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The map label for this gene is fadI [H]

Identifier: 108797221

GI number: 108797221

Start: 267267

End: 268568

Strand: Direct

Name: fadI [H]

Synonym: Mmcs_0241

Alternate gene names: 108797221

Gene position: 267267-268568 (Clockwise)

Preceding gene: 108797216

Following gene: 108797223

Centisome position: 4.68

GC content: 69.12

Gene sequence:

>1302_bases
GTGGCTGACAGCAGAAGCATGCGGCGGGTCGCCGTGCTCGGCGGCAACCGGATACCGTTCGCCCGTTCCGACGGCGCCTA
CGCGAACGCGTCCAACCAGGACATGTTCACCGCGGCCCTGGGTGGGCTCGTCGACCGGTACCACCTGCAGGGCGAGAAGC
TCGGCGCCGTCATCGGCGGTGCGGTGCTCAAGCACAGCCGCGACTTCAACCTCATGCGGGAATGCGTACTCGGCAGCGCG
CTGTCGTCGTACACCCCCGCCTTCGACATCCAGCAGGCCTGCGGCACCGGTCTGCAGGCCGCCATCGCCGCGGCCGACGG
TATCGCTGCCGGACGCTACGAATCGGCGGCGGCAGGCGGGGTGGACACCGCATCGGACGCGCCCATCGCGCTGGGTGACG
ACCTGCGCAAAACCCTGCTGGGGCTGCGTCGCGCCAAGTCGAACGTCGACCGCCTCAAACTCGTCGGCAAGCTGCCCGCC
GCCGTGGGCATCCAGATCCCGGTCAACAGCGAACCGCGCACCGGCATGTCGATGGGTGAACACGCCGCCGTCACCGCCAA
GGAGATGGGCATCAAACGTGTCGACCAGGACGAGTTGGCCGCGGCCAGCCACCGCAACATGGCCGCCGCCTACGACCGTG
GCTTCTTCGACGATCTGGTGACGCCGTTCCTCGGCGTGTACCGCGACAACAACCTGCGCGCGGATTCGTCGGCCGAGAAA
CTGGCCAAGCTCAAGCCGGTGTTCGGCGTCCGCCACGGCGACGCCACCATGACCGCGGGCAACTCGACCCCGCTGACCGA
CGGCGCCTCGGTGGCGCTGCTGGCCTCTGAGGAGTGGGCGCAGCAGCATTCGATCGAACCGCTCGCCTACTACGTCGACG
GCGAGACCGCGGCGGTCGACTACGTCAACGGTCGCGACGGTCTGCTGATGGCGCCCACGTACGCGGTGCCGCGGCTGCTC
GCCCGCAACGGTCTGACGCTGCAGGACTTCGACTTCTACGAGATCCACGAGGCGTTCGCGTCGGTGGTGTTGGCGCACCT
GCAGGCGTGGGAGTCCGAGGAGTACTGCAAGGAACGCCTCGGCCTGGACAGCGCGCTGGGGTCCATCGACCGCTCGAAGC
TCAACGTCAACGGGTCGTCGCTGGCGGCCGGGCATCCCTTCGCCGCCACCGGCGGCCGCATCGTCGCGCAGTTGGCCAAA
CAGCTCGCCGAGAAGAAGAAGCAGACCGGTCAGCCGGTGCGCGGGCTCATCTCCATCTGCGCCGCGGGCGGGCAGGGCGT
GGCGGCCATCCTCGAGGCCTGA

Upstream 100 bases:

>100_bases
TTTCGTCTGCGGAGTGGAGGTCCCGCCTTGAACTTACTCCTGAGTAAGAACGGTGGGTAATATCGGGGATTAGATAACCG
GAACGACAGTGGAGGCAAAC

Downstream 100 bases:

>100_bases
GCGGGCCGGCGGGAAAAGTTCCGCGGAGCCGTGTAACGCCCGCCGATGCCGCGTCGATACACCTGATAGCTCCGTGTTGC
CGTCTGACCCCCCGACCCGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MADSRSMRRVAVLGGNRIPFARSDGAYANASNQDMFTAALGGLVDRYHLQGEKLGAVIGGAVLKHSRDFNLMRECVLGSA
LSSYTPAFDIQQACGTGLQAAIAAADGIAAGRYESAAAGGVDTASDAPIALGDDLRKTLLGLRRAKSNVDRLKLVGKLPA
AVGIQIPVNSEPRTGMSMGEHAAVTAKEMGIKRVDQDELAAASHRNMAAAYDRGFFDDLVTPFLGVYRDNNLRADSSAEK
LAKLKPVFGVRHGDATMTAGNSTPLTDGASVALLASEEWAQQHSIEPLAYYVDGETAAVDYVNGRDGLLMAPTYAVPRLL
ARNGLTLQDFDFYEIHEAFASVVLAHLQAWESEEYCKERLGLDSALGSIDRSKLNVNGSSLAAGHPFAATGGRIVAQLAK
QLAEKKKQTGQPVRGLISICAAGGQGVAAILEA

Sequences:

