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The map label for this gene is yxbG [H]

Identifier: 108797278

GI number: 108797278

Start: 335007

End: 335819

Strand: Direct

Name: yxbG [H]

Synonym: Mmcs_0298

Alternate gene names: 108797278

Gene position: 335007-335819 (Clockwise)

Preceding gene: 108797277

Following gene: 108797279

Centisome position: 5.87

GC content: 69.99

Gene sequence:

>813_bases
GTGACCGAACACATCGATCCGCCGGTGGCCGTCGTGACCGGGGCTTCTCGCGGAGCGGGCCGCGGTATCGCACGGGCGCT
CATCGCCGCCGGGTGGCGGGTGTACCTGACCGGCCGCACCGTCGACAGTCTGGGCGAGGGTTCGGTGGCGGTGCCGCTCG
ACCACCGGGACGACGCGGCGGTGGGCGCCTTGTTCACGCGGGTGGAGGACGAGGCTGGCCGGCTCGACCTGCTGGTCAAC
AACGCCGCCGCGGTCCATGACGCGTTGACGGGTCGAGACCCGTTCTGGCAGAAGCCGGTTGAGCTGGGCGACATTCTCGA
CGTCGGATTGCGGTCGTCCTATGTGGCGGCCTGGTACGCGGCGCCTCTGCTTCTGCGCGGTCCCCGGGGACTGATCGCGT
TCACGTCCTCGCCGGGATCGGTGTGCTACATGCACGGCCCGGCCTACGGCGCGCAGAAGGCGGGTGTCGACAAGATGGCG
GCCGATATGGCTGTCGACTTCCGCGGTACGCCGGTGCACACCGTCTCGATCTGGATGGGCATCCTGCTGACCGAGAAACT
GCGCGGTGCGTTCGACGGTAATCCGGATGGGCTGGCCGCGATGGCCGAGCACGCCGAGACGCCCGAATTCACCGGTCGGG
TGATCGATGCGCTCTACCGTGACCCGGCCCGCGAGTCGCTGAGCGGGCACACCGTGATCGGCGCGGAACTGGCTGCGCGC
TACGGGATCACCGACGAGGGCGGCAGGCAGCCGGTGTCACACCGCGGAATGCTGGGCGCGCCCCGGACGCCGAGTGACGT
GGTGGTCCGCTGA

Upstream 100 bases:

>100_bases
GTCCTGCTCCGAGTTGTCCGAGTCGATCGTCGAGGCGGTGCGTGCGGGCCGGCTGTCCATCGTGGACGAAACGGTGGACG
TCGCGCCGTAGTCTCGCCTG

Downstream 100 bases:

>100_bases
GCGAGCGGATCGCGGCGCTGGAACGGGCGAAGTCCGCCGCGGCGGCTGCGCAGGCACGCGCGACCGCGTTGCTGGACGAG
AAGCGCCGGGCCGCCGAGGC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTEHIDPPVAVVTGASRGAGRGIARALIAAGWRVYLTGRTVDSLGEGSVAVPLDHRDDAAVGALFTRVEDEAGRLDLLVN
NAAAVHDALTGRDPFWQKPVELGDILDVGLRSSYVAAWYAAPLLLRGPRGLIAFTSSPGSVCYMHGPAYGAQKAGVDKMA
ADMAVDFRGTPVHTVSIWMGILLTEKLRGAFDGNPDGLAAMAEHAETPEFTGRVIDALYRDPARESLSGHTVIGAELAAR
YGITDEGGRQPVSHRGMLGAPRTPSDVVVR

Sequences:

>Translated_270_residues
MTEHIDPPVAVVTGASRGAGRGIARALIAAGWRVYLTGRTVDSLGEGSVAVPLDHRDDAAVGALFTRVEDEAGRLDLLVN
NAAAVHDALTGRDPFWQKPVELGDILDVGLRSSYVAAWYAAPLLLRGPRGLIAFTSSPGSVCYMHGPAYGAQKAGVDKMA
ADMAVDFRGTPVHTVSIWMGILLTEKLRGAFDGNPDGLAAMAEHAETPEFTGRVIDALYRDPARESLSGHTVIGAELAAR
YGITDEGGRQPVSHRGMLGAPRTPSDVVVR
>Mature_269_residues
TEHIDPPVAVVTGASRGAGRGIARALIAAGWRVYLTGRTVDSLGEGSVAVPLDHRDDAAVGALFTRVEDEAGRLDLLVNN
AAAVHDALTGRDPFWQKPVELGDILDVGLRSSYVAAWYAAPLLLRGPRGLIAFTSSPGSVCYMHGPAYGAQKAGVDKMAA
DMAVDFRGTPVHTVSIWMGILLTEKLRGAFDGNPDGLAAMAEHAETPEFTGRVIDALYRDPARESLSGHTVIGAELAARY
GITDEGGRQPVSHRGMLGAPRTPSDVVVR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI209862901, Length=270, Percent_Identity=41.4814814814815, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI19923983, Length=270, Percent_Identity=41.4814814814815, Blast_Score=165, Evalue=4e-41,
Organism=Escherichia coli, GI1787335, Length=183, Percent_Identity=30.0546448087432, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787820, Length=185, Percent_Identity=30.2702702702703, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555612, Length=279, Percent_Identity=36.9175627240143, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71997099, Length=285, Percent_Identity=34.7368421052632, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI86565303, Length=285, Percent_Identity=31.2280701754386, Blast_Score=127, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28489; Mature: 28357

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHIDPPVAVVTGASRGAGRGIARALIAAGWRVYLTGRTVDSLGEGSVAVPLDHRDDAA
CCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHCCCCCEEEECCCCCCHH
VGALFTRVEDEAGRLDLLVNNAAAVHDALTGRDPFWQKPVELGDILDVGLRSSYVAAWYA
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHH
APLLLRGPRGLIAFTSSPGSVCYMHGPAYGAQKAGVDKMAADMAVDFRGTPVHTVSIWMG
HHHEEECCCCEEEEECCCCCEEEEECCCCCCHHCCHHHHHHHHEEECCCCCCHHHHHHHH
ILLTEKLRGAFDGNPDGLAAMAEHAETPEFTGRVIDALYRDPARESLSGHTVIGAELAAR
HHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCCEEEHHHHHHH
YGITDEGGRQPVSHRGMLGAPRTPSDVVVR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEHIDPPVAVVTGASRGAGRGIARALIAAGWRVYLTGRTVDSLGEGSVAVPLDHRDDAA
CCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHCCCCCEEEECCCCCCHH
VGALFTRVEDEAGRLDLLVNNAAAVHDALTGRDPFWQKPVELGDILDVGLRSSYVAAWYA
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHH
APLLLRGPRGLIAFTSSPGSVCYMHGPAYGAQKAGVDKMAADMAVDFRGTPVHTVSIWMG
HHHEEECCCCEEEEECCCCCEEEEECCCCCCHHCCHHHHHHHHEEECCCCCCHHHHHHHH
ILLTEKLRGAFDGNPDGLAAMAEHAETPEFTGRVIDALYRDPARESLSGHTVIGAELAAR
HHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCCEEEHHHHHHH
YGITDEGGRQPVSHRGMLGAPRTPSDVVVR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]