity=26.7441860465116, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI33667109, Length=212, Percent_Identity=27.3584905660377, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI5031737, Length=212, Percent_Identity=27.3584905660377, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI126723750, Length=256, Percent_Identity=26.171875, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI7706318, Length=195, Percent_Identity=29.2307692307692, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40254992, Length=233, Percent_Identity=28.3261802575107, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI7705925, Length=219, Percent_Identity=31.9634703196347, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI20149619, Length=254, Percent_Identity=27.1653543307087, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=206, Percent_Identity=32.5242718446602, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082100, Length=278, Percent_Identity=29.4964028776978, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI2367175, Length=205, Percent_Identity=32.6829268292683, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787905, Length=221, Percent_Identity=31.6742081447964, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1788459, Length=290, Percent_Identity=27.9310344827586, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082160, Length=232, Percent_Identity=29.7413793103448, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI2367365, Length=207, Percent_Identity=32.3671497584541, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789208, Length=221, Percent_Identity=26.6968325791855, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789378, Length=214, Percent_Identity=31.3084112149533, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=219, Percent_Identity=31.5068493150685, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17531453, Length=213, Percent_Identity=35.2112676056338, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI193204405, Length=269, Percent_Identity=34.2007434944238, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17560676, Length=237, Percent_Identity=30.379746835443, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562910, Length=213, Percent_Identity=35.6807511737089, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562908, Length=242, Percent_Identity=31.8181818181818, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562906, Length=231, Percent_Identity=32.4675324675325, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=222, Percent_Identity=34.2342342342342, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17560220, Length=217, Percent_Identity=31.7972350230415, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17558628, Length=213, Percent_Identity=30.5164319248826, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=232, Percent_Identity=30.6034482758621, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17561402, Length=225, Percent_Identity=27.5555555555556, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=230, Percent_Identity=29.1304347826087, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17538480, Length=215, Percent_Identity=31.6279069767442, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=214, Percent_Identity=30.8411214953271, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71997099, Length=233, Percent_Identity=30.9012875536481, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=213, Percent_Identity=30.5164319248826, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=217, Percent_Identity=30.8755760368664, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI86565303, Length=262, Percent_Identity=31.2977099236641, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17555612, Length=274, Percent_Identity=28.1021897810219, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=217, Percent_Identity=30.8755760368664, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=212, Percent_Identity=30.6603773584906, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=220, Percent_Identity=29.5454545454545, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=214, Percent_Identity=26.6355140186916, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=222, Percent_Identity=31.5315315315315, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=232, Percent_Identity=29.7413793103448, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=225, Percent_Identity=29.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=243, Percent_Identity=25.1028806584362, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=29.0836653386454, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=218, Percent_Identity=28.8990825688073, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=206, Percent_Identity=26.6990291262136, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=241, Percent_Identity=26.1410788381743, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=203, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357673, Length=223, Percent_Identity=32.7354260089686, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI23397609, Length=211, Percent_Identity=33.175355450237, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357041, Length=208, Percent_Identity=30.7692307692308, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28571526, Length=208, Percent_Identity=31.25, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24644339, Length=210, Percent_Identity=29.5238095238095, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI18859837, Length=282, Percent_Identity=28.7234042553192, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355319, Length=257, Percent_Identity=26.8482490272374, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31119; Mature: 30987

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLLSGKTALVTGSSRGIGRAIAQRLAAEGATVVVTARSHTPSPSVRAGAAAALPGTIG
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHCCCCCHH
ETVEMIEAAGGTAYGVAADLEDQQQRLRLIDEVLDRTGRLDILVNNAGYADYSVVEHMAM
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHH
DTFDRTVEHYLRTPFVLSQCAIPHMRTQGAGWIVNIGSVTGMAPVRPFREYNKSSGDVVY
HHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCEEE
ASVKAALHRFTQGLAAEVVDDDIAVNCVGPSTAVRTPGASQLIPDTFPTEPVEYLAETVL
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AMCHLPAADRTGLVAFSLHYPWSQGLPVHTLDGSAVLPPLEPPATANPNIRPAGL
HHHCCCCCCCCCEEEEEEECCCCCCCEEEECCCCEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRLLSGKTALVTGSSRGIGRAIAQRLAAEGATVVVTARSHTPSPSVRAGAAAALPGTIG
CCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHCCCCCHH
ETVEMIEAAGGTAYGVAADLEDQQQRLRLIDEVLDRTGRLDILVNNAGYADYSVVEHMAM
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHH
DTFDRTVEHYLRTPFVLSQCAIPHMRTQGAGWIVNIGSVTGMAPVRPFREYNKSSGDVVY
HHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCEEE
ASVKAALHRFTQGLAAEVVDDDIAVNCVGPSTAVRTPGASQLIPDTFPTEPVEYLAETVL
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AMCHLPAADRTGLVAFSLHYPWSQGLPVHTLDGSAVLPPLEPPATANPNIRPAGL
HHHCCCCCCCCCEEEEEEECCCCCCCEEEECCCCEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]