>Translated_433_residues
MADSRSMRRVAVLGGNRIPFARSDGAYANASNQDMFTAALGGLVDRYHLQGEKLGAVIGGAVLKHSRDFNLMRECVLGSA
LSSYTPAFDIQQACGTGLQAAIAAADGIAAGRYESAAAGGVDTASDAPIALGDDLRKTLLGLRRAKSNVDRLKLVGKLPA
AVGIQIPVNSEPRTGMSMGEHAAVTAKEMGIKRVDQDELAAASHRNMAAAYDRGFFDDLVTPFLGVYRDNNLRADSSAEK
LAKLKPVFGVRHGDATMTAGNSTPLTDGASVALLASEEWAQQHSIEPLAYYVDGETAAVDYVNGRDGLLMAPTYAVPRLL
ARNGLTLQDFDFYEIHEAFASVVLAHLQAWESEEYCKERLGLDSALGSIDRSKLNVNGSSLAAGHPFAATGGRIVAQLAK
QLAEKKKQTGQPVRGLISICAAGGQGVAAILEA
>Mature_432_residues
ADSRSMRRVAVLGGNRIPFARSDGAYANASNQDMFTAALGGLVDRYHLQGEKLGAVIGGAVLKHSRDFNLMRECVLGSAL
SSYTPAFDIQQACGTGLQAAIAAADGIAAGRYESAAAGGVDTASDAPIALGDDLRKTLLGLRRAKSNVDRLKLVGKLPAA
VGIQIPVNSEPRTGMSMGEHAAVTAKEMGIKRVDQDELAAASHRNMAAAYDRGFFDDLVTPFLGVYRDNNLRADSSAEKL
AKLKPVFGVRHGDATMTAGNSTPLTDGASVALLASEEWAQQHSIEPLAYYVDGETAAVDYVNGRDGLLMAPTYAVPRLLA
RNGLTLQDFDFYEIHEAFASVVLAHLQAWESEEYCKERLGLDSALGSIDRSKLNVNGSSLAAGHPFAATGGRIVAQLAKQ
LAEKKKQTGQPVRGLISICAAGGQGVAAILEA

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=434, Percent_Identity=38.7096774193548, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI167614485, Length=442, Percent_Identity=30.316742081448, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI4501853, Length=437, Percent_Identity=28.3752860411899, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI148539872, Length=431, Percent_Identity=27.6102088167053, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4557237, Length=435, Percent_Identity=27.1264367816092, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=36.1858190709046, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87082165, Length=437, Percent_Identity=30.2059496567506, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI1788554, Length=438, Percent_Identity=30.8219178082192, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787663, Length=440, Percent_Identity=28.8636363636364, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI48994986, Length=440, Percent_Identity=28.8636363636364, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17551802, Length=436, Percent_Identity=36.2385321100917, Blast_Score=254, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17535921, Length=444, Percent_Identity=28.3783783783784, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=434, Percent_Identity=28.3410138248848, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25147385, Length=436, Percent_Identity=26.3761467889908, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17535917, Length=361, Percent_Identity=22.1606648199446, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322031, Length=365, Percent_Identity=29.8630136986301, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6325229, Length=437, Percent_Identity=25.858123569794, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI17137578, Length=436, Percent_Identity=37.1559633027523, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI17648125, Length=441, Percent_Identity=28.3446712018141, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24655093, Length=436, Percent_Identity=26.8348623853211, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24640423, Length=441, Percent_Identity=26.3038548752834, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 45603; Mature: 45472

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSRSMRRVAVLGGNRIPFARSDGAYANASNQDMFTAALGGLVDRYHLQGEKLGAVIGG
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
AVLKHSRDFNLMRECVLGSALSSYTPAFDIQQACGTGLQAAIAAADGIAAGRYESAAAGG
HHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCHHCCCC
VDTASDAPIALGDDLRKTLLGLRRAKSNVDRLKLVGKLPAAVGIQIPVNSEPRTGMSMGE
CCCCCCCCEECCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
HAAVTAKEMGIKRVDQDELAAASHRNMAAAYDRGFFDDLVTPFLGVYRDNNLRADSSAEK
HHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHH
LAKLKPVFGVRHGDATMTAGNSTPLTDGASVALLASEEWAQQHSIEPLAYYVDGETAAVD
HHHHHHHHEEECCCCEEECCCCCCCCCCCCEEEEECHHHHHHCCCCCEEEEECCCEEEEE
YVNGRDGLLMAPTYAVPRLLARNGLTLQDFDFYEIHEAFASVVLAHLQAWESEEYCKERL
EECCCCCEEECCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GLDSALGSIDRSKLNVNGSSLAAGHPFAATGGRIVAQLAKQLAEKKKQTGQPVRGLISIC
CHHHHHCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AAGGQGVAAILEA
HCCCCCHHHHCCC
>Mature Secondary Structure 
ADSRSMRRVAVLGGNRIPFARSDGAYANASNQDMFTAALGGLVDRYHLQGEKLGAVIGG
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
AVLKHSRDFNLMRECVLGSALSSYTPAFDIQQACGTGLQAAIAAADGIAAGRYESAAAGG
HHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCHHCCCC
VDTASDAPIALGDDLRKTLLGLRRAKSNVDRLKLVGKLPAAVGIQIPVNSEPRTGMSMGE
CCCCCCCCEECCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
HAAVTAKEMGIKRVDQDELAAASHRNMAAAYDRGFFDDLVTPFLGVYRDNNLRADSSAEK
HHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHH
LAKLKPVFGVRHGDATMTAGNSTPLTDGASVALLASEEWAQQHSIEPLAYYVDGETAAVD
HHHHHHHHEEECCCCEEECCCCCCCCCCCCEEEEECHHHHHHCCCCCEEEEECCCEEEEE
YVNGRDGLLMAPTYAVPRLLARNGLTLQDFDFYEIHEAFASVVLAHLQAWESEEYCKERL
EECCCCCEEECCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GLDSALGSIDRSKLNVNGSSLAAGHPFAATGGRIVAQLAKQLAEKKKQTGQPVRGLISIC
CHHHHHCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AAGGQGVAAILEA
HCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA