Click here to switch to the map view.

The map label for this gene is camD [H]

Identifier: 108797288

GI number: 108797288

Start: 345192

End: 346298

Strand: Reverse

Name: camD [H]

Synonym: Mmcs_0308

Alternate gene names: 108797288

Gene position: 346298-345192 (Counterclockwise)

Preceding gene: 108797289

Following gene: 108797287

Centisome position: 6.07

GC content: 68.11

Gene sequence:

>1107_bases
GTGTTCGAAGGACGGATCGCGCGTTTCGACGCACCCGGACAACCGTTCGTGATCGACACCGTCGACCTGGCCGACGTCGG
TCCGGGCGAGATCCTCGTCAAGGTCACGCGGACCAACATCTGCGGGTCGGATCTGCACGCCTGGCACGGCACCTTCGCCA
CCCGCGGACTCGGCGGGCAACTGCCCACCGTCCTCGGCCACGAGATGGTGGGTGCCGTCGCCGCACTGGGCGACGGCGTC
ACCGCGGATTCGAACGGCGTGCCGTTGGCCGAGGGCACCCGCGTGGTGTTCCCCTACTTCTACTCGTGCCACCGCTGCCG
CAACTGTCTGCTGGGGCGGCGGGGTGCCTGCCTGAACCTGAAGATGGCGATGCTCGGGCGTGCCGACGAACCGCCGTACT
TCGTCGGTGGGTACGGCGACTACTACCTGCTACCTGCGGGCGCAGTGGTCTACACCGTGCCCGACGTGGTGTCCGACGAG
GTCGCCTCGGGTGCGAATTGTGCACTCTCACAGGTCATGTACGGGCTCGAGCGGGTGGACCAGCAACTCGGTGAGGTGGT
GGTGGTGCAGGGCGCCGGGGCGCTCGGCCTGTACGCGGTCGCCGTGGCCAAGGCCCGCGGCGCCGCCAAGGTCATCGCGA
TCGACGGAGTCCCCGAGCGTCTGGAGTTGGCGACGGCGTTCGGCGCCGACGCGGTCGTCGACATCACCGAGGCGACCACG
GTCAAGGACCGCGCGAAGATCGTGCGCACGCTGACCGACGGCCACGGCGCCGACGTGGTCGTCGAGGTCGTCGGCCACCC
CGCGGCCATCGACGAGGGCCTCAAACTGCTCGGTCAGTTCGGCCGTTACGTCGAGATCGGCAACATCAACATCGGCAAGA
CCTTCGAGTTCGACCCGTCGCGTTTCGTATTCGGCCACAAGACGATGGTCGGTGTCTCGCTCTACGACCCAGCCGTGCTG
TCGCGGGCCCTGACGTTCCTCGAACAGCACCAGGACCACCTGCCGCTGGACCGTCTCGCCGCGGCGCACTACCCGCTCGA
CCACATCAACGAGGCATTCGCCGCCGCCGACGGCAAACGCGATGTCCGCGCGAGCATCATCCCCTGA

Upstream 100 bases:

>100_bases
CTTCGTCGACACACTGCCGAAGAACCCCAGCGGGAAGCTGCTCAAACGCGATCTGCGGCAACGGTTCAGCGCCGCCCACA
GCCACTGAGAGGGAACACCT

Downstream 100 bases:

>100_bases
TCGAGAAGGAATCCATGCACGACTACACCCGGAAGACCCTGTTCATCGACGGCCGCTGGGCGACCCCGGACGGCGGCGAC
GCGATCGAGGTCATCGACCC

Product: zinc-binding alcohol dehydrogenase

Products: L-sorbose; NADH; H+

Alternate protein names: FDEH [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MFEGRIARFDAPGQPFVIDTVDLADVGPGEILVKVTRTNICGSDLHAWHGTFATRGLGGQLPTVLGHEMVGAVAALGDGV
TADSNGVPLAEGTRVVFPYFYSCHRCRNCLLGRRGACLNLKMAMLGRADEPPYFVGGYGDYYLLPAGAVVYTVPDVVSDE
VASGANCALSQVMYGLERVDQQLGEVVVVQGAGALGLYAVAVAKARGAAKVIAIDGVPERLELATAFGADAVVDITEATT
VKDRAKIVRTLTDGHGADVVVEVVGHPAAIDEGLKLLGQFGRYVEIGNINIGKTFEFDPSRFVFGHKTMVGVSLYDPAVL
SRALTFLEQHQDHLPLDRLAAAHYPLDHINEAFAAADGKRDVRASIIP

Sequences:

>Translated_368_residues
MFEGRIARFDAPGQPFVIDTVDLADVGPGEILVKVTRTNICGSDLHAWHGTFATRGLGGQLPTVLGHEMVGAVAALGDGV
TADSNGVPLAEGTRVVFPYFYSCHRCRNCLLGRRGACLNLKMAMLGRADEPPYFVGGYGDYYLLPAGAVVYTVPDVVSDE
VASGANCALSQVMYGLERVDQQLGEVVVVQGAGALGLYAVAVAKARGAAKVIAIDGVPERLELATAFGADAVVDITEATT
VKDRAKIVRTLTDGHGADVVVEVVGHPAAIDEGLKLLGQFGRYVEIGNINIGKTFEFDPSRFVFGHKTMVGVSLYDPAVL
SRALTFLEQHQDHLPLDRLAAAHYPLDHINEAFAAADGKRDVRASIIP
>Mature_368_residues
MFEGRIARFDAPGQPFVIDTVDLADVGPGEILVKVTRTNICGSDLHAWHGTFATRGLGGQLPTVLGHEMVGAVAALGDGV
TADSNGVPLAEGTRVVFPYFYSCHRCRNCLLGRRGACLNLKMAMLGRADEPPYFVGGYGDYYLLPAGAVVYTVPDVVSDE
VASGANCALSQVMYGLERVDQQLGEVVVVQGAGALGLYAVAVAKARGAAKVIAIDGVPERLELATAFGADAVVDITEATT
VKDRAKIVRTLTDGHGADVVVEVVGHPAAIDEGLKLLGQFGRYVEIGNINIGKTFEFDPSRFVFGHKTMVGVSLYDPAVL
SRALTFLEQHQDHLPLDRLAAAHYPLDHINEAFAAADGKRDVRASIIP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=374, Percent_Identity=26.4705882352941, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI262073058, Length=374, Percent_Identity=26.4705882352941, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI156627571, Length=274, Percent_Identity=30.2919708029197, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI71565152, Length=378, Percent_Identity=24.8677248677249, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI71565154, Length=373, Percent_Identity=23.3243967828418, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87082125, Length=301, Percent_Identity=29.9003322259136, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1790045, Length=272, Percent_Identity=29.7794117647059, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786825, Length=276, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790718, Length=346, Percent_Identity=26.5895953757225, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787863, Length=303, Percent_Identity=28.7128712871287, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788073, Length=262, Percent_Identity=27.8625954198473, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081918, Length=234, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI226510992, Length=336, Percent_Identity=25.297619047619, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786552, Length=385, Percent_Identity=25.1948051948052, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788075, Length=316, Percent_Identity=24.0506329113924, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788407, Length=264, Percent_Identity=26.5151515151515, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=360, Percent_Identity=28.8888888888889, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=349, Percent_Identity=27.7936962750716, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI25146526, Length=360, Percent_Identity=25, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=24.8, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=264, Percent_Identity=31.8181818181818, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=323, Percent_Identity=28.1733746130031, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=294, Percent_Identity=30.952380952381, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=366, Percent_Identity=24.5901639344262, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=285, Percent_Identity=30.8771929824561, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=272, Percent_Identity=30.1470588235294, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=263, Percent_Identity=30.4182509505703, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=270, Percent_Identity=28.5185185185185, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=299, Percent_Identity=25.0836120401338, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=26.5415549597855, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17137530, Length=234, Percent_Identity=28.6324786324786, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737897, Length=227, Percent_Identity=29.5154185022026, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.14

Molecular weight: Translated: 39014; Mature: 39014

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEGRIARFDAPGQPFVIDTVDLADVGPGEILVKVTRTNICGSDLHAWHGTFATRGLGGQ
CCCCCEEEECCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCHHHHCCCHHHCCCCCC
LPTVLGHEMVGAVAALGDGVTADSNGVPLAEGTRVVFPYFYSCHRCRNCLLGRRGACLNL
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEE
KMAMLGRADEPPYFVGGYGDYYLLPAGAVVYTVPDVVSDEVASGANCALSQVMYGLERVD
EHHHHCCCCCCCEEECCCCCEEEECCCEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHH
QQLGEVVVVQGAGALGLYAVAVAKARGAAKVIAIDGVPERLELATAFGADAVVDITEATT
HHHCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCEEEEECCCHH
VKDRAKIVRTLTDGHGADVVVEVVGHPAAIDEGLKLLGQFGRYVEIGNINIGKTFEFDPS
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEECCCC
RFVFGHKTMVGVSLYDPAVLSRALTFLEQHQDHLPLDRLAAAHYPLDHINEAFAAADGKR
EEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCC
DVRASIIP
CCEEECCC
>Mature Secondary Structure
MFEGRIARFDAPGQPFVIDTVDLADVGPGEILVKVTRTNICGSDLHAWHGTFATRGLGGQ
CCCCCEEEECCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCHHHHCCCHHHCCCCCC
LPTVLGHEMVGAVAALGDGVTADSNGVPLAEGTRVVFPYFYSCHRCRNCLLGRRGACLNL
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEE
KMAMLGRADEPPYFVGGYGDYYLLPAGAVVYTVPDVVSDEVASGANCALSQVMYGLERVD
EHHHHCCCCCCCEEECCCCCEEEECCCEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHH
QQLGEVVVVQGAGALGLYAVAVAKARGAAKVIAIDGVPERLELATAFGADAVVDITEATT
HHHCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCEEEEECCCHH
VKDRAKIVRTLTDGHGADVVVEVVGHPAAIDEGLKLLGQFGRYVEIGNINIGKTFEFDPS
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEECCCC
RFVFGHKTMVGVSLYDPAVLSRALTFLEQHQDHLPLDRLAAAHYPLDHINEAFAAADGKR
EEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCC
DVRASIIP
CCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-iditol; NAD+

Specific reaction: L-iditol + NAD+ = L-sorbose + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334169; 3011733 [H]